A Pilot Randomized Clinical Trial of an Enhanced Pivotal Response Treatment Approach for Young Children with Autism: The PRISM Model / Ty W. VERNON in Journal of Autism and Developmental Disorders, 49-6 (June 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2358-2373 Titre : A Pilot Randomized Clinical Trial of an Enhanced Pivotal Response Treatment Approach for Young Children with Autism: The PRISM Model Type de document : Texte imprimé et/ou numérique Auteurs : Ty W. VERNON, Auteur ; A. N. HOLDEN, Auteur ; Amy C. BARRETT, Auteur ; Jessica BRADSHAW, Auteur ; J. A. KO, Auteur ; E. S. MCGARRY, Auteur ; E. J. HOROWITZ, Auteur ; Daina M. TAGAVI, Auteur ; T. C. GERMAN, Auteur Article en page(s) : p.2358-2373 Langues : Anglais (eng) Mots-clés : Early intervention  Pilot study  Pivotal response intervention for social motivation (PRISM)  Pivotal response treatment  Randomized clinical trial (RCT) Index. décimale : PER Périodiques Résumé : The symptoms of autism spectrum disorder are conceptualized to alter the quality of parent-children interactions, exposure to social learning exchanges, and ultimately the course of child development. There is evidence that modifying the procedures of Pivotal Response Treatment (PRT) to explicitly target social motivation enhances child engagement and parent-child synchrony in moment-by-moment exchanges. However, it is unclear if these within session improvements ultimately yield favorable developmental outcomes over time. The current investigation presents feasibility, utility, and preliminary efficacy data of a pilot randomized clinical trial (RCT) of a Pivotal Response Intervention for Social Motivation (PRISM) model. Data on participant factors, treatment protocol acceptability, and outcome variance and effect size are highly favorable and support the pursuit of a future, large scale RCT. En ligne : https://dx.doi.org/10.1007/s10803-019-03909-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400 [article] A Pilot Randomized Clinical Trial of an Enhanced Pivotal Response Treatment Approach for Young Children with Autism: The PRISM Model [Texte imprimé et/ou numérique] / Ty W. VERNON, Auteur ; A. N. HOLDEN, Auteur ; Amy C. BARRETT, Auteur ; Jessica BRADSHAW, Auteur ; J. A. KO, Auteur ; E. S. MCGARRY, Auteur ; E. J. HOROWITZ, Auteur ; Daina M. TAGAVI, Auteur ; T. C. GERMAN, Auteur . - p.2358-2373. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-6 (June 2019) . - p.2358-2373 Mots-clés : Early intervention  Pilot study  Pivotal response intervention for social motivation (PRISM)  Pivotal response treatment  Randomized clinical trial (RCT) Index. décimale : PER Périodiques Résumé : The symptoms of autism spectrum disorder are conceptualized to alter the quality of parent-children interactions, exposure to social learning exchanges, and ultimately the course of child development. There is evidence that modifying the procedures of Pivotal Response Treatment (PRT) to explicitly target social motivation enhances child engagement and parent-child synchrony in moment-by-moment exchanges. However, it is unclear if these within session improvements ultimately yield favorable developmental outcomes over time. The current investigation presents feasibility, utility, and preliminary efficacy data of a pilot randomized clinical trial (RCT) of a Pivotal Response Intervention for Social Motivation (PRISM) model. Data on participant factors, treatment protocol acceptability, and outcome variance and effect size are highly favorable and support the pursuit of a future, large scale RCT. En ligne : https://dx.doi.org/10.1007/s10803-019-03909-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=400

A Randomized Controlled Trial of the Social Tools And Rules for Teens (START) Program: An Immersive Socialization Intervention for Adolescents with Autism Spectrum Disorder / Ty W. VERNON in Journal of Autism and Developmental Disorders, 48-3 (March 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.892-904 Titre : A Randomized Controlled Trial of the Social Tools And Rules for Teens (START) Program: An Immersive Socialization Intervention for Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Ty W. VERNON, Auteur ; Amber R. MILLER, Auteur ; A. Ko J, Auteur ; Amy C. BARRETT, Auteur ; S. McGarry E, Auteur Année de publication : 2018 Article en page(s) : p.892-904 Langues : Anglais (eng) Mots-clés : Adolescents with autism spectrum disorder  START program  Social competence  Social motivation  Social readiness  Social skills group Index. décimale : PER Périodiques Résumé : Adolescents with ASD face numerous personal and contextual barriers that impede the development of social motivation and core competencies, warranting the need for targeted intervention. A randomized controlled trial was conducted with 40 adolescents to evaluate the merits of a multi-component socialization intervention that places emphasis on experiential learning. This investigation evaluated the impact of the 20-week START program on the social functioning of adolescents with ASD. Significant Group x Time differences between START and waitlist control groups were found across multiple measures. Secondary analyses of the entire program cohort also yielded significant improvement trends across all measures. These findings may be an important step in identifying optimal strategies to target the complex factors limiting optimal social development in ASD. En ligne : https://doi.org/10.1007/s10803-017-3380-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339 [article] A Randomized Controlled Trial of the Social Tools And Rules for Teens (START) Program: An Immersive Socialization Intervention for Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Ty W. VERNON, Auteur ; Amber R. MILLER, Auteur ; A. Ko J, Auteur ; Amy C. BARRETT, Auteur ; S. McGarry E, Auteur . - 2018 . - p.892-904. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-3 (March 2018) . - p.892-904 Mots-clés : Adolescents with autism spectrum disorder  START program  Social competence  Social motivation  Social readiness  Social skills group Index. décimale : PER Périodiques Résumé : Adolescents with ASD face numerous personal and contextual barriers that impede the development of social motivation and core competencies, warranting the need for targeted intervention. A randomized controlled trial was conducted with 40 adolescents to evaluate the merits of a multi-component socialization intervention that places emphasis on experiential learning. This investigation evaluated the impact of the 20-week START program on the social functioning of adolescents with ASD. Significant Group x Time differences between START and waitlist control groups were found across multiple measures. Secondary analyses of the entire program cohort also yielded significant improvement trends across all measures. These findings may be an important step in identifying optimal strategies to target the complex factors limiting optimal social development in ASD. En ligne : https://doi.org/10.1007/s10803-017-3380-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=339

Social responsiveness and language use associated with an enhanced PRT approach for young children with ASD: Results from a pilot RCT of the PRISM model / Amy C. BARRETT in Research in Autism Spectrum Disorders, 71 (March 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 71 (March 2020) . - p.101497 Titre : Social responsiveness and language use associated with an enhanced PRT approach for young children with ASD: Results from a pilot RCT of the PRISM model Type de document : Texte imprimé et/ou numérique Auteurs : Amy C. BARRETT, Auteur ; Ty W. VERNON, Auteur ; Elizabeth S. MCGARRY, Auteur ; Anahita N. HOLDEN, Auteur ; Jessica BRADSHAW, Auteur ; Jordan A. KO, Auteur ; Erin J. HOROWITZ, Auteur ; Tamsin C. GERMAN, Auteur Article en page(s) : p.101497 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Early intervention  Parent-mediated intervention  Pivotal Response Treatment (PRT)  Pivotal Response Intervention for Social Motivation (PRISM)  Naturalistic Developmental Behavioral Intervention (NDBI) Index. décimale : PER Périodiques Résumé : Background Vulnerabilities in social motivation among children with ASD constrain attention and responsiveness to parents and other social partners. When this limited social responsiveness remains uncorrected, it is hypothesized to restrict the quality and quantity of social learning opportunities and ultimately yield negative long-term effects on development. Early intervention efforts that target social motivation may hold promise for correcting this detrimental chain of events. Method The current pilot RCT examined changes in participant social responsiveness and language use in a trial of 21 young children with ASD who were randomly assigned to treatment or waitlist control groups. Treatment participants received a mean of 6.81 h/week of an enhanced Pivotal Response Intervention for Social Motivation (PRISM) treatment model for six months. Data on social responsiveness to parent bids and expressive language (number of total words, number of different words, mean length of utterance in words) were obtained from behaviorally coding and analyzing video-recorded parent-child play sessions. Results Results indicated that young children who participated in the PRISM treatment model demonstrated significant pre-post improvements in social responsiveness and mean length of utterances. Participants in the waitlist condition experienced negligible improvements. Participants who are minimally verbal appear to experience greater gains as a result of the PRISM model. Additionally, initial levels of social responsiveness with parents appear to be predictive of subsequent language use at post-intervention among minimally verbal participants. Conclusion This study provides preliminary evidence for the importance of using early intervention paradigms that explicitly target social motivation and responsiveness in young children with ASD. Results also suggest that initial social responsiveness to parents may serve as an important predictor of treatment response. En ligne : https://doi.org/10.1016/j.rasd.2019.101497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416 [article] Social responsiveness and language use associated with an enhanced PRT approach for young children with ASD: Results from a pilot RCT of the PRISM model [Texte imprimé et/ou numérique] / Amy C. BARRETT, Auteur ; Ty W. VERNON, Auteur ; Elizabeth S. MCGARRY, Auteur ; Anahita N. HOLDEN, Auteur ; Jessica BRADSHAW, Auteur ; Jordan A. KO, Auteur ; Erin J. HOROWITZ, Auteur ; Tamsin C. GERMAN, Auteur . - p.101497. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 71 (March 2020) . - p.101497 Mots-clés : Autism spectrum disorder  Early intervention  Parent-mediated intervention  Pivotal Response Treatment (PRT)  Pivotal Response Intervention for Social Motivation (PRISM)  Naturalistic Developmental Behavioral Intervention (NDBI) Index. décimale : PER Périodiques Résumé : Background Vulnerabilities in social motivation among children with ASD constrain attention and responsiveness to parents and other social partners. When this limited social responsiveness remains uncorrected, it is hypothesized to restrict the quality and quantity of social learning opportunities and ultimately yield negative long-term effects on development. Early intervention efforts that target social motivation may hold promise for correcting this detrimental chain of events. Method The current pilot RCT examined changes in participant social responsiveness and language use in a trial of 21 young children with ASD who were randomly assigned to treatment or waitlist control groups. Treatment participants received a mean of 6.81 h/week of an enhanced Pivotal Response Intervention for Social Motivation (PRISM) treatment model for six months. Data on social responsiveness to parent bids and expressive language (number of total words, number of different words, mean length of utterance in words) were obtained from behaviorally coding and analyzing video-recorded parent-child play sessions. Results Results indicated that young children who participated in the PRISM treatment model demonstrated significant pre-post improvements in social responsiveness and mean length of utterances. Participants in the waitlist condition experienced negligible improvements. Participants who are minimally verbal appear to experience greater gains as a result of the PRISM model. Additionally, initial levels of social responsiveness with parents appear to be predictive of subsequent language use at post-intervention among minimally verbal participants. Conclusion This study provides preliminary evidence for the importance of using early intervention paradigms that explicitly target social motivation and responsiveness in young children with ASD. Results also suggest that initial social responsiveness to parents may serve as an important predictor of treatment response. En ligne : https://doi.org/10.1016/j.rasd.2019.101497 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=416

The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism / Jessica BRADSHAW in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.779-793 Titre : The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRADSHAW, Auteur ; F. SHIC, Auteur ; A. N. HOLDEN, Auteur ; E. J. HOROWITZ, Auteur ; Amy C. BARRETT, Auteur ; T. C. GERMAN, Auteur ; Ty W. VERNON, Auteur Article en page(s) : p.779-793 Langues : Anglais (eng) Mots-clés : attention  biomarkers  early intervention  eye tracking  social cognition Index. décimale : PER Périodiques Résumé : There is a pressing need for objective, quantifiable outcome measures in intervention trials for children with autism spectrum disorder (ASD). The current study investigated the use of eye tracking as a biomarker of treatment response in the context of a pilot randomized clinical trial of treatment for young children with ASD. Participants included 28 children with ASD, aged 18-48 months, who were randomized to one of two conditions: Pivotal Response Intervention for Social Motivation (PRISM) or community treatment as usual (TAU). Eye-tracking and behavioral assessment of developmental functioning were administered at Time 1 (prior to randomization) and at Time 2 (after 6 months of intervention). Two well-established eye-tracking paradigms were used to measure social attention: social preference and face scanning. As a context for understanding relationships between social attention and developmental ability, we first examined how scanning patterns at Time 1 were associated with concurrent developmental functioning and compared to those of 23 age-matched typically developing (TD) children. Changes in scanning patterns from Time 1 to Time 2 were then compared between PRISM and TAU groups and associated with behavioral change over time. Results showed that the social preference paradigm differentiated children with ASD from TD children. In addition, attention during face scanning was associated with language and adaptive communication skills at Time 1 and change in language skills from Time 1 to Time 2. These findings highlight the importance of examining targeted biomarkers that measure unique aspects of child functioning and that are well-matched to proposed mechanisms of change. Autism Research 2019, 12: 779-793. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Biomarkers have the potential to provide important information about how and why early interventions effect positive change for young children with ASD. The current study suggests that eye-tracking measures of social attention can be used to track change in specific areas of development, such as language, and points to the need for targeted eye-tracking paradigms designed to measure specific behavioral changes. Such biomarkers could inform the development of optimal, individualized, and adaptive interventions for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2093 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism [Texte imprimé et/ou numérique] / Jessica BRADSHAW, Auteur ; F. SHIC, Auteur ; A. N. HOLDEN, Auteur ; E. J. HOROWITZ, Auteur ; Amy C. BARRETT, Auteur ; T. C. GERMAN, Auteur ; Ty W. VERNON, Auteur . - p.779-793. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.779-793 Mots-clés : attention  biomarkers  early intervention  eye tracking  social cognition Index. décimale : PER Périodiques Résumé : There is a pressing need for objective, quantifiable outcome measures in intervention trials for children with autism spectrum disorder (ASD). The current study investigated the use of eye tracking as a biomarker of treatment response in the context of a pilot randomized clinical trial of treatment for young children with ASD. Participants included 28 children with ASD, aged 18-48 months, who were randomized to one of two conditions: Pivotal Response Intervention for Social Motivation (PRISM) or community treatment as usual (TAU). Eye-tracking and behavioral assessment of developmental functioning were administered at Time 1 (prior to randomization) and at Time 2 (after 6 months of intervention). Two well-established eye-tracking paradigms were used to measure social attention: social preference and face scanning. As a context for understanding relationships between social attention and developmental ability, we first examined how scanning patterns at Time 1 were associated with concurrent developmental functioning and compared to those of 23 age-matched typically developing (TD) children. Changes in scanning patterns from Time 1 to Time 2 were then compared between PRISM and TAU groups and associated with behavioral change over time. Results showed that the social preference paradigm differentiated children with ASD from TD children. In addition, attention during face scanning was associated with language and adaptive communication skills at Time 1 and change in language skills from Time 1 to Time 2. These findings highlight the importance of examining targeted biomarkers that measure unique aspects of child functioning and that are well-matched to proposed mechanisms of change. Autism Research 2019, 12: 779-793. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Biomarkers have the potential to provide important information about how and why early interventions effect positive change for young children with ASD. The current study suggests that eye-tracking measures of social attention can be used to track change in specific areas of development, such as language, and points to the need for targeted eye-tracking paradigms designed to measure specific behavioral changes. Such biomarkers could inform the development of optimal, individualized, and adaptive interventions for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2093 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

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