Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder / W. VOORHIES in Autism Research, 11-11 (November 2018)  

Public ISBD [article]  inAutism Research > 11-11 (November 2018) . - p.1468-1478 Titre : Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : W. VOORHIES, Auteur ; Dina R. DAJANI, Auteur ; S. G. VIJ, Auteur ; S. SHANKAR, Auteur ; T. O. TURAN, Auteur ; L. Q. UDDIN, Auteur Article en page(s) : p.1468-1478 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  brain development  functional connectivity  inhibitory control  resting-state fMRI Index. décimale : PER Périodiques Résumé : Development of inhibitory control is a core component of executive function processes and a key aspect of healthy development. Children with autism spectrum disorder (ASD) show impairments in performance on inhibitory control tasks. Nevertheless, the research on the neural correlates of these impairments is inconclusive. Here, we explore the integrity of inhibitory control networks in children with ASD and typically developing (TD) children using resting state functional Magnetic Resonance Imagaing (MRI). In a large multisite sample, we find evidence for significantly greater functional connectivity (FC) of the right inferior frontal junction (rIFJ) with the posterior cingulate gyrus, and left and right frontal poles in children with ASD compared with TD children. Additionally, TD children show greater FC of rIFJ with the superior parietal lobule (SPL) compared with children with ASD. Furthermore, although higher rIFJ-SPL and rIFJ-IPL FC was related to better inhibitory control behaviors in both ASD and TD children, rIFJ-dACC FC was only associated with inhibitory control behaviors in TD children. These results provide preliminary evidence of differences in intrinsic functional networks supporting inhibitory control in children with ASD, and provide a basis for further exploration of the development of inhibitory control in children with the disorder. Autism Research 2018, 11: 1468-1478. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Inhibitory control is an important process in healthy cognitive development. Behavioral studies suggest that inhibitory control is impaired in autism spectrum disorder (ASD). However, research examining the neural correlates underlying inhibitory control differences in children with ASD is inconclusive. This study reveals differences in functional connectivity of brain networks important for inhibitory control in children with ASD compared with typically developing children. Furthermore, it relates brain network differences to parent-reported inhibitory control behaviors in children with ASD. These findings provide support for the hypothesis that differences in brain connectivity may underlie observable behavioral deficits in inhibitory control in children with the disorder. En ligne : http://dx.doi.org/10.1002/aur.2014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370 [article] Aberrant functional connectivity of inhibitory control networks in children with autism spectrum disorder [Texte imprimé et/ou numérique] / W. VOORHIES, Auteur ; Dina R. DAJANI, Auteur ; S. G. VIJ, Auteur ; S. SHANKAR, Auteur ; T. O. TURAN, Auteur ; L. Q. UDDIN, Auteur . - p.1468-1478. Langues : Anglais (eng) in Autism Research > 11-11 (November 2018) . - p.1468-1478 Mots-clés : autism spectrum disorder  brain development  functional connectivity  inhibitory control  resting-state fMRI Index. décimale : PER Périodiques Résumé : Development of inhibitory control is a core component of executive function processes and a key aspect of healthy development. Children with autism spectrum disorder (ASD) show impairments in performance on inhibitory control tasks. Nevertheless, the research on the neural correlates of these impairments is inconclusive. Here, we explore the integrity of inhibitory control networks in children with ASD and typically developing (TD) children using resting state functional Magnetic Resonance Imagaing (MRI). In a large multisite sample, we find evidence for significantly greater functional connectivity (FC) of the right inferior frontal junction (rIFJ) with the posterior cingulate gyrus, and left and right frontal poles in children with ASD compared with TD children. Additionally, TD children show greater FC of rIFJ with the superior parietal lobule (SPL) compared with children with ASD. Furthermore, although higher rIFJ-SPL and rIFJ-IPL FC was related to better inhibitory control behaviors in both ASD and TD children, rIFJ-dACC FC was only associated with inhibitory control behaviors in TD children. These results provide preliminary evidence of differences in intrinsic functional networks supporting inhibitory control in children with ASD, and provide a basis for further exploration of the development of inhibitory control in children with the disorder. Autism Research 2018, 11: 1468-1478. (c) 2018 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Inhibitory control is an important process in healthy cognitive development. Behavioral studies suggest that inhibitory control is impaired in autism spectrum disorder (ASD). However, research examining the neural correlates underlying inhibitory control differences in children with ASD is inconclusive. This study reveals differences in functional connectivity of brain networks important for inhibitory control in children with ASD compared with typically developing children. Furthermore, it relates brain network differences to parent-reported inhibitory control behaviors in children with ASD. These findings provide support for the hypothesis that differences in brain connectivity may underlie observable behavioral deficits in inhibitory control in children with the disorder. En ligne : http://dx.doi.org/10.1002/aur.2014 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=370

Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation / Dina R. DAJANI in Autism Research, 9-1 (January 2016)  

Public ISBD [article]  inAutism Research > 9-1 (January 2016) . - p.43-54 Titre : Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation Type de document : Texte imprimé et/ou numérique Auteurs : Dina R. DAJANI, Auteur ; Lucina Q. UDDIN, Auteur Article en page(s) : p.43-54 Langues : Anglais (eng) Mots-clés : autism  brain development  resting state functional MRI  regional homogeneity Index. décimale : PER Périodiques Résumé : There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long-range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with the disorder. Here, we investigated how regional homogeneity (ReHo), a measure of similarity of a voxel's timeseries to its nearest neighbors, varies across age in individuals with ASD and typically developing (TD) individuals using a cross-sectional design. Resting-state fMRI data obtained from a publicly available database were analyzed to determine group differences in ReHo between three age cohorts: children, adolescents, and adults. In typical development, ReHo across the entire brain was higher in children than in adolescents and adults. In contrast, children with ASD exhibited marginally lower ReHo than TD children, while adolescents and adults with ASD exhibited similar levels of local connectivity as age-matched neurotypical individuals. During all developmental stages, individuals with ASD exhibited lower local connectivity in sensory processing brain regions and higher local connectivity in complex information processing regions. Further, higher local connectivity in ASD corresponded to more severe ASD symptomatology. These results demonstrate that local connectivity is disrupted in ASD across development, with the most pronounced differences occurring in childhood. Developmental changes in ReHo do not mirror findings from fMRI studies of long-range connectivity in ASD, pointing to a need for more nuanced accounts of brain connectivity alterations in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Local brain connectivity across development in autism spectrum disorder: A cross-sectional investigation [Texte imprimé et/ou numérique] / Dina R. DAJANI, Auteur ; Lucina Q. UDDIN, Auteur . - p.43-54. Langues : Anglais (eng) in Autism Research > 9-1 (January 2016) . - p.43-54 Mots-clés : autism  brain development  resting state functional MRI  regional homogeneity Index. décimale : PER Périodiques Résumé : There is a general consensus that autism spectrum disorder (ASD) is accompanied by alterations in brain connectivity. Much of the neuroimaging work has focused on assessing long-range connectivity disruptions in ASD. However, evidence from both animal models and postmortem examination of the human brain suggests that local connections may also be disrupted in individuals with the disorder. Here, we investigated how regional homogeneity (ReHo), a measure of similarity of a voxel's timeseries to its nearest neighbors, varies across age in individuals with ASD and typically developing (TD) individuals using a cross-sectional design. Resting-state fMRI data obtained from a publicly available database were analyzed to determine group differences in ReHo between three age cohorts: children, adolescents, and adults. In typical development, ReHo across the entire brain was higher in children than in adolescents and adults. In contrast, children with ASD exhibited marginally lower ReHo than TD children, while adolescents and adults with ASD exhibited similar levels of local connectivity as age-matched neurotypical individuals. During all developmental stages, individuals with ASD exhibited lower local connectivity in sensory processing brain regions and higher local connectivity in complex information processing regions. Further, higher local connectivity in ASD corresponded to more severe ASD symptomatology. These results demonstrate that local connectivity is disrupted in ASD across development, with the most pronounced differences occurring in childhood. Developmental changes in ReHo do not mirror findings from fMRI studies of long-range connectivity in ASD, pointing to a need for more nuanced accounts of brain connectivity alterations in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1494 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Neural Responses to a Putative Set-shifting Task in Children with Autism Spectrum Disorder / Bryce DIRKS in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1501-1515 Titre : Neural Responses to a Putative Set-shifting Task in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Bryce DIRKS, Auteur ; Celia ROMERO, Auteur ; Willa VOORHIES, Auteur ; Lauren KUPIS, Auteur ; Jason S. NOMI, Auteur ; Dina R. DAJANI, Auteur ; Paola ODRIOZOLA, Auteur ; Catherine A. BURROWS, Auteur ; Amy L. BEAUMONT, Auteur ; Sandra M. CARDONA, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Lucina Q. UDDIN, Auteur Article en page(s) : p.1501-1515 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : While much progress has been made toward understanding the neurobiology of social and communication deficits associated with autism spectrum disorder (ASD), less is known regarding the neurobiological basis of restricted and repetitive behaviors (RRBs) central to the ASD diagnosis. Symptom severity for RRBs in ASD is associated with cognitive inflexibility. Thus, understanding the neural mechanisms underlying cognitive inflexibility in ASD is critical for tailoring therapies to treat this understudied yet pervasive symptom. Here we used a set-shifting paradigm adopted from the developmental cognitive neuroscience literature involving flexible switching between stimulus categories to examine task performance and neural responses in children with ASD. Behaviorally, we found little evidence for group differences in performance on the set-shifting task. Compared with typically developing children, children with ASD exhibited greater activation of the parahippocampal gyrus during performance on trials requiring switching. These findings suggest that children with ASD may need to recruit memory-based neural systems to a greater degree when learning to flexibly associate stimuli with responses. Lay Summary Children with autism often struggle to behave in a flexible way when faced with unexpected challenges. We examined brain responses during a task thought to involve flexible thinking and found that compared with typically developing children, those with autism relied more on brain areas involved in learning and memory to complete the task. This study helps us to understand what types of cognitive tasks are best suited for exploring the neural basis of cognitive flexibility in children with autism. Autism Res 2020, 13: 1501–1515. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] Neural Responses to a Putative Set-shifting Task in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Bryce DIRKS, Auteur ; Celia ROMERO, Auteur ; Willa VOORHIES, Auteur ; Lauren KUPIS, Auteur ; Jason S. NOMI, Auteur ; Dina R. DAJANI, Auteur ; Paola ODRIOZOLA, Auteur ; Catherine A. BURROWS, Auteur ; Amy L. BEAUMONT, Auteur ; Sandra M. CARDONA, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Lucina Q. UDDIN, Auteur . - p.1501-1515. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1501-1515 Index. décimale : PER Périodiques Résumé : While much progress has been made toward understanding the neurobiology of social and communication deficits associated with autism spectrum disorder (ASD), less is known regarding the neurobiological basis of restricted and repetitive behaviors (RRBs) central to the ASD diagnosis. Symptom severity for RRBs in ASD is associated with cognitive inflexibility. Thus, understanding the neural mechanisms underlying cognitive inflexibility in ASD is critical for tailoring therapies to treat this understudied yet pervasive symptom. Here we used a set-shifting paradigm adopted from the developmental cognitive neuroscience literature involving flexible switching between stimulus categories to examine task performance and neural responses in children with ASD. Behaviorally, we found little evidence for group differences in performance on the set-shifting task. Compared with typically developing children, children with ASD exhibited greater activation of the parahippocampal gyrus during performance on trials requiring switching. These findings suggest that children with ASD may need to recruit memory-based neural systems to a greater degree when learning to flexibly associate stimuli with responses. Lay Summary Children with autism often struggle to behave in a flexible way when faced with unexpected challenges. We examined brain responses during a task thought to involve flexible thinking and found that compared with typically developing children, those with autism relied more on brain areas involved in learning and memory to complete the task. This study helps us to understand what types of cognitive tasks are best suited for exploring the neural basis of cognitive flexibility in children with autism. Autism Res 2020, 13: 1501–1515. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. En ligne : http://dx.doi.org/10.1002/aur.2347 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

Parsing Heterogeneity of Executive Function in Typically and Atypically Developing Children: A Conceptual Replication and Exploration of Social Function / Adriana C. BAEZ in Journal of Autism and Developmental Disorders, 50-3 (March 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-3 (March 2020) . - p.707-718 Titre : Parsing Heterogeneity of Executive Function in Typically and Atypically Developing Children: A Conceptual Replication and Exploration of Social Function Type de document : Texte imprimé et/ou numérique Auteurs : Adriana C. BAEZ, Auteur ; Dina R. DAJANI, Auteur ; Willa VOORHIES, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Maria M. LLABRE, Auteur ; Lucina Q. UDDIN, Auteur Article en page(s) : p.707-718 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Behavior Rating Inventory of Executive Function  Dimensional  Latent profile analysis Index. décimale : PER Périodiques Résumé : Executive function (EF), the set of cognitive processes that govern goal-directed behavior, varies within developmental samples and clinical populations. Here, we perform a conceptual replication of prior work (Dajani et al. in Sci Rep 6:36566, 2016) in an independent sample of typically developing children (n = 183) and children with autism spectrum disorder (n = 104). Consistent with previous work, the latent profile analysis of parent-report EF measures provided evidence for three EF classes, which exhibited differential proportions of diagnostic groups. Additionally, children in the impaired EF group exhibited greater levels of social impairment. These results highlight the heterogeneity of EF ability among clinical and non-clinical populations and the link between EF and social abilities. En ligne : http://dx.doi.org/10.1007/s10803-019-04290-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=419 [article] Parsing Heterogeneity of Executive Function in Typically and Atypically Developing Children: A Conceptual Replication and Exploration of Social Function [Texte imprimé et/ou numérique] / Adriana C. BAEZ, Auteur ; Dina R. DAJANI, Auteur ; Willa VOORHIES, Auteur ; Meaghan V. PARLADE, Auteur ; Michael ALESSANDRI, Auteur ; Jennifer C. BRITTON, Auteur ; Maria M. LLABRE, Auteur ; Lucina Q. UDDIN, Auteur . - p.707-718. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-3 (March 2020) . - p.707-718 Mots-clés : Autism spectrum disorder  Behavior Rating Inventory of Executive Function  Dimensional  Latent profile analysis Index. décimale : PER Périodiques Résumé : Executive function (EF), the set of cognitive processes that govern goal-directed behavior, varies within developmental samples and clinical populations. Here, we perform a conceptual replication of prior work (Dajani et al. in Sci Rep 6:36566, 2016) in an independent sample of typically developing children (n = 183) and children with autism spectrum disorder (n = 104). Consistent with previous work, the latent profile analysis of parent-report EF measures provided evidence for three EF classes, which exhibited differential proportions of diagnostic groups. Additionally, children in the impaired EF group exhibited greater levels of social impairment. These results highlight the heterogeneity of EF ability among clinical and non-clinical populations and the link between EF and social abilities. En ligne : http://dx.doi.org/10.1007/s10803-019-04290-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=419

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