Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children / Cynthia E. ROGERS in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 38 p. Titre : Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children Type de document : texte imprimé Auteurs : Cynthia E. ROGERS, Auteur ; Rachel E. LEAN, Auteur ; Muriah D. WHEELOCK, Auteur ; Christopher D. SMYSER, Auteur Année de publication : 2018 Article en page(s) : 38 p. Langues : Anglais (eng) Mots-clés : Functional connectivity  Magnetic resonance imaging  Neurodevelopmental disorders  Prematurity  Structural connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite advances in antenatal and neonatal care, preterm birth remains a leading cause of neurological disabilities in children. Infants born prematurely, particularly those delivered at the earliest gestational ages, commonly demonstrate increased rates of impairment across multiple neurodevelopmental domains. Indeed, the current literature establishes that preterm birth is a leading risk factor for cerebral palsy, is associated with executive function deficits, increases risk for impaired receptive and expressive language skills, and is linked with higher rates of co-occurring attention deficit hyperactivity disorder, anxiety, and autism spectrum disorders. These same infants also demonstrate elevated rates of aberrant cerebral structural and functional connectivity, with persistent changes evident across advanced magnetic resonance imaging modalities as early as the neonatal period. Emerging findings from cross-sectional and longitudinal investigations increasingly suggest that aberrant connectivity within key functional networks and white matter tracts may underlie the neurodevelopmental impairments common in this population. MAIN BODY: This review begins by highlighting the elevated rates of neurodevelopmental disorders across domains in this clinical population, describes the patterns of aberrant structural and functional connectivity common in prematurely-born infants and children, and then reviews the increasingly established body of literature delineating the relationship between these brain abnormalities and adverse neurodevelopmental outcomes. We also detail important, typically understudied, clinical, and social variables that may influence these relationships among preterm children, including heritability and psychosocial risks. CONCLUSION: Future work in this domain should continue to leverage longitudinal evaluations of preterm infants which include both neuroimaging and detailed serial neurodevelopmental assessments to further characterize relationships between imaging measures and impairment, information necessary for advancing our understanding of modifiable risk factors underlying these disorders and best practices for improving neurodevelopmental trajectories in this high-risk clinical population. En ligne : http://dx.doi.org/10.1186/s11689-018-9253-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Aberrant structural and functional connectivity and neurodevelopmental impairment in preterm children [texte imprimé] / Cynthia E. ROGERS, Auteur ; Rachel E. LEAN, Auteur ; Muriah D. WHEELOCK, Auteur ; Christopher D. SMYSER, Auteur . - 2018 . - 38 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 38 p. Mots-clés : Functional connectivity  Magnetic resonance imaging  Neurodevelopmental disorders  Prematurity  Structural connectivity Index. décimale : PER Périodiques Résumé : BACKGROUND: Despite advances in antenatal and neonatal care, preterm birth remains a leading cause of neurological disabilities in children. Infants born prematurely, particularly those delivered at the earliest gestational ages, commonly demonstrate increased rates of impairment across multiple neurodevelopmental domains. Indeed, the current literature establishes that preterm birth is a leading risk factor for cerebral palsy, is associated with executive function deficits, increases risk for impaired receptive and expressive language skills, and is linked with higher rates of co-occurring attention deficit hyperactivity disorder, anxiety, and autism spectrum disorders. These same infants also demonstrate elevated rates of aberrant cerebral structural and functional connectivity, with persistent changes evident across advanced magnetic resonance imaging modalities as early as the neonatal period. Emerging findings from cross-sectional and longitudinal investigations increasingly suggest that aberrant connectivity within key functional networks and white matter tracts may underlie the neurodevelopmental impairments common in this population. MAIN BODY: This review begins by highlighting the elevated rates of neurodevelopmental disorders across domains in this clinical population, describes the patterns of aberrant structural and functional connectivity common in prematurely-born infants and children, and then reviews the increasingly established body of literature delineating the relationship between these brain abnormalities and adverse neurodevelopmental outcomes. We also detail important, typically understudied, clinical, and social variables that may influence these relationships among preterm children, including heritability and psychosocial risks. CONCLUSION: Future work in this domain should continue to leverage longitudinal evaluations of preterm infants which include both neuroimaging and detailed serial neurodevelopmental assessments to further characterize relationships between imaging measures and impairment, information necessary for advancing our understanding of modifiable risk factors underlying these disorders and best practices for improving neurodevelopmental trajectories in this high-risk clinical population. En ligne : http://dx.doi.org/10.1186/s11689-018-9253-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years / Rachel E. LEAN in Journal of Child Psychology and Psychiatry, 61-2 (February 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.157-166 Titre : Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years Type de document : texte imprimé Auteurs : Rachel E. LEAN, Auteur ; Christina N. LESSOV-SHLAGGAR, Auteur ; Emily D. GERSTEIN, Auteur ; Tara A. SMYSER, Auteur ; Rachel A. PAUL, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur Article en page(s) : p.157-166 Langues : Anglais (eng) Mots-clés : Prematurity  latent profile analysis  neurodevelopment  psychiatric impairments Index. décimale : PER Périodiques Résumé : BACKGROUND: Very preterm (VPT; <30 weeks gestation) children are a heterogeneous group, yet the co-occurrence of psychiatric and neurodevelopmental impairments remains unclear. Moreover, the clinical and socio-environmental factors that promote resilient developmental outcomes among VPT children are poorly understood. METHODS: One hundred and twenty five children (85 VPT and 40 full-term) underwent neurodevelopmental evaluation at age 5-years. Parents and teachers completed measures of internalizing, externalizing, attention-deficit/hyperactivity (ADHD), and autism symptoms. Psychiatric and neurodevelopmental measures were analyzed using Latent Profile Analysis. Multinomial regression examined the extent that infant, sociodemographic, and family factors, collected prospectively from birth to follow-up, independently differentiated resilient and impaired children. RESULTS: Four latent profiles were identified, including a Typically Developing Group which represented 27.1% of the VPT group and 65.0% of the full-term group, an At-Risk Group with mild psychiatric and neurodevelopmental problems (VPT 44.7%, full-term 22.5%), a Psychiatric Group with moderate-to-severe psychiatric ratings (VPT 12.9%, full-term 10.0%), and a school-based Inattentive/Hyperactive Group (VPT 15.3%, full-term 2.5%). Clinical diagnoses were highest among the Psychiatric Group (80%). Factors that differentiated resilient and impaired subgroups of VPT children included prolonged exposure to maternal psychosocial distress (p En ligne : http://dx.doi.org/10.1111/jcpp.13116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415 [article] Maternal and family factors differentiate profiles of psychiatric impairments in very preterm children at age 5-years [texte imprimé] / Rachel E. LEAN, Auteur ; Christina N. LESSOV-SHLAGGAR, Auteur ; Emily D. GERSTEIN, Auteur ; Tara A. SMYSER, Auteur ; Rachel A. PAUL, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur . - p.157-166. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-2 (February 2020) . - p.157-166 Mots-clés : Prematurity  latent profile analysis  neurodevelopment  psychiatric impairments Index. décimale : PER Périodiques Résumé : BACKGROUND: Very preterm (VPT; <30 weeks gestation) children are a heterogeneous group, yet the co-occurrence of psychiatric and neurodevelopmental impairments remains unclear. Moreover, the clinical and socio-environmental factors that promote resilient developmental outcomes among VPT children are poorly understood. METHODS: One hundred and twenty five children (85 VPT and 40 full-term) underwent neurodevelopmental evaluation at age 5-years. Parents and teachers completed measures of internalizing, externalizing, attention-deficit/hyperactivity (ADHD), and autism symptoms. Psychiatric and neurodevelopmental measures were analyzed using Latent Profile Analysis. Multinomial regression examined the extent that infant, sociodemographic, and family factors, collected prospectively from birth to follow-up, independently differentiated resilient and impaired children. RESULTS: Four latent profiles were identified, including a Typically Developing Group which represented 27.1% of the VPT group and 65.0% of the full-term group, an At-Risk Group with mild psychiatric and neurodevelopmental problems (VPT 44.7%, full-term 22.5%), a Psychiatric Group with moderate-to-severe psychiatric ratings (VPT 12.9%, full-term 10.0%), and a school-based Inattentive/Hyperactive Group (VPT 15.3%, full-term 2.5%). Clinical diagnoses were highest among the Psychiatric Group (80%). Factors that differentiated resilient and impaired subgroups of VPT children included prolonged exposure to maternal psychosocial distress (p En ligne : http://dx.doi.org/10.1111/jcpp.13116 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=415

Maternal intelligence quotient (IQ) predicts IQ and language in very preterm children at age 5 years / Rachel E. LEAN in Journal of Child Psychology and Psychiatry, 59-2 (February 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.150-159 Titre : Maternal intelligence quotient (IQ) predicts IQ and language in very preterm children at age 5 years Type de document : texte imprimé Auteurs : Rachel E. LEAN, Auteur ; Rachel A. PAUL, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur Article en page(s) : p.150-159 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Sociodemographic factors are linked to cognitive outcomes in children born very preterm (VPT; ≤30 weeks gestation). The influence of maternal intellectual ability, a heritable trait, is unknown. Also undetermined is the extent to which associations between maternal and child intellectual ability vary according to parenting behaviors that target cognitive stimulation in the home. Methods At age 5 years, 84 VPT and 38 demographically matched full‐term (FT) children underwent neurodevelopmental assessment. Children's intellectual ability was assessed using The Wechsler Preschool Primary Scale of Intelligence‐III, and language was assessed with the Clinical Evaluation of Language Fundamentals Preschool‐2. The Wechsler Test of Adult Reading estimated maternal intellectual ability. The StimQ‐Preschool questionnaire provided a measure of cognitive stimulation in the home. Linear mixed‐effects models examined independent effects and interactions between maternal intellectual ability and cognitive stimulation on children's outcomes. Results After covariate adjustment, maternal intellectual ability was associated with child intellectual (p < .001) and language (p = .002) abilities. Stronger associations were observed in FT mother–child dyads (B = .63, p = .04) than VPT dyads (B = .42, p = .01). Mothers of VPT children reported lower levels of Parental Involvement in Developmental Advance (p = .007) and Parental Verbal Responsiveness (p = .04). Group differences in Parental Involvement in Developmental Advance, but not Parental Verbal Responsivity, persisted after adjusting for social background (p = .03). There was no evidence of an interaction between maternal intellectual ability and Parental Involvement in Developmental Advance (p = .34). Instead, maternal intellectual ability (p < .001) and Parental Involvement in Developmental Advance (p = .05) independently predicted VPT children's outcomes. Conclusions Maternal intellectual ability is an important trait linked to VPT and FT children's intellectual and language outcomes. Prematurity increases variation in the heritability of intellectual ability and shifts children from the expected range based on maternal ability. Parental involvement in activities that help children master new skills may promote cognitive development in VPT children born to mothers of lower intellectual ability. En ligne : https://doi.org/10.1111/jcpp.12810 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Maternal intelligence quotient (IQ) predicts IQ and language in very preterm children at age 5 years [texte imprimé] / Rachel E. LEAN, Auteur ; Rachel A. PAUL, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur . - p.150-159. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-2 (February 2018) . - p.150-159 Index. décimale : PER Périodiques Résumé : Background Sociodemographic factors are linked to cognitive outcomes in children born very preterm (VPT; ≤30 weeks gestation). The influence of maternal intellectual ability, a heritable trait, is unknown. Also undetermined is the extent to which associations between maternal and child intellectual ability vary according to parenting behaviors that target cognitive stimulation in the home. Methods At age 5 years, 84 VPT and 38 demographically matched full‐term (FT) children underwent neurodevelopmental assessment. Children's intellectual ability was assessed using The Wechsler Preschool Primary Scale of Intelligence‐III, and language was assessed with the Clinical Evaluation of Language Fundamentals Preschool‐2. The Wechsler Test of Adult Reading estimated maternal intellectual ability. The StimQ‐Preschool questionnaire provided a measure of cognitive stimulation in the home. Linear mixed‐effects models examined independent effects and interactions between maternal intellectual ability and cognitive stimulation on children's outcomes. Results After covariate adjustment, maternal intellectual ability was associated with child intellectual (p < .001) and language (p = .002) abilities. Stronger associations were observed in FT mother–child dyads (B = .63, p = .04) than VPT dyads (B = .42, p = .01). Mothers of VPT children reported lower levels of Parental Involvement in Developmental Advance (p = .007) and Parental Verbal Responsiveness (p = .04). Group differences in Parental Involvement in Developmental Advance, but not Parental Verbal Responsivity, persisted after adjusting for social background (p = .03). There was no evidence of an interaction between maternal intellectual ability and Parental Involvement in Developmental Advance (p = .34). Instead, maternal intellectual ability (p < .001) and Parental Involvement in Developmental Advance (p = .05) independently predicted VPT children's outcomes. Conclusions Maternal intellectual ability is an important trait linked to VPT and FT children's intellectual and language outcomes. Prematurity increases variation in the heritability of intellectual ability and shifts children from the expected range based on maternal ability. Parental involvement in activities that help children master new skills may promote cognitive development in VPT children born to mothers of lower intellectual ability. En ligne : https://doi.org/10.1111/jcpp.12810 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

Socioeconomic disadvantage and parental mood/affective problems links negative parenting and executive dysfunction in children born very preterm / Rachel E. LEAN in Development and Psychopathology, 35-3 (August 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-3 (August 2023) . - p.1092-1107 Titre : Socioeconomic disadvantage and parental mood/affective problems links negative parenting and executive dysfunction in children born very preterm Type de document : texte imprimé Auteurs : Rachel E. LEAN, Auteur ; Emily D. GERSTEIN, Auteur ; Tara A. SMYSER, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur Article en page(s) : p.1092-1107 Langues : Anglais (eng) Mots-clés : executive function  parenting  poverty  prematurity Index. décimale : PER Périodiques Résumé : Poverty increases the risk of poorer executive function (EF) in children born full-term (FT). Stressors associated with poverty, including variability in parenting behavior, may explain links between poverty and poorer EF, but this remains unclear for children born very preterm (VPT). We examine socioeconomic and parental psychosocial adversity on parenting behavior, and whether these factors independently or jointly influence EF in children born VPT. At age five years, 154 children (VPT = 88, FT = 66) completed parent-child interaction and EF tasks. Parental sensitivity, intrusiveness, cognitive stimulation, and positive and negative regard were coded with the Parent-Child Interaction Rating Scale. Socioeconomic adversity spanned maternal demographic stressors, Income-to-Needs ratio, and Area Deprivation Index. Parents completed measures of depression, anxiety, inattention/hyperactivity, parenting stress, and social-communication interaction (SCI) problems. Parental SCI problems were associated with parenting behavior in parents of children born VPT, whereas socioeconomic adversity was significant in parents of FT children. Negative parenting behaviors, but not positive parenting behaviors, were related to child EF. This association was explained by parental depression/anxiety symptoms and socioeconomic adversity. Results persisted after adjustment for parent and child IQ. Findings may inform research on dyadic interventions that embed treatment for parental mood/affective symptoms and SCI problems to improve childhood EF. En ligne : http://dx.doi.org/10.1017/S0954579421000961 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510 [article] Socioeconomic disadvantage and parental mood/affective problems links negative parenting and executive dysfunction in children born very preterm [texte imprimé] / Rachel E. LEAN, Auteur ; Emily D. GERSTEIN, Auteur ; Tara A. SMYSER, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur . - p.1092-1107. Langues : Anglais (eng) in Development and Psychopathology > 35-3 (August 2023) . - p.1092-1107 Mots-clés : executive function  parenting  poverty  prematurity Index. décimale : PER Périodiques Résumé : Poverty increases the risk of poorer executive function (EF) in children born full-term (FT). Stressors associated with poverty, including variability in parenting behavior, may explain links between poverty and poorer EF, but this remains unclear for children born very preterm (VPT). We examine socioeconomic and parental psychosocial adversity on parenting behavior, and whether these factors independently or jointly influence EF in children born VPT. At age five years, 154 children (VPT = 88, FT = 66) completed parent-child interaction and EF tasks. Parental sensitivity, intrusiveness, cognitive stimulation, and positive and negative regard were coded with the Parent-Child Interaction Rating Scale. Socioeconomic adversity spanned maternal demographic stressors, Income-to-Needs ratio, and Area Deprivation Index. Parents completed measures of depression, anxiety, inattention/hyperactivity, parenting stress, and social-communication interaction (SCI) problems. Parental SCI problems were associated with parenting behavior in parents of children born VPT, whereas socioeconomic adversity was significant in parents of FT children. Negative parenting behaviors, but not positive parenting behaviors, were related to child EF. This association was explained by parental depression/anxiety symptoms and socioeconomic adversity. Results persisted after adjustment for parent and child IQ. Findings may inform research on dyadic interventions that embed treatment for parental mood/affective symptoms and SCI problems to improve childhood EF. En ligne : http://dx.doi.org/10.1017/S0954579421000961 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=510

Translating RDoC to real-world impact in developmental psychopathology: A neurodevelopmental framework for application of mental health risk calculators / Leigha A. MACNEILL in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1665-1684 Titre : Translating RDoC to real-world impact in developmental psychopathology: A neurodevelopmental framework for application of mental health risk calculators Type de document : texte imprimé Auteurs : Leigha A. MACNEILL, Auteur ; Norrina B. ALLEN, Auteur ; Roshaye B. POLEON, Auteur ; Teresa VARGAS, Auteur ; K. Juston OSBORNE, Auteur ; Katherine S.F. DAMME, Auteur ; Deanna M. BARCH, Auteur ; Sheila KROGH-JESPERSEN, Auteur ; Ashley N. NIELSEN, Auteur ; Elizabeth S. NORTON, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur ; Joan L. LUBY, Auteur ; Vijay A. MITTAL, Auteur ; Lauren S. WAKSCHLAG, Auteur Article en page(s) : p.1665-1684 Langues : Anglais (eng) Mots-clés : developmental change  prevention/intervention  psychopathology  RDoC  risk calculator Index. décimale : PER Périodiques Résumé : The National Institute of Mental Health's Research Domain Criteria (RDoC) framework has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally based tools for clinical decision making has limited the real-world impact of the RDoC. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between the RDoC multiple units of analysis and developmental science. En ligne : http://dx.doi.org/10.1017/S0954579421000651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Translating RDoC to real-world impact in developmental psychopathology: A neurodevelopmental framework for application of mental health risk calculators [texte imprimé] / Leigha A. MACNEILL, Auteur ; Norrina B. ALLEN, Auteur ; Roshaye B. POLEON, Auteur ; Teresa VARGAS, Auteur ; K. Juston OSBORNE, Auteur ; Katherine S.F. DAMME, Auteur ; Deanna M. BARCH, Auteur ; Sheila KROGH-JESPERSEN, Auteur ; Ashley N. NIELSEN, Auteur ; Elizabeth S. NORTON, Auteur ; Christopher D. SMYSER, Auteur ; Cynthia E. ROGERS, Auteur ; Joan L. LUBY, Auteur ; Vijay A. MITTAL, Auteur ; Lauren S. WAKSCHLAG, Auteur . - p.1665-1684. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1665-1684 Mots-clés : developmental change  prevention/intervention  psychopathology  RDoC  risk calculator Index. décimale : PER Périodiques Résumé : The National Institute of Mental Health's Research Domain Criteria (RDoC) framework has prompted a paradigm shift from categorical psychiatric disorders to considering multiple levels of vulnerability for probabilistic risk of disorder. However, the lack of neurodevelopmentally based tools for clinical decision making has limited the real-world impact of the RDoC. Integration with developmental psychopathology principles and statistical methods actualize the clinical implementation of RDoC to inform neurodevelopmental risk. In this conceptual paper, we introduce the probabilistic mental health risk calculator as an innovation for such translation and lay out a research agenda for generating an RDoC- and developmentally informed paradigm that could be applied to predict a range of developmental psychopathologies from early childhood to young adulthood. We discuss methods that weigh the incremental utility for prediction based on intensity and burden of assessment, the addition of developmental change patterns, considerations for assessing outcomes, and integrative data approaches. Throughout, we illustrate the risk calculator approach with different neurodevelopmental pathways and phenotypes. Finally, we discuss real-world implementation of these methods for improving early identification and prevention of developmental psychopathology. We propose that mental health risk calculators can build a needed bridge between the RDoC multiple units of analysis and developmental science. En ligne : http://dx.doi.org/10.1017/S0954579421000651 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

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