Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology / Edward D. BARKER in Journal of Child Psychology and Psychiatry, 59-4 (April 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.303-322 Titre : Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; E. WALTON, Auteur ; Charlotte A. M. CECIL, Auteur Article en page(s) : p.303-322 Langues : Anglais (eng) Mots-clés : DNA methylation  adolescence  childhood  developmental psychopathology  environmental risk  epigenetics  externalising problems  internalising problems Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) is a potential mechanism for propagating the effects of environmental exposures on child and adolescent mental health. In recent years, this field has experienced steady growth. METHODS: We provide a strategic review of the current child and adolescent literature to evaluate evidence for a mediating role of DNAm in the link between environmental risks and psychopathological outcomes, with a focus on internalising and externalising difficulties. RESULTS: Based on the studies presented, we conclude that there is preliminary evidence to support that (a) environmental factors, such as diet, neurotoxic exposures and stress, influence offspring DNAm, and that (b) variability in DNAm, in turn, is associated with child and adolescent psychopathology. Overall, very few studies have examined DNAm in relation to both exposures and outcomes, and almost all analyses have been correlational in nature. CONCLUSIONS: DNAm holds potential as a biomarker indexing both environmental risk exposure and vulnerability for child psychopathology. However, the extent to which it may represent a causal mediator is not clear. In future, collection of prospective risk exposure, DNAm and outcomes - as well as functional characterisation of epigenetic findings - will assist in determining the role of DNAm in the link between risk exposure and psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353 [article] Annual Research Review: DNA methylation as a mediator in the association between risk exposure and child and adolescent psychopathology [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; E. WALTON, Auteur ; Charlotte A. M. CECIL, Auteur . - p.303-322. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-4 (April 2018) . - p.303-322 Mots-clés : DNA methylation  adolescence  childhood  developmental psychopathology  environmental risk  epigenetics  externalising problems  internalising problems Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) is a potential mechanism for propagating the effects of environmental exposures on child and adolescent mental health. In recent years, this field has experienced steady growth. METHODS: We provide a strategic review of the current child and adolescent literature to evaluate evidence for a mediating role of DNAm in the link between environmental risks and psychopathological outcomes, with a focus on internalising and externalising difficulties. RESULTS: Based on the studies presented, we conclude that there is preliminary evidence to support that (a) environmental factors, such as diet, neurotoxic exposures and stress, influence offspring DNAm, and that (b) variability in DNAm, in turn, is associated with child and adolescent psychopathology. Overall, very few studies have examined DNAm in relation to both exposures and outcomes, and almost all analyses have been correlational in nature. CONCLUSIONS: DNAm holds potential as a biomarker indexing both environmental risk exposure and vulnerability for child psychopathology. However, the extent to which it may represent a causal mediator is not clear. In future, collection of prospective risk exposure, DNAm and outcomes - as well as functional characterisation of epigenetic findings - will assist in determining the role of DNAm in the link between risk exposure and psychopathology. En ligne : http://dx.doi.org/10.1111/jcpp.12782 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=353

Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence / Edward D. BARKER in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Titre : Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur Article en page(s) : p.1145-1156 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367 [article] Inflammation-related epigenetic risk and child and adolescent mental health: A prospective study from pregnancy to middle adolescence [Texte imprimé et/ou numérique] / Edward D. BARKER, Auteur ; Charlotte A. M. CECIL, Auteur ; E. WALTON, Auteur ; L. C. HOUTEPEN, Auteur ; T. G. O'CONNOR, Auteur ; A. DANESE, Auteur ; Sara R. JAFFEE, Auteur ; S. K. G. JENSEN, Auteur ; C. PARIANTE, Auteur ; W. MCARDLE, Auteur ; T. R. GAUNT, Auteur ; C. L. RELTON, Auteur ; S. ROBERTS, Auteur . - p.1145-1156. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.1145-1156 Index. décimale : PER Périodiques Résumé : In 785 mother-child (50% male) pairs from a longitudinal epidemiological birth cohort, we investigated associations between inflammation-related epigenetic polygenic risk scores (i-ePGS), environmental exposures, cognitive function, and child and adolescent internalizing and externalizing problems. We examined prenatal and postnatal effects. For externalizing problems, one prenatal effect was found: i-ePGS at birth associated with higher externalizing problems (ages 7-15) indirectly through lower cognitive function (age 7). For internalizing problems, we identified two effects. For a prenatal effect, i-ePGS at birth associated with higher internalizing symptoms via continuity in i-ePGS at age 7. For a postnatal effect, higher postnatal adversity exposure (birth through age 7) associated with higher internalizing problems (ages 7-15) via higher i-ePGS (age 7). Hence, externalizing problems were related mainly to prenatal effects involving lower cognitive function, whereas internalizing problems appeared related to both prenatal and postnatal effects. The present study supports a link between i-ePGS and child and adolescent mental health. En ligne : http://dx.doi.org/10.1017/s0954579418000330 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=367

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