Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder / J. MANFREDONIA in Journal of Autism and Developmental Disorders, 49-1 (January 2019)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.279-293 Titre : Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. MANFREDONIA, Auteur ; Abigail BANGERTER, Auteur ; N. V. MANYAKOV, Auteur ; S. NESS, Auteur ; D. LEWIN, Auteur ; A. SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; M. S. GOODWIN, Auteur ; G. DAWSON, Auteur ; R. HENDREN, Auteur ; B. LEVENTHAL, Auteur ; F. SHIC, Auteur ; Gahan PANDINA, Auteur Article en page(s) : p.279-293 Langues : Anglais (eng) Mots-clés : Asd  Automated  Emotion  Expression  Facet  Facial Index. décimale : PER Périodiques Résumé : Facial expression is impaired in autism spectrum disorder (ASD), but rarely systematically studied. We focus on the ability of individuals with ASD to produce facial expressions of emotions in response to a verbal prompt. We used the Janssen Autism Knowledge Engine (JAKE((R))), including automated facial expression analysis software (FACET) to measure facial expressions in individuals with ASD (n = 144) and a typically developing (TD) comparison group (n = 41). Differences in ability to produce facial expressions were observed between ASD and TD groups, demonstrated by activation of facial action units (happy, scared, surprised, disgusted, but not angry or sad). Activation of facial action units correlated with parent-reported social communication skills. This approach has potential for diagnostic and response to intervention measures.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-018-3757-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377 [article] Automatic Recognition of Posed Facial Expression of Emotion in Individuals with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. MANFREDONIA, Auteur ; Abigail BANGERTER, Auteur ; N. V. MANYAKOV, Auteur ; S. NESS, Auteur ; D. LEWIN, Auteur ; A. SKALKIN, Auteur ; Matthew A. BOICE, Auteur ; M. S. GOODWIN, Auteur ; G. DAWSON, Auteur ; R. HENDREN, Auteur ; B. LEVENTHAL, Auteur ; F. SHIC, Auteur ; Gahan PANDINA, Auteur . - p.279-293. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 49-1 (January 2019) . - p.279-293 Mots-clés : Asd  Automated  Emotion  Expression  Facet  Facial Index. décimale : PER Périodiques Résumé : Facial expression is impaired in autism spectrum disorder (ASD), but rarely systematically studied. We focus on the ability of individuals with ASD to produce facial expressions of emotions in response to a verbal prompt. We used the Janssen Autism Knowledge Engine (JAKE((R))), including automated facial expression analysis software (FACET) to measure facial expressions in individuals with ASD (n = 144) and a typically developing (TD) comparison group (n = 41). Differences in ability to produce facial expressions were observed between ASD and TD groups, demonstrated by activation of facial action units (happy, scared, surprised, disgusted, but not angry or sad). Activation of facial action units correlated with parent-reported social communication skills. This approach has potential for diagnostic and response to intervention measures.Trial Registration NCT02299700. En ligne : http://dx.doi.org/10.1007/s10803-018-3757-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=377

Challenges of Females with Autism: A Parental Perspective / M. MADEMTZI in Journal of Autism and Developmental Disorders, 48-4 (April 2018)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1301-1310 Titre : Challenges of Females with Autism: A Parental Perspective Type de document : Texte imprimé et/ou numérique Auteurs : M. MADEMTZI, Auteur ; P. SINGH, Auteur ; F. SHIC, Auteur ; K. KOENIG, Auteur Article en page(s) : p.1301-1310 Langues : Anglais (eng) Mots-clés : Autism  Autism Spectrum Disorders  Females  Focus group  Girls  Parents Index. décimale : PER Périodiques Résumé : Most studies investigating the experiences and needs of individuals with ASD have largely focused on males. Hence, this study investigates parents' perspectives on the challenges that their daughters with ASD face. In total, 40 parents of 40 females with autism (age range = 4-29 years; mean = 15.9) participated in the study. Five separate, 2-h long focus groups were conducted, with 7-10 participants in each group. Field notes were analyzed using thematic analysis. Some of the issues parents discussed were similar to those experienced by males with ASD, such as challenges in social interactions. However, other issues discussed were of particular relevance to girls with ASD, including difficulties socializing with other girls, sex-specific puberty issues, barriers in accessing intervention and sexual vulnerability. En ligne : http://dx.doi.org/10.1007/s10803-017-3341-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 [article] Challenges of Females with Autism: A Parental Perspective [Texte imprimé et/ou numérique] / M. MADEMTZI, Auteur ; P. SINGH, Auteur ; F. SHIC, Auteur ; K. KOENIG, Auteur . - p.1301-1310. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 48-4 (April 2018) . - p.1301-1310 Mots-clés : Autism  Autism Spectrum Disorders  Females  Focus group  Girls  Parents Index. décimale : PER Périodiques Résumé : Most studies investigating the experiences and needs of individuals with ASD have largely focused on males. Hence, this study investigates parents' perspectives on the challenges that their daughters with ASD face. In total, 40 parents of 40 females with autism (age range = 4-29 years; mean = 15.9) participated in the study. Five separate, 2-h long focus groups were conducted, with 7-10 participants in each group. Field notes were analyzed using thematic analysis. Some of the issues parents discussed were similar to those experienced by males with ASD, such as challenges in social interactions. However, other issues discussed were of particular relevance to girls with ASD, including difficulties socializing with other girls, sex-specific puberty issues, barriers in accessing intervention and sexual vulnerability. En ligne : http://dx.doi.org/10.1007/s10803-017-3341-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352

In Search of Biomarkers for Autism Spectrum Disorder / Marta DEL VALLE RUBIDO in Autism Research, 11-11 (November 2018)  

Public ISBD [article]  inAutism Research > 11-11 (November 2018) . - p.1567-1579 Titre : In Search of Biomarkers for Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Marta DEL VALLE RUBIDO, Auteur ; J. T. MCCRACKEN, Auteur ; E. HOLLANDER, Auteur ; F. SHIC, Auteur ; J. NOELDEKE, Auteur ; Lauren BOAK, Auteur ; O. KHWAJA, Auteur ; S. SADIKHOV, Auteur ; P. FONTOURA, Auteur ; D. UMBRICHT, Auteur Article en page(s) : p.1567-1579 Langues : Anglais (eng) Mots-clés : biomarker  eye movement  olfactory  social cognition Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) lacks validated measures of core social functions across development stages suitable for clinical trials. We assessed the concurrent validity between ASD clinical measures and putative biomarkers of core deficits, and their feasibility of implementation in human studies. Datasets from two adult ASD studies were combined (observational study [n = 19] and interventional study baseline data [n = 19]). Potential biomarkers included eye-tracking, olfaction, and auditory and visual emotion recognition assessed via the Affective Speech Recognition test (ASR) and Reading-the-Mind-in-the-Eyes Test (RMET). Current functioning was assessed with intelligence quotient (IQ), adaptive skill testing, and behavioral ratings. Autism severity was determined by the Autism Diagnostic Observation Scale-2 and Social Communication Interaction Test (SCIT). Exploratory measures showed varying significant associations across ASD severity, adaptive skills, and behavior. Eye tracking endpoints showed little relationship to adaptive ability but correlated with severity and behavior. ASR scores significantly correlated with most adaptive behavior domains, as well as severity. Olfaction predicted visual and auditory emotion recognition. SCIT scores related moderately to multiple severity domains, and was the only measure not related with IQ. RMET accuracy was less related to ASD features. Eye tracking, SCIT, and ASR showed high test-retest reliability. We documented associations of proximal biomarkers of social functioning with multiple ASD dimensions. With the exception of SCIT, most correlations were modest, limiting utility as proxy measures of social communication. Feasibility and reliability were high for eye-tracking, ASR, and SCIT. Overall, several novel experimental paradigms showed potential as social biomarkers or surrogate markers in ASD. Autism Research 2018, 11: 1567-1579. (c) 2018 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: More accurate measurements of treatment effects are needed to help the development of new drug treatments for autism spectrum disorders (ASD). This study evaluates the relationship between assessments designed to measure behaviors associated with social communication and cognition in ASD with clinical and diagnostic assessments of symptom severity as well as their implementation. The assessments including eye-tracking, auditory and visual social stimuli recognition, and olfaction identification showed potential for use in the evaluation of treatments for social difficulties in ASD. En ligne : http://dx.doi.org/10.1002/aur.2026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] In Search of Biomarkers for Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Marta DEL VALLE RUBIDO, Auteur ; J. T. MCCRACKEN, Auteur ; E. HOLLANDER, Auteur ; F. SHIC, Auteur ; J. NOELDEKE, Auteur ; Lauren BOAK, Auteur ; O. KHWAJA, Auteur ; S. SADIKHOV, Auteur ; P. FONTOURA, Auteur ; D. UMBRICHT, Auteur . - p.1567-1579. Langues : Anglais (eng) in Autism Research > 11-11 (November 2018) . - p.1567-1579 Mots-clés : biomarker  eye movement  olfactory  social cognition Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) lacks validated measures of core social functions across development stages suitable for clinical trials. We assessed the concurrent validity between ASD clinical measures and putative biomarkers of core deficits, and their feasibility of implementation in human studies. Datasets from two adult ASD studies were combined (observational study [n = 19] and interventional study baseline data [n = 19]). Potential biomarkers included eye-tracking, olfaction, and auditory and visual emotion recognition assessed via the Affective Speech Recognition test (ASR) and Reading-the-Mind-in-the-Eyes Test (RMET). Current functioning was assessed with intelligence quotient (IQ), adaptive skill testing, and behavioral ratings. Autism severity was determined by the Autism Diagnostic Observation Scale-2 and Social Communication Interaction Test (SCIT). Exploratory measures showed varying significant associations across ASD severity, adaptive skills, and behavior. Eye tracking endpoints showed little relationship to adaptive ability but correlated with severity and behavior. ASR scores significantly correlated with most adaptive behavior domains, as well as severity. Olfaction predicted visual and auditory emotion recognition. SCIT scores related moderately to multiple severity domains, and was the only measure not related with IQ. RMET accuracy was less related to ASD features. Eye tracking, SCIT, and ASR showed high test-retest reliability. We documented associations of proximal biomarkers of social functioning with multiple ASD dimensions. With the exception of SCIT, most correlations were modest, limiting utility as proxy measures of social communication. Feasibility and reliability were high for eye-tracking, ASR, and SCIT. Overall, several novel experimental paradigms showed potential as social biomarkers or surrogate markers in ASD. Autism Research 2018, 11: 1567-1579. (c) 2018 The Authors. Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: More accurate measurements of treatment effects are needed to help the development of new drug treatments for autism spectrum disorders (ASD). This study evaluates the relationship between assessments designed to measure behaviors associated with social communication and cognition in ASD with clinical and diagnostic assessments of symptom severity as well as their implementation. The assessments including eye-tracking, auditory and visual social stimuli recognition, and olfaction identification showed potential for use in the evaluation of treatments for social difficulties in ASD. En ligne : http://dx.doi.org/10.1002/aur.2026 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Neurogenetic analysis of childhood disintegrative disorder / A. R. GUPTA in Molecular Autism, 8 (2017)  

Public ISBD [article]  inMolecular Autism > 8 (2017) . - 19p. Titre : Neurogenetic analysis of childhood disintegrative disorder Type de document : Texte imprimé et/ou numérique Auteurs : A. R. GUPTA, Auteur ; A. WESTPHAL, Auteur ; D. Y. J. YANG, Auteur ; C. A. W. SULLIVAN, Auteur ; J. EILBOTT, Auteur ; S. ZAIDI, Auteur ; A. VOOS, Auteur ; B. C. VANDER WYK, Auteur ; Pamela VENTOLA, Auteur ; Z. WAQAR, Auteur ; T. V. FERNANDEZ, Auteur ; A. G. ERCAN-SENCICEK, Auteur ; M. F. WALKER, Auteur ; M. CHOI, Auteur ; A. SCHNEIDER, Auteur ; T. HEDDERLY, Auteur ; Gillian BAIRD, Auteur ; H. FRIEDMAN, Auteur ; C. CORDEAUX, Auteur ; A. RISTOW, Auteur ; F. SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur Article en page(s) : 19p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder (ASD)  Childhood disintegrative disorder (CDD)  Eye tracking  Functional magnetic resonance imaging (fMRI)  Genetics  Intellectual disability (ID)  Regression Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood disintegrative disorder (CDD) is a rare form of autism spectrum disorder (ASD) of unknown etiology. It is characterized by late-onset regression leading to significant intellectual disability (ID) and severe autism. Although there are phenotypic differences between CDD and other forms of ASD, it is unclear if there are neurobiological differences. METHODS: We pursued a multidisciplinary study of CDD (n = 17) and three comparison groups: low-functioning ASD (n = 12), high-functioning ASD (n = 50), and typically developing (n = 26) individuals. We performed whole-exome sequencing (WES), copy number variant (CNV), and gene expression analyses of CDD and, on subsets of each cohort, non-sedated functional magnetic resonance imaging (fMRI) while viewing socioemotional (faces) and non-socioemotional (houses) stimuli and eye tracking while viewing emotional faces. RESULTS: We observed potential differences between CDD and other forms of ASD. WES and CNV analyses identified one or more rare de novo, homozygous, and/or hemizygous (mother-to-son transmission on chrX) variants for most probands that were not shared by unaffected sibling controls. There were no clearly deleterious variants or highly recurrent candidate genes. Candidate genes that were found to be most conserved at variant position and most intolerant of variation, such as TRRAP, ZNF236, and KIAA2018, play a role or may be involved in transcription. Using the human BrainSpan transcriptome dataset, CDD candidate genes were found to be more highly expressed in non-neocortical regions than neocortical regions. This expression profile was similar to that of an independent cohort of ASD probands with regression. The non-neocortical regions overlapped with those identified by fMRI as abnormally hyperactive in response to viewing faces, such as the thalamus, cerebellum, caudate, and hippocampus. Eye-tracking analysis showed that, among individuals with ASD, subjects with CDD focused on eyes the most when shown pictures of faces. CONCLUSIONS: Given that cohort sizes were limited by the rarity of CDD, and the challenges of conducting non-sedated fMRI and eye tracking in subjects with ASD and significant ID, this is an exploratory study designed to investigate the neurobiological features of CDD. In addition to reporting the first multimodal analysis of CDD, a combination of fMRI and eye-tracking analyses are being presented for the first time for low-functioning individuals with ASD. Our results suggest differences between CDD and other forms of ASD on the neurobiological as well as clinical level. En ligne : http://dx.doi.org/10.1186/s13229-017-0133-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330 [article] Neurogenetic analysis of childhood disintegrative disorder [Texte imprimé et/ou numérique] / A. R. GUPTA, Auteur ; A. WESTPHAL, Auteur ; D. Y. J. YANG, Auteur ; C. A. W. SULLIVAN, Auteur ; J. EILBOTT, Auteur ; S. ZAIDI, Auteur ; A. VOOS, Auteur ; B. C. VANDER WYK, Auteur ; Pamela VENTOLA, Auteur ; Z. WAQAR, Auteur ; T. V. FERNANDEZ, Auteur ; A. G. ERCAN-SENCICEK, Auteur ; M. F. WALKER, Auteur ; M. CHOI, Auteur ; A. SCHNEIDER, Auteur ; T. HEDDERLY, Auteur ; Gillian BAIRD, Auteur ; H. FRIEDMAN, Auteur ; C. CORDEAUX, Auteur ; A. RISTOW, Auteur ; F. SHIC, Auteur ; Fred R. VOLKMAR, Auteur ; Kevin A. PELPHREY, Auteur . - 19p. Langues : Anglais (eng) in Molecular Autism > 8 (2017) . - 19p. Mots-clés : Autism spectrum disorder (ASD)  Childhood disintegrative disorder (CDD)  Eye tracking  Functional magnetic resonance imaging (fMRI)  Genetics  Intellectual disability (ID)  Regression Index. décimale : PER Périodiques Résumé : BACKGROUND: Childhood disintegrative disorder (CDD) is a rare form of autism spectrum disorder (ASD) of unknown etiology. It is characterized by late-onset regression leading to significant intellectual disability (ID) and severe autism. Although there are phenotypic differences between CDD and other forms of ASD, it is unclear if there are neurobiological differences. METHODS: We pursued a multidisciplinary study of CDD (n = 17) and three comparison groups: low-functioning ASD (n = 12), high-functioning ASD (n = 50), and typically developing (n = 26) individuals. We performed whole-exome sequencing (WES), copy number variant (CNV), and gene expression analyses of CDD and, on subsets of each cohort, non-sedated functional magnetic resonance imaging (fMRI) while viewing socioemotional (faces) and non-socioemotional (houses) stimuli and eye tracking while viewing emotional faces. RESULTS: We observed potential differences between CDD and other forms of ASD. WES and CNV analyses identified one or more rare de novo, homozygous, and/or hemizygous (mother-to-son transmission on chrX) variants for most probands that were not shared by unaffected sibling controls. There were no clearly deleterious variants or highly recurrent candidate genes. Candidate genes that were found to be most conserved at variant position and most intolerant of variation, such as TRRAP, ZNF236, and KIAA2018, play a role or may be involved in transcription. Using the human BrainSpan transcriptome dataset, CDD candidate genes were found to be more highly expressed in non-neocortical regions than neocortical regions. This expression profile was similar to that of an independent cohort of ASD probands with regression. The non-neocortical regions overlapped with those identified by fMRI as abnormally hyperactive in response to viewing faces, such as the thalamus, cerebellum, caudate, and hippocampus. Eye-tracking analysis showed that, among individuals with ASD, subjects with CDD focused on eyes the most when shown pictures of faces. CONCLUSIONS: Given that cohort sizes were limited by the rarity of CDD, and the challenges of conducting non-sedated fMRI and eye tracking in subjects with ASD and significant ID, this is an exploratory study designed to investigate the neurobiological features of CDD. In addition to reporting the first multimodal analysis of CDD, a combination of fMRI and eye-tracking analyses are being presented for the first time for low-functioning individuals with ASD. Our results suggest differences between CDD and other forms of ASD on the neurobiological as well as clinical level. En ligne : http://dx.doi.org/10.1186/s13229-017-0133-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=330

Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach / Q. WANG in Molecular Autism, 9 (2018)  

Public ISBD [article]  inMolecular Autism > 9 (2018) . - 25p. Titre : Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach Type de document : Texte imprimé et/ou numérique Auteurs : Q. WANG, Auteur ; Daniel J. CAMPBELL, Auteur ; S. L. MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur ; F. SHIC, Auteur Article en page(s) : 25p. Langues : Anglais (eng) Mots-clés : Attention  Autism Spectrum Disorder/diagnosis/physiopathology  Case-Control Studies  Child, Preschool  Female  Fixation, Ocular  Humans  Infant  Male  Social Behavior  Visual Perception  asd  Attentional synchrony  Atypicality  Autism  Cohesion  Eye tracking  Visual attention Index. décimale : PER Périodiques Résumé : Background: Multiple eye-tracking studies have highlighted the "atypical" nature of social attention in autism. However, it is unclear how "atypical" or "typical" should be quantified. Methods: We developed a method for identifying moments when members of a group looked at similar places (High-Cohesion Time Frames; HCTFs). We defined typicality as the proximity of gaze points to typically developing (TD) gaze points during TD HCTFs. Comparing toddlers with ASD (n = 112) to developmentally delayed (DD, n = 36) and TD (n = 163) toddlers during a video with Dyadic Bid, Sandwich-Making, Joint Attention, and Animated Toys conditions, we examined (a) individual typicality scores, (b) the relationship between typicality and symptom severity, and (c) HCTF distributions associated with each diagnostic group. Results: The ASD group had lower gaze typicality scores compared to the TD and DD groups in the Dyadic Bid and Sandwich-Making conditions but not during Animated Toys. The DD and TD groups did not differ in any condition. Correlational analyses indicated that higher typicality scores were associated with increased looking at pre-planned locations of the scene indexed by each experimental condition. In the ASD group, lower gaze typicality was associated with more severe autism symptoms. Examining ASD HCTFs, the gaze of toddlers with ASD was least cohesive during Dyadic Bid and most cohesive during Animated Toys. Conclusion: In contrast to non-ASD groups, toddlers with ASD show high cohesion during salient nonsocial events, suggesting that consistency in looking strategies may depend more on perceptual features. These findings are consequential for understanding individual differences in visual attention in ASD and for the design of more sensitive biomarker tasks for stratification, between-group differentiation, and measuring response to treatment. En ligne : https://dx.doi.org/10.1186/s13229-018-0211-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371 [article] Operationalizing atypical gaze in toddlers with autism spectrum disorders: a cohesion-based approach [Texte imprimé et/ou numérique] / Q. WANG, Auteur ; Daniel J. CAMPBELL, Auteur ; S. L. MACARI, Auteur ; Katarzyna CHAWARSKA, Auteur ; F. SHIC, Auteur . - 25p. Langues : Anglais (eng) in Molecular Autism > 9 (2018) . - 25p. Mots-clés : Attention  Autism Spectrum Disorder/diagnosis/physiopathology  Case-Control Studies  Child, Preschool  Female  Fixation, Ocular  Humans  Infant  Male  Social Behavior  Visual Perception  asd  Attentional synchrony  Atypicality  Autism  Cohesion  Eye tracking  Visual attention Index. décimale : PER Périodiques Résumé : Background: Multiple eye-tracking studies have highlighted the "atypical" nature of social attention in autism. However, it is unclear how "atypical" or "typical" should be quantified. Methods: We developed a method for identifying moments when members of a group looked at similar places (High-Cohesion Time Frames; HCTFs). We defined typicality as the proximity of gaze points to typically developing (TD) gaze points during TD HCTFs. Comparing toddlers with ASD (n = 112) to developmentally delayed (DD, n = 36) and TD (n = 163) toddlers during a video with Dyadic Bid, Sandwich-Making, Joint Attention, and Animated Toys conditions, we examined (a) individual typicality scores, (b) the relationship between typicality and symptom severity, and (c) HCTF distributions associated with each diagnostic group. Results: The ASD group had lower gaze typicality scores compared to the TD and DD groups in the Dyadic Bid and Sandwich-Making conditions but not during Animated Toys. The DD and TD groups did not differ in any condition. Correlational analyses indicated that higher typicality scores were associated with increased looking at pre-planned locations of the scene indexed by each experimental condition. In the ASD group, lower gaze typicality was associated with more severe autism symptoms. Examining ASD HCTFs, the gaze of toddlers with ASD was least cohesive during Dyadic Bid and most cohesive during Animated Toys. Conclusion: In contrast to non-ASD groups, toddlers with ASD show high cohesion during salient nonsocial events, suggesting that consistency in looking strategies may depend more on perceptual features. These findings are consequential for understanding individual differences in visual attention in ASD and for the design of more sensitive biomarker tasks for stratification, between-group differentiation, and measuring response to treatment. En ligne : https://dx.doi.org/10.1186/s13229-018-0211-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=371

Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers / L. MASON in Molecular Autism, 12 (2021)  

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Sex-Differences in Children Referred for Assessment: An Exploratory Analysis of the Autism Mental Status Exam (AMSE) / Roald A. ØIEN in Journal of Autism and Developmental Disorders, 48-7 (July 2018)  

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The Use of Eye Tracking as a Biomarker of Treatment Outcome in a Pilot Randomized Clinical Trial for Young Children with Autism / Jessica BRADSHAW in Autism Research, 12-5 (May 2019)  

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Visual Exploration in Autism Spectrum Disorder: Exploring Age Differences and Dynamic Features Using Recurrence Quantification Analysis / N. V. MANYAKOV in Autism Research, 11-11 (November 2018)  

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Visual Preference for Biological Motion in Children and Adults with Autism Spectrum Disorder: An Eye-Tracking Study / Dzmitry A. KALIUKHOVICH in Journal of Autism and Developmental Disorders, 51-7 (July 2021)  

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What are we optimizing for in autism screening? Examination of algorithmic changes in the M-CHAT / Synnve SCHJØLBERG in Autism Research, 15-2 (February 2022)  

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