Accuracy of the Screening Tool for Autism in Toddlers and Young Children in the primary care setting / Rebecca MCNALLY KEEHN in Autism, 29-4 (April 2025)  

Public ISBD [article]  inAutism > 29-4 (April 2025) . - p.945-957 Titre : Accuracy of the Screening Tool for Autism in Toddlers and Young Children in the primary care setting Type de document : Texte imprimé et/ou numérique Auteurs : Rebecca MCNALLY KEEHN, Auteur ; Noha F. MINSHAWI, Auteur ; Qing TANG, Auteur ; Brett ENNEKING, Auteur ; Tybytha RYAN, Auteur ; Ann Marie MARTIN, Auteur ; Angela PAXTON, Auteur ; Patrick O. MONAHAN, Auteur ; Mary CICCARELLI, Auteur ; Brandon KEEHN, Auteur Article en page(s) : p.945-957 Langues : Anglais (eng) Mots-clés : autism  diagnosis  primary care Index. décimale : PER Périodiques Résumé : Feasible and accurate assessment tools developed for non-specialists are needed to scale community-based models of autism evaluation. The purpose of this study was to evaluate use of the Screening Tool for Autism in Toddlers and Young Children (STAT) when used by primary care practitioners (n = 10) across a statewide system of early diagnosis set within seven United States primary care practices. Specifically, for 130, 14- to 48-month-old children, we examined (1) agreement between STAT classification and Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) outcome and expert diagnosis of autism, (2) characteristics of children with inaccurate STAT classifications, (3) consistency between STAT classification and primary care practitioner diagnosis, and (4) the relationship between STAT/primary care practitioner classification and expert diagnosis. The STAT demonstrated good concurrent validity with the ADOS-2 (77% agreement). Concordance between specialty trained primary care practitioners with expert diagnosis was 80%-87% across three age-based subgroups of children. Children misclassified by the STAT were older, had higher developmental and adaptive skills, and lower autism symptoms. Primary care practitioner diagnosis aligned with STAT categorical risk classification in 86% of cases, and 73% of consistent classifications between STAT and primary care practitioner diagnosis matched expert diagnosis. Overall, the STAT demonstrates good accuracy when used by non-specialists as part of a diagnostic evaluation.Lay summary Specialists conduct autism evaluations using tools that are expensive and difficult to get trained on. Families often wait a long time and travel far to get a diagnosis for their child. To help with this problem, primary care practitioners can be trained to provide evaluations in local communities. However, usable and accurate tools developed for non-specialists are needed. The Screening Tool for Autism in Toddlers and Young Children (STAT) was created for this purpose, but limited research has been done on accuracy of the tool in community primary care. This study tested the STAT when used by primary care practitioners as part of a diagnostic evaluation in 130, 14- to 48-month-old children. We tested (1) STAT agreement with the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), and diagnosis based on an expert research evaluation, and (2) the relationship between STAT classification, primary care practitioner diagnosis, and expert diagnosis. STAT classification matched the ADOS-2 in 77% of cases and expert diagnosis in 78% of cases. Autistic children incorrectly classified by the STAT were older, had higher developmental and adaptive skills, and fewer autism symptoms. In 86% of cases, the STAT classification agreed with primary care practitioner diagnosis. STAT classification, primary care practitioner diagnosis, and expert diagnosis agreed in 73% of cases. Overall, the STAT shows good accuracy when used by primary care practitioners as part of a community primary care autism evaluation. En ligne : https://dx.doi.org/10.1177/13623613241292850 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552 [article] Accuracy of the Screening Tool for Autism in Toddlers and Young Children in the primary care setting [Texte imprimé et/ou numérique] / Rebecca MCNALLY KEEHN, Auteur ; Noha F. MINSHAWI, Auteur ; Qing TANG, Auteur ; Brett ENNEKING, Auteur ; Tybytha RYAN, Auteur ; Ann Marie MARTIN, Auteur ; Angela PAXTON, Auteur ; Patrick O. MONAHAN, Auteur ; Mary CICCARELLI, Auteur ; Brandon KEEHN, Auteur . - p.945-957. Langues : Anglais (eng) in Autism > 29-4 (April 2025) . - p.945-957 Mots-clés : autism  diagnosis  primary care Index. décimale : PER Périodiques Résumé : Feasible and accurate assessment tools developed for non-specialists are needed to scale community-based models of autism evaluation. The purpose of this study was to evaluate use of the Screening Tool for Autism in Toddlers and Young Children (STAT) when used by primary care practitioners (n = 10) across a statewide system of early diagnosis set within seven United States primary care practices. Specifically, for 130, 14- to 48-month-old children, we examined (1) agreement between STAT classification and Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) outcome and expert diagnosis of autism, (2) characteristics of children with inaccurate STAT classifications, (3) consistency between STAT classification and primary care practitioner diagnosis, and (4) the relationship between STAT/primary care practitioner classification and expert diagnosis. The STAT demonstrated good concurrent validity with the ADOS-2 (77% agreement). Concordance between specialty trained primary care practitioners with expert diagnosis was 80%-87% across three age-based subgroups of children. Children misclassified by the STAT were older, had higher developmental and adaptive skills, and lower autism symptoms. Primary care practitioner diagnosis aligned with STAT categorical risk classification in 86% of cases, and 73% of consistent classifications between STAT and primary care practitioner diagnosis matched expert diagnosis. Overall, the STAT demonstrates good accuracy when used by non-specialists as part of a diagnostic evaluation.Lay summary Specialists conduct autism evaluations using tools that are expensive and difficult to get trained on. Families often wait a long time and travel far to get a diagnosis for their child. To help with this problem, primary care practitioners can be trained to provide evaluations in local communities. However, usable and accurate tools developed for non-specialists are needed. The Screening Tool for Autism in Toddlers and Young Children (STAT) was created for this purpose, but limited research has been done on accuracy of the tool in community primary care. This study tested the STAT when used by primary care practitioners as part of a diagnostic evaluation in 130, 14- to 48-month-old children. We tested (1) STAT agreement with the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2), and diagnosis based on an expert research evaluation, and (2) the relationship between STAT classification, primary care practitioner diagnosis, and expert diagnosis. STAT classification matched the ADOS-2 in 77% of cases and expert diagnosis in 78% of cases. Autistic children incorrectly classified by the STAT were older, had higher developmental and adaptive skills, and fewer autism symptoms. In 86% of cases, the STAT classification agreed with primary care practitioner diagnosis. STAT classification, primary care practitioner diagnosis, and expert diagnosis agreed in 73% of cases. Overall, the STAT shows good accuracy when used by primary care practitioners as part of a community primary care autism evaluation. En ligne : https://dx.doi.org/10.1177/13623613241292850 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=552

Brief Report: Reduced Heart Rate Variability in Children with Autism Spectrum Disorder / Catharine LORY in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4183-4190 Titre : Brief Report: Reduced Heart Rate Variability in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Catharine LORY, Auteur ; Girija KADLASKAR, Auteur ; Rebecca MCNALLY KEEHN, Auteur ; Alexander L FRANCIS, Auteur ; Brandon KEEHN, Auteur Article en page(s) : p.4183-4190 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Autonomic arousal  Ecg  Heart rate variability Index. décimale : PER Périodiques Résumé : Dysregulation of the autonomic nervous system (ANS), which can be indexed by heart rate variability (HRV), has been posited to contribute to core features of autism spectrum disorder (ASD). However, the relationship between ASD and HRV remains uncertain. We assessed tonic and phasic HRV of 21 children with ASD and 21 age- and IQ-matched typically developing (TD) children and examined (1) group differences in HRV and (2) associations between HRV and ASD symptomatology. Children with ASD showed significantly lower tonic HRV, but similar phasic HRV compared to TD children. Additionally, reduced tonic HRV was associated with atypical attentional responsivity in ASD. Our findings suggest ANS dysregulation is present in ASD and may contribute to atypical attentional responses to sensory stimulation. En ligne : http://dx.doi.org/10.1007/s10803-020-04458-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Brief Report: Reduced Heart Rate Variability in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Catharine LORY, Auteur ; Girija KADLASKAR, Auteur ; Rebecca MCNALLY KEEHN, Auteur ; Alexander L FRANCIS, Auteur ; Brandon KEEHN, Auteur . - p.4183-4190. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4183-4190 Mots-clés : Autism spectrum disorder  Autonomic arousal  Ecg  Heart rate variability Index. décimale : PER Périodiques Résumé : Dysregulation of the autonomic nervous system (ANS), which can be indexed by heart rate variability (HRV), has been posited to contribute to core features of autism spectrum disorder (ASD). However, the relationship between ASD and HRV remains uncertain. We assessed tonic and phasic HRV of 21 children with ASD and 21 age- and IQ-matched typically developing (TD) children and examined (1) group differences in HRV and (2) associations between HRV and ASD symptomatology. Children with ASD showed significantly lower tonic HRV, but similar phasic HRV compared to TD children. Additionally, reduced tonic HRV was associated with atypical attentional responsivity in ASD. Our findings suggest ANS dysregulation is present in ASD and may contribute to atypical attentional responses to sensory stimulation. En ligne : http://dx.doi.org/10.1007/s10803-020-04458-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Case Report: Autism Risk Within the Context of Two Chromosome 15 Syndromes / Ashleigh M. KELLERMAN in Journal of Autism and Developmental Disorders, 53-1 (January 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.503-513 Titre : Case Report: Autism Risk Within the Context of Two Chromosome 15 Syndromes Type de document : Texte imprimé et/ou numérique Auteurs : Ashleigh M. KELLERMAN, Auteur ; Mehreen Z. HASSAN, Auteur ; Emily A. ABEL, Auteur ; Molly REILLY, Auteur ; Rebecca MCNALLY KEEHN, Auteur ; A. J. SCHWICHTENBERG, Auteur Article en page(s) : p.503-513 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-021-05422-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Case Report: Autism Risk Within the Context of Two Chromosome 15 Syndromes [Texte imprimé et/ou numérique] / Ashleigh M. KELLERMAN, Auteur ; Mehreen Z. HASSAN, Auteur ; Emily A. ABEL, Auteur ; Molly REILLY, Auteur ; Rebecca MCNALLY KEEHN, Auteur ; A. J. SCHWICHTENBERG, Auteur . - p.503-513. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-1 (January 2023) . - p.503-513 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-021-05422-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

A Magnetic Resonance Spectroscopy Study of Superior Visual Search Abilities in Children with Autism Spectrum Disorder / David A. EDMONDSON in Autism Research, 13-4 (April 2020)  

Public ISBD [article]  inAutism Research > 13-4 (April 2020) . - p.550-562 Titre : A Magnetic Resonance Spectroscopy Study of Superior Visual Search Abilities in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : David A. EDMONDSON, Auteur ; Pingyu XIA, Auteur ; Rebecca MCNALLY KEEHN, Auteur ; Ulrike DYDAK, Auteur ; Brandon KEEHN, Auteur Article en page(s) : p.550-562 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  frontal eye field  gamma-aminobutyric acid  magnetic resonance spectroscopy  temporal-parietal junction  visual cortex  visual search Index. décimale : PER Périodiques Résumé : Although diagnosed on the basis of deficits in social communication and interaction, autism spectrum disorder (ASD) is also characterized by superior performance on a variety of visuospatial tasks, including visual search. In neurotypical individuals, region-specific concentrations of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) are associated with individual differences in attention and perception. While it has been hypothesized that ASD may be associated with an excitatory-inhibitory imbalance, it remains unclear how this may contribute to accelerated visual search performance in individuals with ASD. To investigate this, 21 children with ASD and 20 typically developing children participated in a visual search task and a magnetic resonance spectroscopy study to detect neurochemical concentrations, including GABA. Region-specific neurochemicals were examined in the right frontal eye fields, right temporal-parietal junction (rTPJ), and bilateral visual cortex (VIS). GABA concentrations did not differ between groups; however, in children with ASD, greater GABA concentration in the VIS was related to more efficient search. Additionally, lower VIS GABA levels were also associated with increased social impairment. Finally, we found reduced N-acetyl aspartate, total creatine, glutamate and glutamine (Glx), GABA/Glx in the rTPJ, suggestive of neuronal dysfunction in a critical network hub. Our results show that GABA concentrations in the VIS are related to efficient search in ASD, thus providing further evidence of enhanced discrimination in ASD. Autism Res 2020, 13: 550-562. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Children with autism spectrum disorder (ASD) often perform better than their non-ASD peers on visual search tasks; however, it is unclear how they achieve this superior performance. Using magnetic resonance spectroscopy to measure neurochemicals in the brain, we found that the level of one, gamma-aminobutyric acid, in the visual cortex was directly related to search abilities in children with ASD. These results suggest that faster search may relate to enhanced perceptual functioning in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421 [article] A Magnetic Resonance Spectroscopy Study of Superior Visual Search Abilities in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / David A. EDMONDSON, Auteur ; Pingyu XIA, Auteur ; Rebecca MCNALLY KEEHN, Auteur ; Ulrike DYDAK, Auteur ; Brandon KEEHN, Auteur . - p.550-562. Langues : Anglais (eng) in Autism Research > 13-4 (April 2020) . - p.550-562 Mots-clés : autism spectrum disorder  frontal eye field  gamma-aminobutyric acid  magnetic resonance spectroscopy  temporal-parietal junction  visual cortex  visual search Index. décimale : PER Périodiques Résumé : Although diagnosed on the basis of deficits in social communication and interaction, autism spectrum disorder (ASD) is also characterized by superior performance on a variety of visuospatial tasks, including visual search. In neurotypical individuals, region-specific concentrations of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) are associated with individual differences in attention and perception. While it has been hypothesized that ASD may be associated with an excitatory-inhibitory imbalance, it remains unclear how this may contribute to accelerated visual search performance in individuals with ASD. To investigate this, 21 children with ASD and 20 typically developing children participated in a visual search task and a magnetic resonance spectroscopy study to detect neurochemical concentrations, including GABA. Region-specific neurochemicals were examined in the right frontal eye fields, right temporal-parietal junction (rTPJ), and bilateral visual cortex (VIS). GABA concentrations did not differ between groups; however, in children with ASD, greater GABA concentration in the VIS was related to more efficient search. Additionally, lower VIS GABA levels were also associated with increased social impairment. Finally, we found reduced N-acetyl aspartate, total creatine, glutamate and glutamine (Glx), GABA/Glx in the rTPJ, suggestive of neuronal dysfunction in a critical network hub. Our results show that GABA concentrations in the VIS are related to efficient search in ASD, thus providing further evidence of enhanced discrimination in ASD. Autism Res 2020, 13: 550-562. (c) 2019 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Children with autism spectrum disorder (ASD) often perform better than their non-ASD peers on visual search tasks; however, it is unclear how they achieve this superior performance. Using magnetic resonance spectroscopy to measure neurochemicals in the brain, we found that the level of one, gamma-aminobutyric acid, in the visual cortex was directly related to search abilities in children with ASD. These results suggest that faster search may relate to enhanced perceptual functioning in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.2258 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=421

Provider and Caregiver Satisfaction with Telehealth Evaluation of Autism Spectrum Disorder in Young Children During the COVID-19 Pandemic / Debra L. REISINGER in Journal of Autism and Developmental Disorders, 52-12 (December 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5099-5113 Titre : Provider and Caregiver Satisfaction with Telehealth Evaluation of Autism Spectrum Disorder in Young Children During the COVID-19 Pandemic Type de document : Texte imprimé et/ou numérique Auteurs : Debra L. REISINGER, Auteur ; Elesia HINES, Auteur ; Christine RACHES, Auteur ; Qing TANG, Auteur ; Cristina JAMES, Auteur ; Rebecca MCNALLY KEEHN, Auteur Année de publication : 2022 Article en page(s) : p.5099-5113 Langues : Anglais (eng) Mots-clés : Child  Humans  Child, Preschool  Infant  covid-19  Autism Spectrum Disorder/diagnosis/epidemiology/therapy  Pandemics  Caregivers  SARS-CoV-2  Personal Satisfaction  Telemedicine  Autism spectrum disorder  Diagnostic evaluation  Satisfaction  Telehealth  Young children Index. décimale : PER Périodiques Résumé : The present study examines provider and caregiver satisfaction with telehealth evaluation of autism spectrum disorder (ASD) in young children during the coronavirus SARS-CoV-2 (COVID-19) pandemic. A telehealth model of ASD evaluation was implemented with 308 children ages 14 to 78 months between May 2020 to June 2021. Data were gathered from electronic health records, autism-specific telehealth diagnostic tools, and post-evaluation surveys. Overall, the majority of providers and caregivers were satisfied with telehealth ASD evaluation. Multiple variables were associated with ratings of satisfaction, differing by providers and caregivers. Findings have important implications for the feasibility and acceptability of telehealth ASD evaluations, in addition to key factors to consider in optimizing and sustaining telehealth evaluations beyond the COVID-19 pandemic. En ligne : http://dx.doi.org/10.1007/s10803-022-05576-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489 [article] Provider and Caregiver Satisfaction with Telehealth Evaluation of Autism Spectrum Disorder in Young Children During the COVID-19 Pandemic [Texte imprimé et/ou numérique] / Debra L. REISINGER, Auteur ; Elesia HINES, Auteur ; Christine RACHES, Auteur ; Qing TANG, Auteur ; Cristina JAMES, Auteur ; Rebecca MCNALLY KEEHN, Auteur . - 2022 . - p.5099-5113. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-12 (December 2022) . - p.5099-5113 Mots-clés : Child  Humans  Child, Preschool  Infant  covid-19  Autism Spectrum Disorder/diagnosis/epidemiology/therapy  Pandemics  Caregivers  SARS-CoV-2  Personal Satisfaction  Telemedicine  Autism spectrum disorder  Diagnostic evaluation  Satisfaction  Telehealth  Young children Index. décimale : PER Périodiques Résumé : The present study examines provider and caregiver satisfaction with telehealth evaluation of autism spectrum disorder (ASD) in young children during the coronavirus SARS-CoV-2 (COVID-19) pandemic. A telehealth model of ASD evaluation was implemented with 308 children ages 14 to 78 months between May 2020 to June 2021. Data were gathered from electronic health records, autism-specific telehealth diagnostic tools, and post-evaluation surveys. Overall, the majority of providers and caregivers were satisfied with telehealth ASD evaluation. Multiple variables were associated with ratings of satisfaction, differing by providers and caregivers. Findings have important implications for the feasibility and acceptability of telehealth ASD evaluations, in addition to key factors to consider in optimizing and sustaining telehealth evaluations beyond the COVID-19 pandemic. En ligne : http://dx.doi.org/10.1007/s10803-022-05576-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=489

Tele-assessment of young children referred for autism spectrum disorder evaluation during COVID-19: Associations among clinical characteristics and diagnostic outcome / Rebecca MCNALLY KEEHN in Autism, 27-5 (July 2023)  

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