Decades of Progress in the Psychopharmacology of Autism Spectrum Disorder / E. HENNEBERRY in Journal of Autism and Developmental Disorders, 51-12 (December 2021)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4370-4394 Titre : Decades of Progress in the Psychopharmacology of Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : E. HENNEBERRY, Auteur ; M. LAMY, Auteur ; K. C. DOMINICK, Auteur ; C. A. ERICKSON, Auteur Article en page(s) : p.4370-4394 Langues : Anglais (eng) Mots-clés : Antipsychotic Agents/therapeutic use  Autism Spectrum Disorder/drug therapy  Autistic Disorder/drug therapy  Humans  Irritable Mood  Psychopharmacology  Anti-psychotic  Autism  Autism spectrum disorder  Drug treatment  Irritability Index. décimale : PER Périodiques Résumé : Recent decades have been marked by a wave drug treatment research in autism spectrum disorder (ASD). This work has resulted in improved ability to treat commonly occurring behavioral challenges associated with ASD including most prominently irritability marked by aggression, self-injurious behavior, and severe tantrums. While treatment of interfering behavior has progressed in our field, there remain several areas of unmet medical need including most prominently a lack of any approved drug therapies for the core, defining symptoms of autism. We outline the progress to date in the field of autism drug treatment while taking a future look forward into how decades of work can inform better future steps in this field. En ligne : http://dx.doi.org/10.1007/s10803-021-05237-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454 [article] Decades of Progress in the Psychopharmacology of Autism Spectrum Disorder [Texte imprimé et/ou numérique] / E. HENNEBERRY, Auteur ; M. LAMY, Auteur ; K. C. DOMINICK, Auteur ; C. A. ERICKSON, Auteur . - p.4370-4394. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 51-12 (December 2021) . - p.4370-4394 Mots-clés : Antipsychotic Agents/therapeutic use  Autism Spectrum Disorder/drug therapy  Autistic Disorder/drug therapy  Humans  Irritable Mood  Psychopharmacology  Anti-psychotic  Autism  Autism spectrum disorder  Drug treatment  Irritability Index. décimale : PER Périodiques Résumé : Recent decades have been marked by a wave drug treatment research in autism spectrum disorder (ASD). This work has resulted in improved ability to treat commonly occurring behavioral challenges associated with ASD including most prominently irritability marked by aggression, self-injurious behavior, and severe tantrums. While treatment of interfering behavior has progressed in our field, there remain several areas of unmet medical need including most prominently a lack of any approved drug therapies for the core, defining symptoms of autism. We outline the progress to date in the field of autism drug treatment while taking a future look forward into how decades of work can inform better future steps in this field. En ligne : http://dx.doi.org/10.1007/s10803-021-05237-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=454

Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis: a pilot study / M. P. HONG in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 1 p. Titre : Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis: a pilot study Type de document : Texte imprimé et/ou numérique Auteurs : M. P. HONG, Auteur ; E. M. ECKERT, Auteur ; Ernest V. PEDAPATI, Auteur ; R. C. SHAFFER, Auteur ; K. C. DOMINICK, Auteur ; L. K. WINK, Auteur ; J. A. SWEENEY, Auteur ; C. A. ERICKSON, Auteur Article en page(s) : 1 p. Langues : Anglais (eng) Mots-clés : Autism  Eye tracking  Fragile X syndrome  Gaze aversion  Social anxiety  Social interest Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is the leading inherited cause of autism spectrum disorder, but there remains debate regarding the clinical presentation of social deficits in FXS. The aim of this study was to compare individuals with FXS to typically developing controls (TDC) and individuals with idiopathic autism spectrum disorder (ASD) across two social eye tracking paradigms. METHODS: Individuals with FXS and age- and gender-matched TDC and individuals with idiopathic ASD completed emotional face and social preference eye tracking tasks to evaluate gaze aversion and social interest, respectively. Participants completed a battery of cognitive testing and caregiver-reported measures for neurobehavioral characterization. RESULTS: Individuals with FXS exhibited reduced eye and increased mouth gaze to emotional faces compared to TDC. Gaze aversive findings were found to correlate with measures of anxiety, social communication deficits, and behavioral problems. In the social interest task, while individuals with idiopathic ASD showed significantly less social preference, individuals with FXS displayed social preference similar to TDC. CONCLUSIONS: These findings suggest fragile X syndrome social deficits center on social anxiety without the prominent reduction in social interest associated with autism spectrum disorder. Specifically designed eye tracking techniques clarify the nature of social deficits in fragile X syndrome and may have applications to improve phenotyping and evaluate interventions targeting social functioning impairments. En ligne : http://dx.doi.org/10.1186/s11689-019-9262-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis: a pilot study [Texte imprimé et/ou numérique] / M. P. HONG, Auteur ; E. M. ECKERT, Auteur ; Ernest V. PEDAPATI, Auteur ; R. C. SHAFFER, Auteur ; K. C. DOMINICK, Auteur ; L. K. WINK, Auteur ; J. A. SWEENEY, Auteur ; C. A. ERICKSON, Auteur . - 1 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 1 p. Mots-clés : Autism  Eye tracking  Fragile X syndrome  Gaze aversion  Social anxiety  Social interest Index. décimale : PER Périodiques Résumé : BACKGROUND: Fragile X syndrome (FXS) is the leading inherited cause of autism spectrum disorder, but there remains debate regarding the clinical presentation of social deficits in FXS. The aim of this study was to compare individuals with FXS to typically developing controls (TDC) and individuals with idiopathic autism spectrum disorder (ASD) across two social eye tracking paradigms. METHODS: Individuals with FXS and age- and gender-matched TDC and individuals with idiopathic ASD completed emotional face and social preference eye tracking tasks to evaluate gaze aversion and social interest, respectively. Participants completed a battery of cognitive testing and caregiver-reported measures for neurobehavioral characterization. RESULTS: Individuals with FXS exhibited reduced eye and increased mouth gaze to emotional faces compared to TDC. Gaze aversive findings were found to correlate with measures of anxiety, social communication deficits, and behavioral problems. In the social interest task, while individuals with idiopathic ASD showed significantly less social preference, individuals with FXS displayed social preference similar to TDC. CONCLUSIONS: These findings suggest fragile X syndrome social deficits center on social anxiety without the prominent reduction in social interest associated with autism spectrum disorder. Specifically designed eye tracking techniques clarify the nature of social deficits in fragile X syndrome and may have applications to improve phenotyping and evaluate interventions targeting social functioning impairments. En ligne : http://dx.doi.org/10.1186/s11689-019-9262-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Pharmacologic Interventions for Irritability, Aggression, Agitation and Self-Injurious Behavior in Fragile X Syndrome: An Initial Cross-Sectional Analysis / E. M. ECKERT in Journal of Autism and Developmental Disorders, 49-11 (November 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4595-4602 Titre : Pharmacologic Interventions for Irritability, Aggression, Agitation and Self-Injurious Behavior in Fragile X Syndrome: An Initial Cross-Sectional Analysis Type de document : Texte imprimé et/ou numérique Auteurs : E. M. ECKERT, Auteur ; K. C. DOMINICK, Auteur ; Ernest V. PEDAPATI, Auteur ; L. K. WINK, Auteur ; R. C. SHAFFER, Auteur ; H. ANDREWS, Auteur ; Tse-Hwei CHOO, Auteur ; C. CHEN, Auteur ; W. E. KAUFMANN, Auteur ; N. TARTAGLIA, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; C. A. ERICKSON, Auteur Article en page(s) : p.4595-4602 Langues : Anglais (eng) Mots-clés : Fragile X syndrome  Irritability  Pharmacotherapy Index. décimale : PER Périodiques Résumé : Using a dataset involving 415 individuals with irritability, aggression, agitation and self-injury (IAAS) behaviors from the fragile X syndrome (FXS) FORWARD database, we describe the psychopharmacologic management of IAAS and features of the population of persons with FXS treated with drug therapy for IAAS. Among those with FXS exhibiting IAAS, individuals with FXS receiving drug treatment of IAAS were older, more predominantly male, have more significant intellectual disability, more like to have comorbid autism, hyperarousal, and social impairments. The most commonly utilized medications for IAAS in FXS are antipsychotic medications, specifically aripiprazole and risperidone (37% and 27%, respectively). The majority of subjects (63%) experienced no side effects noted from the use of their psychopharmacologic medications. En ligne : http://dx.doi.org/10.1007/s10803-019-04173-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Pharmacologic Interventions for Irritability, Aggression, Agitation and Self-Injurious Behavior in Fragile X Syndrome: An Initial Cross-Sectional Analysis [Texte imprimé et/ou numérique] / E. M. ECKERT, Auteur ; K. C. DOMINICK, Auteur ; Ernest V. PEDAPATI, Auteur ; L. K. WINK, Auteur ; R. C. SHAFFER, Auteur ; H. ANDREWS, Auteur ; Tse-Hwei CHOO, Auteur ; C. CHEN, Auteur ; W. E. KAUFMANN, Auteur ; N. TARTAGLIA, Auteur ; Elizabeth BERRY-KRAVIS, Auteur ; C. A. ERICKSON, Auteur . - p.4595-4602. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-11 (November 2019) . - p.4595-4602 Mots-clés : Fragile X syndrome  Irritability  Pharmacotherapy Index. décimale : PER Périodiques Résumé : Using a dataset involving 415 individuals with irritability, aggression, agitation and self-injury (IAAS) behaviors from the fragile X syndrome (FXS) FORWARD database, we describe the psychopharmacologic management of IAAS and features of the population of persons with FXS treated with drug therapy for IAAS. Among those with FXS exhibiting IAAS, individuals with FXS receiving drug treatment of IAAS were older, more predominantly male, have more significant intellectual disability, more like to have comorbid autism, hyperarousal, and social impairments. The most commonly utilized medications for IAAS in FXS are antipsychotic medications, specifically aripiprazole and risperidone (37% and 27%, respectively). The majority of subjects (63%) experienced no side effects noted from the use of their psychopharmacologic medications. En ligne : http://dx.doi.org/10.1007/s10803-019-04173-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

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