[article]
| Titre : |
Elevated autistic traits and social anxiety, and reduced empathy in adult women with triple X syndrome |
| Type de document : |
texte imprimé |
| Auteurs : |
Marie-Anne CROYÉ, Auteur ; Petra FREILINGER, Auteur ; Hendrik JÜRGENLIMKE, Auteur ; Gregor DOMES, Auteur ; Jobst MEYER, Auteur |
| Langues : |
Anglais (eng) |
| Mots-clés : |
Humans Female Adult Empathy/physiology Anxiety/psychology Young Adult Autistic Disorder/psychology Chromosomes, Human, X Adaptation, Psychological Case-Control Studies Sex Chromosome Aberrations Trisomy Sex Chromosome Disorders of Sex Development 47,xxx Autistic traits Chronic stress Sex chromosome aneuploidy Social anxiety Social functioning Somatization Stress coping mechanisms Triple X syndrome Trisomy X conducted in accordance with the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of the University of Trier (Ref. No. 30/2021). All participants provided written informed consent prior to their participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Triple X syndrome (TXS, 47,XXX) is a sex chromosome aneuploidy affecting females. The condition is associated with cognitive, emotional, and social challenges. While prior research has primarily focused on children, the social and psychological profile of adult women with TXS remains understudied. This study aims to provide a comprehensive assessment of these aspects in adult women with TXS compared to matched controls. METHODS: A cohort of 44 women with TXS (mean age 30.5 years) was compared to 50 age- and education-matched controls (mean age 29.7 years). Standardized assessments measured verbal IQ, psychological distress, chronic stress, emotion regulation, coping mechanisms, social anxiety, empathy, autistic traits, and personality traits. Group comparisons were conducted using ANOVAs and MANOVAs, with additional χ² tests for categorical variables. RESULTS: Depression and trait anxiety did not significantly differ between groups, though both groups exhibited notably high scores. However, a greater number of individuals in the TXS group reported elevated social anxiety and autistic traits, and reduced empathy. Moreover, there were indications of increased self-reported social tensions, personal distress, and somatization within the TXS group. No significant differences were found in personality traits, verbal IQ, chronic stress levels, and emotion regulation. Additionally, TXS participants tended to rely less on the maladaptive coping strategy of alcohol and cigarette consumption. CONCLUSION: Our findings underscore autistic traits, social anxiety, and reduced empathy as significant challenges for adult women with TXS. While cognitive and emotional characteristics were largely comparable to those of age- and education-matched controls, the heightened social difficulties suggest a potential benefit of targeted interventions, such as social skills training, to support affected individuals. Longitudinal studies are essential to understand the long-term progression of these challenges and to develop effective therapeutic strategies. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09631-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
in Journal of Neurodevelopmental Disorders > 17 (2025)
[article] Elevated autistic traits and social anxiety, and reduced empathy in adult women with triple X syndrome [texte imprimé] / Marie-Anne CROYÉ, Auteur ; Petra FREILINGER, Auteur ; Hendrik JÜRGENLIMKE, Auteur ; Gregor DOMES, Auteur ; Jobst MEYER, Auteur. Langues : Anglais ( eng) in Journal of Neurodevelopmental Disorders > 17 (2025)
| Mots-clés : |
Humans Female Adult Empathy/physiology Anxiety/psychology Young Adult Autistic Disorder/psychology Chromosomes, Human, X Adaptation, Psychological Case-Control Studies Sex Chromosome Aberrations Trisomy Sex Chromosome Disorders of Sex Development 47,xxx Autistic traits Chronic stress Sex chromosome aneuploidy Social anxiety Social functioning Somatization Stress coping mechanisms Triple X syndrome Trisomy X conducted in accordance with the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of the University of Trier (Ref. No. 30/2021). All participants provided written informed consent prior to their participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
| Index. décimale : |
PER Périodiques |
| Résumé : |
BACKGROUND: Triple X syndrome (TXS, 47,XXX) is a sex chromosome aneuploidy affecting females. The condition is associated with cognitive, emotional, and social challenges. While prior research has primarily focused on children, the social and psychological profile of adult women with TXS remains understudied. This study aims to provide a comprehensive assessment of these aspects in adult women with TXS compared to matched controls. METHODS: A cohort of 44 women with TXS (mean age 30.5 years) was compared to 50 age- and education-matched controls (mean age 29.7 years). Standardized assessments measured verbal IQ, psychological distress, chronic stress, emotion regulation, coping mechanisms, social anxiety, empathy, autistic traits, and personality traits. Group comparisons were conducted using ANOVAs and MANOVAs, with additional χ² tests for categorical variables. RESULTS: Depression and trait anxiety did not significantly differ between groups, though both groups exhibited notably high scores. However, a greater number of individuals in the TXS group reported elevated social anxiety and autistic traits, and reduced empathy. Moreover, there were indications of increased self-reported social tensions, personal distress, and somatization within the TXS group. No significant differences were found in personality traits, verbal IQ, chronic stress levels, and emotion regulation. Additionally, TXS participants tended to rely less on the maladaptive coping strategy of alcohol and cigarette consumption. CONCLUSION: Our findings underscore autistic traits, social anxiety, and reduced empathy as significant challenges for adult women with TXS. While cognitive and emotional characteristics were largely comparable to those of age- and education-matched controls, the heightened social difficulties suggest a potential benefit of targeted interventions, such as social skills training, to support affected individuals. Longitudinal studies are essential to understand the long-term progression of these challenges and to develop effective therapeutic strategies. |
| En ligne : |
https://dx.doi.org/10.1186/s11689-025-09631-7 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 |
|  |
Elevated autistic traits and social anxiety, and reduced empathy in adult women with triple X syndrome in Journal of Neurodevelopmental Disorders, 17 (2025)
