Heart rate mean and variability as a biomarker for phenotypic variation in preschoolers with autism spectrum disorder / Tessel BAZELMANS in Autism Research, 12-1 (January 2019)  

Public ISBD [article]  inAutism Research > 12-1 (January 2019) . - p.39-52 Titre : Heart rate mean and variability as a biomarker for phenotypic variation in preschoolers with autism spectrum disorder Type de document : texte imprimé Auteurs : Tessel BAZELMANS, Auteur ; Emily Jane Harrison JONES, Auteur ; Sheila S. GHODS, Auteur ; Sarah CORRIGAN, Auteur ; Karen TOTH, Auteur ; Tony CHARMAN, Auteur ; Sara J. WEBB, Auteur Article en page(s) : p.39-52 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  autonomic control  biomarker  cognition  heart rate  language  reliability Index. décimale : PER Périodiques Résumé : Interest in autonomic arousal in autism spectrum disorder (ASD) is increasing; however, reliability of these measures in ASD is unknown, and previously reported associations with social and cognitive abilities are inconsistent. This study assesses heart rate (HR) and HR variability (HRV) in preschoolers with ASD or typical development (TD) while they passively watched naturalistic videos. Measurement reliability, group differences, and the relationship with social and cognitive abilities were evaluated. Seventy one ASD and 66 TD children (2-4 years) provided cardiac data from two sessions. Test-retest intraclass correlations of HR and HRV over a 3-week period were moderate to good in both groups. Groups did not differ in mean level of HR or HRV. Intra-individual variability of HR between video segments within a session was higher in the ASD group, but intraclass correlations of this metric were low. Higher HR related to better language skills in TD children, but not after accounting for age and nonverbal ability. Higher HRV related to better expressive and receptive language in ASD children after controlling for age and nonverbal ability. HR/HRV were not related to social or executive functioning skills and did not explain any additional variance in abilities at a 12-month follow-up visit. In summary, variation in language abilities is associated with HR in the TD group and HRV in the ASD group. While preliminary, these results are promising for consideration of autonomic control as a biomarker for individual differences in ASD and may help us understand the mechanisms that contribute to communication skills. Autism Research 2019, 12: 39-52. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cardiac activity, such as heart rate and heart rate variability, is linked to a wide range of psychological functions. This study shows that there is an association between heart rate and heart rate variability and language skills in young children with autism spectrum disorder (ASD). These results may help us understand what underlies individual differences in developmental abilities in young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1982 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376 [article] Heart rate mean and variability as a biomarker for phenotypic variation in preschoolers with autism spectrum disorder [texte imprimé] / Tessel BAZELMANS, Auteur ; Emily Jane Harrison JONES, Auteur ; Sheila S. GHODS, Auteur ; Sarah CORRIGAN, Auteur ; Karen TOTH, Auteur ; Tony CHARMAN, Auteur ; Sara J. WEBB, Auteur . - p.39-52. Langues : Anglais (eng) in Autism Research > 12-1 (January 2019) . - p.39-52 Mots-clés : autism spectrum disorder  autonomic control  biomarker  cognition  heart rate  language  reliability Index. décimale : PER Périodiques Résumé : Interest in autonomic arousal in autism spectrum disorder (ASD) is increasing; however, reliability of these measures in ASD is unknown, and previously reported associations with social and cognitive abilities are inconsistent. This study assesses heart rate (HR) and HR variability (HRV) in preschoolers with ASD or typical development (TD) while they passively watched naturalistic videos. Measurement reliability, group differences, and the relationship with social and cognitive abilities were evaluated. Seventy one ASD and 66 TD children (2-4 years) provided cardiac data from two sessions. Test-retest intraclass correlations of HR and HRV over a 3-week period were moderate to good in both groups. Groups did not differ in mean level of HR or HRV. Intra-individual variability of HR between video segments within a session was higher in the ASD group, but intraclass correlations of this metric were low. Higher HR related to better language skills in TD children, but not after accounting for age and nonverbal ability. Higher HRV related to better expressive and receptive language in ASD children after controlling for age and nonverbal ability. HR/HRV were not related to social or executive functioning skills and did not explain any additional variance in abilities at a 12-month follow-up visit. In summary, variation in language abilities is associated with HR in the TD group and HRV in the ASD group. While preliminary, these results are promising for consideration of autonomic control as a biomarker for individual differences in ASD and may help us understand the mechanisms that contribute to communication skills. Autism Research 2019, 12: 39-52. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Cardiac activity, such as heart rate and heart rate variability, is linked to a wide range of psychological functions. This study shows that there is an association between heart rate and heart rate variability and language skills in young children with autism spectrum disorder (ASD). These results may help us understand what underlies individual differences in developmental abilities in young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1982 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=376

Mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder / Tony CHARMAN in Journal of Child Psychology and Psychiatry, 67-2 (February 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-2 (February 2026) . - p.282-295 Titre : Mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder Type de document : texte imprimé Auteurs : Tony CHARMAN, Auteur ; Tessel BAZELMANS, Auteur ; Greg PASCO, Auteur ; Jannath BEGUM ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Basis Staars Team THE, Auteur Article en page(s) : p.282-295 Langues : Anglais (eng) Mots-clés : Autism  ADHD  family history  infants  mid-childhood outcomes  behaviour  development Index. décimale : PER Périodiques Résumé : Background Prospective studies of autism family history infants primarily report recurrence and predictors of autism at 3?years. Less is known about ADHD family history infants and later childhood outcomes. We characterise profiles of mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or ADHD to identify potential support needs and patterns of co-occurrence across domains. Methods Two hundred and sixty-three infants (51% male; N?=?198 autism/ADHD family history; N?=?65 no family history) were assessed at 6?12?years. A latent profile analysis (LPA) with indicator variables measuring developmental abilities (IQ, adaptive function) and behavioural traits (autism, ADHD, anxiety) identified dimensional, data-derived outcome classes. Results A seven-class solution was the most robust and clinically meaningful. Two classes (27% and 23%) had typical development; two classes had high autism, ADHD, and anxiety traits?one with low IQ and adaptive function (10%) and one with average IQ but low adaptive function (13%); one class had elevated autism and ADHD but not anxiety traits (10%); and the final two classes had elevated ADHD (9%) and anxiety (8%) traits in isolation. Sex distribution was balanced across all classes. Children with autism were found in all classes but predominantly in the classes with low IQ/adaptive functioning and high behavioural traits, as well as in the class with elevated autism and ADHD traits. We found only partial continuity between membership of similarly derived 3-year LPA classes and mid-childhood LPA classes. Conclusions Many autism/ADHD family history infants develop typically. However, by mid-childhood, in addition to those with autism, others show elevated neurodevelopmental (autism, ADHD) and neuropsychiatric (anxiety) behavioural traits. Lower developmental abilities (IQ and adaptive function) are primarily seen in children with an autism diagnosis. Family history infants should be monitored through childhood, and support provided should challenges emerge. En ligne : https://doi.org/10.1111/jcpp.70048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or attention deficit hyperactivity disorder [texte imprimé] / Tony CHARMAN, Auteur ; Tessel BAZELMANS, Auteur ; Greg PASCO, Auteur ; Jannath BEGUM ALI, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur ; Basis Staars Team THE, Auteur . - p.282-295. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-2 (February 2026) . - p.282-295 Mots-clés : Autism  ADHD  family history  infants  mid-childhood outcomes  behaviour  development Index. décimale : PER Périodiques Résumé : Background Prospective studies of autism family history infants primarily report recurrence and predictors of autism at 3?years. Less is known about ADHD family history infants and later childhood outcomes. We characterise profiles of mid-childhood developmental and behavioural outcomes in infants with a family history of autism and/or ADHD to identify potential support needs and patterns of co-occurrence across domains. Methods Two hundred and sixty-three infants (51% male; N?=?198 autism/ADHD family history; N?=?65 no family history) were assessed at 6?12?years. A latent profile analysis (LPA) with indicator variables measuring developmental abilities (IQ, adaptive function) and behavioural traits (autism, ADHD, anxiety) identified dimensional, data-derived outcome classes. Results A seven-class solution was the most robust and clinically meaningful. Two classes (27% and 23%) had typical development; two classes had high autism, ADHD, and anxiety traits?one with low IQ and adaptive function (10%) and one with average IQ but low adaptive function (13%); one class had elevated autism and ADHD but not anxiety traits (10%); and the final two classes had elevated ADHD (9%) and anxiety (8%) traits in isolation. Sex distribution was balanced across all classes. Children with autism were found in all classes but predominantly in the classes with low IQ/adaptive functioning and high behavioural traits, as well as in the class with elevated autism and ADHD traits. We found only partial continuity between membership of similarly derived 3-year LPA classes and mid-childhood LPA classes. Conclusions Many autism/ADHD family history infants develop typically. However, by mid-childhood, in addition to those with autism, others show elevated neurodevelopmental (autism, ADHD) and neuropsychiatric (anxiety) behavioural traits. Lower developmental abilities (IQ and adaptive function) are primarily seen in children with an autism diagnosis. Family history infants should be monitored through childhood, and support provided should challenges emerge. En ligne : https://doi.org/10.1111/jcpp.70048 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Parent-child similarity on autism and ADHD traits and children's social functioning and psychological well-being at 3 years / Daniel L. WECHSLER in Journal of Child Psychology and Psychiatry, 66-12 (December 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1818-1828 Titre : Parent-child similarity on autism and ADHD traits and children's social functioning and psychological well-being at 3 years Type de document : texte imprimé Auteurs : Daniel L. WECHSLER, Auteur ; Emily J.H. JONES, Auteur ; Greg PASCO, Auteur ; Tessel BAZELMANS, Auteur ; Jannath BEGUM-ALI, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Basis Staars Team THE, Auteur Article en page(s) : p.1818-1828 Langues : Anglais (eng) Mots-clés : Autism  ADHD  parent-child similarity  resilience  positive development Index. décimale : PER Périodiques Résumé : Background There is a pressing need for research on neurodevelopmental conditions to focus on predictors of resilient or positive outcomes, rather than core symptoms and impairment. One promising avenue is to consider whether child?parent similarity contributes to a protective family environment. For instance, investigations of the similarity?fit hypothesis have shown that parent?child attention-deficit/hyperactivity disorder (ADHD) trait similarity is associated with more favourable parent or child ratings of parenting and parent?child interaction. However, very little similarity?fit research has focused on autism, and none to date has investigated whether parent?child trait similarity is more broadly predictive of children's outcomes beyond parent?child interaction. We assessed whether parent?child autism and ADHD trait similarity predicted children's social functioning and psychological well-being in early childhood in a family history cohort. Methods Our analytic sample comprised 222 children (45.5% female) and their parents from a longitudinal family history (autism and/or ADHD) cohort. A novel parent?child trait similarity measure was computed for autism and ADHD traits in each parent?child pair, and robust hierarchical regression was used to assess whether mother?child and father?child autism and ADHD similarity predicted children's social functioning and psychological well-being at age 3?years, after accounting for the main effects of parent and child traits. Results Mother?child autism trait similarity positively predicted both social functioning and psychological well-being in children, while mother?child ADHD trait similarity positively predicted children's social functioning (but not well-being). Furthermore, father?child autism trait similarity positively predicted children's social functioning, though it fell just short of statistical significance in outlier-robust regression. Conclusions Our findings suggest that parent?child neurodevelopmental trait similarity may act as a protective or promotive factor for children's early social functioning and psychological well-being. Further work is warranted to determine whether there are similar effects in later childhood and to investigate the potential mechanisms underlying similarity?fit effects on children's outcomes. En ligne : https://doi.org/10.1111/jcpp.70014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Parent-child similarity on autism and ADHD traits and children's social functioning and psychological well-being at 3 years [texte imprimé] / Daniel L. WECHSLER, Auteur ; Emily J.H. JONES, Auteur ; Greg PASCO, Auteur ; Tessel BAZELMANS, Auteur ; Jannath BEGUM-ALI, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Basis Staars Team THE, Auteur . - p.1818-1828. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-12 (December 2025) . - p.1818-1828 Mots-clés : Autism  ADHD  parent-child similarity  resilience  positive development Index. décimale : PER Périodiques Résumé : Background There is a pressing need for research on neurodevelopmental conditions to focus on predictors of resilient or positive outcomes, rather than core symptoms and impairment. One promising avenue is to consider whether child?parent similarity contributes to a protective family environment. For instance, investigations of the similarity?fit hypothesis have shown that parent?child attention-deficit/hyperactivity disorder (ADHD) trait similarity is associated with more favourable parent or child ratings of parenting and parent?child interaction. However, very little similarity?fit research has focused on autism, and none to date has investigated whether parent?child trait similarity is more broadly predictive of children's outcomes beyond parent?child interaction. We assessed whether parent?child autism and ADHD trait similarity predicted children's social functioning and psychological well-being in early childhood in a family history cohort. Methods Our analytic sample comprised 222 children (45.5% female) and their parents from a longitudinal family history (autism and/or ADHD) cohort. A novel parent?child trait similarity measure was computed for autism and ADHD traits in each parent?child pair, and robust hierarchical regression was used to assess whether mother?child and father?child autism and ADHD similarity predicted children's social functioning and psychological well-being at age 3?years, after accounting for the main effects of parent and child traits. Results Mother?child autism trait similarity positively predicted both social functioning and psychological well-being in children, while mother?child ADHD trait similarity positively predicted children's social functioning (but not well-being). Furthermore, father?child autism trait similarity positively predicted children's social functioning, though it fell just short of statistical significance in outlier-robust regression. Conclusions Our findings suggest that parent?child neurodevelopmental trait similarity may act as a protective or promotive factor for children's early social functioning and psychological well-being. Further work is warranted to determine whether there are similar effects in later childhood and to investigate the potential mechanisms underlying similarity?fit effects on children's outcomes. En ligne : https://doi.org/10.1111/jcpp.70014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

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