Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder / J. P. HEGARTY in Journal of Autism and Developmental Disorders, 48-10 (October 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3460-3473 Titre : Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. P. HEGARTY, Auteur ; D. J. WEBER, Auteur ; C. M. CIRSTEA, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.3460-3473 Langues : Anglais (eng) Mots-clés : Cerebellum  Dorsolateral prefrontal cortex  Functional connectivity  Gamma-aminobutyric acid (GABA)  Glutamate  Magnetic resonance spectroscopy (MRS) Index. décimale : PER Périodiques Résumé : Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy ((1)H-MRS) to examine the relationships between E/I (glutamate + glutamine/GABA) and FC of the dorsolateral prefrontal cortex and posterolateral cerebellar hemisphere from 14 adolescents/adults with ASD and 12 age/sex/IQ-matched controls. In this pilot sample, cerebro-cerebellar FC was positively associated with cerebellar E/I and listening comprehension abilities in individuals with ASD but not controls. Additionally, a subgroup of individuals with ASD and low FC (n = 5) exhibited reduced E/I and impaired listening comprehension. Thus, altered functional coherence of cerebro-cerebellar circuits in ASD may be related with a cerebellar E/I imbalance. En ligne : http://dx.doi.org/10.1007/s10803-018-3613-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. P. HEGARTY, Auteur ; D. J. WEBER, Auteur ; C. M. CIRSTEA, Auteur ; David Q. BEVERSDORF, Auteur . - p.3460-3473. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-10 (October 2018) . - p.3460-3473 Mots-clés : Cerebellum  Dorsolateral prefrontal cortex  Functional connectivity  Gamma-aminobutyric acid (GABA)  Glutamate  Magnetic resonance spectroscopy (MRS) Index. décimale : PER Périodiques Résumé : Atypical functional connectivity (FC) and an imbalance of excitation-to-inhibition (E/I) have been previously reported in cerebro-cerebellar circuits in autism spectrum disorder (ASD). The current investigation used resting state fMRI and proton magnetic resonance spectroscopy ((1)H-MRS) to examine the relationships between E/I (glutamate + glutamine/GABA) and FC of the dorsolateral prefrontal cortex and posterolateral cerebellar hemisphere from 14 adolescents/adults with ASD and 12 age/sex/IQ-matched controls. In this pilot sample, cerebro-cerebellar FC was positively associated with cerebellar E/I and listening comprehension abilities in individuals with ASD but not controls. Additionally, a subgroup of individuals with ASD and low FC (n = 5) exhibited reduced E/I and impaired listening comprehension. Thus, altered functional coherence of cerebro-cerebellar circuits in ASD may be related with a cerebellar E/I imbalance. En ligne : http://dx.doi.org/10.1007/s10803-018-3613-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

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