Assessing gender differences in autism spectrum disorder using the Gendered Autism Behavioral Scale (GABS): An exploratory study / Elaine B. CLARKE in Research in Autism Spectrum Disorders, 88 (October 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 88 (October 2021) . - 101844 Titre : Assessing gender differences in autism spectrum disorder using the Gendered Autism Behavioral Scale (GABS): An exploratory study Type de document : texte imprimé Auteurs : Elaine B. CLARKE, Auteur ; Laura HULL, Auteur ; Rachel LOOMES, Auteur ; Carolyn MCCORMICK, Auteur ; Stephen J. SHEINKOPF, Auteur ; William MANDY, Auteur Article en page(s) : 101844 Langues : Anglais (eng) Mots-clés : Gender  Sex  Diagnosis  ADOS  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Introduction Gendered differences in autism spectrum disorder (hereafter, ‘autism’) symptomatology, may contribute to delayed diagnoses for autistic females. The aim of this study was to develop a coding system, the Gendered Autism Behavioral Scale (GABS), to identify and measure hypothesized components of non-traditional autism phenotypes. Methods Two independent cohorts of autistic individuals completed modules 3 and 4 of the Autism Diagnostic Observation Schedule (ADOS, 2nd edition). Video-recorded ADOS administrations were coded using the GABS, and separate coding teams analyzed each cohort. Cohort 1 from the United Kingdom consisted of 22 males and 22 females, aged 9–15 years. Cohort 2 from the United States consisted of 40 males and 20 females, aged 4–59 years. Results The coders achieved acceptable inter-rater reliability both within and across coding teams. In exploratory analyses, gender differences between codes were assessed within cohorts. Within Cohort 1, there were significant gender differences, of a moderate size, on several individual items as well as the Managing Emotions subscale and the Total GABS score. Within Cohort 2, significant gender differences were found for two individual items. Conclusions This study demonstrated the feasibility of the GABS across different sites. Validity tests resulted in partial replication of gender differences on the GABS. Preliminary evidence from the GABS suggests that valuable data on hypothesized non-traditional autism phenotypes could be extracted from widely employed assessments such as the ADOS. Future work could capitalize on the GABS’ utility for secondary data analysis to study gender differences in ASD in larger, adequately powered samples. En ligne : https://doi.org/10.1016/j.rasd.2021.101844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Assessing gender differences in autism spectrum disorder using the Gendered Autism Behavioral Scale (GABS): An exploratory study [texte imprimé] / Elaine B. CLARKE, Auteur ; Laura HULL, Auteur ; Rachel LOOMES, Auteur ; Carolyn MCCORMICK, Auteur ; Stephen J. SHEINKOPF, Auteur ; William MANDY, Auteur . - 101844. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101844 Mots-clés : Gender  Sex  Diagnosis  ADOS  Autism spectrum disorder Index. décimale : PER Périodiques Résumé : Introduction Gendered differences in autism spectrum disorder (hereafter, ‘autism’) symptomatology, may contribute to delayed diagnoses for autistic females. The aim of this study was to develop a coding system, the Gendered Autism Behavioral Scale (GABS), to identify and measure hypothesized components of non-traditional autism phenotypes. Methods Two independent cohorts of autistic individuals completed modules 3 and 4 of the Autism Diagnostic Observation Schedule (ADOS, 2nd edition). Video-recorded ADOS administrations were coded using the GABS, and separate coding teams analyzed each cohort. Cohort 1 from the United Kingdom consisted of 22 males and 22 females, aged 9–15 years. Cohort 2 from the United States consisted of 40 males and 20 females, aged 4–59 years. Results The coders achieved acceptable inter-rater reliability both within and across coding teams. In exploratory analyses, gender differences between codes were assessed within cohorts. Within Cohort 1, there were significant gender differences, of a moderate size, on several individual items as well as the Managing Emotions subscale and the Total GABS score. Within Cohort 2, significant gender differences were found for two individual items. Conclusions This study demonstrated the feasibility of the GABS across different sites. Validity tests resulted in partial replication of gender differences on the GABS. Preliminary evidence from the GABS suggests that valuable data on hypothesized non-traditional autism phenotypes could be extracted from widely employed assessments such as the ADOS. Future work could capitalize on the GABS’ utility for secondary data analysis to study gender differences in ASD in larger, adequately powered samples. En ligne : https://doi.org/10.1016/j.rasd.2021.101844 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study / Carolyn MCCORMICK in Autism Research, 13-3 (March 2020)  

Public ISBD [article]  inAutism Research > 13-3 (March 2020) . - p.474-488 Titre : Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study Type de document : texte imprimé Auteurs : Carolyn MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur Article en page(s) : p.474-488 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study [texte imprimé] / Carolyn MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur . - p.474-488. Langues : Anglais (eng) in Autism Research > 13-3 (March 2020) . - p.474-488 Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Autism Treatment in the First Year of Life: A Pilot Study of Infant Start, a Parent-Implemented Intervention for Symptomatic Infants / Sally J. ROGERS in Journal of Autism and Developmental Disorders, 44-12 (December 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.2981-2995 Titre : Autism Treatment in the First Year of Life: A Pilot Study of Infant Start, a Parent-Implemented Intervention for Symptomatic Infants Type de document : texte imprimé Auteurs : Sally J. ROGERS, Auteur ; Laura VISMARA, Auteur ; Amy L. WAGNER, Auteur ; Carolyn MCCORMICK, Auteur ; Gregory YOUNG, Auteur ; Sally OZONOFF, Auteur Article en page(s) : p.2981-2995 Langues : Anglais (eng) Mots-clés : ASD  Infants  Early intervention  Parents  Early Start Denver Model Index. décimale : PER Périodiques Résumé : The goal of early autism screening is earlier treatment. We pilot-tested a 12-week, low-intensity treatment with seven symptomatic infants ages 7–15 months. Parents mastered the intervention and maintained skills after treatment ended. Four comparison groups were matched from a study of infant siblings. The treated group of infants was significantly more symptomatic than most of the comparison groups at 9 months of age but was significantly less symptomatic than the two most affected groups between 18 and 36 months. At 36 months, the treated group had much lower rates of both ASD and DQs under 70 than a similarly symptomatic group who did not enroll in the treatment study. It appears feasible to identify and enroll symptomatic infants in parent-implemented intervention before 12 months, and the pilot study outcomes are promising, but testing the treatment’s efficacy awaits a randomized trial. En ligne : http://dx.doi.org/10.1007/s10803-014-2202-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Autism Treatment in the First Year of Life: A Pilot Study of Infant Start, a Parent-Implemented Intervention for Symptomatic Infants [texte imprimé] / Sally J. ROGERS, Auteur ; Laura VISMARA, Auteur ; Amy L. WAGNER, Auteur ; Carolyn MCCORMICK, Auteur ; Gregory YOUNG, Auteur ; Sally OZONOFF, Auteur . - p.2981-2995. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-12 (December 2014) . - p.2981-2995 Mots-clés : ASD  Infants  Early intervention  Parents  Early Start Denver Model Index. décimale : PER Périodiques Résumé : The goal of early autism screening is earlier treatment. We pilot-tested a 12-week, low-intensity treatment with seven symptomatic infants ages 7–15 months. Parents mastered the intervention and maintained skills after treatment ended. Four comparison groups were matched from a study of infant siblings. The treated group of infants was significantly more symptomatic than most of the comparison groups at 9 months of age but was significantly less symptomatic than the two most affected groups between 18 and 36 months. At 36 months, the treated group had much lower rates of both ASD and DQs under 70 than a similarly symptomatic group who did not enroll in the treatment study. It appears feasible to identify and enroll symptomatic infants in parent-implemented intervention before 12 months, and the pilot study outcomes are promising, but testing the treatment’s efficacy awaits a randomized trial. En ligne : http://dx.doi.org/10.1007/s10803-014-2202-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Brief Report: Aggression and Stereotypic Behavior in Males with Fragile X Syndrome—Moderating Secondary Genes in a “Single Gene” Disorder / David HESSL in Journal of Autism and Developmental Disorders, 38-1 (January 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.184-189 Titre : Brief Report: Aggression and Stereotypic Behavior in Males with Fragile X Syndrome—Moderating Secondary Genes in a “Single Gene” Disorder Type de document : texte imprimé Auteurs : David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Flora TASSONE, Auteur ; Lisa CORDEIRO, Auteur ; Kami KOLDEWYN, Auteur ; Carolyn MCCORMICK, Auteur ; Cherie C. GREEN, Auteur ; Jacob WEGELIN, Auteur ; Jennifer YUHAS, Auteur Année de publication : 2008 Article en page(s) : p.184-189 Langues : Anglais (eng) Mots-clés : Serotonin-transporter Monoamine-oxidase-A Polymorphism 5-HTTLPR - MAOA -FMR1-gene Self-injurious-behavior Index. décimale : PER Périodiques Résumé : Although fragile X syndrome (FXS) is a single gene disorder with a well-described phenotype, it is not known why some individuals develop more significant maladaptive behaviors such as aggression or autistic symptoms. Here, we studied two candidate genes known to affect mood and aggression, the serotonin transporter (5-HTTLPR) and monoamine oxidase A (MAOA-VNTR) polymorphisms, in 50 males with FXS ages 8–24 years. Mothers and fathers of participants reported the frequency and severity of aggressive/destructive, self-injurious, and stereotypic behaviors. Polymorphism genotypes were unrelated to age and IQ. Results showed a significant effect of 5-HTTLPR genotype on aggressive/destructive and stereotypic behavior; males with FXS who were homozygous for the high-transcribing long (L/L) genotype had the most aggressive and destructive behavior, and individuals homozygous for the short (S/S) genotype had the least aggression. Those with the L/L genotype also had the highest levels of stereotypic behavior. There was no effect of MAOA-VNTR on behavior; however those with the high-activity, 4-repeat genotype were more likely to be taking SSRI or SNRI medication. This preliminary study prompts consideration of secondary genes that may modify behavioral phenotype expression in neurodevelopmental disorders, even those with a single gene etiology such as FXS. En ligne : http://dx.doi.org/10.1007/s10803-007-0365-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Brief Report: Aggression and Stereotypic Behavior in Males with Fragile X Syndrome—Moderating Secondary Genes in a “Single Gene” Disorder [texte imprimé] / David HESSL, Auteur ; Randi J. HAGERMAN, Auteur ; Flora TASSONE, Auteur ; Lisa CORDEIRO, Auteur ; Kami KOLDEWYN, Auteur ; Carolyn MCCORMICK, Auteur ; Cherie C. GREEN, Auteur ; Jacob WEGELIN, Auteur ; Jennifer YUHAS, Auteur . - 2008 . - p.184-189. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-1 (January 2008) . - p.184-189 Mots-clés : Serotonin-transporter Monoamine-oxidase-A Polymorphism 5-HTTLPR - MAOA -FMR1-gene Self-injurious-behavior Index. décimale : PER Périodiques Résumé : Although fragile X syndrome (FXS) is a single gene disorder with a well-described phenotype, it is not known why some individuals develop more significant maladaptive behaviors such as aggression or autistic symptoms. Here, we studied two candidate genes known to affect mood and aggression, the serotonin transporter (5-HTTLPR) and monoamine oxidase A (MAOA-VNTR) polymorphisms, in 50 males with FXS ages 8–24 years. Mothers and fathers of participants reported the frequency and severity of aggressive/destructive, self-injurious, and stereotypic behaviors. Polymorphism genotypes were unrelated to age and IQ. Results showed a significant effect of 5-HTTLPR genotype on aggressive/destructive and stereotypic behavior; males with FXS who were homozygous for the high-transcribing long (L/L) genotype had the most aggressive and destructive behavior, and individuals homozygous for the short (S/S) genotype had the least aggression. Those with the L/L genotype also had the highest levels of stereotypic behavior. There was no effect of MAOA-VNTR on behavior; however those with the high-activity, 4-repeat genotype were more likely to be taking SSRI or SNRI medication. This preliminary study prompts consideration of secondary genes that may modify behavioral phenotype expression in neurodevelopmental disorders, even those with a single gene etiology such as FXS. En ligne : http://dx.doi.org/10.1007/s10803-007-0365-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Brief Report: Factors Influencing Healthcare Satisfaction in Adults with Autism Spectrum Disorder / Alan H. GERBER in Journal of Autism and Developmental Disorders, 47-6 (June 2017)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1896-1903 Titre : Brief Report: Factors Influencing Healthcare Satisfaction in Adults with Autism Spectrum Disorder Type de document : texte imprimé Auteurs : Alan H. GERBER, Auteur ; Carolyn MCCORMICK, Auteur ; Todd P. LEVINE, Auteur ; Eric M. MORROW, Auteur ; Thomas F. ANDERS, Auteur ; Stephen J. SHEINKOPF, Auteur Article en page(s) : p.1896-1903 Langues : Anglais (eng) Mots-clés : ASD  Autism  Adult  Healthcare  Satisfaction Index. décimale : PER Périodiques Résumé : The current study investigated healthcare satisfaction and factors related to satisfaction in 92 adults with Autism Spectrum Disorder (ASD). Participants or their caregiver completed a survey about their experiences with primary care and specialty physicians. Respondents reported a high level of satisfaction with their healthcare. The only factor significantly associated with satisfaction was age, with participants under age 26 reporting significantly higher levels of satisfaction than participants above age 26. Participants under age 26 also were significantly more likely to live at home, have private health insurance, and have others making their healthcare decisions than participants above age 26. Results indicate that healthcare satisfaction can be high for adults with ASD that have good family and community support. En ligne : http://dx.doi.org/10.1007/s10803-017-3087-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 [article] Brief Report: Factors Influencing Healthcare Satisfaction in Adults with Autism Spectrum Disorder [texte imprimé] / Alan H. GERBER, Auteur ; Carolyn MCCORMICK, Auteur ; Todd P. LEVINE, Auteur ; Eric M. MORROW, Auteur ; Thomas F. ANDERS, Auteur ; Stephen J. SHEINKOPF, Auteur . - p.1896-1903. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1896-1903 Mots-clés : ASD  Autism  Adult  Healthcare  Satisfaction Index. décimale : PER Périodiques Résumé : The current study investigated healthcare satisfaction and factors related to satisfaction in 92 adults with Autism Spectrum Disorder (ASD). Participants or their caregiver completed a survey about their experiences with primary care and specialty physicians. Respondents reported a high level of satisfaction with their healthcare. The only factor significantly associated with satisfaction was age, with participants under age 26 reporting significantly higher levels of satisfaction than participants above age 26. Participants under age 26 also were significantly more likely to live at home, have private health insurance, and have others making their healthcare decisions than participants above age 26. Results indicate that healthcare satisfaction can be high for adults with ASD that have good family and community support. En ligne : http://dx.doi.org/10.1007/s10803-017-3087-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308

Diminished respiratory sinus arrhythmia response in infants later diagnosed with autism spectrum disorder / Carolyn MCCORMICK in Autism Research, 11-5 (May 2018)  

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Electrodermal and Behavioral Responses of Children With Autism Spectrum Disorders to Sensory and Repetitive Stimuli / Carolyn MCCORMICK in Autism Research, 7-4 (August 2014)  

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Extending the Parent-Delivered Early Start Denver Model to Young Children with Fragile X Syndrome / Laurie A. VISMARA in Journal of Autism and Developmental Disorders, 49-3 (March 2019)  

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Preliminary Findings of a Telehealth Approach to Parent Training in Autism / Laurie A. VISMARA in Journal of Autism and Developmental Disorders, 43-12 (December 2013)  

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Sensitivity to audio-visual synchrony and its relation to language abilities in children with and without ASD / Giulia RIGHI in Autism Research, 11-4 (April 2018)  

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Sensory symptoms in children with autism spectrum disorder, other developmental disorders and typical development: A longitudinal study / Carolyn MCCORMICK in Autism, 20-5 (July 2016)  

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Telehealth Parent Training in the Early Start Denver Model: Results From a Randomized Controlled Study / Laurie A. VISMARA in Focus on Autism and Other Developmental Disabilities, 33-2 (June 2018)  

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