Age-related differences in white matter diffusion measures in autism spectrum condition / Abigail THOMPSON in Molecular Autism, 11 (2020)  

Public ISBD [article]  inMolecular Autism > 11 (2020) . - 36 p. Titre : Age-related differences in white matter diffusion measures in autism spectrum condition Type de document : Texte imprimé et/ou numérique Auteurs : Abigail THOMPSON, Auteur ; Asal SHAHIDIANI, Auteur ; Anne FRITZ, Auteur ; Jonathan O'MUIRCHEARTAIGH, Auteur ; Lindsay WALKER, Auteur ; Vera D'ALMEIDA, Auteur ; Clodagh M. MURPHY, Auteur ; Eileen DALY, Auteur ; Declan MURPHY, Auteur ; Steve WILLIAMS, Auteur ; Sean DEONI, Auteur ; Christine ECKER, Auteur Article en page(s) : 36 p. Langues : Anglais (eng) Mots-clés : Autism  Connectivity  Diffusion weighted imaging  Tract-based spatial statistics Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum condition (ASC) is accompanied by developmental differences in brain anatomy and connectivity. White matter differences in ASC have been widely studied with diffusion imaging but results are heterogeneous and vary across the age range of study participants and varying methodological approaches. To characterize the neurodevelopmental trajectory of white matter maturation, it is necessary to examine a broad age range of individuals on the autism spectrum and typically developing controls, and investigate age × group interactions. METHODS: Here, we employed a spatially unbiased tract-based spatial statistics (TBSS) approach to examine age-related differences in white matter connectivity in a sample of 41 individuals with ASC, and 41 matched controls between 7-17 years of age. RESULTS: We found significant age-related differences between the ASC and control group in widespread brain regions. This included age-related differences in the uncinate fasciculus, corticospinal tract, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, superior longitudinal fasciculus and forceps major. Measures of fractional anisotropy (FA) were significantly positively associated with age in both groups. However, this relationship was significantly stronger in the ASC group relative to controls. Measures of radial diffusivity (RD) were significantly negatively associated with age in both groups, but this relationship was significantly stronger in the ASC group relative to controls. LIMITATIONS: The generalisability of our findings is limited by the restriction of the sample to right-handed males with an IQ > 70. Furthermore, a longitudinal design would be required to fully investigate maturational processes across this age group. CONCLUSIONS: Taken together, our findings suggest that autistic males have an altered trajectory of white matter maturation relative to controls. Future longitudinal analyses are required to further characterize the extent and time course of these differences. En ligne : http://dx.doi.org/10.1186/s13229-020-00325-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427 [article] Age-related differences in white matter diffusion measures in autism spectrum condition [Texte imprimé et/ou numérique] / Abigail THOMPSON, Auteur ; Asal SHAHIDIANI, Auteur ; Anne FRITZ, Auteur ; Jonathan O'MUIRCHEARTAIGH, Auteur ; Lindsay WALKER, Auteur ; Vera D'ALMEIDA, Auteur ; Clodagh M. MURPHY, Auteur ; Eileen DALY, Auteur ; Declan MURPHY, Auteur ; Steve WILLIAMS, Auteur ; Sean DEONI, Auteur ; Christine ECKER, Auteur . - 36 p. Langues : Anglais (eng) in Molecular Autism > 11 (2020) . - 36 p. Mots-clés : Autism  Connectivity  Diffusion weighted imaging  Tract-based spatial statistics Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum condition (ASC) is accompanied by developmental differences in brain anatomy and connectivity. White matter differences in ASC have been widely studied with diffusion imaging but results are heterogeneous and vary across the age range of study participants and varying methodological approaches. To characterize the neurodevelopmental trajectory of white matter maturation, it is necessary to examine a broad age range of individuals on the autism spectrum and typically developing controls, and investigate age × group interactions. METHODS: Here, we employed a spatially unbiased tract-based spatial statistics (TBSS) approach to examine age-related differences in white matter connectivity in a sample of 41 individuals with ASC, and 41 matched controls between 7-17 years of age. RESULTS: We found significant age-related differences between the ASC and control group in widespread brain regions. This included age-related differences in the uncinate fasciculus, corticospinal tract, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, anterior thalamic radiation, superior longitudinal fasciculus and forceps major. Measures of fractional anisotropy (FA) were significantly positively associated with age in both groups. However, this relationship was significantly stronger in the ASC group relative to controls. Measures of radial diffusivity (RD) were significantly negatively associated with age in both groups, but this relationship was significantly stronger in the ASC group relative to controls. LIMITATIONS: The generalisability of our findings is limited by the restriction of the sample to right-handed males with an IQ > 70. Furthermore, a longitudinal design would be required to fully investigate maturational processes across this age group. CONCLUSIONS: Taken together, our findings suggest that autistic males have an altered trajectory of white matter maturation relative to controls. Future longitudinal analyses are required to further characterize the extent and time course of these differences. En ligne : http://dx.doi.org/10.1186/s13229-020-00325-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=427

Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program / Marisa A. PATTI in Autism Research, 17-5 (May 2024)  

Public ISBD [article]  inAutism Research > 17-5 (May 2024) Titre : Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program Type de document : Texte imprimé et/ou numérique Auteurs : Marisa A. PATTI, Auteur ; Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program [Texte imprimé et/ou numérique] / Marisa A. PATTI, Auteur ; Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur. Langues : Anglais (eng) in Autism Research > 17-5 (May 2024) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program / Lisa A. CROEN ; Aisha S. DICKERSON ; Robert M. JOSEPH ; Jennifer L. AMES ; Christine LADD-ACOSTA ; Sally OZONOFF ; Rebecca J. SCHMIDT ; Heather E. VOLK ; Alison E. HIPWELL ; Kelsey E. MAGEE ; Margaret KARAGAS ; Cindy MCEVOY ; Rebecca LANDA ; Michael R. ELLIOTT ; Daphne Koinis MITCHELL ; Viren D'SA ; Sean DEONI ; Michelle PIEVSKY ; Pei-Chi WU ; Fatoumata BARRY ; Joseph B. STANFORD ; Deborah A. BILDER ; Leonardo TRASANDE ; Nicole R. BUSH ; Kristen LYALL ; program collaborators for Environmental influences on Child Health OUTCOMES in Autism Research, 17-6 (June 2024)  

Public ISBD [article]  inAutism Research > 17-6 (June 2024) . - p.1187-1204 Titre : Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program Type de document : Texte imprimé et/ou numérique Auteurs : Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur Article en page(s) : p.1187-1204 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531 [article] Reproducibility between preschool and school-age Social Responsiveness Scale forms in the Environmental influences on Child Health Outcomes program [Texte imprimé et/ou numérique] / Lisa A. CROEN, Auteur ; Aisha S. DICKERSON, Auteur ; Robert M. JOSEPH, Auteur ; Jennifer L. AMES, Auteur ; Christine LADD-ACOSTA, Auteur ; Sally OZONOFF, Auteur ; Rebecca J. SCHMIDT, Auteur ; Heather E. VOLK, Auteur ; Alison E. HIPWELL, Auteur ; Kelsey E. MAGEE, Auteur ; Margaret KARAGAS, Auteur ; Cindy MCEVOY, Auteur ; Rebecca LANDA, Auteur ; Michael R. ELLIOTT, Auteur ; Daphne Koinis MITCHELL, Auteur ; Viren D'SA, Auteur ; Sean DEONI, Auteur ; Michelle PIEVSKY, Auteur ; Pei-Chi WU, Auteur ; Fatoumata BARRY, Auteur ; Joseph B. STANFORD, Auteur ; Deborah A. BILDER, Auteur ; Leonardo TRASANDE, Auteur ; Nicole R. BUSH, Auteur ; Kristen LYALL, Auteur ; program collaborators for Environmental influences on Child Health OUTCOMES, Auteur . - p.1187-1204. Langues : Anglais (eng) in Autism Research > 17-6 (June 2024) . - p.1187-1204 Index. décimale : PER Périodiques Résumé : Abstract Evidence suggests core autism trait consistency in older children, but development of these traits is variable in early childhood. The Social Responsiveness Scale (SRS) measures autism-related traits and broader autism phenotype, with two age-dependent forms in childhood (preschool, 2.5-4.5?years; school age, 4-18?years). Score consistency has been observed within forms, though reliability across forms has not been evaluated. Using data from the Environmental Influences on Child Health Outcomes (ECHO) program (n = 853), preschool, and school-age SRS scores were collected via maternal report when children were an average of 3.0 and 5.8?years, respectively. We compared reproducibility of SRS total scores (T-scores) and agreement above a clinically meaningful cutoff (T-scores???60) and examined predictors of discordance in cutoff scores across forms. Participant scores across forms were similar (mean difference: 3.3 points; standard deviation: 7), though preschool scores were on average lower than school-age scores. Most children (88%) were classified below the cutoff on both forms, and overall concordance was high (92%). However, discordance was higher in cohorts following younger siblings of autistic children (16%). Proportions of children with an autism diagnoses were also higher among those with discordant scores (27%) than among those with concordant scores (4%). Our findings indicate SRS scores are broadly reproducible across preschool and school-age forms, particularly for capturing broader, nonclinical traits, but also suggest that greater variability of autism-related traits in preschool-age children may reduce reliability with later school-age scores for those in the clinical range. En ligne : https://doi.org/10.1002/aur.3147 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=531

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