[article]
| Titre : |
Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort |
| Type de document : |
Texte imprimé et/ou numérique |
| Auteurs : |
Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; M. FRANCHINI, Auteur ; Susan E. BRYSON, Auteur ; T. VAILLANCOURT, Auteur ; V. ARMSTRONG, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur |
| Article en page(s) : |
p.1435-1443 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Autism Spectrum Disorder/epidemiology Autistic Disorder Child Child, Preschool Cohort Studies Humans Infant Prospective Studies Siblings Autism spectrum disorder early detection high-risk studies longitudinal studies |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Although early autism spectrum disorder (ASD) detection strategies tend to focus on differences at a point in time, behavioral symptom trajectories may also be informative. METHODS: Developmental trajectories of early signs of ASD were examined in younger siblings of children diagnosed with ASD (n?=?499) and infants with no family history of ASD (n?=?177). Participants were assessed using the Autism Observation Scale for Infants (AOSI) from 6 to 18?months. Diagnostic outcomes were determined at age 3?years blind to previous assessments. RESULTS: Semiparametric group-based modeling using AOSI scores identified three distinct trajectories: Group 1 ('Low', n?=?435, 64.3%) was characterized by a low level and stable evolution of ASD signs, group 2 ('Intermediate', n?=?180, 26.6%) had intermediate and stable levels, and group 3 ('Inclining', n?=?61, 9.3%) had higher and progressively elevated levels of ASD signs. Among younger siblings, ASD rates at age 3 varied by trajectory of early signs and were highest in the Inclining group, membership in which was highly specific (94.5%) but poorly sensitive (28.5%) to ASD. Children with ASD assigned to the inclining trajectory had more severe symptoms at age 3, but developmental and adaptive functioning did not differ by trajectory membership. CONCLUSIONS: These prospective data emphasize variable early-onset patterns and the importance of a multipronged approach to early surveillance and screening for ASD. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.13417 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 |
in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1435-1443
[article] Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort [Texte imprimé et/ou numérique] / Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; Lori-Ann R. SACREY, Auteur ; M. FRANCHINI, Auteur ; Susan E. BRYSON, Auteur ; T. VAILLANCOURT, Auteur ; V. ARMSTRONG, Auteur ; E. DUKU, Auteur ; P. SZATMARI, Auteur ; W. ROBERTS, Auteur ; C. RONCADIN, Auteur . - p.1435-1443. Langues : Anglais ( eng) in Journal of Child Psychology and Psychiatry > 62-12 (December 2021) . - p.1435-1443
| Mots-clés : |
Autism Spectrum Disorder/epidemiology Autistic Disorder Child Child, Preschool Cohort Studies Humans Infant Prospective Studies Siblings Autism spectrum disorder early detection high-risk studies longitudinal studies |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Although early autism spectrum disorder (ASD) detection strategies tend to focus on differences at a point in time, behavioral symptom trajectories may also be informative. METHODS: Developmental trajectories of early signs of ASD were examined in younger siblings of children diagnosed with ASD (n?=?499) and infants with no family history of ASD (n?=?177). Participants were assessed using the Autism Observation Scale for Infants (AOSI) from 6 to 18?months. Diagnostic outcomes were determined at age 3?years blind to previous assessments. RESULTS: Semiparametric group-based modeling using AOSI scores identified three distinct trajectories: Group 1 ('Low', n?=?435, 64.3%) was characterized by a low level and stable evolution of ASD signs, group 2 ('Intermediate', n?=?180, 26.6%) had intermediate and stable levels, and group 3 ('Inclining', n?=?61, 9.3%) had higher and progressively elevated levels of ASD signs. Among younger siblings, ASD rates at age 3 varied by trajectory of early signs and were highest in the Inclining group, membership in which was highly specific (94.5%) but poorly sensitive (28.5%) to ASD. Children with ASD assigned to the inclining trajectory had more severe symptoms at age 3, but developmental and adaptive functioning did not differ by trajectory membership. CONCLUSIONS: These prospective data emphasize variable early-onset patterns and the importance of a multipronged approach to early surveillance and screening for ASD. |
| En ligne : |
http://dx.doi.org/10.1111/jcpp.13417 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 |
|
Symptom trajectories in the first 18 months and autism risk in a prospective high-risk cohort in Journal of Child Psychology and Psychiatry, 62-12 (December 2021)
