ADHD medication adherence reduces risk of committing minor offenses in adolescents / Paul T. ROSENAU in Journal of Child Psychology and Psychiatry, 65-11 (November 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1478-1485 Titre : ADHD medication adherence reduces risk of committing minor offenses in adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Paul T. ROSENAU, Auteur ; Andrea DIETRICH, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Pieter J. HOEKSTRA, Auteur Article en page(s) : p.1478-1485 Langues : Anglais (eng) Mots-clés : Adolescents  ADHD medication  risk reduction  crime  survival analysis Index. décimale : PER Périodiques Résumé : Background This study aimed to investigate the association between adolescents? adherence to attention-deficit/hyperactivity disorder (ADHD) medication and their risk of committing minor offenses. Methods Using two Dutch databases, Statistics Netherlands (CBS) and the Foundation for Pharmaceutical Statistics (SFK), we aimed to investigate the association between adherence to ADHD medication and registered minor offenses between 2005 and 2019 of 18,234 adolescents (12?18?years). We used Cox regression analyses to compare the rate of committing minor offenses of adolescents during periods of high ADHD medication adherence compared to periods of low adherence (i.e., periods with or without sufficient amounts of dispensed medication). We additionally tested associations with adherence to selective serotonin reuptake inhibitors (SSRIs) as control medication and analyzed potential reverse causation. Results High ADHD medication adherence was associated with a reduced risk of committing a minor offense of between 33% and 38% compared to low adherence periods of ?3?months (hazard ratio [HR] 0.67, confidence interval [CI] 0.64?0.71) or ?6?months (HR 0.62, CI 0.59?0.65). The reduction in risk can likely be attributed to ADHD medication, given the absence of effects of SSRIs and no reverse causation. The reduction rate remained between 16% and 55% per sex, stimulant versus non-stimulant medication, different offense categories and further sensitivity analyses. Conclusions Among adolescents using ADHD medication, rates of criminality were lower during periods of high medication adherence, suggesting that adherence to ADHD medication may contribute to prevention of minor offenses in adolescents. En ligne : https://doi.org/10.1111/jcpp.13997 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] ADHD medication adherence reduces risk of committing minor offenses in adolescents [Texte imprimé et/ou numérique] / Paul T. ROSENAU, Auteur ; Andrea DIETRICH, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Pieter J. HOEKSTRA, Auteur . - p.1478-1485. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-11 (November 2024) . - p.1478-1485 Mots-clés : Adolescents  ADHD medication  risk reduction  crime  survival analysis Index. décimale : PER Périodiques Résumé : Background This study aimed to investigate the association between adolescents? adherence to attention-deficit/hyperactivity disorder (ADHD) medication and their risk of committing minor offenses. Methods Using two Dutch databases, Statistics Netherlands (CBS) and the Foundation for Pharmaceutical Statistics (SFK), we aimed to investigate the association between adherence to ADHD medication and registered minor offenses between 2005 and 2019 of 18,234 adolescents (12?18?years). We used Cox regression analyses to compare the rate of committing minor offenses of adolescents during periods of high ADHD medication adherence compared to periods of low adherence (i.e., periods with or without sufficient amounts of dispensed medication). We additionally tested associations with adherence to selective serotonin reuptake inhibitors (SSRIs) as control medication and analyzed potential reverse causation. Results High ADHD medication adherence was associated with a reduced risk of committing a minor offense of between 33% and 38% compared to low adherence periods of ?3?months (hazard ratio [HR] 0.67, confidence interval [CI] 0.64?0.71) or ?6?months (HR 0.62, CI 0.59?0.65). The reduction in risk can likely be attributed to ADHD medication, given the absence of effects of SSRIs and no reverse causation. The reduction rate remained between 16% and 55% per sex, stimulant versus non-stimulant medication, different offense categories and further sensitivity analyses. Conclusions Among adolescents using ADHD medication, rates of criminality were lower during periods of high medication adherence, suggesting that adherence to ADHD medication may contribute to prevention of minor offenses in adolescents. En ligne : https://doi.org/10.1111/jcpp.13997 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Commentary: Why treatment is the best choice for childhood mental disorders - a commentary on Roest et al. (2022) / Tycho J. DEKKERS in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.470-473 Titre : Commentary: Why treatment is the best choice for childhood mental disorders - a commentary on Roest et al. (2022) Type de document : Texte imprimé et/ou numérique Auteurs : Tycho J. DEKKERS, Auteur ; Annabeth P. GROENMAN, Auteur ; Pim CUIJPERS, Auteur ; Pieter J. HOEKSTRA, Auteur ; Marjolein LUMAN, Auteur ; Bram OROBIO DE CASTRO, Auteur ; Geertjan OVERBEEK, Auteur ; Arne POPMA, Auteur ; Nanda N. ROMMELSE, Auteur ; Elske SALEMINK, Auteur ; Yvonne A.J. STIKKELBROEK, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Saskia VAN DER OORD, Auteur ; Patty LEIJTEN, Auteur Article en page(s) : p.470-473 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : An important question in mental healthcare for children is whether treatments are effective and safe in the long run. Here, we comment on a recent editorial perspective by Roest et al. (2022), who argue, based on an overview of systematic reviews, ˜that there is no convincing evidence that interventions for the most common childhood disorders are beneficial in the long term’. We believe that the available evidence does not justify this conclusion and express our concern regarding the harmful effects of their message. We show that there is evidence to suggest beneficial longer term treatment effects for each of the disorders and explain why evidence-based treatment should be offered to children with mental disorders. En ligne : https://doi.org/10.1111/jcpp.13715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Commentary: Why treatment is the best choice for childhood mental disorders - a commentary on Roest et al. (2022) [Texte imprimé et/ou numérique] / Tycho J. DEKKERS, Auteur ; Annabeth P. GROENMAN, Auteur ; Pim CUIJPERS, Auteur ; Pieter J. HOEKSTRA, Auteur ; Marjolein LUMAN, Auteur ; Bram OROBIO DE CASTRO, Auteur ; Geertjan OVERBEEK, Auteur ; Arne POPMA, Auteur ; Nanda N. ROMMELSE, Auteur ; Elske SALEMINK, Auteur ; Yvonne A.J. STIKKELBROEK, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Saskia VAN DER OORD, Auteur ; Patty LEIJTEN, Auteur . - p.470-473. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.470-473 Index. décimale : PER Périodiques Résumé : An important question in mental healthcare for children is whether treatments are effective and safe in the long run. Here, we comment on a recent editorial perspective by Roest et al. (2022), who argue, based on an overview of systematic reviews, ˜that there is no convincing evidence that interventions for the most common childhood disorders are beneficial in the long term’. We believe that the available evidence does not justify this conclusion and express our concern regarding the harmful effects of their message. We show that there is evidence to suggest beneficial longer term treatment effects for each of the disorders and explain why evidence-based treatment should be offered to children with mental disorders. En ligne : https://doi.org/10.1111/jcpp.13715 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Early-Life Environmental and Child Factors Associated with the Presence of Disruptive Behaviors in Seven-Year-Old Children with Autistic Traits in the Avon Longitudinal Study of Parents and Children / Simone BREIDER in Journal of Autism and Developmental Disorders, 52-6 (June 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2747-2761 Titre : Early-Life Environmental and Child Factors Associated with the Presence of Disruptive Behaviors in Seven-Year-Old Children with Autistic Traits in the Avon Longitudinal Study of Parents and Children Type de document : Texte imprimé et/ou numérique Auteurs : Simone BREIDER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Klaas J. WARDENAAR, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Andrea DIETRICH, Auteur ; Annelies DE BILDT, Auteur Article en page(s) : p.2747-2761 Langues : Anglais (eng) Mots-clés : Alspac  Autism spectrum disorder  Disruptive behaviors  Early-life  Environmental  Risk factors Index. décimale : PER Périodiques Résumé : We studied the association of early-life environmental and child factors with disruptive behaviors in children with autistic traits around age 7, in the Avon Longitudinal Study of Parents and Children (n=6,401). Logistic regression with the least absolute shrinkage and selection operator indicated that disruptive behaviors were associated with prenatal smoking, no seafood-consumption during pregnancy, breech presentation at delivery, neonatal feeding problems, low social-economic situation, suboptimal preschool family environment, maternal depression, maternal antisocial behavior, male sex, and difficult child temperament. Compared to controls, male sex, maternal depression, and suboptimal preschool family environment were related to autistic traits without disruptive behaviors. Thus, there may be a difference in early-life factors related to autism spectrum disorder with and without disruptive behaviors. En ligne : http://dx.doi.org/10.1007/s10803-021-05081-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Early-Life Environmental and Child Factors Associated with the Presence of Disruptive Behaviors in Seven-Year-Old Children with Autistic Traits in the Avon Longitudinal Study of Parents and Children [Texte imprimé et/ou numérique] / Simone BREIDER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Klaas J. WARDENAAR, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Andrea DIETRICH, Auteur ; Annelies DE BILDT, Auteur . - p.2747-2761. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2747-2761 Mots-clés : Alspac  Autism spectrum disorder  Disruptive behaviors  Early-life  Environmental  Risk factors Index. décimale : PER Périodiques Résumé : We studied the association of early-life environmental and child factors with disruptive behaviors in children with autistic traits around age 7, in the Avon Longitudinal Study of Parents and Children (n=6,401). Logistic regression with the least absolute shrinkage and selection operator indicated that disruptive behaviors were associated with prenatal smoking, no seafood-consumption during pregnancy, breech presentation at delivery, neonatal feeding problems, low social-economic situation, suboptimal preschool family environment, maternal depression, maternal antisocial behavior, male sex, and difficult child temperament. Compared to controls, male sex, maternal depression, and suboptimal preschool family environment were related to autistic traits without disruptive behaviors. Thus, there may be a difference in early-life factors related to autism spectrum disorder with and without disruptive behaviors. En ligne : http://dx.doi.org/10.1007/s10803-021-05081-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder / David DALEY in Journal of Child Psychology and Psychiatry, 59-9 (September 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.932-947 Titre : Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder Type de document : Texte imprimé et/ou numérique Auteurs : David DALEY, Auteur ; Saskia VAN DER OORD, Auteur ; Maite FERRIN, Auteur ; Samuele CORTESE, Auteur ; Marina DANCKAERTS, Auteur ; Manfred DOEPFNER, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; David COGHILL, Auteur ; Margaret THOMPSON, Auteur ; Philip ASHERSON, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur ; Jan K. BUITELAAR, Auteur ; Ralf W. DITTMANN, Auteur ; Chris HOLLIS, Auteur ; Martin HOLTMANN, Auteur ; Eric KONOFAL, Auteur ; Michel LECENDREUX, Auteur ; Aribert ROTHENBERGER, Auteur ; Paramala SANTOSH, Auteur ; Emily SIMONOFF, Auteur ; Cesar SOUTULLO, Auteur ; Hans Christoph STEINHAUSEN, Auteur ; Argyris STRINGARIS, Auteur ; Eric TAYLOR, Auteur ; Ian C. K. WONG, Auteur ; Alessandro ZUDDAS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur Article en page(s) : p.932-947 Langues : Anglais (eng) Mots-clés : ADHD  behaviour therapy  conduct disorder  parent training  treatment trials Index. décimale : PER Périodiques Résumé : Background Behavioural interventions are recommended for use with children and young people with attention deficit hyperactivity disorder (ADHD); however, specific guidance for their implementation based on the best available evidence is currently lacking. Methods This review used an explicit question and answer format to address issues of clinical concern, based on expert interpretation of the evidence with precedence given to meta-analyses of randomised controlled trials. Results On the basis of current evidence that takes into account whether outcomes are blinded, behavioural intervention cannot be supported as a front-line treatment for core ADHD symptoms. There is, however, evidence from measures that are probably blinded that these interventions benefit parenting practices and improve conduct problems which commonly co-occur with ADHD, and are often the main reason for referral. Initial positive results have also been found in relation to parental knowledge, children's emotional, social and academic functioning ? although most studies have not used blinded outcomes. Generic and specialised ADHD parent training approaches ? delivered either individually or in groups ? have reported beneficial effects. High-quality training, supervision of therapists and practice with the child, may improve outcomes but further evidence is required. Evidence for who benefits the most from behavioural interventions is scant. There is no evidence to limit behavioural treatments to parents with parenting difficulties or children with conduct problems. There are positive effects of additive school-based intervention for the inattentive subtype. Targeting parental depression may enhance the effects of behavioural interventions. Conclusions Parent training is an important part of the multimodal treatment of children with ADHD, which improves parenting, reduces levels of oppositional and noncompliant behaviours and may improve other aspects of functioning. However, blinded evidence does not support it as a specific treatment for core ADHD symptoms. More research is required to understand how to optimise treatment effectiveness either in general or for individual patients and explore potential barriers to treatment uptake and engagement. In terms of selecting which intervention formats to use, it seems important to acknowledge and respond to parental treatment preferences. En ligne : https://doi.org/10.1111/jcpp.12825 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368 [article] Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder [Texte imprimé et/ou numérique] / David DALEY, Auteur ; Saskia VAN DER OORD, Auteur ; Maite FERRIN, Auteur ; Samuele CORTESE, Auteur ; Marina DANCKAERTS, Auteur ; Manfred DOEPFNER, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; David COGHILL, Auteur ; Margaret THOMPSON, Auteur ; Philip ASHERSON, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur ; Jan K. BUITELAAR, Auteur ; Ralf W. DITTMANN, Auteur ; Chris HOLLIS, Auteur ; Martin HOLTMANN, Auteur ; Eric KONOFAL, Auteur ; Michel LECENDREUX, Auteur ; Aribert ROTHENBERGER, Auteur ; Paramala SANTOSH, Auteur ; Emily SIMONOFF, Auteur ; Cesar SOUTULLO, Auteur ; Hans Christoph STEINHAUSEN, Auteur ; Argyris STRINGARIS, Auteur ; Eric TAYLOR, Auteur ; Ian C. K. WONG, Auteur ; Alessandro ZUDDAS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur . - p.932-947. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-9 (September 2018) . - p.932-947 Mots-clés : ADHD  behaviour therapy  conduct disorder  parent training  treatment trials Index. décimale : PER Périodiques Résumé : Background Behavioural interventions are recommended for use with children and young people with attention deficit hyperactivity disorder (ADHD); however, specific guidance for their implementation based on the best available evidence is currently lacking. Methods This review used an explicit question and answer format to address issues of clinical concern, based on expert interpretation of the evidence with precedence given to meta-analyses of randomised controlled trials. Results On the basis of current evidence that takes into account whether outcomes are blinded, behavioural intervention cannot be supported as a front-line treatment for core ADHD symptoms. There is, however, evidence from measures that are probably blinded that these interventions benefit parenting practices and improve conduct problems which commonly co-occur with ADHD, and are often the main reason for referral. Initial positive results have also been found in relation to parental knowledge, children's emotional, social and academic functioning ? although most studies have not used blinded outcomes. Generic and specialised ADHD parent training approaches ? delivered either individually or in groups ? have reported beneficial effects. High-quality training, supervision of therapists and practice with the child, may improve outcomes but further evidence is required. Evidence for who benefits the most from behavioural interventions is scant. There is no evidence to limit behavioural treatments to parents with parenting difficulties or children with conduct problems. There are positive effects of additive school-based intervention for the inattentive subtype. Targeting parental depression may enhance the effects of behavioural interventions. Conclusions Parent training is an important part of the multimodal treatment of children with ADHD, which improves parenting, reduces levels of oppositional and noncompliant behaviours and may improve other aspects of functioning. However, blinded evidence does not support it as a specific treatment for core ADHD symptoms. More research is required to understand how to optimise treatment effectiveness either in general or for individual patients and explore potential barriers to treatment uptake and engagement. In terms of selecting which intervention formats to use, it seems important to acknowledge and respond to parental treatment preferences. En ligne : https://doi.org/10.1111/jcpp.12825 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=368

Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data / Hermien H. DIJK ; Barbara J. VAN DEN HOOFDAKKER ; Pieter J. HOEKSTRA ; Annabeth P. GROENMAN in Journal of Child Psychology and Psychiatry, 66-3 (March 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.289-300 Titre : Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data Type de document : Texte imprimé et/ou numérique Auteurs : Hermien H. DIJK, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Annabeth P. GROENMAN, Auteur Article en page(s) : p.289-300 Langues : Anglais (eng) Mots-clés : Economic evaluation  pharmacotherapy  behaviour problems  ADHD  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Economic evaluations of treatments for children with behavioural difficulties (i.e., characteristics of attention-deficit/hyperactivity disorder (ADHD) and/or oppositional defiant disorder (ODD)) usually rely on data of randomised controlled trials or are model-based. Findings of such studies may not be representative of cost-effectiveness and cost-utility in clinical practice. The current longitudinal study aimed to perform an economic evaluation of treatments for children with hyperactivity, impulsive behaviours, inattention, and/or behavioural difficulties using observational data that were obtained in clinical practice. Methods Parents of 209 children (aged 5?12) who were referred to 1 of 10 Dutch youth mental healthcare institutions and who received treatment with (n?=?108) or without (n?=?101) the use of medication, filled out questionnaires at three timepoints (baseline, and ~?6 and ~12?months later). Propensity score matching was used to make both groups comparable. Outcomes included quality-adjusted life years (QALYs), ADHD and ODD symptom severity, and impairment. Costs were measured from a societal perspective. Incremental cost-effectiveness ratios (ICERs) were estimated, and cost-effectiveness acceptability curves (CEACs) were derived to show uncertainty around the ICER. Results Results did not show statistically significant differences in costs and effects between children who were treated with medication (alone or in combination with non-medication treatment) and those who were treated without medication. CEAC suggested that medication treatment has a 55% probability of being cost-effective at the ?80,000 threshold and 36% at the ?20,000 threshold compared with treatment without medication. Conclusions Using observational data, our study did not provide clear evidence of the cost-effectiveness and cost-utility of treatment with medication compared with treatment without medication in clinical practice. En ligne : https://doi.org/10.1111/jcpp.14057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548 [article] Treatments with versus without medication for children with behavioural difficulties in clinical practice: an economic evaluation with observational data [Texte imprimé et/ou numérique] / Hermien H. DIJK, Auteur ; Barbara J. VAN DEN HOOFDAKKER, Auteur ; Pieter J. HOEKSTRA, Auteur ; Annabeth P. GROENMAN, Auteur . - p.289-300. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-3 (March 2025) . - p.289-300 Mots-clés : Economic evaluation  pharmacotherapy  behaviour problems  ADHD  longitudinal studies Index. décimale : PER Périodiques Résumé : Background Economic evaluations of treatments for children with behavioural difficulties (i.e., characteristics of attention-deficit/hyperactivity disorder (ADHD) and/or oppositional defiant disorder (ODD)) usually rely on data of randomised controlled trials or are model-based. Findings of such studies may not be representative of cost-effectiveness and cost-utility in clinical practice. The current longitudinal study aimed to perform an economic evaluation of treatments for children with hyperactivity, impulsive behaviours, inattention, and/or behavioural difficulties using observational data that were obtained in clinical practice. Methods Parents of 209 children (aged 5?12) who were referred to 1 of 10 Dutch youth mental healthcare institutions and who received treatment with (n?=?108) or without (n?=?101) the use of medication, filled out questionnaires at three timepoints (baseline, and ~?6 and ~12?months later). Propensity score matching was used to make both groups comparable. Outcomes included quality-adjusted life years (QALYs), ADHD and ODD symptom severity, and impairment. Costs were measured from a societal perspective. Incremental cost-effectiveness ratios (ICERs) were estimated, and cost-effectiveness acceptability curves (CEACs) were derived to show uncertainty around the ICER. Results Results did not show statistically significant differences in costs and effects between children who were treated with medication (alone or in combination with non-medication treatment) and those who were treated without medication. CEAC suggested that medication treatment has a 55% probability of being cost-effective at the ?80,000 threshold and 36% at the ?20,000 threshold compared with treatment without medication. Conclusions Using observational data, our study did not provide clear evidence of the cost-effectiveness and cost-utility of treatment with medication compared with treatment without medication in clinical practice. En ligne : https://doi.org/10.1111/jcpp.14057 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=548

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