Associations between physiological and neural measures of sensory reactivity in youth with autism / J. JUNG in Journal of Child Psychology and Psychiatry, 62-10 (October 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1183-1194 Titre : Associations between physiological and neural measures of sensory reactivity in youth with autism Type de document : Texte imprimé et/ou numérique Auteurs : J. JUNG, Auteur ; T. D. ZBOZINEK, Auteur ; K. K. CUMMINGS, Auteur ; F. H. WILHELM, Auteur ; Mirella DAPRETTO, Auteur ; M. G. CRASKE, Auteur ; Susan Y. BOOKHEIMER, Auteur ; S. A. GREEN, Auteur Article en page(s) : p.1183-1194 Langues : Anglais (eng) Mots-clés : Adolescent  Attention  Autism Spectrum Disorder  Autistic Disorder  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Autism spectrum disorders  fMRI  physiology  sensory over-responsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorder (ASD) commonly show sensory over-responsivity (SOR), an impairing condition related to over-reactive brain and behavioral responses to aversive stimuli. While individuals with ASD often show atypically high physiological arousal, it is unclear how this relates to sensory reactivity. We therefore investigated how physiological arousal relates to brain and behavioral indices of SOR, to inform understanding of the biological mechanisms underlying SOR and to determine whether physiological measures are associated with SOR-related brain responses. METHODS: Youth aged 8-18 (49 ASD; 30 age- and performance-IQ-matched typically developing (TD)) experienced mildly aversive tactile and auditory stimuli first during functional magnetic resonance imaging (N = 41 ASD, 26 TD) and then during skin conductance (SCR) (N = 48 ASD, 28 TD) and heart rate (HR) measurements (N = 48 ASD, 30 TD). Parents reported on their children's SOR severity. RESULTS: Autism Spectrum Disorder youth overall displayed greater SCR to aversive sensory stimulation than TD youth and greater baseline HR. Within ASD, higher SOR was associated with higher mean HR across all stimuli after controlling for baseline HR. Furthermore, the ASD group overall, and the ASD-high-SOR group in particular, showed reduced HR deceleration/greater acceleration to sensory stimulation compared to the TD group. Both SCR and HR were associated with brain responses to sensory stimulation in regions previously associated with SOR and sensory regulation. CONCLUSIONS: Autism Spectrum Disorder youth displayed heightened physiological arousal to mildly aversive sensory stimulation, with HR responses in particular showing associations with brain and behavioral measures of SOR. These results have implications for using psychophysiological measures to assess SOR, particularly in individuals with ASD who cannot undergo MRI. En ligne : http://dx.doi.org/10.1111/jcpp.13387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Associations between physiological and neural measures of sensory reactivity in youth with autism [Texte imprimé et/ou numérique] / J. JUNG, Auteur ; T. D. ZBOZINEK, Auteur ; K. K. CUMMINGS, Auteur ; F. H. WILHELM, Auteur ; Mirella DAPRETTO, Auteur ; M. G. CRASKE, Auteur ; Susan Y. BOOKHEIMER, Auteur ; S. A. GREEN, Auteur . - p.1183-1194. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-10 (October 2021) . - p.1183-1194 Mots-clés : Adolescent  Attention  Autism Spectrum Disorder  Autistic Disorder  Brain/diagnostic imaging  Child  Humans  Magnetic Resonance Imaging  Autism spectrum disorders  fMRI  physiology  sensory over-responsivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with Autism Spectrum Disorder (ASD) commonly show sensory over-responsivity (SOR), an impairing condition related to over-reactive brain and behavioral responses to aversive stimuli. While individuals with ASD often show atypically high physiological arousal, it is unclear how this relates to sensory reactivity. We therefore investigated how physiological arousal relates to brain and behavioral indices of SOR, to inform understanding of the biological mechanisms underlying SOR and to determine whether physiological measures are associated with SOR-related brain responses. METHODS: Youth aged 8-18 (49 ASD; 30 age- and performance-IQ-matched typically developing (TD)) experienced mildly aversive tactile and auditory stimuli first during functional magnetic resonance imaging (N = 41 ASD, 26 TD) and then during skin conductance (SCR) (N = 48 ASD, 28 TD) and heart rate (HR) measurements (N = 48 ASD, 30 TD). Parents reported on their children's SOR severity. RESULTS: Autism Spectrum Disorder youth overall displayed greater SCR to aversive sensory stimulation than TD youth and greater baseline HR. Within ASD, higher SOR was associated with higher mean HR across all stimuli after controlling for baseline HR. Furthermore, the ASD group overall, and the ASD-high-SOR group in particular, showed reduced HR deceleration/greater acceleration to sensory stimulation compared to the TD group. Both SCR and HR were associated with brain responses to sensory stimulation in regions previously associated with SOR and sensory regulation. CONCLUSIONS: Autism Spectrum Disorder youth displayed heightened physiological arousal to mildly aversive sensory stimulation, with HR responses in particular showing associations with brain and behavioral measures of SOR. These results have implications for using psychophysiological measures to assess SOR, particularly in individuals with ASD who cannot undergo MRI. En ligne : http://dx.doi.org/10.1111/jcpp.13387 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

How sex of children with autism spectrum disorders and access to treatment services relates to parental stress / Irina ZAMORA in Autism Research and Treatment, 2014 (2014)  

Public ISBD [article]  inAutism Research and Treatment > 2014 (2014) Titre : How sex of children with autism spectrum disorders and access to treatment services relates to parental stress Type de document : Texte imprimé et/ou numérique Auteurs : Irina ZAMORA, Auteur ; E. K. HARLEY, Auteur ; S. A. GREEN, Auteur ; K. SMITH, Auteur ; M. D. KIPKE, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Parents of children with autism spectrum disorders (ASD) experience higher levels of stress in comparison to parents of neurotypical children and consequently are more susceptible to negative health and social outcomes (Dunn et al., 2001). However, less is known about how individual child characteristics impact stress levels in parents of children with ASD. In this study, we examined the relationship between individual characteristics (i.e., sex) of children with ASD and parental stress. Access to comprehensive treatment services was also examined as a contributing factor to parental stress. Parenting stress was higher for parents of girls than for parents of boys, and for parents of girls (but not boys) fewer services predicted higher parental distress. Findings highlight the importance of providing parents of girls with ASD with more tailored support. En ligne : http://dx.doi.org/10.1155/2014/721418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=332 [article] How sex of children with autism spectrum disorders and access to treatment services relates to parental stress [Texte imprimé et/ou numérique] / Irina ZAMORA, Auteur ; E. K. HARLEY, Auteur ; S. A. GREEN, Auteur ; K. SMITH, Auteur ; M. D. KIPKE, Auteur. Langues : Anglais (eng) in Autism Research and Treatment > 2014 (2014) Index. décimale : PER Périodiques Résumé : Parents of children with autism spectrum disorders (ASD) experience higher levels of stress in comparison to parents of neurotypical children and consequently are more susceptible to negative health and social outcomes (Dunn et al., 2001). However, less is known about how individual child characteristics impact stress levels in parents of children with ASD. In this study, we examined the relationship between individual characteristics (i.e., sex) of children with ASD and parental stress. Access to comprehensive treatment services was also examined as a contributing factor to parental stress. Parenting stress was higher for parents of girls than for parents of boys, and for parents of girls (but not boys) fewer services predicted higher parental distress. Findings highlight the importance of providing parents of girls with ASD with more tailored support. En ligne : http://dx.doi.org/10.1155/2014/721418 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=332

Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism / G. PATTERSON ; K. K. CUMMINGS ; J. JUNG ; M. E. CAKAR ; L. ABBAS ; S. Y. BOOKHEIMER ; M. DAPRETTO ; S. A. GREEN in Autism Research, 17-7 (July 2024)  

Public ISBD [article]  inAutism Research > 17-7 (July 2024) . - p.1328-1343 Titre : Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism Type de document : Texte imprimé et/ou numérique Auteurs : G. PATTERSON, Auteur ; K. K. CUMMINGS, Auteur ; J. JUNG, Auteur ; M. E. CAKAR, Auteur ; L. ABBAS, Auteur ; S. Y. BOOKHEIMER, Auteur ; M. DAPRETTO, Auteur ; S. A. GREEN, Auteur Article en page(s) : p.1328-1343 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Although aversive responses to sensory stimuli are common in autism spectrum disorder (ASD), it remains unknown whether the social relevance of aversive sensory inputs affects their processing. We used functional magnetic resonance imaging (fMRI) to investigate neural responses to mildly aversive nonsocial and social sensory stimuli as well as how sensory over-responsivity (SOR) severity relates to these responses. Participants included 21 ASD and 25 typically-developing (TD) youth, aged 8.6-18.0?years. Results showed that TD youth exhibited significant neural discrimination of socially relevant versus irrelevant aversive sensory stimuli, particularly in the amygdala and orbitofrontal cortex (OFC), regions that are crucial for sensory and social processing. In contrast, ASD youth showed reduced neural discrimination of social versus nonsocial stimuli in the amygdala and OFC, as well as overall greater neural responses to nonsocial compared with social stimuli. Moreover, higher SOR in ASD was associated with heightened responses in sensory-motor regions to socially-relevant stimuli. These findings further our understanding of the relationship between sensory and social processing in ASD, suggesting limited attention to the social relevance compared with aversiveness level of sensory input in ASD versus TD youth, particularly in ASD youth with higher SOR. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism [Texte imprimé et/ou numérique] / G. PATTERSON, Auteur ; K. K. CUMMINGS, Auteur ; J. JUNG, Auteur ; M. E. CAKAR, Auteur ; L. ABBAS, Auteur ; S. Y. BOOKHEIMER, Auteur ; M. DAPRETTO, Auteur ; S. A. GREEN, Auteur . - p.1328-1343. Langues : Anglais (eng) in Autism Research > 17-7 (July 2024) . - p.1328-1343 Index. décimale : PER Périodiques Résumé : Abstract Although aversive responses to sensory stimuli are common in autism spectrum disorder (ASD), it remains unknown whether the social relevance of aversive sensory inputs affects their processing. We used functional magnetic resonance imaging (fMRI) to investigate neural responses to mildly aversive nonsocial and social sensory stimuli as well as how sensory over-responsivity (SOR) severity relates to these responses. Participants included 21 ASD and 25 typically-developing (TD) youth, aged 8.6-18.0?years. Results showed that TD youth exhibited significant neural discrimination of socially relevant versus irrelevant aversive sensory stimuli, particularly in the amygdala and orbitofrontal cortex (OFC), regions that are crucial for sensory and social processing. In contrast, ASD youth showed reduced neural discrimination of social versus nonsocial stimuli in the amygdala and OFC, as well as overall greater neural responses to nonsocial compared with social stimuli. Moreover, higher SOR in ASD was associated with heightened responses in sensory-motor regions to socially-relevant stimuli. These findings further our understanding of the relationship between sensory and social processing in ASD, suggesting limited attention to the social relevance compared with aversiveness level of sensory input in ASD versus TD youth, particularly in ASD youth with higher SOR. En ligne : https://dx.doi.org/https://doi.org/10.1002/aur.3179 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

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