Cohortes internationales et trajectoires critiques à l’adolescence / Jean-Luc MARTINOT in Bulletin Scientifique de l'arapi (Le), 44 (Hiver 2019)

Public ISBD [article]  inBulletin Scientifique de l'arapi (Le) > 44 (Hiver 2019) . - p.24-26 Titre : Cohortes internationales et trajectoires critiques à l’adolescence Type de document : texte imprimé Auteurs : Jean-Luc MARTINOT, Auteur Année de publication : 2019 Article en page(s) : p.24-26 Langues : Français (fre) Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569 [article] Cohortes internationales et trajectoires critiques à l’adolescence [texte imprimé] / Jean-Luc MARTINOT, Auteur . - 2019 . - p.24-26. Langues : Français (fre) in Bulletin Scientifique de l'arapi (Le) > 44 (Hiver 2019) . - p.24-26 Index. décimale : PER Périodiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=569

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents / Barbara RUGGERI in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Titre : Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents Type de document : texte imprimé Auteurs : Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents [texte imprimé] / Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur . - p.650-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Neuro-imagerie. Des toxicomanies usuelles aux adolescents expérimentateurs / Jean-Luc MARTINOT

Public ISBD in Addictions et comorbidités / Amine BENYAMINA Titre : Neuro-imagerie. Des toxicomanies usuelles aux adolescents expérimentateurs Type de document : texte imprimé Auteurs : Jean-Luc MARTINOT, Auteur ; Laurent KARILA, Auteur ; Claire LEROY, Auteur ; Marie-Laure PAILLERE, Auteur ; Stéphanie MENA, Auteur ; Éric ARTIGES, Auteur Année de publication : 2014 Importance : p.55-65 Langues : Français (fre) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=395 in Addictions et comorbidités / Amine BENYAMINA Neuro-imagerie. Des toxicomanies usuelles aux adolescents expérimentateurs [texte imprimé] / Jean-Luc MARTINOT, Auteur ; Laurent KARILA, Auteur ; Claire LEROY, Auteur ; Marie-Laure PAILLERE, Auteur ; Stéphanie MENA, Auteur ; Éric ARTIGES, Auteur . - 2014 . - p.55-65. Langues : Français (fre) Index. décimale : TRO-F TRO-F - Autres Troubles Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=395

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Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach / Tochukwu NWEZE in Journal of Child Psychology and Psychiatry, 64-8 (August 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175 Titre : Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach Type de document : texte imprimé Auteurs : Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L.W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÃœHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; IMAGEN CONSORTIUM, Auteur Article en page(s) : p.1159-1175 Langues : Anglais (eng) Mots-clés : Stress  cortical development  cognitive functioning  longitudinal models  bivariate latent change score model  longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Trajectories of cortical structures associated with stress across adolescence: a bivariate latent change score approach [texte imprimé] / Tochukwu NWEZE, Auteur ; Tobias BANASCHEWSKI, Auteur ; Cyracius AJAELU, Auteur ; Chukwuemeka OKOYE, Auteur ; Michael EZENWA, Auteur ; Robert WHELAN, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Arun L.W. BOKDE, Auteur ; Sylvane DESRIVIERES, Auteur ; Antoine GRIGIS, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Rüdiger BRÃœHL, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Éric ARTIGES, Auteur ; Frauke NEES, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Sarah HOHMANN, Auteur ; Sabina MILLENET, Auteur ; Juliane H. FRÖHNER, Auteur ; Michael N. SMOLKA, Auteur ; Henrik WALTER, Auteur ; Gunter SCHUMANN, Auteur ; Jamie L. HANSON, Auteur ; IMAGEN CONSORTIUM, Auteur . - p.1159-1175. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-8 (August 2023) . - p.1159-1175 Mots-clés : Stress  cortical development  cognitive functioning  longitudinal models  bivariate latent change score model  longitudinal mediation analysis Index. décimale : PER Périodiques Résumé : Background Stress exposure in childhood and adolescence has been linked to reductions in cortical structures and cognitive functioning. However, to date, most of these studies have been cross-sectional, limiting the ability to make long-term inferences, given that most cortical structures continue to develop through adolescence. Methods Here, we used a subset of the IMAGEN population cohort sample (N = 502; assessment ages: 14, 19, and 22 years; mean age: 21.945 years; SD = 0.610) to understand longitudinally the long-term interrelations between stress, cortical development, and cognitive functioning. To these ends, we first used a latent change score model to examine four bivariate relations assessing individual differences in change in the relations between adolescent stress exposure and volume, surface area, and cortical thickness of cortical structures, as well as cognitive outcomes. Second, we probed for indirect neurocognitive effects linking stress to cortical brain structures and cognitive functions using rich longitudinal mediation modeling. Results Latent change score modeling showed that greater baseline adolescence stress at age 14 predicted a small reduction in the right anterior cingulate volume (Std. = .327, p = .042, 95% CI [ 0.643, 0.012]) and right anterior cingulate surface area (Std. = .274, p = .038, 95% CI [ 0.533, 0.015]) across ages 14 22. These effects were very modest in nature and became nonsignificant after correcting for multiple comparisons. Our longitudinal analyses found no evidence of indirect effects in the two neurocognitive pathways linking adolescent stress to brain and cognitive outcomes. Conclusion Findings shed light on the impact of stress on brain reductions, particularly in the prefrontal cortex that have consistently been implicated in the previous cross-sectional studies. However, the magnitude of effects observed in our study is smaller than that has been reported in past cross-sectional work. This suggests that the potential impact of stress during adolescence on brain structures may likely be more modest than previously noted. En ligne : https://doi.org/10.1111/jcpp.13793 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

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