Dépouillements

Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors / David G. AMARAL in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.700-714 Titre : Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors Type de document : Texte imprimé et/ou numérique Auteurs : David G. AMARAL, Auteur ; George M. ANDERSON, Auteur ; A. BAILEY, Auteur ; Raphael BERNIER, Auteur ; Somer L. BISHOP, Auteur ; Gene J. BLATT, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Tony CHARMAN, Auteur ; G. DAWSON, Auteur ; P. J. DE VRIES, Auteur ; Emanuel DICICCO-BLOOM, Auteur ; Cheryl DISSANAYAKE, Auteur ; Y. KAMIO, Auteur ; R. KANA, Auteur ; N. Z. KHAN, Auteur ; A. KNOLL, Auteur ; F. KOOY, Auteur ; J. LAINHART, Auteur ; P. LEVITT, Auteur ; K. LOVELAND, Auteur ; N. MINSHEW, Auteur ; R. A. MUELLER, Auteur ; D. MURPHY, Auteur ; Peter C. MUNDY, Auteur ; S. PALENCIA, Auteur ; J. PINTO-MARTIN, Auteur ; A. RATTAZZI, Auteur ; S. ROGERS, Auteur ; W. L. STONE, Auteur ; S. J. WEBB, Auteur ; Andrew J. O. WHITEHOUSE, Auteur Article en page(s) : p.700-714 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Gaps in Current Autism Research: The Thoughts of the Autism Research Editorial Board and Associate Editors [Texte imprimé et/ou numérique] / David G. AMARAL, Auteur ; George M. ANDERSON, Auteur ; A. BAILEY, Auteur ; Raphael BERNIER, Auteur ; Somer L. BISHOP, Auteur ; Gene J. BLATT, Auteur ; Ricardo CANAL-BEDIA, Auteur ; Tony CHARMAN, Auteur ; G. DAWSON, Auteur ; P. J. DE VRIES, Auteur ; Emanuel DICICCO-BLOOM, Auteur ; Cheryl DISSANAYAKE, Auteur ; Y. KAMIO, Auteur ; R. KANA, Auteur ; N. Z. KHAN, Auteur ; A. KNOLL, Auteur ; F. KOOY, Auteur ; J. LAINHART, Auteur ; P. LEVITT, Auteur ; K. LOVELAND, Auteur ; N. MINSHEW, Auteur ; R. A. MUELLER, Auteur ; D. MURPHY, Auteur ; Peter C. MUNDY, Auteur ; S. PALENCIA, Auteur ; J. PINTO-MARTIN, Auteur ; A. RATTAZZI, Auteur ; S. ROGERS, Auteur ; W. L. STONE, Auteur ; S. J. WEBB, Auteur ; Andrew J. O. WHITEHOUSE, Auteur . - p.700-714. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.700-714 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.2101 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

The relation between parent verbal responsiveness and child communication in young children with or at risk for autism spectrum disorder: A systematic review and meta-analysis / S. R. EDMUNDS in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.715-731 Titre : The relation between parent verbal responsiveness and child communication in young children with or at risk for autism spectrum disorder: A systematic review and meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : S. R. EDMUNDS, Auteur ; S. T. KOVER, Auteur ; W. L. STONE, Auteur Article en page(s) : p.715-731 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  child  communication  language development  parent-child relations  parents Index. décimale : PER Périodiques Résumé : Among preschool-age children with autism spectrum disorder (ASD) and typically developing children, parents' verbal responsiveness (PVR) has long been shown to predict children's later language ability. However, before the age of three, when language develops most rapidly, the early social communication deficits associated with ASD may impact parents' opportunities to facilitate early language development. The aim of this review was to characterize the relation between PVR and the vocal communication ability of children with or at high risk for ASD early in development. Specifically, we examined whether the relation between PVR and child communication varied by type of PVR and by child diagnostic status, as well as whether interventions increased PVR. A systematic multi-database search yielded 25 empirical studies (804 parent-toddler dyads; 30 effect sizes) that met inclusion criteria and related a variable of PVR to a variable of child vocalization or language. Meta-regression analyses revealed that the relation between PVR and child communication was significant regardless of PVR type or child diagnostic status. To date, interventions targeting both PVR and child communication were found to significantly increase PVR, but not child communication, for these populations. Future research should examine parent-child communication in a transactional, longitudinal manner. In addition, these findings have implications for interventions designed to target parents' responsiveness and child communication. Autism Research 2019, 12: 715-731. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: For families with children under 3 years old who are at risk for or diagnosed with ASD, this study revealed empirical evidence of a robust relation between parents'' verbal responsiveness to their children's play and communication and children's communication ability. This relation is similar to that reported in research on typically developing children. Interventions designed to improve parent-child interaction in children with or at risk for ASD may be effective in increasing parents' responsiveness. En ligne : http://dx.doi.org/10.1002/aur.2100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] The relation between parent verbal responsiveness and child communication in young children with or at risk for autism spectrum disorder: A systematic review and meta-analysis [Texte imprimé et/ou numérique] / S. R. EDMUNDS, Auteur ; S. T. KOVER, Auteur ; W. L. STONE, Auteur . - p.715-731. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.715-731 Mots-clés : autism spectrum disorder  child  communication  language development  parent-child relations  parents Index. décimale : PER Périodiques Résumé : Among preschool-age children with autism spectrum disorder (ASD) and typically developing children, parents' verbal responsiveness (PVR) has long been shown to predict children's later language ability. However, before the age of three, when language develops most rapidly, the early social communication deficits associated with ASD may impact parents' opportunities to facilitate early language development. The aim of this review was to characterize the relation between PVR and the vocal communication ability of children with or at high risk for ASD early in development. Specifically, we examined whether the relation between PVR and child communication varied by type of PVR and by child diagnostic status, as well as whether interventions increased PVR. A systematic multi-database search yielded 25 empirical studies (804 parent-toddler dyads; 30 effect sizes) that met inclusion criteria and related a variable of PVR to a variable of child vocalization or language. Meta-regression analyses revealed that the relation between PVR and child communication was significant regardless of PVR type or child diagnostic status. To date, interventions targeting both PVR and child communication were found to significantly increase PVR, but not child communication, for these populations. Future research should examine parent-child communication in a transactional, longitudinal manner. In addition, these findings have implications for interventions designed to target parents' responsiveness and child communication. Autism Research 2019, 12: 715-731. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: For families with children under 3 years old who are at risk for or diagnosed with ASD, this study revealed empirical evidence of a robust relation between parents'' verbal responsiveness to their children's play and communication and children's communication ability. This relation is similar to that reported in research on typically developing children. Interventions designed to improve parent-child interaction in children with or at risk for ASD may be effective in increasing parents' responsiveness. En ligne : http://dx.doi.org/10.1002/aur.2100 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice / A. M. J. ANACKER in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.732-743 Titre : Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice Type de document : Texte imprimé et/ou numérique Auteurs : A. M. J. ANACKER, Auteur ; J. T. MORAN, Auteur ; S. SANTARELLI, Auteur ; C. G. FORSBERG, Auteur ; T. D. ROGERS, Auteur ; G. D. STANWOOD, Auteur ; B. J. HALL, Auteur ; E. DELPIRE, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur ; M. D. SAXE, Auteur Article en page(s) : p.732-743 Langues : Anglais (eng) Mots-clés : Gaba  autism  dominance  excitatory  inhibitory  social Index. décimale : PER Périodiques Résumé : The K-Cl cotransporter KCC2 is essential in the development of the "GABA switch" that produces a change in neuronal responses to GABA signaling from excitatory to inhibitory early in brain development, and alterations in this progression have previously been hypothesized to play a causal role in autism spectrum disorder (ASD). We investigated the KCC2b (Slc12a5) heterozygous knockout mouse using a battery of rodent behavioral tests relevant to core and comorbid ASD symptoms. Compared to wild-type littermates, KCC2(+/-) mice were normal in standard measures of locomotor activity, grooming and digging behaviors, and social, vocalization, and anxiety-like behaviors. However, KCC2(+/-) mice exhibited increased social dominance behaviors and increased amplitude of spontaneous postsynaptic currents in the medial prefrontal cortex (PFC) that were previously implicated in governing social hierarchy and dominance behaviors. Treatment of wild-type mouse brain slices with the KCC2 inhibitor VU0240511 increased the amplitude and frequency of excitatory postsynaptic currents, partially recapitulating the phenotype of KCC2(+/-) mice. These findings indicate that the activity of KCC2 plays a role in social dominance, in parallel with effects on PFC signaling, further suggesting that KCC2 function has some relevance to social behavior but without the breadth of impact on autism-like behavior suggested by previous studies. Further testing could assess whether KCC2 alters other circuits and whether additional factors such as environmental insults may precipitate autism-related behavioral phenotypes. Autism Research 2019, 12: 732-743. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: A mouse model of altered chloride transporter expression was used to look for a role in behaviors and brain function relevant to autism. There was an imbalance in signaling in the prefrontal cortex, and increased social dominance behavior, although other autism-related behaviors were not changed. These findings indicate that altered chloride transporter function affects prefrontal cortex function and social dominance without a broader impact on autism-like behaviors. En ligne : http://dx.doi.org/10.1002/aur.2098 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Enhanced Social Dominance and Altered Neuronal Excitability in the Prefrontal Cortex of Male KCC2b Mutant Mice [Texte imprimé et/ou numérique] / A. M. J. ANACKER, Auteur ; J. T. MORAN, Auteur ; S. SANTARELLI, Auteur ; C. G. FORSBERG, Auteur ; T. D. ROGERS, Auteur ; G. D. STANWOOD, Auteur ; B. J. HALL, Auteur ; E. DELPIRE, Auteur ; J. VEENSTRA-VANDERWEELE, Auteur ; M. D. SAXE, Auteur . - p.732-743. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.732-743 Mots-clés : Gaba  autism  dominance  excitatory  inhibitory  social Index. décimale : PER Périodiques Résumé : The K-Cl cotransporter KCC2 is essential in the development of the "GABA switch" that produces a change in neuronal responses to GABA signaling from excitatory to inhibitory early in brain development, and alterations in this progression have previously been hypothesized to play a causal role in autism spectrum disorder (ASD). We investigated the KCC2b (Slc12a5) heterozygous knockout mouse using a battery of rodent behavioral tests relevant to core and comorbid ASD symptoms. Compared to wild-type littermates, KCC2(+/-) mice were normal in standard measures of locomotor activity, grooming and digging behaviors, and social, vocalization, and anxiety-like behaviors. However, KCC2(+/-) mice exhibited increased social dominance behaviors and increased amplitude of spontaneous postsynaptic currents in the medial prefrontal cortex (PFC) that were previously implicated in governing social hierarchy and dominance behaviors. Treatment of wild-type mouse brain slices with the KCC2 inhibitor VU0240511 increased the amplitude and frequency of excitatory postsynaptic currents, partially recapitulating the phenotype of KCC2(+/-) mice. These findings indicate that the activity of KCC2 plays a role in social dominance, in parallel with effects on PFC signaling, further suggesting that KCC2 function has some relevance to social behavior but without the breadth of impact on autism-like behavior suggested by previous studies. Further testing could assess whether KCC2 alters other circuits and whether additional factors such as environmental insults may precipitate autism-related behavioral phenotypes. Autism Research 2019, 12: 732-743. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: A mouse model of altered chloride transporter expression was used to look for a role in behaviors and brain function relevant to autism. There was an imbalance in signaling in the prefrontal cortex, and increased social dominance behavior, although other autism-related behaviors were not changed. These findings indicate that altered chloride transporter function affects prefrontal cortex function and social dominance without a broader impact on autism-like behaviors. En ligne : http://dx.doi.org/10.1002/aur.2098 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Early processing (N170) of infant faces in mothers of children with autism spectrum disorder and its association with maternal sensitivity / C. MARQUEZ in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.744-758 Titre : Early processing (N170) of infant faces in mothers of children with autism spectrum disorder and its association with maternal sensitivity Type de document : Texte imprimé et/ou numérique Auteurs : C. MARQUEZ, Auteur ; H. NICOLINI, Auteur ; M. J. CROWLEY, Auteur ; R. SOLIS-VIVANCO, Auteur Article en page(s) : p.744-758 Langues : Anglais (eng) Mots-clés : N170  autism spectrum disorder  event-related potential  infant face processing  maternal sensitivity  mothers Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit impaired adult facial processing, as shown by the N170 event-related potential. However, few studies explore such processing in mothers of children with ASD, and none has assessed the early processing of infant faces in these women. Moreover, whether processing of infant facial expressions in mothers of children with ASD is related to their response to their child's needs (maternal sensitivity [MS]) remains unknown. This study explored the N170 related to infant faces in a group of mothers of children with ASD (MA) and a reference group of mothers of children without ASD. For both emotional (crying, smiling) and neutral expressions, the MA group exhibited larger amplitudes of N170 in the right hemisphere, while the reference group showed similar interhemispheric amplitudes. This lateralization effect within the MA group was not present for nonfaces and was stronger in the mothers with higher MS. We propose that mothers of ASD children use specialized perceptual resources to process infant faces, and this specialization is mediated by MS. Our findings suggest that having an ASD child modulates mothers' early neurophysiological responsiveness to infant cues. Whether this modulation represents a biological marker or a response given by experience remains to be explored. Autism Research 2019, 12: 744-758. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: When mothers of children with autism spectrum disorder (ASD) see baby faces expressing emotions, they show a right-sided electrical response in the brain. This lateralization was stronger in mothers who were more sensitive to their children's needs. We conclude that having a child with ASD and being more attuned to their behavior generates a specialized pattern of brain activity when processing infant faces. Whether this pattern is biological or given by experience remains to be explored. En ligne : http://dx.doi.org/10.1002/aur.2102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Early processing (N170) of infant faces in mothers of children with autism spectrum disorder and its association with maternal sensitivity [Texte imprimé et/ou numérique] / C. MARQUEZ, Auteur ; H. NICOLINI, Auteur ; M. J. CROWLEY, Auteur ; R. SOLIS-VIVANCO, Auteur . - p.744-758. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.744-758 Mots-clés : N170  autism spectrum disorder  event-related potential  infant face processing  maternal sensitivity  mothers Index. décimale : PER Périodiques Résumé : Individuals with autism spectrum disorder (ASD) exhibit impaired adult facial processing, as shown by the N170 event-related potential. However, few studies explore such processing in mothers of children with ASD, and none has assessed the early processing of infant faces in these women. Moreover, whether processing of infant facial expressions in mothers of children with ASD is related to their response to their child's needs (maternal sensitivity [MS]) remains unknown. This study explored the N170 related to infant faces in a group of mothers of children with ASD (MA) and a reference group of mothers of children without ASD. For both emotional (crying, smiling) and neutral expressions, the MA group exhibited larger amplitudes of N170 in the right hemisphere, while the reference group showed similar interhemispheric amplitudes. This lateralization effect within the MA group was not present for nonfaces and was stronger in the mothers with higher MS. We propose that mothers of ASD children use specialized perceptual resources to process infant faces, and this specialization is mediated by MS. Our findings suggest that having an ASD child modulates mothers' early neurophysiological responsiveness to infant cues. Whether this modulation represents a biological marker or a response given by experience remains to be explored. Autism Research 2019, 12: 744-758. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: When mothers of children with autism spectrum disorder (ASD) see baby faces expressing emotions, they show a right-sided electrical response in the brain. This lateralization was stronger in mothers who were more sensitive to their children's needs. We conclude that having a child with ASD and being more attuned to their behavior generates a specialized pattern of brain activity when processing infant faces. Whether this pattern is biological or given by experience remains to be explored. En ligne : http://dx.doi.org/10.1002/aur.2102 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Short report: Relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in autism spectrum disorder and Williams syndrome / M. GLOD in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.759-765 Titre : Short report: Relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in autism spectrum disorder and Williams syndrome Type de document : Texte imprimé et/ou numérique Auteurs : M. GLOD, Auteur ; D. M. RIBY, Auteur ; J. RODGERS, Auteur Article en page(s) : p.759-765 Langues : Anglais (eng) Mots-clés : Williams syndrome  anxiety  autism spectrum disorder  restricted/repetitive behaviors  sensory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and Williams syndrome (WS) share psychopathology relating to sensory processing and repetitive behaviors. The relationships between the sensory features and repetitive behaviors in both disorders, and the mechanisms underlying these relationships are not well understood. The aim of this study was to examine the relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in children with ASD and those with WS to better understand the complexity of psychopathology in these disorders. Parents of 19 children with ASD and 16 children with WS, aged between 4 and 9 years, were asked to complete questionnaires assessing their children's sensory experiences, anxiety symptoms, severity and frequency of repetitive behaviors, and level of intolerance of uncertainty. Serial mediation analysis was performed. Direct significant relationships between sensory features and repetitive behaviors were found only for the ASD group. The relationship between sensory processing difficulties and repetitive behaviors was mediated via intolerance of uncertainty in WS. The findings support the value of considering the complexity of the mechanisms underlying the relationship between sensory processing and repetitive behaviors across neurodevelopmental disorders and the mechanisms underlying these aspects of psychopathology in these groups. Understanding these relationships will shed light on some of the most challenging and intractable characteristics of both conditions and inform suitable interventions to improve quality of life for individuals with either ASD or WS. Autism Research 2019, 12: 759-765. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In autism spectrum disorder (ASD) and Williams syndrome (WS) difficulties processing the sensory aspects of the environment, repetitive behaviors and high levels of anxiety co-occur, but the relationships between these features are not well understood. This study found that sensory difficulties were directly associated with repetitive behaviors in children with ASD, but not WS, and in WS this relationship was mediated by intolerance of uncertainty. The findings support the value of considering the complexity of the mechanisms underlying the relationship between sensory processing and repetitive behaviors across neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Short report: Relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in autism spectrum disorder and Williams syndrome [Texte imprimé et/ou numérique] / M. GLOD, Auteur ; D. M. RIBY, Auteur ; J. RODGERS, Auteur . - p.759-765. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.759-765 Mots-clés : Williams syndrome  anxiety  autism spectrum disorder  restricted/repetitive behaviors  sensory Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) and Williams syndrome (WS) share psychopathology relating to sensory processing and repetitive behaviors. The relationships between the sensory features and repetitive behaviors in both disorders, and the mechanisms underlying these relationships are not well understood. The aim of this study was to examine the relationships between sensory processing, repetitive behaviors, anxiety, and intolerance of uncertainty in children with ASD and those with WS to better understand the complexity of psychopathology in these disorders. Parents of 19 children with ASD and 16 children with WS, aged between 4 and 9 years, were asked to complete questionnaires assessing their children's sensory experiences, anxiety symptoms, severity and frequency of repetitive behaviors, and level of intolerance of uncertainty. Serial mediation analysis was performed. Direct significant relationships between sensory features and repetitive behaviors were found only for the ASD group. The relationship between sensory processing difficulties and repetitive behaviors was mediated via intolerance of uncertainty in WS. The findings support the value of considering the complexity of the mechanisms underlying the relationship between sensory processing and repetitive behaviors across neurodevelopmental disorders and the mechanisms underlying these aspects of psychopathology in these groups. Understanding these relationships will shed light on some of the most challenging and intractable characteristics of both conditions and inform suitable interventions to improve quality of life for individuals with either ASD or WS. Autism Research 2019, 12: 759-765. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In autism spectrum disorder (ASD) and Williams syndrome (WS) difficulties processing the sensory aspects of the environment, repetitive behaviors and high levels of anxiety co-occur, but the relationships between these features are not well understood. This study found that sensory difficulties were directly associated with repetitive behaviors in children with ASD, but not WS, and in WS this relationship was mediated by intolerance of uncertainty. The findings support the value of considering the complexity of the mechanisms underlying the relationship between sensory processing and repetitive behaviors across neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.2096 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Psychometric Evaluation of Social Cognitive Measures for Adults with Autism / K. E. MORRISON in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.766-778 Titre : Psychometric Evaluation of Social Cognitive Measures for Adults with Autism Type de document : Texte imprimé et/ou numérique Auteurs : K. E. MORRISON, Auteur ; A. E. PINKHAM, Auteur ; S. KELSVEN, Auteur ; K. LUDWIG, Auteur ; D. L. PENN, Auteur ; Noah J. SASSON, Auteur Article en page(s) : p.766-778 Langues : Anglais (eng) Mots-clés : adults  autism spectrum disorder  reliability  social social cognition  validity Index. décimale : PER Périodiques Résumé : Although social cognition is frequently identified as a target in clinical trials and psychosocial interventions for adults with autism spectrum disorder (ASD), these efforts are hampered by a lack of consensus and validation of social cognitive measures. The current study provides psychometric evaluation of 11 frequently used measures encompassing different subdomains of social cognition. Adults with autism (N = 103) and typically developing controls (N = 95) completed 11 commonly used social cognitive tasks spanning the domains of emotion processing, social perception, and mentalizing/theory of mind. We examined each measure's internal reliability and sensitivity to group differences, how performance related to general intellectual ability, and alignment of measures with a proposed two-factor structure of social cognition in ASD. Controls outperformed the ASD group on 8 of the 11 social cognitive tasks, with the largest group differences occurring on two mentalizing measures, The awareness of social inference task (TASIT) and hinting task. In ASD, all tasks demonstrated strong internal consistency and avoided ceiling and floor effects. Social cognitive performance was also related to, but not redundant with, intellectual functioning. We also found support for a two-factor structure of social cognition, with basic social perception and emotional processing aligning into a lower-order social perception factor, while mentalizing tasks aligned into a higher-order social appraisal factor. In sum, eight tasks showed adequate to strong psychometric properties. The psychometric data, effect size estimates, and correlations between measures reported here can be used for study planning for social cognitive interventions in autism. Autism Research 2019, 12: 766-778. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: We examined 11 tasks that measure how adults with autism perceive and interpret social information. Eight of the tasks were reliable and showed lower performance in adults with autism compared to typically-developing controls. Task performance was related to but distinguishable from IQ. These measures evaluated here may be useful in assessing the effectiveness of interventions and treatments to improve social abilities in adults with autism. En ligne : http://dx.doi.org/10.1002/aur.2084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Psychometric Evaluation of Social Cognitive Measures for Adults with Autism [Texte imprimé et/ou numérique] / K. E. MORRISON, Auteur ; A. E. PINKHAM, Auteur ; S. KELSVEN, Auteur ; K. LUDWIG, Auteur ; D. L. PENN, Auteur ; Noah J. SASSON, Auteur . - p.766-778. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.766-778 Mots-clés : adults  autism spectrum disorder  reliability  social social cognition  validity Index. décimale : PER Périodiques Résumé : Although social cognition is frequently identified as a target in clinical trials and psychosocial interventions for adults with autism spectrum disorder (ASD), these efforts are hampered by a lack of consensus and validation of social cognitive measures. The current study provides psychometric evaluation of 11 frequently used measures encompassing different subdomains of social cognition. Adults with autism (N = 103) and typically developing controls (N = 95) completed 11 commonly used social cognitive tasks spanning the domains of emotion processing, social perception, and mentalizing/theory of mind. We examined each measure's internal reliability and sensitivity to group differences, how performance related to general intellectual ability, and alignment of measures with a proposed two-factor structure of social cognition in ASD. Controls outperformed the ASD group on 8 of the 11 social cognitive tasks, with the largest group differences occurring on two mentalizing measures, The awareness of social inference task (TASIT) and hinting task. In ASD, all tasks demonstrated strong internal consistency and avoided ceiling and floor effects. Social cognitive performance was also related to, but not redundant with, intellectual functioning. We also found support for a two-factor structure of social cognition, with basic social perception and emotional processing aligning into a lower-order social perception factor, while mentalizing tasks aligned into a higher-order social appraisal factor. In sum, eight tasks showed adequate to strong psychometric properties. The psychometric data, effect size estimates, and correlations between measures reported here can be used for study planning for social cognitive interventions in autism. Autism Research 2019, 12: 766-778. (c) 2019 The Authors. Autism Research published by International Society for Autism Research published by Wiley Periodicals, Inc. LAY SUMMARY: We examined 11 tasks that measure how adults with autism perceive and interpret social information. Eight of the tasks were reliable and showed lower performance in adults with autism compared to typically-developing controls. Task performance was related to but distinguishable from IQ. These measures evaluated here may be useful in assessing the effectiveness of interventions and treatments to improve social abilities in adults with autism. En ligne : http://dx.doi.org/10.1002/aur.2084 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism / Jessica BRADSHAW in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.779-793 Titre : The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism Type de document : Texte imprimé et/ou numérique Auteurs : Jessica BRADSHAW, Auteur ; F. SHIC, Auteur ; A. N. HOLDEN, Auteur ; E. J. HOROWITZ, Auteur ; Amy C. BARRETT, Auteur ; T. C. GERMAN, Auteur ; Ty W. VERNON, Auteur Article en page(s) : p.779-793 Langues : Anglais (eng) Mots-clés : attention  biomarkers  early intervention  eye tracking  social cognition Index. décimale : PER Périodiques Résumé : There is a pressing need for objective, quantifiable outcome measures in intervention trials for children with autism spectrum disorder (ASD). The current study investigated the use of eye tracking as a biomarker of treatment response in the context of a pilot randomized clinical trial of treatment for young children with ASD. Participants included 28 children with ASD, aged 18-48 months, who were randomized to one of two conditions: Pivotal Response Intervention for Social Motivation (PRISM) or community treatment as usual (TAU). Eye-tracking and behavioral assessment of developmental functioning were administered at Time 1 (prior to randomization) and at Time 2 (after 6 months of intervention). Two well-established eye-tracking paradigms were used to measure social attention: social preference and face scanning. As a context for understanding relationships between social attention and developmental ability, we first examined how scanning patterns at Time 1 were associated with concurrent developmental functioning and compared to those of 23 age-matched typically developing (TD) children. Changes in scanning patterns from Time 1 to Time 2 were then compared between PRISM and TAU groups and associated with behavioral change over time. Results showed that the social preference paradigm differentiated children with ASD from TD children. In addition, attention during face scanning was associated with language and adaptive communication skills at Time 1 and change in language skills from Time 1 to Time 2. These findings highlight the importance of examining targeted biomarkers that measure unique aspects of child functioning and that are well-matched to proposed mechanisms of change. Autism Research 2019, 12: 779-793. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Biomarkers have the potential to provide important information about how and why early interventions effect positive change for young children with ASD. The current study suggests that eye-tracking measures of social attention can be used to track change in specific areas of development, such as language, and points to the need for targeted eye-tracking paradigms designed to measure specific behavioral changes. Such biomarkers could inform the development of optimal, individualized, and adaptive interventions for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2093 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism [Texte imprimé et/ou numérique] / Jessica BRADSHAW, Auteur ; F. SHIC, Auteur ; A. N. HOLDEN, Auteur ; E. J. HOROWITZ, Auteur ; Amy C. BARRETT, Auteur ; T. C. GERMAN, Auteur ; Ty W. VERNON, Auteur . - p.779-793. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.779-793 Mots-clés : attention  biomarkers  early intervention  eye tracking  social cognition Index. décimale : PER Périodiques Résumé : There is a pressing need for objective, quantifiable outcome measures in intervention trials for children with autism spectrum disorder (ASD). The current study investigated the use of eye tracking as a biomarker of treatment response in the context of a pilot randomized clinical trial of treatment for young children with ASD. Participants included 28 children with ASD, aged 18-48 months, who were randomized to one of two conditions: Pivotal Response Intervention for Social Motivation (PRISM) or community treatment as usual (TAU). Eye-tracking and behavioral assessment of developmental functioning were administered at Time 1 (prior to randomization) and at Time 2 (after 6 months of intervention). Two well-established eye-tracking paradigms were used to measure social attention: social preference and face scanning. As a context for understanding relationships between social attention and developmental ability, we first examined how scanning patterns at Time 1 were associated with concurrent developmental functioning and compared to those of 23 age-matched typically developing (TD) children. Changes in scanning patterns from Time 1 to Time 2 were then compared between PRISM and TAU groups and associated with behavioral change over time. Results showed that the social preference paradigm differentiated children with ASD from TD children. In addition, attention during face scanning was associated with language and adaptive communication skills at Time 1 and change in language skills from Time 1 to Time 2. These findings highlight the importance of examining targeted biomarkers that measure unique aspects of child functioning and that are well-matched to proposed mechanisms of change. Autism Research 2019, 12: 779-793. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Biomarkers have the potential to provide important information about how and why early interventions effect positive change for young children with ASD. The current study suggests that eye-tracking measures of social attention can be used to track change in specific areas of development, such as language, and points to the need for targeted eye-tracking paradigms designed to measure specific behavioral changes. Such biomarkers could inform the development of optimal, individualized, and adaptive interventions for young children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2093 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Sleep determines quality of life in autistic adults: A longitudinal study / Marie K. DESERNO in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.794-801 Titre : Sleep determines quality of life in autistic adults: A longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Marie K. DESERNO, Auteur ; Denny BORSBOOM, Auteur ; Sander BEGEER, Auteur ; Joost A. AGELINK VAN RENTERGEM, Auteur ; K. MATAW, Auteur ; H. M. GEURTS, Auteur Article en page(s) : p.794-801 Langues : Anglais (eng) Mots-clés : autistic adults  large-scale longitudinal data  quality of life  regression tree analysis  sleep problems Index. décimale : PER Périodiques Résumé : Many individuals with autism report generally low quality of life (QoL). Identifying predictors for pathways underlying this outcome is an urgent priority. We aim to examine multivariate patterns that predict later subjective and objective QoL in autistic individuals. Autistic characteristics, comorbid complaints, aspects of daily functioning, and demographics were assessed online in a 2-year longitudinal study with 598 autistic adults. Regression trees were fitted to baseline data to identify factors that could predict QoL at follow-up. We found that sleep problems are an important predictor of later subjective QoL, while the subjective experience of a person's societal contribution is important when it comes to predicting the level of daily activities. Sleep problems are the most important predictor of QoL in autistic adults and may offer an important treatment target for improving QoL. Our results additionally suggest that social satisfaction can buffer this association. Autism Research 2019, 12: 794-801. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Many individuals with autism report generally low quality of life (QoL). In this study, we looked at factors that predict long-term QoL and found that sleep problems are highly influential. Our results additionally suggest that social satisfaction can buffer this influence. These findings suggest that sleep and social satisfaction could be monitored to increase QoL in autistic adults. En ligne : http://dx.doi.org/10.1002/aur.2103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Sleep determines quality of life in autistic adults: A longitudinal study [Texte imprimé et/ou numérique] / Marie K. DESERNO, Auteur ; Denny BORSBOOM, Auteur ; Sander BEGEER, Auteur ; Joost A. AGELINK VAN RENTERGEM, Auteur ; K. MATAW, Auteur ; H. M. GEURTS, Auteur . - p.794-801. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.794-801 Mots-clés : autistic adults  large-scale longitudinal data  quality of life  regression tree analysis  sleep problems Index. décimale : PER Périodiques Résumé : Many individuals with autism report generally low quality of life (QoL). Identifying predictors for pathways underlying this outcome is an urgent priority. We aim to examine multivariate patterns that predict later subjective and objective QoL in autistic individuals. Autistic characteristics, comorbid complaints, aspects of daily functioning, and demographics were assessed online in a 2-year longitudinal study with 598 autistic adults. Regression trees were fitted to baseline data to identify factors that could predict QoL at follow-up. We found that sleep problems are an important predictor of later subjective QoL, while the subjective experience of a person's societal contribution is important when it comes to predicting the level of daily activities. Sleep problems are the most important predictor of QoL in autistic adults and may offer an important treatment target for improving QoL. Our results additionally suggest that social satisfaction can buffer this association. Autism Research 2019, 12: 794-801. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Many individuals with autism report generally low quality of life (QoL). In this study, we looked at factors that predict long-term QoL and found that sleep problems are highly influential. Our results additionally suggest that social satisfaction can buffer this influence. These findings suggest that sleep and social satisfaction could be monitored to increase QoL in autistic adults. En ligne : http://dx.doi.org/10.1002/aur.2103 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Parent-reported prevalence of food allergies in children with autism spectrum disorder: National health interview survey, 2011-2015 / Y. TAN in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.802-805 Titre : Parent-reported prevalence of food allergies in children with autism spectrum disorder: National health interview survey, 2011-2015 Type de document : Texte imprimé et/ou numérique Auteurs : Y. TAN, Auteur ; S. THOMAS, Auteur ; Brian K. LEE, Auteur Article en page(s) : p.802-805 Langues : Anglais (eng) Mots-clés : allergy  children  co-morbid conditions  epidemiology Index. décimale : PER Périodiques Résumé : Food allergies are frequently reported to co-occur with autism spectrum disorder (ASD), but the prevalence of this co-occurrence remains uncertain. In the present study, we examined parent-reported prevalence of co-occurring food allergy and ASD in a nationally representative sample of US children ages 2-17 in the National Health Interview Survey, study years 2011-2015. All analyses used survey weights to account for the complex sampling design. In the analytic sample of 53,365 children ages 2-17, there were 905 children with parent-reported ASD (prevalence of 1.7%) and 2,977 children with parent-reported food allergy (prevalence of 5.6%). Parent-reported food allergies were nearly 2.5 times more common in children with ASD (prevalence of 13.1%) than in children without ASD (5.4%). These results indicate that food allergies commonly co-occur with ASD, which may have etiological implications. Autism Research 2019, 12: 802-805. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Food allergies are frequently reported to occur with autism spectrum disorder (ASD), but the prevalence of this co-occurrence remains uncertain. In the present study, we examined parent-reported prevalence of co-occurring food allergy and ASD in a nationally representative sample of United States children. In the sample of 53,365 children ages 2-17, 1.7% of children were reported to have ASD, and 5.6% were reported to have food allergies. Parent-reported food allergies were nearly 2.5 times more common in children with ASD (13.1%) than in children without ASD (5.4%). En ligne : http://dx.doi.org/10.1002/aur.2106 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Parent-reported prevalence of food allergies in children with autism spectrum disorder: National health interview survey, 2011-2015 [Texte imprimé et/ou numérique] / Y. TAN, Auteur ; S. THOMAS, Auteur ; Brian K. LEE, Auteur . - p.802-805. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.802-805 Mots-clés : allergy  children  co-morbid conditions  epidemiology Index. décimale : PER Périodiques Résumé : Food allergies are frequently reported to co-occur with autism spectrum disorder (ASD), but the prevalence of this co-occurrence remains uncertain. In the present study, we examined parent-reported prevalence of co-occurring food allergy and ASD in a nationally representative sample of US children ages 2-17 in the National Health Interview Survey, study years 2011-2015. All analyses used survey weights to account for the complex sampling design. In the analytic sample of 53,365 children ages 2-17, there were 905 children with parent-reported ASD (prevalence of 1.7%) and 2,977 children with parent-reported food allergy (prevalence of 5.6%). Parent-reported food allergies were nearly 2.5 times more common in children with ASD (prevalence of 13.1%) than in children without ASD (5.4%). These results indicate that food allergies commonly co-occur with ASD, which may have etiological implications. Autism Research 2019, 12: 802-805. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Food allergies are frequently reported to occur with autism spectrum disorder (ASD), but the prevalence of this co-occurrence remains uncertain. In the present study, we examined parent-reported prevalence of co-occurring food allergy and ASD in a nationally representative sample of United States children. In the sample of 53,365 children ages 2-17, 1.7% of children were reported to have ASD, and 5.6% were reported to have food allergies. Parent-reported food allergies were nearly 2.5 times more common in children with ASD (13.1%) than in children without ASD (5.4%). En ligne : http://dx.doi.org/10.1002/aur.2106 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Mortality and cause of death of Australians on the autism spectrum / Y. I. J. HWANG in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.806-815 Titre : Mortality and cause of death of Australians on the autism spectrum Type de document : Texte imprimé et/ou numérique Auteurs : Y. I. J. HWANG, Auteur ; P. SRASUEBKUL, Auteur ; K. R. FOLEY, Auteur ; S. ARNOLD, Auteur ; J. N. TROLLOR, Auteur Article en page(s) : p.806-815 Langues : Anglais (eng) Mots-clés : autism  cause of death  intellectual disability  linked data  mortality Index. décimale : PER Périodiques Résumé : Focused investigations regarding mortality rates, risk factors, and cause of death in autistic populations remain scarce. The present study used large linked datasets spanning 2001-2015 to report the rates and risk factors for mortality and cause of death in individuals on the autism spectrum (n = 35,929 age range 5-64) with and without concurrent intellectual disability (ID) in New South Wales, Australia. Mortality rates for those on the autism spectrum were 2.06 times that of the general population. Concurrent ID, epilepsy, mental health conditions, and chronic physical health conditions were associated with a higher risk of death for those on the spectrum, whereas demographic variables such as gender and socioeconomic status were not. A differing profile of top causes of death was found for autistic individuals relative to the general population, with "nervous system and sense disorders" and "injury and poisoning" being the top-ranked causes for those on the spectrum. The findings alert the need for health promotion and management of concurrent physical and mental health conditions for those on the autism spectrum. There is also a need for better identification, diagnosis, and documentation of older adults on the autism spectrum. Autism Research 2019, 12: 806-815. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Rates of death are higher for autistic individuals compared to the general population. There is higher risk of death for autistic individuals who have additional mental and physical health conditions. The leading causes of death for autistic individuals with and without ID are "nervous system and sense disorders", which includes epilepsy and "injury and poisoning", respectively. To minimize risk of death, it is important to manage the mental and physical health individuals on the autism spectrum and to better understand the circumstances surrounding preventable deaths for this population. En ligne : http://dx.doi.org/10.1002/aur.2086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Mortality and cause of death of Australians on the autism spectrum [Texte imprimé et/ou numérique] / Y. I. J. HWANG, Auteur ; P. SRASUEBKUL, Auteur ; K. R. FOLEY, Auteur ; S. ARNOLD, Auteur ; J. N. TROLLOR, Auteur . - p.806-815. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.806-815 Mots-clés : autism  cause of death  intellectual disability  linked data  mortality Index. décimale : PER Périodiques Résumé : Focused investigations regarding mortality rates, risk factors, and cause of death in autistic populations remain scarce. The present study used large linked datasets spanning 2001-2015 to report the rates and risk factors for mortality and cause of death in individuals on the autism spectrum (n = 35,929 age range 5-64) with and without concurrent intellectual disability (ID) in New South Wales, Australia. Mortality rates for those on the autism spectrum were 2.06 times that of the general population. Concurrent ID, epilepsy, mental health conditions, and chronic physical health conditions were associated with a higher risk of death for those on the spectrum, whereas demographic variables such as gender and socioeconomic status were not. A differing profile of top causes of death was found for autistic individuals relative to the general population, with "nervous system and sense disorders" and "injury and poisoning" being the top-ranked causes for those on the spectrum. The findings alert the need for health promotion and management of concurrent physical and mental health conditions for those on the autism spectrum. There is also a need for better identification, diagnosis, and documentation of older adults on the autism spectrum. Autism Research 2019, 12: 806-815. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Rates of death are higher for autistic individuals compared to the general population. There is higher risk of death for autistic individuals who have additional mental and physical health conditions. The leading causes of death for autistic individuals with and without ID are "nervous system and sense disorders", which includes epilepsy and "injury and poisoning", respectively. To minimize risk of death, it is important to manage the mental and physical health individuals on the autism spectrum and to better understand the circumstances surrounding preventable deaths for this population. En ligne : http://dx.doi.org/10.1002/aur.2086 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development / G. N. SOKE in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.816-829 Titre : Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development Type de document : Texte imprimé et/ou numérique Auteurs : G. N. SOKE, Auteur ; M. MAENNER, Auteur ; G. WINDHAM, Auteur ; E. MOODY, Auteur ; J. KACZANIUK, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Laura A. SCHIEVE, Auteur Article en page(s) : p.816-829 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies report inconsistent findings on the relationship between ASD and breastfeeding. We explored associations between ASD and breastfeeding initiation (yes/no) and duration (months categorized in tertiles) in the Study to Explore Early Development, a community-based case-control study in six sites in the Unites States. We adjusted for various child and mother demographic and pregnancy factors. Breastfeeding initiation was reported in 85.7% of mothers of children with ASD and 90.6% of mothers of controls. After adjustment, we found no significant difference in breastfeeding initiation (adjusted odds-ratio [aOR]: 0.88 and 95% confidence interval (CI) 0.60-1.28). However, mothers of children with ASD were less likely to report duration of breastfeeding in the high (>/=12 months) versus low tertile (<6 months) (aOR and 95% CI: 0.61 [0.45-0.84]) or the middle (6-<12 months) versus low tertile (0.72: 0.54-0.98). The association of ASD and breastfeeding duration was slightly attenuated when the presence of the broader autism phenotype (BAP) in the mother was accounted for, but still remained for the highest tertile. This association does not appear to be totally explained by maternal BAP. We were unable to distinguish whether the difference in duration was due to difficulties breastfeeding children who later develop ASD, other factors not adjusted in our study, or greater ASD risk resulting from shorter breastfeeding duration. Longitudinal studies that compare reasons why mothers stop breastfeeding between ASD and controls and establish a temporal relation between ASD and breastfeeding are needed. Future studies should also evaluate interactions between ASD risk genes and breastfeeding. Autism Research 2019, 12: 816-829. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we compared breastfeeding practices between mothers of children with and without autism spectrum disorder (ASD). We found that the percentage of mothers who started breastfeeding was similar between the two groups, but mothers of children with ASD breastfed for a shorter amount of time compared to mothers of children without ASD. Future studies are needed to evaluate the reasons why the duration of breastfeeding was shorter for mothers of children with ASD compared to those without ASD. En ligne : http://dx.doi.org/10.1002/aur.2091 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Association Between Breastfeeding Initiation and Duration and Autism Spectrum Disorder in Preschool Children Enrolled in the Study to Explore Early Development [Texte imprimé et/ou numérique] / G. N. SOKE, Auteur ; M. MAENNER, Auteur ; G. WINDHAM, Auteur ; E. MOODY, Auteur ; J. KACZANIUK, Auteur ; Carolyn G. DIGUISEPPI, Auteur ; Laura A. SCHIEVE, Auteur . - p.816-829. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.816-829 Index. décimale : PER Périodiques Résumé : Studies report inconsistent findings on the relationship between ASD and breastfeeding. We explored associations between ASD and breastfeeding initiation (yes/no) and duration (months categorized in tertiles) in the Study to Explore Early Development, a community-based case-control study in six sites in the Unites States. We adjusted for various child and mother demographic and pregnancy factors. Breastfeeding initiation was reported in 85.7% of mothers of children with ASD and 90.6% of mothers of controls. After adjustment, we found no significant difference in breastfeeding initiation (adjusted odds-ratio [aOR]: 0.88 and 95% confidence interval (CI) 0.60-1.28). However, mothers of children with ASD were less likely to report duration of breastfeeding in the high (>/=12 months) versus low tertile (<6 months) (aOR and 95% CI: 0.61 [0.45-0.84]) or the middle (6-<12 months) versus low tertile (0.72: 0.54-0.98). The association of ASD and breastfeeding duration was slightly attenuated when the presence of the broader autism phenotype (BAP) in the mother was accounted for, but still remained for the highest tertile. This association does not appear to be totally explained by maternal BAP. We were unable to distinguish whether the difference in duration was due to difficulties breastfeeding children who later develop ASD, other factors not adjusted in our study, or greater ASD risk resulting from shorter breastfeeding duration. Longitudinal studies that compare reasons why mothers stop breastfeeding between ASD and controls and establish a temporal relation between ASD and breastfeeding are needed. Future studies should also evaluate interactions between ASD risk genes and breastfeeding. Autism Research 2019, 12: 816-829. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: In this study, we compared breastfeeding practices between mothers of children with and without autism spectrum disorder (ASD). We found that the percentage of mothers who started breastfeeding was similar between the two groups, but mothers of children with ASD breastfed for a shorter amount of time compared to mothers of children without ASD. Future studies are needed to evaluate the reasons why the duration of breastfeeding was shorter for mothers of children with ASD compared to those without ASD. En ligne : http://dx.doi.org/10.1002/aur.2091 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Profiles of vocalization change in children with autism receiving early intervention / D. TREMBATH in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.830-842 Titre : Profiles of vocalization change in children with autism receiving early intervention Type de document : Texte imprimé et/ou numérique Auteurs : D. TREMBATH, Auteur ; Marleen F. WESTERVELD, Auteur ; S. TEPPALA, Auteur ; A. THIRUMANICKAM, Auteur ; R. SULEK, Auteur ; V. ROSE, Auteur ; M. TUCKER, Auteur ; J. PAYNTER, Auteur ; O. HETZRONI, Auteur ; D. KEEN, Auteur ; G. VIVANTI, Auteur Article en page(s) : p.830-842 Langues : Anglais (eng) Mots-clés : children  individual variability/heterogeneity  language  longitudinal data analysis  treatment Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) commonly present with comorbid language impairment, negatively impacting their learning and participation across settings. Addressing these needs requires a detailed understanding of their communication trajectories. In this study, we used the language environment and analysis (LENA) system to examine possible changes in children's (a) vocalizations and (b) ratio of speech to nonspeech vocalizations over a 10-month period. Data for 23 children with ASD (17M, 6F; ages 32-67 months) were analyzed, including monthly 3-hr in-class recordings and standardized measures of language, cognition, and ASD characteristics. Using hierarchical generalized linear models, we found significant time-trends for child vocalizations (P En ligne : http://dx.doi.org/10.1002/aur.2075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Profiles of vocalization change in children with autism receiving early intervention [Texte imprimé et/ou numérique] / D. TREMBATH, Auteur ; Marleen F. WESTERVELD, Auteur ; S. TEPPALA, Auteur ; A. THIRUMANICKAM, Auteur ; R. SULEK, Auteur ; V. ROSE, Auteur ; M. TUCKER, Auteur ; J. PAYNTER, Auteur ; O. HETZRONI, Auteur ; D. KEEN, Auteur ; G. VIVANTI, Auteur . - p.830-842. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.830-842 Mots-clés : children  individual variability/heterogeneity  language  longitudinal data analysis  treatment Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorder (ASD) commonly present with comorbid language impairment, negatively impacting their learning and participation across settings. Addressing these needs requires a detailed understanding of their communication trajectories. In this study, we used the language environment and analysis (LENA) system to examine possible changes in children's (a) vocalizations and (b) ratio of speech to nonspeech vocalizations over a 10-month period. Data for 23 children with ASD (17M, 6F; ages 32-67 months) were analyzed, including monthly 3-hr in-class recordings and standardized measures of language, cognition, and ASD characteristics. Using hierarchical generalized linear models, we found significant time-trends for child vocalizations (P En ligne : http://dx.doi.org/10.1002/aur.2075 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397

Using latent class analysis to identify treatment-use subgroups among parents of children with autism spectrum disorder / S. S. MIRE in Autism Research, 12-5 (May 2019)  

Public ISBD [article]  inAutism Research > 12-5 (May 2019) . - p.843-854 Titre : Using latent class analysis to identify treatment-use subgroups among parents of children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : S. S. MIRE, Auteur ; S. MCQUILLIN, Auteur ; M. RACINE, Auteur ; R. P. GOIN-KOCHEL, Auteur Article en page(s) : p.843-854 Langues : Anglais (eng) Mots-clés : Asd  autism  developmental regression  latent class analysis  treatment Index. décimale : PER Périodiques Résumé : Among parents of 2,582 children (ages 4-17 years old) with autism spectrum disorder (ASD), we used latent class analysis to identify subgroups and profiles of treatment users and included annual household income in the specification of the models, then described characteristics of each subgroup. Based on three indicators of fit (Akaike's Information Criterion, Bayesian Information Criterion, and Lo-Mendell-Rubin), six latent classes of treatment users emerged. Subgroups included users of: (a) mostly private and school speech and occupational therapies; (b) nearly all treatment types; (c) mostly speech and occupational therapies, plus intensive behavioral and "other" treatments, but little medication use; (d) private therapies almost exclusively; (e) primarily psychotropic medications; and (f) mostly school-based therapies. Income significantly predicted class differences for all but one latent class. Probabilities of families' lifetime use of nine treatment types varied depending on latent classification. Proportions of families reporting having observed children's developmental regression were largest in those with the highest overall treatment use, and these children also had the lowest cognitive and adaptive-functioning scores and the highest ASD symptom scores. Understanding patterns of treatment use among families of children with ASD is an important first step in enhancing treatment-related selection and implementation. Autism Research 2019, 12: 843-854. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We identified six different groups of treatment users to help explain patterns in treatment implementation among parents of children and adolescents with autism. These included families who used: (a) mostly used private and school speech and occupational therapies; (b) nearly all treatment types (private and school therapies, intensive behavioral, biomedical, psychotropic medications, and other treatments); (c) mostly speech and occupational therapies, plus intensive behavioral and "other" treatments, but little medication use; (d) private therapies almost exclusively; (e) primarily psychotropic medications; and (f) mostly school-based therapies. En ligne : http://dx.doi.org/10.1002/aur.2107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397 [article] Using latent class analysis to identify treatment-use subgroups among parents of children with autism spectrum disorder [Texte imprimé et/ou numérique] / S. S. MIRE, Auteur ; S. MCQUILLIN, Auteur ; M. RACINE, Auteur ; R. P. GOIN-KOCHEL, Auteur . - p.843-854. Langues : Anglais (eng) in Autism Research > 12-5 (May 2019) . - p.843-854 Mots-clés : Asd  autism  developmental regression  latent class analysis  treatment Index. décimale : PER Périodiques Résumé : Among parents of 2,582 children (ages 4-17 years old) with autism spectrum disorder (ASD), we used latent class analysis to identify subgroups and profiles of treatment users and included annual household income in the specification of the models, then described characteristics of each subgroup. Based on three indicators of fit (Akaike's Information Criterion, Bayesian Information Criterion, and Lo-Mendell-Rubin), six latent classes of treatment users emerged. Subgroups included users of: (a) mostly private and school speech and occupational therapies; (b) nearly all treatment types; (c) mostly speech and occupational therapies, plus intensive behavioral and "other" treatments, but little medication use; (d) private therapies almost exclusively; (e) primarily psychotropic medications; and (f) mostly school-based therapies. Income significantly predicted class differences for all but one latent class. Probabilities of families' lifetime use of nine treatment types varied depending on latent classification. Proportions of families reporting having observed children's developmental regression were largest in those with the highest overall treatment use, and these children also had the lowest cognitive and adaptive-functioning scores and the highest ASD symptom scores. Understanding patterns of treatment use among families of children with ASD is an important first step in enhancing treatment-related selection and implementation. Autism Research 2019, 12: 843-854. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: We identified six different groups of treatment users to help explain patterns in treatment implementation among parents of children and adolescents with autism. These included families who used: (a) mostly used private and school speech and occupational therapies; (b) nearly all treatment types (private and school therapies, intensive behavioral, biomedical, psychotropic medications, and other treatments); (c) mostly speech and occupational therapies, plus intensive behavioral and "other" treatments, but little medication use; (d) private therapies almost exclusively; (e) primarily psychotropic medications; and (f) mostly school-based therapies. En ligne : http://dx.doi.org/10.1002/aur.2107 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=397