Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study / Carolyn E. B. MCCORMICK in Autism Research, 13-3 (March 2020)  

Public ISBD [article]  inAutism Research > 13-3 (March 2020) . - p.474-488 Titre : Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study Type de document : Texte imprimé et/ou numérique Auteurs : Carolyn E. B. MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur Article en page(s) : p.474-488 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] Autism Heterogeneity in a Densely Sampled U.S. Population: Results From the First 1,000 Participants in the RI-CART Study [Texte imprimé et/ou numérique] / Carolyn E. B. MCCORMICK, Auteur ; Brian C. KAVANAUGH, Auteur ; Danielle SIPSOCK, Auteur ; Giulia RIGHI, Auteur ; Lindsay M. OBERMAN, Auteur ; Daniel MORENO DE LUCA, Auteur ; Ece D. GAMSIZ UZUN, Auteur ; Carrie R. BEST, Auteur ; Beth A. JERSKEY, Auteur ; Joanne G. QUINN, Auteur ; Susan B. JEWEL, Auteur ; Pei-Chi WU, Auteur ; Rebecca L. MCLEAN, Auteur ; Todd P. LEVINE, Auteur ; Hasmik TOKADJIAN, Auteur ; Kayla A. PERKINS, Auteur ; Elaine B. CLARKE, Auteur ; Brittany DUNN, Auteur ; Alan H. GERBER, Auteur ; Elena J. TENENBAUM, Auteur ; Thomas F. ANDERS, Auteur . - p.474-488. Langues : Anglais (eng) in Autism Research > 13-3 (March 2020) . - p.474-488 Mots-clés : autism spectrum disorder  comorbidity  female autism  population study  registry Index. décimale : PER Périodiques Résumé : The objective of this study was to establish a large, densely sampled, U.S. population-based cohort of people with autism spectrum disorder (ASD). The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by ASD. Diagnosis was based on direct behavioral observation via the Autism Diagnostic Observation Schedule, Second Edition. For the first 1,000 participants, ages ranged from 21 months to 64 years. Using Geographic Information System and published prevalence rates, the overall cohort is estimated to represent between 20% and 49% of pediatric age persons in Rhode Island with ASD, with demographics representative of U.S. Census. We observed a high rate of co-occurring medical and psychiatric conditions in affected individuals. Among the most prominent findings of immediate clinical importance, we found that females received a first diagnosis of ASD at a later age than males, potentially due to more advanced language abilities in females with ASD. In summary, this is the first analysis of a large, population-based U.S. cohort with ASD. Given the depth of sampling, the RI-CART study reflects an important new resource for studying ASD in a representative U.S. population. Psychiatric and medical comorbidities in ASD constitute a substantial burden and warrant adequate attention as part of overall treatment. Our study also suggests that new strategies for earlier diagnosis of ASD in females may be warranted. Autism Res 2020, 13: 474-488. (c) 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: The Rhode Island Consortium for Autism Research and Treatment (RI-CART) represents a unique public-private-academic collaboration involving all major points of service for families in Rhode Island affected by autism spectrum disorder (ASD). In this article, we provide results from the first 1,000 participants, estimated to represent >20% of affected families in the state. Importantly, we find a later age at first diagnosis of ASD in females, which potentially calls attention to the need for improved early diagnosis in girls. Also, we report a high rate of co-occurring medical and psychiatric conditions in affected individuals. En ligne : http://dx.doi.org/10.1002/aur.2261 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program / Marisa A. PATTI in Autism Research, 17-5 (May 2024)  

Public ISBD [article]  inAutism Research > 17-5 (May 2024) Titre : Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program Type de document : Texte imprimé et/ou numérique Auteurs : Marisa A. PATTI, Auteur ; Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program [Texte imprimé et/ou numérique] / Marisa A. PATTI, Auteur ; Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur. Langues : Anglais (eng) in Autism Research > 17-5 (May 2024) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program / Lisa A. CROEN ; Aisha S. DICKERSON ; Robert M. JOSEPH ; Jennifer L. AMES ; Christine LADD-ACOSTA ; Sally OZONOFF ; Rebecca J. SCHMIDT ; Heather E. VOLK ; Alison E. HIPWELL ; Kelsey E. MAGEE ; Margaret KARAGAS ; Cindy MCEVOY ; Rebecca LANDA ; Michael R. ELLIOTT ; Daphne Koinis MITCHELL ; Viren D'SA ; Sean DEONI ; Michelle PIEVSKY ; Pei-Chi WU ; Fatoumata BARRY ; Joseph B. STANFORD ; Deborah A. BILDER ; Leonardo TRASANDE ; Nicole R. BUSH ; Kristen LYALL ; program collaborators for Environmental influences on Child Health OUTCOMES in Autism Research, 17-6 (June 2024)  

Public ISBD [article]  inAutism Research > 17-6 (June 2024) . - p.1187-1204 Titre : Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.1187-1204 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531 [article] Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.1187-1204. Langues : Anglais (eng) in Autism Research > 17-6 (June 2024) . - p.1187-1204 Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531

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