Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance / Andrée-Anne BOUVETTE-TURCOT in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.605-613 Titre : Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance Type de document : texte imprimé Auteurs : Andrée-Anne BOUVETTE-TURCOT, Auteur ; Alison S. FLEMING, Auteur ; Eva UNTERNAEHRER, Auteur ; Andrea GONZALEZ, Auteur ; Leslie ATKINSON, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; Michael J. MEANEY, Auteur Article en page(s) : p.605-613 Langues : Anglais (eng) Mots-clés : intergenerational risk transmission  maternal adversity  maternal depression  maternal sensitivity  negative emotionality/behavioral dysregulation Index. décimale : PER Périodiques Résumé : We examined maternal depression and maternal sensitivity as mediators of the association between maternal childhood adversity and her child's temperament in 239 mother-child dyads from a longitudinal, birth cohort study. We used an integrated measure of maternal childhood adversity that included the Childhood Trauma Questionnaire and the Parental Bonding Index. Maternal depression was assessed with the Edinburgh Postnatal Depression Scale at 6 months postpartum. Maternal sensitivity was assessed with the Ainsworth maternal sensitivity scales at 6 months. A measure of "negative emotionality/behavioral dysregulation" was derived from the Early Childhood Behaviour Questionnaire administered at 36 months. Bootstrapping-based mediation analyses revealed that maternal depression mediated the effect of maternal childhood adversity on offspring negative emotionality/behavioral dysregulation (95% confidence interval [0.026, 0.144]). We also found a serial, indirect effect of maternal childhood adversity on child negative emotionality/behavioral mediated first by maternal depression and then by maternal sensitivity (95% confidence interval [0.031, 0.156]). Results suggest the intergenerational transmission of the effects of maternal childhood adversity to the offspring occurs through a two-step, serial pathway, involving maternal depression and maternal sensitivity. En ligne : http://dx.doi.org/10.1017/s0954579419000488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Maternal symptoms of depression and sensitivity mediate the relation between maternal history of early adversity and her child temperament: The inheritance of circumstance [texte imprimé] / Andrée-Anne BOUVETTE-TURCOT, Auteur ; Alison S. FLEMING, Auteur ; Eva UNTERNAEHRER, Auteur ; Andrea GONZALEZ, Auteur ; Leslie ATKINSON, Auteur ; Helene GAUDREAU, Auteur ; Meir STEINER, Auteur ; Michael J. MEANEY, Auteur . - p.605-613. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.605-613 Mots-clés : intergenerational risk transmission  maternal adversity  maternal depression  maternal sensitivity  negative emotionality/behavioral dysregulation Index. décimale : PER Périodiques Résumé : We examined maternal depression and maternal sensitivity as mediators of the association between maternal childhood adversity and her child's temperament in 239 mother-child dyads from a longitudinal, birth cohort study. We used an integrated measure of maternal childhood adversity that included the Childhood Trauma Questionnaire and the Parental Bonding Index. Maternal depression was assessed with the Edinburgh Postnatal Depression Scale at 6 months postpartum. Maternal sensitivity was assessed with the Ainsworth maternal sensitivity scales at 6 months. A measure of "negative emotionality/behavioral dysregulation" was derived from the Early Childhood Behaviour Questionnaire administered at 36 months. Bootstrapping-based mediation analyses revealed that maternal depression mediated the effect of maternal childhood adversity on offspring negative emotionality/behavioral dysregulation (95% confidence interval [0.026, 0.144]). We also found a serial, indirect effect of maternal childhood adversity on child negative emotionality/behavioral mediated first by maternal depression and then by maternal sensitivity (95% confidence interval [0.031, 0.156]). Results suggest the intergenerational transmission of the effects of maternal childhood adversity to the offspring occurs through a two-step, serial pathway, involving maternal depression and maternal sensitivity. En ligne : http://dx.doi.org/10.1017/s0954579419000488 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial / Christine M. FREITAG ; Arne POPMA ; Lucres NAUTA-JANSEN ; Kerstin KONRAD ; Eva UNTERNAEHRER ; Katharina ACKERMANN ; Anka BERNHARD ; Anne MARTINELLI ; Helena OLDENHOF ; Malou GUNDLACH ; Gregor KOHLS ; Martin PRÄTZLICH ; Meinhard KIESER ; Ronald LIMPRECHT ; Nora RASCHLE ; Noortje VRIENDS ; Robert L. TRESTMAN ; Marietta KIRCHNER ; Linda KERSTEN in Journal of Child Psychology and Psychiatry, 65-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.316-327 Titre : START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial Type de document : texte imprimé Auteurs : Christine M. FREITAG, Auteur ; Arne POPMA, Auteur ; Lucres NAUTA-JANSEN, Auteur ; Kerstin KONRAD, Auteur ; Eva UNTERNAEHRER, Auteur ; Katharina ACKERMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Helena OLDENHOF, Auteur ; Malou GUNDLACH, Auteur ; Gregor KOHLS, Auteur ; Martin PRÄTZLICH, Auteur ; Meinhard KIESER, Auteur ; Ronald LIMPRECHT, Auteur ; Nora RASCHLE, Auteur ; Noortje VRIENDS, Auteur ; Robert L. TRESTMAN, Auteur ; Marietta KIRCHNER, Auteur ; Linda KERSTEN, Auteur Article en page(s) : p.316-327 Index. décimale : PER Périodiques Résumé : Background Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive-behavioral, dialectical behavior therapy-oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods A total of 127 girls were included in this prospective, cluster randomized, multi-center, parallel group, quasi-randomized, controlled phase III trial, which tested the efficacy of START NOW (n 72) compared with standard care (treatment as usual, TAU, n 55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (+1.5) years on average (range: 12 20 years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post-treatment (T3), and (2) between T1 and 12-week follow-up (T4). Results Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW 4.87, 2.49; TAU 4.94, 2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU ( 0.056; 95% CI 1.860, 1.749; Hedge's g 0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 ( 2.326; 95% CI 4.274, 0.378; Hedge's g 0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent-reported irritability at post assessment. Conclusions Although START NOW did not result in greater symptom reduction from baseline to post-treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow-up with a medium effect size, which indicates a clinically meaningful delayed treatment effect. En ligne : https://doi.org/10.1111/jcpp.13896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial [texte imprimé] / Christine M. FREITAG, Auteur ; Arne POPMA, Auteur ; Lucres NAUTA-JANSEN, Auteur ; Kerstin KONRAD, Auteur ; Eva UNTERNAEHRER, Auteur ; Katharina ACKERMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Helena OLDENHOF, Auteur ; Malou GUNDLACH, Auteur ; Gregor KOHLS, Auteur ; Martin PRÄTZLICH, Auteur ; Meinhard KIESER, Auteur ; Ronald LIMPRECHT, Auteur ; Nora RASCHLE, Auteur ; Noortje VRIENDS, Auteur ; Robert L. TRESTMAN, Auteur ; Marietta KIRCHNER, Auteur ; Linda KERSTEN, Auteur . - p.316-327. in Journal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.316-327 Index. décimale : PER Périodiques Résumé : Background Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive-behavioral, dialectical behavior therapy-oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods A total of 127 girls were included in this prospective, cluster randomized, multi-center, parallel group, quasi-randomized, controlled phase III trial, which tested the efficacy of START NOW (n 72) compared with standard care (treatment as usual, TAU, n 55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (+1.5) years on average (range: 12 20 years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post-treatment (T3), and (2) between T1 and 12-week follow-up (T4). Results Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW 4.87, 2.49; TAU 4.94, 2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU ( 0.056; 95% CI 1.860, 1.749; Hedge's g 0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 ( 2.326; 95% CI 4.274, 0.378; Hedge's g 0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent-reported irritability at post assessment. Conclusions Although START NOW did not result in greater symptom reduction from baseline to post-treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow-up with a medium effect size, which indicates a clinically meaningful delayed treatment effect. En ligne : https://doi.org/10.1111/jcpp.13896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

The early care environment and DNA methylome variation in childhood / Elika GARG in Development and Psychopathology, 30-3 (August 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-3 (August 2018) . - p.891-903 Titre : The early care environment and DNA methylome variation in childhood Type de document : texte imprimé Auteurs : Elika GARG, Auteur ; Li CHEN, Auteur ; Thao T.T. NGUYEN, Auteur ; Irina POKHVISNEVA, Auteur ; Lauwrence M. CHEN, Auteur ; Eva UNTERNAEHRER, Auteur ; Julia L. MACISAAC, Auteur ; Lisa M. MCEWEN, Auteur ; Sarah M. MAH, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Ellen MOSS, Auteur ; M.B. SOKOLOWSKI, Auteur ; James L. KENNEDY, Auteur ; Meir S. STEINER, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur ; Patricia P. SILVEIRA, Auteur ; Neerja KARNANI, Auteur ; Michael S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur Année de publication : 2018 Article en page(s) : p.891-903 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366 [article] The early care environment and DNA methylome variation in childhood [texte imprimé] / Elika GARG, Auteur ; Li CHEN, Auteur ; Thao T.T. NGUYEN, Auteur ; Irina POKHVISNEVA, Auteur ; Lauwrence M. CHEN, Auteur ; Eva UNTERNAEHRER, Auteur ; Julia L. MACISAAC, Auteur ; Lisa M. MCEWEN, Auteur ; Sarah M. MAH, Auteur ; Helene GAUDREAU, Auteur ; Robert LEVITAN, Auteur ; Ellen MOSS, Auteur ; M.B. SOKOLOWSKI, Auteur ; James L. KENNEDY, Auteur ; Meir S. STEINER, Auteur ; Michael J. MEANEY, Auteur ; Joanna D. HOLBROOK, Auteur ; Patricia P. SILVEIRA, Auteur ; Neerja KARNANI, Auteur ; Michael S. KOBOR, Auteur ; Kieran J. O'DONNELL, Auteur . - 2018 . - p.891-903. Langues : Anglais (eng) in Development and Psychopathology > 30-3 (August 2018) . - p.891-903 Index. décimale : PER Périodiques Résumé : Prenatal adversity shapes child neurodevelopment and risk for later mental health problems. The quality of the early care environment can buffer some of the negative effects of prenatal adversity on child development. Retrospective studies, in adult samples, highlight epigenetic modifications as sentinel markers of the quality of the early care environment; however, comparable data from pediatric cohorts are lacking. Participants were drawn from the Maternal Adversity Vulnerability and Neurodevelopment (MAVAN) study, a longitudinal cohort with measures of infant attachment, infant development, and child mental health. Children provided buccal epithelial samples (mean age = 6.99, SD = 1.33 years, n = 226), which were used for analyses of genome-wide DNA methylation and genetic variation. We used a series of linear models to describe the association between infant attachment and (a) measures of child outcome and (b) DNA methylation across the genome. Paired genetic data was used to determine the genetic contribution to DNA methylation at attachment-associated sites. Infant attachment style was associated with infant cognitive development (Mental Development Index) and behavior (Behavior Rating Scale) assessed with the Bayley Scales of Infant Development at 36 months. Infant attachment style moderated the effects of prenatal adversity on Behavior Rating Scale scores at 36 months. Infant attachment was also significantly associated with a principal component that accounted for 11.9% of the variation in genome-wide DNA methylation. These effects were most apparent when comparing children with a secure versus a disorganized attachment style and most pronounced in females. The availability of paired genetic data revealed that DNA methylation at approximately half of all infant attachment-associated sites was best explained by considering both infant attachment and child genetic variation. This study provides further evidence that infant attachment can buffer some of the negative effects of early adversity on measures of infant behavior. We also highlight the interplay between infant attachment and child genotype in shaping variation in DNA methylation. Such findings provide preliminary evidence for a molecular signature of infant attachment and may help inform attachment-focused early intervention programs. En ligne : http://dx.doi.org/10.1017/s0954579418000627 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=366

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