Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not? / Ozge OZTAN in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 8p. Titre : Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not? Type de document : Texte imprimé et/ou numérique Auteurs : Ozge OZTAN, Auteur ; Laura A. DEL ROSSO, Auteur ; Sierra M. SIMMONS, Auteur ; Duyen K. K. NGUYEN, Auteur ; Catherine F. TALBOT, Auteur ; John P. CAPITANIO, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur Article en page(s) : 8p. Langues : Anglais (eng) Mots-clés : Child  Animals  Humans  Male  Female  Autistic Disorder  Autism Spectrum Disorder  Macaca mulatta  Social Behavior  Arginine Vasopressin/cerebrospinal fluid  Oxytocin  Animal model  Arginine vasopressin  Autism spectrum disorder  Cerebrospinal fluid  Dominance rank  Rhesus macaque  Social functioning  Social responsiveness scale  applications related to data reviewed herein: PCT/US2019/019029 ("Methods for  diagnosing and determining severity of an autism spectrum disorder") and  PCT/US2019/041250 ("Intranasal Vasopressin Treatment for Social Deficits in  Children with Autism"). These patents have not been granted or licensed, and no  study author is receiving any financial compensation at this time. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by persistent social interaction impairments and is male-biased in prevalence. We have established naturally occurring low sociality in male rhesus monkeys as a model for the social features of ASD. Low-social male monkeys exhibit reduced social interactions and increased autistic-like trait burden, with both measures highly correlated and strongly linked to low cerebrospinal fluid (CSF) arginine vasopressin (AVP) concentration. Little is known, however, about the behavioral and neurochemical profiles of female rhesus monkeys, and whether low sociality in females is a tractable model for ASD. METHODS: Social behavior assessments (ethological observations; a reverse-translated autistic trait measurement scale, the macaque Social Responsiveness Scale-Revised [mSRS-R]) were completed on N = 88 outdoor-housed female rhesus monkeys during the non-breeding season. CSF and blood samples were collected from a subset of N = 16 monkeys across the frequency distribution of non-social behavior, and AVP and oxytocin (OXT) concentrations were quantified. Data were analyzed using general linear models. RESULTS: Non-social behavior frequency and mSRS-R scores were continuously distributed across the general female monkey population, as previously found for male monkeys. However, dominance rank significantly predicted mSRS-R scores in females, with higher-ranking individuals showing fewer autistic-like traits, a relationship not previously observed in males from this colony. Females differed from males in several other respects: Social behavior frequencies were unrelated to mSRS-R scores, and AVP concentration was unrelated to any social behavior measure. Blood and CSF concentrations of AVP were positively correlated in females; no significant relationship involving any OXT measure was found. LIMITATIONS: This study sample was small, and did not consider genetic, environmental, or other neurochemical measures that may be related to female mSRS-R scores. CONCLUSIONS: Dominance rank is the most significant predictor of autistic-like traits in female rhesus monkeys, and CSF neuropeptide concentrations are unrelated to measures of female social functioning (in contrast to prior CSF AVP findings in male rhesus monkeys and male and female autistic children). Although preliminary, this evidence suggests that the strong matrilineal organization of this species may limit the usefulness of low sociality in female rhesus monkeys as a tractable model for ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00588-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not? [Texte imprimé et/ou numérique] / Ozge OZTAN, Auteur ; Laura A. DEL ROSSO, Auteur ; Sierra M. SIMMONS, Auteur ; Duyen K. K. NGUYEN, Auteur ; Catherine F. TALBOT, Auteur ; John P. CAPITANIO, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur . - 8p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 8p. Mots-clés : Child  Animals  Humans  Male  Female  Autistic Disorder  Autism Spectrum Disorder  Macaca mulatta  Social Behavior  Arginine Vasopressin/cerebrospinal fluid  Oxytocin  Animal model  Arginine vasopressin  Autism spectrum disorder  Cerebrospinal fluid  Dominance rank  Rhesus macaque  Social functioning  Social responsiveness scale  applications related to data reviewed herein: PCT/US2019/019029 ("Methods for  diagnosing and determining severity of an autism spectrum disorder") and  PCT/US2019/041250 ("Intranasal Vasopressin Treatment for Social Deficits in  Children with Autism"). These patents have not been granted or licensed, and no  study author is receiving any financial compensation at this time. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by persistent social interaction impairments and is male-biased in prevalence. We have established naturally occurring low sociality in male rhesus monkeys as a model for the social features of ASD. Low-social male monkeys exhibit reduced social interactions and increased autistic-like trait burden, with both measures highly correlated and strongly linked to low cerebrospinal fluid (CSF) arginine vasopressin (AVP) concentration. Little is known, however, about the behavioral and neurochemical profiles of female rhesus monkeys, and whether low sociality in females is a tractable model for ASD. METHODS: Social behavior assessments (ethological observations; a reverse-translated autistic trait measurement scale, the macaque Social Responsiveness Scale-Revised [mSRS-R]) were completed on N = 88 outdoor-housed female rhesus monkeys during the non-breeding season. CSF and blood samples were collected from a subset of N = 16 monkeys across the frequency distribution of non-social behavior, and AVP and oxytocin (OXT) concentrations were quantified. Data were analyzed using general linear models. RESULTS: Non-social behavior frequency and mSRS-R scores were continuously distributed across the general female monkey population, as previously found for male monkeys. However, dominance rank significantly predicted mSRS-R scores in females, with higher-ranking individuals showing fewer autistic-like traits, a relationship not previously observed in males from this colony. Females differed from males in several other respects: Social behavior frequencies were unrelated to mSRS-R scores, and AVP concentration was unrelated to any social behavior measure. Blood and CSF concentrations of AVP were positively correlated in females; no significant relationship involving any OXT measure was found. LIMITATIONS: This study sample was small, and did not consider genetic, environmental, or other neurochemical measures that may be related to female mSRS-R scores. CONCLUSIONS: Dominance rank is the most significant predictor of autistic-like traits in female rhesus monkeys, and CSF neuropeptide concentrations are unrelated to measures of female social functioning (in contrast to prior CSF AVP findings in male rhesus monkeys and male and female autistic children). Although preliminary, this evidence suggests that the strong matrilineal organization of this species may limit the usefulness of low sociality in female rhesus monkeys as a tractable model for ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00588-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

A Psychometrically Robust Screening Tool To Rapidly Identify Socially Impaired Monkeys In The General Population / Catherine F. TALBOT in Autism Research, 13-9 (September 2020)  

Public ISBD [article]  inAutism Research > 13-9 (September 2020) . - p.1465-1475 Titre : A Psychometrically Robust Screening Tool To Rapidly Identify Socially Impaired Monkeys In The General Population Type de document : Texte imprimé et/ou numérique Auteurs : Catherine F. TALBOT, Auteur ; Joseph P. GARNER, Auteur ; Alyssa C. MANESS, Auteur ; Brenda MCCOWAN, Auteur ; John P. CAPITANIO, Auteur ; Karen J. PARKER, Auteur Article en page(s) : p.1465-1475 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Naturally low-social rhesus macaques exhibit social impairments with direct relevance to autism spectrum disorder (ASD). To more efficiently identify low-social individuals in a large colony, we exploited, refined, and psychometrically assessed the macaque Social Responsiveness Scale (mSRS), an instrument previously derived from the human ASD screening tool. We performed quantitative social behavior assessments and mSRS ratings on a total of N = 349 rhesus macaques (Macaca mulatta) housed in large, outdoor corrals. In one cohort (N = 116), we conducted inter-rater and test-retest reliabilities, and in a second cohort (N = 233), we evaluated the convergent construct and predictive validity of the mSRS-Revised (mSRS-R). Only 17 of the original 36 items demonstrated inter-rater and test–retest reliability, resulting in the 17-item mSRS-R. The mSRS-R showed strong validity: mSRS-R scores robustly predicted monkeys' social behavior frequencies in home corrals. Monkeys that scored 1.5 standard deviations from the mean on nonsocial behavior likewise exhibited significantly more autistic-like traits, and mSRS-R scores predicted individuals' social classification (low-social vs. high-social) with 96% accuracy (likelihood ratio chi-square = 25.07; P? En ligne : http://dx.doi.org/10.1002/aur.2335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431 [article] A Psychometrically Robust Screening Tool To Rapidly Identify Socially Impaired Monkeys In The General Population [Texte imprimé et/ou numérique] / Catherine F. TALBOT, Auteur ; Joseph P. GARNER, Auteur ; Alyssa C. MANESS, Auteur ; Brenda MCCOWAN, Auteur ; John P. CAPITANIO, Auteur ; Karen J. PARKER, Auteur . - p.1465-1475. Langues : Anglais (eng) in Autism Research > 13-9 (September 2020) . - p.1465-1475 Index. décimale : PER Périodiques Résumé : Naturally low-social rhesus macaques exhibit social impairments with direct relevance to autism spectrum disorder (ASD). To more efficiently identify low-social individuals in a large colony, we exploited, refined, and psychometrically assessed the macaque Social Responsiveness Scale (mSRS), an instrument previously derived from the human ASD screening tool. We performed quantitative social behavior assessments and mSRS ratings on a total of N = 349 rhesus macaques (Macaca mulatta) housed in large, outdoor corrals. In one cohort (N = 116), we conducted inter-rater and test-retest reliabilities, and in a second cohort (N = 233), we evaluated the convergent construct and predictive validity of the mSRS-Revised (mSRS-R). Only 17 of the original 36 items demonstrated inter-rater and test–retest reliability, resulting in the 17-item mSRS-R. The mSRS-R showed strong validity: mSRS-R scores robustly predicted monkeys' social behavior frequencies in home corrals. Monkeys that scored 1.5 standard deviations from the mean on nonsocial behavior likewise exhibited significantly more autistic-like traits, and mSRS-R scores predicted individuals' social classification (low-social vs. high-social) with 96% accuracy (likelihood ratio chi-square = 25.07; P? En ligne : http://dx.doi.org/10.1002/aur.2335 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=431

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