Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 51-2 (February 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187 Titre : Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur Année de publication : 2010 Article en page(s) : p.180-187 Langues : Anglais (eng) Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20. Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S. Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant. Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941 [article] Chronic and acute stress, gender, and serotonin transporter gene–environment interactions predicting depression symptoms in youth [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Jake M. NAJMAN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nicholas A. HAZEL, Auteur . - 2010 . - p.180-187. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-2 (February 2010) . - p.180-187 Mots-clés : Depression serotonin-transporter-gene acute-stress chronic-stress gender-differences gene–environment-interactions Index. décimale : PER Périodiques Résumé : Background: Many recent studies of serotonin transporter gene by environment effects predicting depression have used stress assessments with undefined or poor psychometric methods, possibly contributing to wide variation in findings. The present study attempted to distinguish between effects of acute and chronic stress to predict depressive symptoms at age 20 among 346 youth varying in polymorphisms of the 5HTT gene who had been assessed at ages 15 and 20. Methods: Interview measures assessed major acute life events between 15 and 19, and multiple interviews and questionnaires with youths and their parents at youth age 15 provided an index of chronic family stress. Lg alleles were reclassified as S. Results: Chronic family stress at age 15 predicted higher depression scores at 20 among those with one or two S alleles, and the effects of genetic moderation were significant only for females. Gene–environment interactions with acute stress were nonsignificant. Conclusions: Careful measurement and separation of the effects of chronic and acute stress, and gender, are encouraged in the study of mechanisms of the stress–depression association. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02177.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=941

Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates / Constance HAMMEN in Journal of Child Psychology and Psychiatry, 49-4 (April 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440 Titre : Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates Type de document : Texte imprimé et/ou numérique Auteurs : Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur Année de publication : 2008 Article en page(s) : p.433–440 Langues : Anglais (eng) Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed. Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles. Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20. Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] Early onset recurrent subtype of adolescent depression: clinical and psychosocial correlates [Texte imprimé et/ou numérique] / Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur ; Danielle KEENAN-MILLER, Auteur ; Nathaniel R. HERR, Auteur . - 2008 . - p.433–440. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-4 (April 2008) . - p.433–440 Mots-clés : Adolescent-depression early-onset recurrent community-sample interpersonal-functioning longitudinal-studies Index. décimale : PER Périodiques Résumé : Background: Evaluated trajectories of adolescent depression and their correlates in a longitudinal study of a community sample: early onset (by age 15) with major depression (MDE) recurrence between 15 and 20; early onset with no recurrence; later onset of major depression after age 15 with and without recurrence by 20; and never-depressed. Methods: Eight-hundred sixteen youth were studied at age 15, and 699 were included at age 20, with diagnostic evaluations and assessments of functioning in major roles. Results: Youth with early onset and recurrent MDE differed from both those with early onset but nonrecurrent MDE and those with later onset-no recurrence in terms of clinical features, adolescent social functioning, and later psychosocial adjustment. The early onset recurrent depressed youth had more severe, chronic, suicidal depressions, greater anxiety comorbidity, worse social functioning at 15, and poorer psychosocial, especially social, outcomes at 20. Conclusions: Youth with depression by 15 with recurrence by age 20 may represent a high-risk group, with likely life-course-persistent depression and maladjustment. Community youth whose early depression does not recur by age 20, or who have onset with no recurrence after age 15, may have more benign and possibly limited depressions. Later onset with recurrence is also a group at risk for dysfunctional outcomes, requiring further follow-up. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2007.01850.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program / Aisha S. DICKERSON ; Tingju HSU ; Aseel AL-JADIRI ; Carlos A. CAMARGO ; Julie B. SCHWEITZER ; Coral L. SHUSTER ; Margaret R. KARAGAS ; Juliette C. MADAN ; Bibiana RESTREPO ; Rebecca J. SCHMIDT ; Claudia LUGO-CANDELAS ; Jenae NEIDERHISER ; Sheela SATHYANARAYANA ; Anne L. DUNLOP ; Patricia A. BRENNAN ; program collaborators for Environmental influences on Child Health OUTCOMES in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1651-1664 Titre : Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program Type de document : Texte imprimé et/ou numérique Auteurs : Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.1651-1664 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Examining the association between prenatal cannabis exposure and child autism traits: A multi-cohort investigation in the environmental influences on child health outcome program [Texte imprimé et/ou numérique] / Aisha S. DICKERSON, Auteur ; Tingju HSU, Auteur ; Aseel AL-JADIRI, Auteur ; Carlos A. CAMARGO, Auteur ; Julie B. SCHWEITZER, Auteur ; Coral L. SHUSTER, Auteur ; Margaret R. KARAGAS, Auteur ; Juliette C. MADAN, Auteur ; Bibiana RESTREPO, Auteur ; Rebecca J. SCHMIDT, Auteur ; Claudia LUGO-CANDELAS, Auteur ; Jenae NEIDERHISER, Auteur ; Sheela SATHYANARAYANA, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.1651-1664. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1651-1664 Index. décimale : PER Périodiques Résumé : Abstract This study examined the association between prenatal cannabis exposure and autism spectrum disorder (ASD) diagnoses and traits. A total sample of 11,570 children (ages 1-18; 53% male; 25% Hispanic; 60% White) from 34 cohorts of the National Institutes of Health-funded environmental influences on child health outcomes consortium were included in analyses. Results from generalized linear mixed models replicated previous studies showing that associations between prenatal cannabis exposure and ASD traits in children are not significant when controlling for relevant covariates, particularly tobacco exposure. Child biological sex did not moderate the association between prenatal cannabis exposure and ASD. In a large sample and measuring ASD traits continuously, there was no evidence that prenatal cannabis exposure increases the risk for ASD. This work helps to clarify previous mixed findings by addressing concerns about statistical power and ASD measurement. En ligne : https://doi.org/10.1002/aur.3185 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood / Brooke G. MCKENNA in Development and Psychopathology, 33-1 (February 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-1 (February 2021) . - p.122-134 Titre : HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood Type de document : Texte imprimé et/ou numérique Auteurs : Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.122-134 Langues : Anglais (eng) Mots-clés : HPA Axis  depression  fetal programming  polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442 [article] HPA-axis multilocus genetic profile score moderates the association between maternal prenatal perceived stress and offspring depression in early adulthood [Texte imprimé et/ou numérique] / Brooke G. MCKENNA, Auteur ; Constance HAMMEN, Auteur ; Patricia A. BRENNAN, Auteur . - p.122-134. Langues : Anglais (eng) in Development and Psychopathology > 33-1 (February 2021) . - p.122-134 Mots-clés : HPA Axis  depression  fetal programming  polygenic risk Index. décimale : PER Périodiques Résumé : Maternal stress during pregnancy can cause alterations to the fetal hypothalamus-pituitary-adrenal (HPA) axis, a phenomenon known as fetal programming that may have lasting effects on offspring outcomes, including depression. Evidence suggests that these effects may vary with respect to the offspring's genetic risk. Nonetheless, few studies have examined these effects into adulthood, when risk for depression onset is highest. The present study builds upon the extant literature by examining the interaction of maternal prenatal perceived stress (MPPS) and offspring HPA-axis polygenic risk to predict offspring depression in early adulthood. A total of 381 mother-child dyads participated in a prospective, longitudinal study that spanned from pregnancy until offspring were 20 years of age. Polygenic risk was defined by a multilocus genetic profile score (MGPS) that reflected the additive risk of three HPA-axis candidate genes. The results indicated that the interaction of MPPS and HPA-axis MGPS confers risk for offspring depression at age 20, in line with the differential susceptibility model. This interaction may be specific to prenatal stress, as maternal stress during early childhood did not interact with genetic risk to predict depression. These findings provide the first evidence that genetic variants that are associated with the HPA axis may act in a polygenic, additive fashion to moderate the association between fetal programming and adult depression. En ligne : http://dx.doi.org/10.1017/s0954579419001639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=442

Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology / Brooke G. MCKENNA in Development and Psychopathology, 36-4 (October 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-4 (October 2024) . - p.1890-1902 Titre : Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Brooke G. MCKENNA, Auteur ; Anna K. KNIGHT, Auteur ; Alicia K. SMITH, Auteur ; Elizabeth J. CORWIN, Auteur ; Sierra E. CARTER, Auteur ; Rohan H. C. PALMER, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur Article en page(s) : p.1890-1902 Langues : Anglais (eng) Mots-clés : child psychopathology  epigenetic aging  intergenerational  trauma Index. décimale : PER Périodiques Résumé : Although offspring of women exposed to childhood trauma exhibit elevated rates of psychopathology, many children demonstrate resilience to these intergenerational impacts. Among the variety of factors that likely contribute to resilience, epigenetic processes have been suggested to play an important role. The current study used a prospective design to test the novel hypothesis that offspring epigenetic aging - a measure of methylation differences that are associated with infant health outcomes - moderates the relationship between maternal exposure to childhood adversity and offspring symptomatology. Maternal childhood adversity was self-reported during pregnancy via the ACEs survey and the CTQ, which assessed total childhood trauma as well as maltreatment subtypes (i.e., emotional, physical, and sexual abuse). Offspring blood samples were collected at or shortly after birth and assayed on a DNA methylation microarray, and offspring symptomatology was assessed with the CBCL/1.5-5 when offspring were 2-4 years old. Results indicated that maternal childhood trauma, particularly sexual abuse, was predictive of offspring symptoms (ps = 0.003-0.03). However, the associations between maternal sexual abuse and offspring symptomatology were significantly attenuated in offspring with accelerated epigenetic aging. These findings further our understanding of how epigenetic processes may contribute to and attenuate the intergenerational link between stress and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579423001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539 [article] Infant epigenetic aging moderates the link between Black maternal childhood trauma and offspring symptoms of psychopathology [Texte imprimé et/ou numérique] / Brooke G. MCKENNA, Auteur ; Anna K. KNIGHT, Auteur ; Alicia K. SMITH, Auteur ; Elizabeth J. CORWIN, Auteur ; Sierra E. CARTER, Auteur ; Rohan H. C. PALMER, Auteur ; Anne L. DUNLOP, Auteur ; Patricia A. BRENNAN, Auteur . - p.1890-1902. Langues : Anglais (eng) in Development and Psychopathology > 36-4 (October 2024) . - p.1890-1902 Mots-clés : child psychopathology  epigenetic aging  intergenerational  trauma Index. décimale : PER Périodiques Résumé : Although offspring of women exposed to childhood trauma exhibit elevated rates of psychopathology, many children demonstrate resilience to these intergenerational impacts. Among the variety of factors that likely contribute to resilience, epigenetic processes have been suggested to play an important role. The current study used a prospective design to test the novel hypothesis that offspring epigenetic aging - a measure of methylation differences that are associated with infant health outcomes - moderates the relationship between maternal exposure to childhood adversity and offspring symptomatology. Maternal childhood adversity was self-reported during pregnancy via the ACEs survey and the CTQ, which assessed total childhood trauma as well as maltreatment subtypes (i.e., emotional, physical, and sexual abuse). Offspring blood samples were collected at or shortly after birth and assayed on a DNA methylation microarray, and offspring symptomatology was assessed with the CBCL/1.5-5 when offspring were 2-4 years old. Results indicated that maternal childhood trauma, particularly sexual abuse, was predictive of offspring symptoms (ps = 0.003-0.03). However, the associations between maternal sexual abuse and offspring symptomatology were significantly attenuated in offspring with accelerated epigenetic aging. These findings further our understanding of how epigenetic processes may contribute to and attenuate the intergenerational link between stress and psychopathology. En ligne : https://dx.doi.org/10.1017/S0954579423001232 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=539

Maternal depression and infant cortisol: influences of timing, comorbidity and treatment / Patricia A. BRENNAN in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)  

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Physiological attunement in mother–infant dyads at clinical high risk: The influence of maternal depression and positive parenting / Cassandra L. HENDRIX in Development and Psychopathology, 30-2 (May 2018)  

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Physiological regulation in infants of women with a mood disorder: examining associations with maternal symptoms and stress / Katrina C. JOHNSON in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)  

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Prenatal depression and risk of child autism-related traits among participants in the Environmental influences on Child Health Outcomes program / Lyndsay A. AVALOS in Autism Research, 16-9 (September 2023)  

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School-age social behavior and pragmatic language ability in children with prenatal serotonin reuptake inhibitor exposure / Erica L. SMEARMAN in Development and Psychopathology, 32-1 (February 2020)  

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Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study / Lisa R. STARR in Development and Psychopathology, 26-4 (Part 2) (November 2014)  

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Social stress and the oxytocin receptor gene interact to predict antisocial behavior in an at-risk cohort / Erica L. SMEARMAN in Development and Psychopathology, 27-1 (February 2015)  

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Transdiagnostic pathways from early social stress to psychopathology: a 20-year prospective study / C. C. CONWAY in Journal of Child Psychology and Psychiatry, 59-8 (August 2018)  

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