Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder / Yumi UMESAWA in Journal of Autism and Developmental Disorders, 50-8 (August 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2710-2722 Titre : Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Yumi UMESAWA, Auteur ; Kanae MATSUSHIMA, Auteur ; Takeshi ATSUMI, Auteur ; Toshihiro KATO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur ; Masakazu IDE, Auteur Article en page(s) : p.2710-2722 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Developmental coordination disorder  Gamma-aminobutyric acid  Magnetic resonance spectroscopy  Primary motor area  Supplementary motor area Index. décimale : PER Périodiques Résumé : Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using (1)H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428 [article] Altered GABA Concentration in Brain Motor Area Is Associated with the Severity of Motor Disabilities in Individuals with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Yumi UMESAWA, Auteur ; Kanae MATSUSHIMA, Auteur ; Takeshi ATSUMI, Auteur ; Toshihiro KATO, Auteur ; Reiko FUKATSU, Auteur ; Makoto WADA, Auteur ; Masakazu IDE, Auteur . - p.2710-2722. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-8 (August 2020) . - p.2710-2722 Mots-clés : Autism spectrum disorder  Developmental coordination disorder  Gamma-aminobutyric acid  Magnetic resonance spectroscopy  Primary motor area  Supplementary motor area Index. décimale : PER Périodiques Résumé : Several motor disabilities accompanied with autism spectrum disorder (ASD) are widely known despite limited reports of underlying neural mechanisms. Gamma-aminobutyric acid (GABA) levels in the motor-related cortical areas modulate several motor performances in healthy participants. We hypothesized that abnormal GABA concentrations in the primary motor area (M1) and supplementary motor area (SMA) associate with different motor difficulties for ASD adolescents/adults. We found that increased GABA concentrations in M1 measured using (1)H-magnetic resonance spectroscopy exhibited lower motor performance in tasks requiring increased muscle strength while lower GABA concentrations in SMA were associated with lower scores in tests measuring body coordination. The degrees of neural inhibition in the M1 and SMA regions would contribute to different dimensions of motor disabilities in autism. En ligne : http://dx.doi.org/10.1007/s10803-020-04382-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=428

Hand-foot coordination is significantly influenced by motion direction in individuals with autism spectrum disorder / Kanae MATSUSHIMA ; Reiko FUKATSU ; Yasuo TERAO ; Masakazu IDE in Autism Research, 16-1 (January 2023)  

Public ISBD [article]  inAutism Research > 16-1 (January 2023) . - p.40-51 Titre : Hand-foot coordination is significantly influenced by motion direction in individuals with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kanae MATSUSHIMA, Auteur ; Reiko FUKATSU, Auteur ; Yasuo TERAO, Auteur ; Masakazu IDE, Auteur Article en page(s) : p.40-51 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Generally, when individuals attempt to move two limbs rhythmically in the opposite direction (e.g., flex the left hand and extend the left foot along the sagittal plane), the movements tend to be instead performed in the same direction. This phenomenon, known as directional constraint, can be harnessed to examine the difficulties in movement coordination exhibited by most individuals with autism spectrum disorder (ASD). While such difficulties have already been investigated through standardized clinical assessments, they have not been examined through kinematic methods. Thus, we employed a clinical assessment scale in an experimentally controlled environment to investigate whether stronger directional constraint during the rhythmic movement of two limbs is more pronounced and associated with decreased movement coordination in individuals with ASD. ASD and typically developing (TD) participants were asked to rhythmically move two limbs either in the same or opposite directions. In addition, the coordination skills of participants were assessed using the Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2). Subjects with ASD showed significantly stronger directional constraint than TD participants during the contralateral and ipsilateral movement of the hand and foot. According to the pooled data from both groups, participants who showed stronger directional constraint during these two movement conditions also exhibited poorer coordinated movement skills in the BOT-2. These results suggest that people with ASD may have difficulties in inhibiting the neural signals that synchronize the direction of inter-limb movements, thus resulting in coordination disabilities. Lay Summary Individuals with autism spectrum disorder (ASD) often exhibit difficulties in coordinated movements. We asked those with ASD and typically developing (TD) participants to move two limbs (e.g., left hand and left foot) either in the same or the opposite direction. Results demonstrated that participants with ASD had more difficulties in counteracting the tendency of their hand and foot to synchronously move in the same direction. Our findings suggested that difficulties to suppress synchronized movements of the hand and foot result in coordination disabilities. En ligne : https://doi.org/10.1002/aur.2837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492 [article] Hand-foot coordination is significantly influenced by motion direction in individuals with autism spectrum disorder [Texte imprimé et/ou numérique] / Kanae MATSUSHIMA, Auteur ; Reiko FUKATSU, Auteur ; Yasuo TERAO, Auteur ; Masakazu IDE, Auteur . - p.40-51. Langues : Anglais (eng) in Autism Research > 16-1 (January 2023) . - p.40-51 Index. décimale : PER Périodiques Résumé : Abstract Generally, when individuals attempt to move two limbs rhythmically in the opposite direction (e.g., flex the left hand and extend the left foot along the sagittal plane), the movements tend to be instead performed in the same direction. This phenomenon, known as directional constraint, can be harnessed to examine the difficulties in movement coordination exhibited by most individuals with autism spectrum disorder (ASD). While such difficulties have already been investigated through standardized clinical assessments, they have not been examined through kinematic methods. Thus, we employed a clinical assessment scale in an experimentally controlled environment to investigate whether stronger directional constraint during the rhythmic movement of two limbs is more pronounced and associated with decreased movement coordination in individuals with ASD. ASD and typically developing (TD) participants were asked to rhythmically move two limbs either in the same or opposite directions. In addition, the coordination skills of participants were assessed using the Bruininks-Oseretsky Test of Motor Proficiency Second Edition (BOT-2). Subjects with ASD showed significantly stronger directional constraint than TD participants during the contralateral and ipsilateral movement of the hand and foot. According to the pooled data from both groups, participants who showed stronger directional constraint during these two movement conditions also exhibited poorer coordinated movement skills in the BOT-2. These results suggest that people with ASD may have difficulties in inhibiting the neural signals that synchronize the direction of inter-limb movements, thus resulting in coordination disabilities. Lay Summary Individuals with autism spectrum disorder (ASD) often exhibit difficulties in coordinated movements. We asked those with ASD and typically developing (TD) participants to move two limbs (e.g., left hand and left foot) either in the same or the opposite direction. Results demonstrated that participants with ASD had more difficulties in counteracting the tendency of their hand and foot to synchronously move in the same direction. Our findings suggested that difficulties to suppress synchronized movements of the hand and foot result in coordination disabilities. En ligne : https://doi.org/10.1002/aur.2837 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=492

Sensory and Social Subtypes of Japanese Individuals with Autism Spectrum Disorders / Ayako KANEKO in Journal of Autism and Developmental Disorders, 53-8 (August 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3133-3143 Titre : Sensory and Social Subtypes of Japanese Individuals with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Ayako KANEKO, Auteur ; Remi OHSHIMA, Auteur ; Haruka NODA, Auteur ; Tomoko MATSUMARU, Auteur ; Ryoichiro IWANAGA, Auteur ; Masakazu IDE, Auteur Article en page(s) : p.3133-3143 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies have proposed that individuals with autism spectrum disorder (ASD) can be divided into several subtypes depending on their sensory features. However, consideration of social communication features is also crucial for configuring ASD subtypes, because social and sensory features are tightly interrelated. In this study, we asked Japanese individuals with ASD to answer the Short Sensory Profile (SSP) and the Social Responsiveness Scale, Second Edition (SRS-2), which measure sensory and social aspects, respectively. Consequent latent profile analysis demonstrated that the participants could be divided into five subgroups: two groups exhibited opposite or inconsistent patterns between the SSP and SRS-2 scores, while the other groups exhibited consistent patterns. Our findings indicate the existence of diverse phenotypes in individuals with ASD. En ligne : https://doi.org/10.1007/s10803-022-05577-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Sensory and Social Subtypes of Japanese Individuals with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Ayako KANEKO, Auteur ; Remi OHSHIMA, Auteur ; Haruka NODA, Auteur ; Tomoko MATSUMARU, Auteur ; Ryoichiro IWANAGA, Auteur ; Masakazu IDE, Auteur . - p.3133-3143. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-8 (August 2023) . - p.3133-3143 Index. décimale : PER Périodiques Résumé : Studies have proposed that individuals with autism spectrum disorder (ASD) can be divided into several subtypes depending on their sensory features. However, consideration of social communication features is also crucial for configuring ASD subtypes, because social and sensory features are tightly interrelated. In this study, we asked Japanese individuals with ASD to answer the Short Sensory Profile (SSP) and the Social Responsiveness Scale, Second Edition (SRS-2), which measure sensory and social aspects, respectively. Consequent latent profile analysis demonstrated that the participants could be divided into five subgroups: two groups exhibited opposite or inconsistent patterns between the SSP and SRS-2 scores, while the other groups exhibited consistent patterns. Our findings indicate the existence of diverse phenotypes in individuals with ASD. En ligne : https://doi.org/10.1007/s10803-022-05577-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

---

1 (1 - 3 / 3)