Adaptive behavior in autism: Minimal clinically important differences on the Vineland?II / Christopher H. CHATHAM in Autism Research, 11-2 (February 2018)  

Public ISBD [article]  inAutism Research > 11-2 (February 2018) . - p.270-283 Titre : Adaptive behavior in autism: Minimal clinically important differences on the Vineland?II Type de document : Texte imprimé et/ou numérique Auteurs : Christopher H. CHATHAM, Auteur ; K. I. TAYLOR, Auteur ; Tony CHARMAN, Auteur ; X. Liogier D'ARDHUY, Auteur ; E. EULE, Auteur ; A. FEDELE, Auteur ; A. Y. HARDAN, Auteur ; E. LOTH, Auteur ; L. MURTAGH, Auteur ; M. del Valle RUBIDO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; J. SEVIGNY, Auteur ; L. SIKICH, Auteur ; L. SNYDER, Auteur ; J. E. TILLMANN, Auteur ; Pamela VENTOLA, Auteur ; Karen WALTON-BOWEN, Auteur ; P. P. WANG, Auteur ; T. WILLGOSS, Auteur ; Federico BOLOGNANI, Auteur Année de publication : 2018 Article en page(s) : p.270-283 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with persistent impairments in adaptive abilities across multiple domains. These social, personal, and communicative impairments become increasingly pronounced with development, and are present regardless of IQ. The Vineland Adaptive Behavior Scales, Second Edition (Vineland?II) is the most commonly used instrument for quantifying these impairments, but minimal clinically important differences (MCIDs) on Vineland?II scores have not been rigorously established in ASD. We pooled data from several consortia/registries (EU?AIMS LEAP study, ABIDE?I, ABIDE?II, INFOR, Simons Simplex Collection and Autism Treatment Network [ATN]) and clinical investigations and trials (Stanford, Yale, Roche) resulting in a data set of over 9,000 individuals with ASD. Two approaches were used to estimate MCIDs: distribution?based methods and anchor?based methods. Distribution?based MCID [d?MCID] estimates included the standard error of the measurement, as well as one?fifth and one?half of the covariate?adjusted standard deviation (both cross?sectionally and longitudinally). Anchor?based MCID [a?MCID] estimates include the slope of linear regression of clinician ratings of severity on the Vineland?II score, the slope of linear regression of clinician ratings of longitudinal improvement category on Vineland?II change, the Vineland?II change score maximally differentiating clinical impressions of minimal versus no improvement, and equipercentile equating. Across strata, the Vineland?II Adaptive Behavior Composite standardized score MCID estimates range from 2.01 to 3.2 for distribution?based methods, and from 2.42 to 3.75 for sample?size?weighted anchor?based methods. Lower Vineland?II standardized score MCID estimates were observed for younger and more cognitively impaired populations. These MCID estimates enable users of Vineland?II to assess both the statistical and clinical significance of any observed change. Autism Res 2018, 11: 270–283. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The Vineland Adaptive Behavior Scales (2nd edition; Vineland?II) is the most widely used scale for assessing day?to?day “adaptive” skills. Yet, it is unknown how much Vineland?II scores must change for those changes to be regarded as clinically significant. We pooled data from over 9,000 individuals with ASD to show that changes of 2–3.75 points on the Vineland?II Composite score represent the “minimal clinically?important difference.” These estimates will help evaluate the benefits of potential new treatments for ASD. En ligne : https://doi.org/10.1002/aur.1874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 [article] Adaptive behavior in autism: Minimal clinically important differences on the Vineland?II [Texte imprimé et/ou numérique] / Christopher H. CHATHAM, Auteur ; K. I. TAYLOR, Auteur ; Tony CHARMAN, Auteur ; X. Liogier D'ARDHUY, Auteur ; E. EULE, Auteur ; A. FEDELE, Auteur ; A. Y. HARDAN, Auteur ; E. LOTH, Auteur ; L. MURTAGH, Auteur ; M. del Valle RUBIDO, Auteur ; Antonia SAN JOSE CACERES, Auteur ; J. SEVIGNY, Auteur ; L. SIKICH, Auteur ; L. SNYDER, Auteur ; J. E. TILLMANN, Auteur ; Pamela VENTOLA, Auteur ; Karen WALTON-BOWEN, Auteur ; P. P. WANG, Auteur ; T. WILLGOSS, Auteur ; Federico BOLOGNANI, Auteur . - 2018 . - p.270-283. Langues : Anglais (eng) in Autism Research > 11-2 (February 2018) . - p.270-283 Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is associated with persistent impairments in adaptive abilities across multiple domains. These social, personal, and communicative impairments become increasingly pronounced with development, and are present regardless of IQ. The Vineland Adaptive Behavior Scales, Second Edition (Vineland?II) is the most commonly used instrument for quantifying these impairments, but minimal clinically important differences (MCIDs) on Vineland?II scores have not been rigorously established in ASD. We pooled data from several consortia/registries (EU?AIMS LEAP study, ABIDE?I, ABIDE?II, INFOR, Simons Simplex Collection and Autism Treatment Network [ATN]) and clinical investigations and trials (Stanford, Yale, Roche) resulting in a data set of over 9,000 individuals with ASD. Two approaches were used to estimate MCIDs: distribution?based methods and anchor?based methods. Distribution?based MCID [d?MCID] estimates included the standard error of the measurement, as well as one?fifth and one?half of the covariate?adjusted standard deviation (both cross?sectionally and longitudinally). Anchor?based MCID [a?MCID] estimates include the slope of linear regression of clinician ratings of severity on the Vineland?II score, the slope of linear regression of clinician ratings of longitudinal improvement category on Vineland?II change, the Vineland?II change score maximally differentiating clinical impressions of minimal versus no improvement, and equipercentile equating. Across strata, the Vineland?II Adaptive Behavior Composite standardized score MCID estimates range from 2.01 to 3.2 for distribution?based methods, and from 2.42 to 3.75 for sample?size?weighted anchor?based methods. Lower Vineland?II standardized score MCID estimates were observed for younger and more cognitively impaired populations. These MCID estimates enable users of Vineland?II to assess both the statistical and clinical significance of any observed change. Autism Res 2018, 11: 270–283. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary The Vineland Adaptive Behavior Scales (2nd edition; Vineland?II) is the most widely used scale for assessing day?to?day “adaptive” skills. Yet, it is unknown how much Vineland?II scores must change for those changes to be regarded as clinically significant. We pooled data from over 9,000 individuals with ASD to show that changes of 2–3.75 points on the Vineland?II Composite score represent the “minimal clinically?important difference.” These estimates will help evaluate the benefits of potential new treatments for ASD. En ligne : https://doi.org/10.1002/aur.1874 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334

Correction to: Psychometric Validation of the Autism Impact Measure (AIM) / R. HOUGHTON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2571 Titre : Correction to: Psychometric Validation of the Autism Impact Measure (AIM) Type de document : Texte imprimé et/ou numérique Auteurs : R. HOUGHTON, Auteur ; B. MONZ, Auteur ; K. LAW, Auteur ; G. LOSS, Auteur ; S. LE SCOUILLER, Auteur ; F. DE VRIES, Auteur ; T. WILLGOSS, Auteur Article en page(s) : p.2571 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The article Psychometric Validation of the Autism Impact Measure (AIM), written by Richard Houghton, Brigitta Monz, Kiely Law, Georg Loss, Stephanie Le Scouiller, Frank de Vries and Tom Willgoss was originally published electronically on the publisher's internet portal (currently SpringerLink) on 09 April 2019 without open access.With the author(s)' decision to opt for Open Choice the copyright of the article changed on May 2019 to (c) The Author(s) 2019 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. En ligne : https://dx.doi.org/10.1007/s10803-019-04076-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Correction to: Psychometric Validation of the Autism Impact Measure (AIM) [Texte imprimé et/ou numérique] / R. HOUGHTON, Auteur ; B. MONZ, Auteur ; K. LAW, Auteur ; G. LOSS, Auteur ; S. LE SCOUILLER, Auteur ; F. DE VRIES, Auteur ; T. WILLGOSS, Auteur . - p.2571. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2571 Index. décimale : PER Périodiques Résumé : The article Psychometric Validation of the Autism Impact Measure (AIM), written by Richard Houghton, Brigitta Monz, Kiely Law, Georg Loss, Stephanie Le Scouiller, Frank de Vries and Tom Willgoss was originally published electronically on the publisher's internet portal (currently SpringerLink) on 09 April 2019 without open access.With the author(s)' decision to opt for Open Choice the copyright of the article changed on May 2019 to (c) The Author(s) 2019 and the article is forthwith distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made. En ligne : https://dx.doi.org/10.1007/s10803-019-04076-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

Development of a patient-centered conceptual model of the impact of living with autism spectrum disorder / F. MCDOUGALL in Autism, 22-8 (November 2018)  

Public ISBD [article]  inAutism > 22-8 (November 2018) . - p.953-969 Titre : Development of a patient-centered conceptual model of the impact of living with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : F. MCDOUGALL, Auteur ; T. WILLGOSS, Auteur ; S. HWANG, Auteur ; Federico BOLOGNANI, Auteur ; L. MURTAGH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; D. ROFAIL, Auteur Article en page(s) : p.953-969 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  conceptual model  qualitative research Index. décimale : PER Périodiques Résumé : The aim of this study was to generate a patient-centered conceptual model of the impact of living with autism spectrum disorder, which can be used to support the selection of outcome measures for clinical trials. Following an initial literature review to identify preliminary concepts and inform an interview guide, in-depth face-to-face interviews were conducted with adolescents and adults with autism spectrum disorder (IQ 70) (n = 10), as well as parents of children, adolescents, and adults with autism spectrum disorder (IQ 70) (n = 26). Data were analyzed using established qualitative research methods. The resultant conceptual model contains three interrelated domains reflecting core symptoms of autism spectrum disorder (communication deficits, socialization deficits, and restrictive, repetitive patterns of behavior), three domains reflecting associated symptoms of autism spectrum disorder (physical, cognitive, and emotional/behavioral), and three domains representing the impacts of living with autism spectrum disorder (impacts on activities of daily living, school/work, and social life). Interview respondents also cited social communication deficits as priority targets for new treatments. The conceptual model provides a patient-centered perspective of relevant concepts of autism spectrum disorder from the perspectives of people with autism spectrum disorder and their parents and offers a valuable tool for identifying valid patient-centered outcome measures for future clinical trials. En ligne : http://dx.doi.org/10.1177/1362361317718987 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Development of a patient-centered conceptual model of the impact of living with autism spectrum disorder [Texte imprimé et/ou numérique] / F. MCDOUGALL, Auteur ; T. WILLGOSS, Auteur ; S. HWANG, Auteur ; Federico BOLOGNANI, Auteur ; L. MURTAGH, Auteur ; Evdokia ANAGNOSTOU, Auteur ; D. ROFAIL, Auteur . - p.953-969. Langues : Anglais (eng) in Autism > 22-8 (November 2018) . - p.953-969 Mots-clés : autism spectrum disorder  conceptual model  qualitative research Index. décimale : PER Périodiques Résumé : The aim of this study was to generate a patient-centered conceptual model of the impact of living with autism spectrum disorder, which can be used to support the selection of outcome measures for clinical trials. Following an initial literature review to identify preliminary concepts and inform an interview guide, in-depth face-to-face interviews were conducted with adolescents and adults with autism spectrum disorder (IQ 70) (n = 10), as well as parents of children, adolescents, and adults with autism spectrum disorder (IQ 70) (n = 26). Data were analyzed using established qualitative research methods. The resultant conceptual model contains three interrelated domains reflecting core symptoms of autism spectrum disorder (communication deficits, socialization deficits, and restrictive, repetitive patterns of behavior), three domains reflecting associated symptoms of autism spectrum disorder (physical, cognitive, and emotional/behavioral), and three domains representing the impacts of living with autism spectrum disorder (impacts on activities of daily living, school/work, and social life). Interview respondents also cited social communication deficits as priority targets for new treatments. The conceptual model provides a patient-centered perspective of relevant concepts of autism spectrum disorder from the perspectives of people with autism spectrum disorder and their parents and offers a valuable tool for identifying valid patient-centered outcome measures for future clinical trials. En ligne : http://dx.doi.org/10.1177/1362361317718987 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Psychometric Validation of the Autism Impact Measure (AIM) / R. HOUGHTON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2559-2570 Titre : Psychometric Validation of the Autism Impact Measure (AIM) Type de document : Texte imprimé et/ou numérique Auteurs : R. HOUGHTON, Auteur ; B. MONZ, Auteur ; K. LAW, Auteur ; G. LOSS, Auteur ; S. LE SCOUILLER, Auteur ; F. DE VRIES, Auteur ; T. WILLGOSS, Auteur Article en page(s) : p.2559-2570 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Outcome  Psychometric validation  Symptoms  Treatment Index. décimale : PER Périodiques Résumé : The Autism impact measure (AIM) is a caregiver-reported questionnaire assessing autism symptom frequency and impact in children, previously shown to have good test-retest reliability, convergent validity and structural validity. This study extended previous work by exploring the AIM's ability to discriminate between 'known-groups' of children, and estimating thresholds for clinically important responses. Data were collected online and electronically on computer and mobile devices; hence, it was also possible to confirm other psychometric properties of the AIM in this format. This study provides confirmatory and additional psychometric validation of the AIM. The AIM offers a valid, quick and inexpensive method for caregivers to report core symptoms of autism spectrum disorder (ASD) including communication deficits, difficulties with social interactions and repetitive behaviors. En ligne : https://dx.doi.org/10.1007/s10803-019-04011-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] Psychometric Validation of the Autism Impact Measure (AIM) [Texte imprimé et/ou numérique] / R. HOUGHTON, Auteur ; B. MONZ, Auteur ; K. LAW, Auteur ; G. LOSS, Auteur ; S. LE SCOUILLER, Auteur ; F. DE VRIES, Auteur ; T. WILLGOSS, Auteur . - p.2559-2570. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2559-2570 Mots-clés : Autism spectrum disorder  Outcome  Psychometric validation  Symptoms  Treatment Index. décimale : PER Périodiques Résumé : The Autism impact measure (AIM) is a caregiver-reported questionnaire assessing autism symptom frequency and impact in children, previously shown to have good test-retest reliability, convergent validity and structural validity. This study extended previous work by exploring the AIM's ability to discriminate between 'known-groups' of children, and estimating thresholds for clinically important responses. Data were collected online and electronically on computer and mobile devices; hence, it was also possible to confirm other psychometric properties of the AIM in this format. This study provides confirmatory and additional psychometric validation of the AIM. The AIM offers a valid, quick and inexpensive method for caregivers to report core symptoms of autism spectrum disorder (ASD) including communication deficits, difficulties with social interactions and repetitive behaviors. En ligne : https://dx.doi.org/10.1007/s10803-019-04011-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

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