[article]
| Titre : |
Mapping autism in Egypt: population-based insights into prevalence, risk determinants, and severity among children aged 1-12 years |
| Type de document : |
texte imprimé |
| Auteurs : |
Ammal M. METWALLY, Auteur ; Ebtissam M. SALAH EL-DIN, Auteur ; Samia M. SAMI, Auteur ; Ehab R. ABDELRAOUF, Auteur ; Sara F. SALLAM, Auteur ; Amal ELSAEID, Auteur ; Mostafa M. EL-SAIED, Auteur ; Engy A. ASHAAT, Auteur ; Asmaa M. FATHY, Auteur ; Hazem M. EL-HARIRI, Auteur ; Ghada A. ELSHAARAWY, Auteur ; Maysa S. NASSAR, Auteur ; Manal A. SHEHATA, Auteur ; Inas R. EL-ALAMEEY, Auteur ; Randa I. BASSIOUNI, Auteur ; Mohamed H. ABDOU, Auteur ; Mona A. HELMY, Auteur ; Nahed A. ELGHAREEB, Auteur ; Mohamed ABDALLAH, Auteur ; Thanaa M. RABAH, Auteur ; Somia I. SALAMA, Auteur ; Rehan M. SALEH, Auteur ; Lobna A. EL ETREBY, Auteur ; Dalia M. ELMOSALAMI, Auteur ; Eman ELTAHLAWY, Auteur ; Dina Abu ZEID, Auteur ; Ammal M. Secondary METWALLY, Auteur ; Ebtissam M. SALAH EL-DIN, Auteur ; Samia M. SAMI, Auteur ; Ehab R. ABDELRAOUF, Auteur ; Sara F. SALLAM, Auteur ; Amal ELSAEID, Auteur ; Mostafa M. EL-SAIED, Auteur ; Engy A. ASHAAT, Auteur ; Asmaa M. FATHY, Auteur ; Hazem M. EL-HARIRI, Auteur ; Ghada A. ELSHAARAWY, Auteur ; Maysa S. NASSAR, Auteur ; Manal A. SHEHATA, Auteur ; Inas R. EL-ALAMEEY, Auteur ; Randa I. BASSIOUNI, Auteur ; Mohamed H. ABDOU, Auteur ; Mona A. HELMY, Auteur ; Nahed A. ELGHAREEB, Auteur ; Mohamed ABDALLAH, Auteur ; Thanaa M. RABAH, Auteur ; Somia I. SALAMA, Auteur ; Rehan M. SALEH, Auteur ; Lobna A. EL ETREBY, Auteur ; Dalia M. ELMOSALAMI, Auteur ; Eman ELTAHLAWY, Auteur ; Dina Abu ZEID, Auteur |
| Article en page(s) : |
32 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Humans Egypt/epidemiology Female Male Child, Preschool Prevalence Risk Factors Infant Child Severity of Illness Index Autism Spectrum Disorder/epidemiology/diagnosis Autistic Disorder/epidemiology/diagnosis Autism spectrum disorder National survey Severity after getting the approval of the Medical Research Ethics Committee of the National Research Centre with an ethical approval number of 17034. Written informed consent was taken from the parents/guardians of all children enrolled in the study. For participants who were unable to write, a right thumbprint was used as a signature. The study was fully voluntary, and data was collected in a confidential manner. Data were de-identified and stored in a safe location. The conduct of the study complied with the International Ethical Guidelines for Biomedical Research Involving Human Subjects [132]. The information disclosure for “Making sure parents/guardians understand” was guaranteed according to the recommendations of the Egyptian patients and guardians’ perception that clinical informed consent is the preferred purpose for Informed Consent practices [133] CConsent for publication: Not applicable. Competing interests: All authors report no conflict of interest. “No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this manuscript. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: The prevalence of autism spectrum disorder (ASD), a common developmental disorder, has surged in recent years. Accordingly, the identification and early management of possible risk factors can diminish ASD incidence. AIM: To determine the prevalence and severity of idiopathic ASD in Egyptian children aged 12 months to 12 years, and to identify the epidemiological, sociodemographic, and environmental risk factors contributing to this disorder. METHODS: This study comprised 41,640 children from the main eight geographic areas in Egypt. It was conducted through four phases: household screening, facility-based screening for high-risk children, diagnosis confirmation, and risk factor assessment. RESULTS: The prevalence of ASD as confirmed by the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Childhood Autism Rating Scale (CARS) was 1.1% (455 out of 41,640), with significant geographic variability. Urban areas had a significantly higher prevalence than rural areas. Children aged 3-6 years showed the highest prevalence at 1.5%. Boys were four times more affected than girls, with prevalence rates of 1.7% and 0.4%, respectively. Significant risk factors included: a history of convulsions (AOR = 4.7; 95% CI: 3.3-6.79), low birth weight (AOR = 2.08; 95% CI: 1.54-2.79), prolonged stays in neonatal intensive care unit (NICU) longer than two days (AOR = 1.91; 95% CI: 1.46-2.49) and maternal health problems during pregnancy (AOR = 1.66; 95% CI:1.36-1.95). Regarding severity, 45% of diagnosed children had moderate ASD, 39% had severe ASD, and 16% had mild ASD. Female gender and older age were significant predictors of greater ASD severity. CONCLUSION: ASD prevalence in Egypt is comparable to other Middle Eastern countries. Policymakers should utilize these findings to design targeted public health interventions aimed at early detection, management, and prevention of ASD progression. |
| En ligne : |
https://dx.doi.org/10.1186/s13229-025-00665-1 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 |
in Molecular Autism > 16 (2025) . - 32
[article] Mapping autism in Egypt: population-based insights into prevalence, risk determinants, and severity among children aged 1-12 years [texte imprimé] / Ammal M. METWALLY, Auteur ; Ebtissam M. SALAH EL-DIN, Auteur ; Samia M. SAMI, Auteur ; Ehab R. ABDELRAOUF, Auteur ; Sara F. SALLAM, Auteur ; Amal ELSAEID, Auteur ; Mostafa M. EL-SAIED, Auteur ; Engy A. ASHAAT, Auteur ; Asmaa M. FATHY, Auteur ; Hazem M. EL-HARIRI, Auteur ; Ghada A. ELSHAARAWY, Auteur ; Maysa S. NASSAR, Auteur ; Manal A. SHEHATA, Auteur ; Inas R. EL-ALAMEEY, Auteur ; Randa I. BASSIOUNI, Auteur ; Mohamed H. ABDOU, Auteur ; Mona A. HELMY, Auteur ; Nahed A. ELGHAREEB, Auteur ; Mohamed ABDALLAH, Auteur ; Thanaa M. RABAH, Auteur ; Somia I. SALAMA, Auteur ; Rehan M. SALEH, Auteur ; Lobna A. EL ETREBY, Auteur ; Dalia M. ELMOSALAMI, Auteur ; Eman ELTAHLAWY, Auteur ; Dina Abu ZEID, Auteur ; Ammal M. Secondary METWALLY, Auteur ; Ebtissam M. SALAH EL-DIN, Auteur ; Samia M. SAMI, Auteur ; Ehab R. ABDELRAOUF, Auteur ; Sara F. SALLAM, Auteur ; Amal ELSAEID, Auteur ; Mostafa M. EL-SAIED, Auteur ; Engy A. ASHAAT, Auteur ; Asmaa M. FATHY, Auteur ; Hazem M. EL-HARIRI, Auteur ; Ghada A. ELSHAARAWY, Auteur ; Maysa S. NASSAR, Auteur ; Manal A. SHEHATA, Auteur ; Inas R. EL-ALAMEEY, Auteur ; Randa I. BASSIOUNI, Auteur ; Mohamed H. ABDOU, Auteur ; Mona A. HELMY, Auteur ; Nahed A. ELGHAREEB, Auteur ; Mohamed ABDALLAH, Auteur ; Thanaa M. RABAH, Auteur ; Somia I. SALAMA, Auteur ; Rehan M. SALEH, Auteur ; Lobna A. EL ETREBY, Auteur ; Dalia M. ELMOSALAMI, Auteur ; Eman ELTAHLAWY, Auteur ; Dina Abu ZEID, Auteur . - 32. Langues : Anglais ( eng) in Molecular Autism > 16 (2025) . - 32
| Mots-clés : |
Humans Egypt/epidemiology Female Male Child, Preschool Prevalence Risk Factors Infant Child Severity of Illness Index Autism Spectrum Disorder/epidemiology/diagnosis Autistic Disorder/epidemiology/diagnosis Autism spectrum disorder National survey Severity after getting the approval of the Medical Research Ethics Committee of the National Research Centre with an ethical approval number of 17034. Written informed consent was taken from the parents/guardians of all children enrolled in the study. For participants who were unable to write, a right thumbprint was used as a signature. The study was fully voluntary, and data was collected in a confidential manner. Data were de-identified and stored in a safe location. The conduct of the study complied with the International Ethical Guidelines for Biomedical Research Involving Human Subjects [132]. The information disclosure for “Making sure parents/guardians understand” was guaranteed according to the recommendations of the Egyptian patients and guardians’ perception that clinical informed consent is the preferred purpose for Informed Consent practices [133] CConsent for publication: Not applicable. Competing interests: All authors report no conflict of interest. “No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this manuscript. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: The prevalence of autism spectrum disorder (ASD), a common developmental disorder, has surged in recent years. Accordingly, the identification and early management of possible risk factors can diminish ASD incidence. AIM: To determine the prevalence and severity of idiopathic ASD in Egyptian children aged 12 months to 12 years, and to identify the epidemiological, sociodemographic, and environmental risk factors contributing to this disorder. METHODS: This study comprised 41,640 children from the main eight geographic areas in Egypt. It was conducted through four phases: household screening, facility-based screening for high-risk children, diagnosis confirmation, and risk factor assessment. RESULTS: The prevalence of ASD as confirmed by the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) and the Childhood Autism Rating Scale (CARS) was 1.1% (455 out of 41,640), with significant geographic variability. Urban areas had a significantly higher prevalence than rural areas. Children aged 3-6 years showed the highest prevalence at 1.5%. Boys were four times more affected than girls, with prevalence rates of 1.7% and 0.4%, respectively. Significant risk factors included: a history of convulsions (AOR = 4.7; 95% CI: 3.3-6.79), low birth weight (AOR = 2.08; 95% CI: 1.54-2.79), prolonged stays in neonatal intensive care unit (NICU) longer than two days (AOR = 1.91; 95% CI: 1.46-2.49) and maternal health problems during pregnancy (AOR = 1.66; 95% CI:1.36-1.95). Regarding severity, 45% of diagnosed children had moderate ASD, 39% had severe ASD, and 16% had mild ASD. Female gender and older age were significant predictors of greater ASD severity. CONCLUSION: ASD prevalence in Egypt is comparable to other Middle Eastern countries. Policymakers should utilize these findings to design targeted public health interventions aimed at early detection, management, and prevention of ASD progression. |
| En ligne : |
https://dx.doi.org/10.1186/s13229-025-00665-1 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 |
|  |
Mapping autism in Egypt: population-based insights into prevalence, risk determinants, and severity among children aged 1-12 years in Molecular Autism, 16 (2025)
