7 recherche sur le mot-clé 'Cerebrospinal fluid'

Cerebrospinal fluid and the early brain development of autism / Mark D. SHEN in Journal of Neurodevelopmental Disorders, 10-1 (December 2018)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 39 p. Titre : Cerebrospinal fluid and the early brain development of autism Type de document : texte imprimé Auteurs : Mark D. SHEN, Auteur Année de publication : 2018 Article en page(s) : 39 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Biomarkers  Brain development  Brain enlargement  Cerebrospinal fluid  Early risk signs  Extra-axial cerebrospinal fluid  Glymphatic system  Heterogeneity  Infancy  Lateral ventricles  Neural meningeal lymphatic system  Neuroinflammation  Stratification biomarker Index. décimale : PER Périodiques Résumé : BACKGROUND: There is currently a renaissance of interest in the many functions of cerebrospinal fluid (CSF). Altered flow of CSF, for example, has been shown to impair the clearance of pathogenic inflammatory proteins involved in neurodegenerative diseases, such as amyloid-beta. In addition, the role of CSF in the newly discovered lymphatic system of the brain has become a prominently researched area in clinical neuroscience, as CSF serves as a conduit between the central nervous system and immune system. MAIN BODY: This article will review the importance of CSF in regulating normal brain development and function, from the prenatal period throughout the lifespan, and highlight recent research that CSF abnormalities in autism spectrum disorder (ASD) are present in infancy, are detectable by conventional structural MRI, and could serve as an early indicator of altered neurodevelopment. CONCLUSION: The identification of early CSF abnormalities in children with ASD, along with emerging knowledge of the underlying pathogenic mechanisms, has the potential to serve as early stratification biomarkers that separate children with ASD into biological subtypes that share a common pathophysiology. Such subtypes could help parse the phenotypic heterogeneity of ASD and map on to targeted, biologically based treatments. En ligne : http://dx.doi.org/10.1186/s11689-018-9256-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386 [article] Cerebrospinal fluid and the early brain development of autism [texte imprimé] / Mark D. SHEN, Auteur . - 2018 . - 39 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 10-1 (December 2018) . - 39 p. Mots-clés : Autism spectrum disorder  Biomarkers  Brain development  Brain enlargement  Cerebrospinal fluid  Early risk signs  Extra-axial cerebrospinal fluid  Glymphatic system  Heterogeneity  Infancy  Lateral ventricles  Neural meningeal lymphatic system  Neuroinflammation  Stratification biomarker Index. décimale : PER Périodiques Résumé : BACKGROUND: There is currently a renaissance of interest in the many functions of cerebrospinal fluid (CSF). Altered flow of CSF, for example, has been shown to impair the clearance of pathogenic inflammatory proteins involved in neurodegenerative diseases, such as amyloid-beta. In addition, the role of CSF in the newly discovered lymphatic system of the brain has become a prominently researched area in clinical neuroscience, as CSF serves as a conduit between the central nervous system and immune system. MAIN BODY: This article will review the importance of CSF in regulating normal brain development and function, from the prenatal period throughout the lifespan, and highlight recent research that CSF abnormalities in autism spectrum disorder (ASD) are present in infancy, are detectable by conventional structural MRI, and could serve as an early indicator of altered neurodevelopment. CONCLUSION: The identification of early CSF abnormalities in children with ASD, along with emerging knowledge of the underlying pathogenic mechanisms, has the potential to serve as early stratification biomarkers that separate children with ASD into biological subtypes that share a common pathophysiology. Such subtypes could help parse the phenotypic heterogeneity of ASD and map on to targeted, biologically based treatments. En ligne : http://dx.doi.org/10.1186/s11689-018-9256-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=386

Cerebrospinal Fluid Vasopressin Concentration Is a Biomarker of Autistic Social Impairment and Hypothalamic Vasopressin Gene Expression in Humans / Ozge OZTAN in Autism Research, 19-3 (March 2026)  

Public ISBD [article]  inAutism Research > 19-3 (March 2026) . - e70181 Titre : Cerebrospinal Fluid Vasopressin Concentration Is a Biomarker of Autistic Social Impairment and Hypothalamic Vasopressin Gene Expression in Humans Type de document : texte imprimé Auteurs : Ozge OZTAN, Auteur ; Chunfang ZHU, Auteur ; Duyen K. K. NGUYEN, Auteur ; Robert B. WEST, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur Article en page(s) : e70181 Langues : Anglais (eng) Mots-clés : arginine vasopressin  autism spectrum disorder  cerebrospinal fluid  hypothalamus  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social interaction difficulties and restricted, repetitive behaviors. Recent ASD biomarker discovery efforts have found that cerebrospinal fluid (CSF) concentration of vasopressin, a hypothalamic neuropeptide critical for mammalian social functioning, is significantly lower in children with ASD and newborns later diagnosed with ASD. Low CSF vasopressin concentration is also linked to ASD social (but not repetitive) behavior symptom severity. These findings suggest that CSF vasopressin measurement may have clinical utility, but CSF surveillance requires invasive sampling procedures that will be difficult to integrate into routine clinical care without strong justification (i.e., CSF vasopressin is a valid proxy for hypothalamic vasopressin production, whereas blood vasopressin is not). We therefore obtained neuropathological specimens and patient data (N?=?18) to investigate this possibility. In Study 1, we capitalized on the unique opportunity to test the reproducibility and robustness of the relationship between CSF vasopressin concentration and ASD behavioral symptoms in a sample demographically and methodologically distinct from prior work. This relationship held across age, antemortem to postmortem biospecimens, quantification platforms, clinical instruments, evaluators, and symptom type. In Study 2, we found in concomitantly collected postmortem samples that CSF vasopressin concentration significantly and positively predicted hypothalamic vasopressin gene expression, whereas blood vasopressin concentration did not. These findings establish CSF vasopressin as a brain-derived, mechanistically relevant biomarker of social difficulties in ASD, and suggest that CSF vasopressin measurement may be useful for ASD detection and/or identification of individuals who will benefit from pharmacological enhancement of brain vasopressin signaling. En ligne : https://doi.org/10.1002/aur.70181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583 [article] Cerebrospinal Fluid Vasopressin Concentration Is a Biomarker of Autistic Social Impairment and Hypothalamic Vasopressin Gene Expression in Humans [texte imprimé] / Ozge OZTAN, Auteur ; Chunfang ZHU, Auteur ; Duyen K. K. NGUYEN, Auteur ; Robert B. WEST, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur . - e70181. Langues : Anglais (eng) in Autism Research > 19-3 (March 2026) . - e70181 Mots-clés : arginine vasopressin  autism spectrum disorder  cerebrospinal fluid  hypothalamus  social functioning Index. décimale : PER Périodiques Résumé : ABSTRACT Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social interaction difficulties and restricted, repetitive behaviors. Recent ASD biomarker discovery efforts have found that cerebrospinal fluid (CSF) concentration of vasopressin, a hypothalamic neuropeptide critical for mammalian social functioning, is significantly lower in children with ASD and newborns later diagnosed with ASD. Low CSF vasopressin concentration is also linked to ASD social (but not repetitive) behavior symptom severity. These findings suggest that CSF vasopressin measurement may have clinical utility, but CSF surveillance requires invasive sampling procedures that will be difficult to integrate into routine clinical care without strong justification (i.e., CSF vasopressin is a valid proxy for hypothalamic vasopressin production, whereas blood vasopressin is not). We therefore obtained neuropathological specimens and patient data (N?=?18) to investigate this possibility. In Study 1, we capitalized on the unique opportunity to test the reproducibility and robustness of the relationship between CSF vasopressin concentration and ASD behavioral symptoms in a sample demographically and methodologically distinct from prior work. This relationship held across age, antemortem to postmortem biospecimens, quantification platforms, clinical instruments, evaluators, and symptom type. In Study 2, we found in concomitantly collected postmortem samples that CSF vasopressin concentration significantly and positively predicted hypothalamic vasopressin gene expression, whereas blood vasopressin concentration did not. These findings establish CSF vasopressin as a brain-derived, mechanistically relevant biomarker of social difficulties in ASD, and suggest that CSF vasopressin measurement may be useful for ASD detection and/or identification of individuals who will benefit from pharmacological enhancement of brain vasopressin signaling. En ligne : https://doi.org/10.1002/aur.70181 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=583

No difference in extra-axial cerebrospinal fluid volumes across neurodevelopmental and psychiatric conditions in later childhood and adolescence / Madeline PETERSON in Journal of Neurodevelopmental Disorders, 15 (2023)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 15 (2023) Titre : No difference in extra-axial cerebrospinal fluid volumes across neurodevelopmental and psychiatric conditions in later childhood and adolescence Type de document : texte imprimé Auteurs : Madeline PETERSON, Auteur ; Christopher WHETTEN, Auteur ; Anne M. CLARK, Auteur ; Jared A. NIELSEN, Auteur Langues : Anglais (eng) Mots-clés : Humans  Child  Adolescent  Infant  Child, Preschool  Autism Spectrum Disorder/cerebrospinal fluid  Cross-Sectional Studies  Magnetic Resonance Imaging/methods  Autistic Disorder  Brain  Autism spectrum disorder  Brain development  Cerebrospinal fluid  Extra-axial cerebrospinal fluid  Mri Index. décimale : PER Périodiques Résumé : BACKGROUND: While autism spectrum disorder has been associated with various organizational and developmental aberrations in the brain, an increase in extra-axial cerebrospinal fluid volume has recently garnered attention. A series of studies indicate that an increased volume between the ages of 6 months and 4 years was both predictive of the autism diagnosis and symptom severity regardless of genetic risk for the condition. However, there remains a minimal understanding regarding the specificity of an increased volume of extra-axial cerebrospinal fluid to autism. METHODS: In the present study, we explored extra-axial cerebrospinal fluid volumes in children and adolescents ages 5-21 years with various neurodevelopmental and psychiatric conditions. We hypothesized that an elevated extra-axial cerebrospinal fluid volume would be found in autism compared with typical development and the other diagnostic group. We tested this hypothesis by employing a cross-sectional dataset of 446 individuals (85 autistic, 60 typically developing, and 301 other diagnosis). An analysis of covariance was used to examine differences in extra-axial cerebrospinal fluid volumes between these groups as well as a group by age interaction in extra-axial cerebrospinal fluid volumes. RESULTS: Inconsistent with our hypothesis, we found no group differences in extra-axial cerebrospinal fluid volume in this cohort. However, in replication of previous work, a doubling of extra-axial cerebrospinal fluid volume across adolescence was found. Further investigation into the relationship between extra-axial cerebrospinal fluid volume and cortical thickness suggested that this increase in extra-axial cerebrospinal fluid volume may be driven by a decrease in cortical thickness. Furthermore, an exploratory analysis found no relationship between extra-axial cerebrospinal fluid volume and sleep disturbances. CONCLUSIONS: These results indicate that an increased volume of extra-axial cerebrospinal fluid may be limited to autistic individuals younger than 5 years. Additionally, extra-axial cerebrospinal fluid volume does not differ between autistic, neurotypical, and other psychiatric conditions after age 4. En ligne : https://dx.doi.org/10.1186/s11689-023-09477-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575 [article] No difference in extra-axial cerebrospinal fluid volumes across neurodevelopmental and psychiatric conditions in later childhood and adolescence [texte imprimé] / Madeline PETERSON, Auteur ; Christopher WHETTEN, Auteur ; Anne M. CLARK, Auteur ; Jared A. NIELSEN, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 15 (2023) Mots-clés : Humans  Child  Adolescent  Infant  Child, Preschool  Autism Spectrum Disorder/cerebrospinal fluid  Cross-Sectional Studies  Magnetic Resonance Imaging/methods  Autistic Disorder  Brain  Autism spectrum disorder  Brain development  Cerebrospinal fluid  Extra-axial cerebrospinal fluid  Mri Index. décimale : PER Périodiques Résumé : BACKGROUND: While autism spectrum disorder has been associated with various organizational and developmental aberrations in the brain, an increase in extra-axial cerebrospinal fluid volume has recently garnered attention. A series of studies indicate that an increased volume between the ages of 6 months and 4 years was both predictive of the autism diagnosis and symptom severity regardless of genetic risk for the condition. However, there remains a minimal understanding regarding the specificity of an increased volume of extra-axial cerebrospinal fluid to autism. METHODS: In the present study, we explored extra-axial cerebrospinal fluid volumes in children and adolescents ages 5-21 years with various neurodevelopmental and psychiatric conditions. We hypothesized that an elevated extra-axial cerebrospinal fluid volume would be found in autism compared with typical development and the other diagnostic group. We tested this hypothesis by employing a cross-sectional dataset of 446 individuals (85 autistic, 60 typically developing, and 301 other diagnosis). An analysis of covariance was used to examine differences in extra-axial cerebrospinal fluid volumes between these groups as well as a group by age interaction in extra-axial cerebrospinal fluid volumes. RESULTS: Inconsistent with our hypothesis, we found no group differences in extra-axial cerebrospinal fluid volume in this cohort. However, in replication of previous work, a doubling of extra-axial cerebrospinal fluid volume across adolescence was found. Further investigation into the relationship between extra-axial cerebrospinal fluid volume and cortical thickness suggested that this increase in extra-axial cerebrospinal fluid volume may be driven by a decrease in cortical thickness. Furthermore, an exploratory analysis found no relationship between extra-axial cerebrospinal fluid volume and sleep disturbances. CONCLUSIONS: These results indicate that an increased volume of extra-axial cerebrospinal fluid may be limited to autistic individuals younger than 5 years. Additionally, extra-axial cerebrospinal fluid volume does not differ between autistic, neurotypical, and other psychiatric conditions after age 4. En ligne : https://dx.doi.org/10.1186/s11689-023-09477-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=575

Autism-associated biomarkers: test-retest reliability and relationship to quantitative social trait variation in rhesus monkeys / Ozge OZTAN in Molecular Autism, 12 (2021)  

Public ISBD [article]  inMolecular Autism > 12 (2021) . - 50 p. Titre : Autism-associated biomarkers: test-retest reliability and relationship to quantitative social trait variation in rhesus monkeys Type de document : texte imprimé Auteurs : Ozge OZTAN, Auteur ; Catherine F. TALBOT, Auteur ; Emanuela ARGILLI, Auteur ; Alyssa C. MANESS, Auteur ; Sierra M. SIMMONS, Auteur ; Noreen MOHSIN, Auteur ; Laura A. DEL ROSSO, Auteur ; Joseph P. GARNER, Auteur ; Elliott H. SHERR, Auteur ; John P. CAPITANIO, Auteur ; Karen J. PARKER, Auteur Article en page(s) : 50 p. Langues : Anglais (eng) Mots-clés : Arginine vasopressin  Autism spectrum disorder  Biomarker  Cerebrospinal fluid  Kinase signaling pathway  Oxytocin  Rhesus macaque  Social responsiveness scale  Social trait variation  the University of California, San Francisco (UCSF) have filed patent applications  related to biological measures studied herein (Stanford University:  PCT/US2019/019029 “Methods for diagnosing and for determining severity of an autism  spectrum disorder”  UCSF: PCT/US2016/014623 “Methods of diagnosing and treating  autism spectrum disorders”). These patents have not been granted or licensed, and no  study author is receiving any financial compensation at this time. EHS serves on the  advisory board for Retrophin Inc. All other authors declare that they have no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Rhesus monkeys (Macaca mulatta) exhibit pronounced individual differences in social traits as measured by the macaque Social Responsiveness Scale-Revised. The macaque Social Responsiveness Scale was previously adapted from the Social Responsiveness Scale, an instrument designed to assess social and autistic trait variation in humans. To better understand potential biological underpinnings of this behavioral variation, we evaluated the trait-like consistency of several biological measures previously implicated in autism (e.g., arginine vasopressin, oxytocin, and their receptors, as well as ERK1/2, PTEN, and AKT(1-3) from the RAS-MAPK and PI3K-AKT pathways). We also tested which biological measures predicted macaque Social Responsiveness Scale-Revised scores. METHODS: Cerebrospinal fluid and blood samples were collected from N = 76 male monkeys, which, as a sample, showed a continuous distribution on the macaque Social Responsiveness Scale-Revised. In a subset of these subjects (n = 43), samples were collected thrice over a 10-month period. The following statistical tests were used: "Case 2A" intra-class correlation coefficients of consistency, principal component analysis, and general linear modeling. RESULTS: All biological measures (except AKT) showed significant test-retest reliability within individuals across time points. We next performed principal component analysis on data from monkeys with complete biological measurement sets at the first time point (n = 57), to explore potential correlations between the reliable biological measures and their relationship to macaque Social Responsiveness Scale-Revised score; a three-component solution was found. Follow-up analyses revealed that cerebrospinal fluid arginine vasopressin concentration, but no other biological measure, robustly predicted individual differences in macaque Social Responsiveness Scale-Revised scores, such that monkeys with the lowest cerebrospinal fluid arginine vasopressin concentration exhibited the greatest social impairment. Finally, we confirmed that this result held in the larger study sample (in which cerebrospinal fluid arginine vasopressin values were available from n = 75 of the subjects). CONCLUSIONS: These findings indicate that cerebrospinal fluid arginine vasopressin concentration is a stable trait-like measure and that it is linked to quantitative social trait variation in male rhesus monkeys. En ligne : http://dx.doi.org/10.1186/s13229-021-00442-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 [article] Autism-associated biomarkers: test-retest reliability and relationship to quantitative social trait variation in rhesus monkeys [texte imprimé] / Ozge OZTAN, Auteur ; Catherine F. TALBOT, Auteur ; Emanuela ARGILLI, Auteur ; Alyssa C. MANESS, Auteur ; Sierra M. SIMMONS, Auteur ; Noreen MOHSIN, Auteur ; Laura A. DEL ROSSO, Auteur ; Joseph P. GARNER, Auteur ; Elliott H. SHERR, Auteur ; John P. CAPITANIO, Auteur ; Karen J. PARKER, Auteur . - 50 p. Langues : Anglais (eng) in Molecular Autism > 12 (2021) . - 50 p. Mots-clés : Arginine vasopressin  Autism spectrum disorder  Biomarker  Cerebrospinal fluid  Kinase signaling pathway  Oxytocin  Rhesus macaque  Social responsiveness scale  Social trait variation  the University of California, San Francisco (UCSF) have filed patent applications  related to biological measures studied herein (Stanford University:  PCT/US2019/019029 “Methods for diagnosing and for determining severity of an autism  spectrum disorder”  UCSF: PCT/US2016/014623 “Methods of diagnosing and treating  autism spectrum disorders”). These patents have not been granted or licensed, and no  study author is receiving any financial compensation at this time. EHS serves on the  advisory board for Retrophin Inc. All other authors declare that they have no  competing interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Rhesus monkeys (Macaca mulatta) exhibit pronounced individual differences in social traits as measured by the macaque Social Responsiveness Scale-Revised. The macaque Social Responsiveness Scale was previously adapted from the Social Responsiveness Scale, an instrument designed to assess social and autistic trait variation in humans. To better understand potential biological underpinnings of this behavioral variation, we evaluated the trait-like consistency of several biological measures previously implicated in autism (e.g., arginine vasopressin, oxytocin, and their receptors, as well as ERK1/2, PTEN, and AKT(1-3) from the RAS-MAPK and PI3K-AKT pathways). We also tested which biological measures predicted macaque Social Responsiveness Scale-Revised scores. METHODS: Cerebrospinal fluid and blood samples were collected from N = 76 male monkeys, which, as a sample, showed a continuous distribution on the macaque Social Responsiveness Scale-Revised. In a subset of these subjects (n = 43), samples were collected thrice over a 10-month period. The following statistical tests were used: "Case 2A" intra-class correlation coefficients of consistency, principal component analysis, and general linear modeling. RESULTS: All biological measures (except AKT) showed significant test-retest reliability within individuals across time points. We next performed principal component analysis on data from monkeys with complete biological measurement sets at the first time point (n = 57), to explore potential correlations between the reliable biological measures and their relationship to macaque Social Responsiveness Scale-Revised score; a three-component solution was found. Follow-up analyses revealed that cerebrospinal fluid arginine vasopressin concentration, but no other biological measure, robustly predicted individual differences in macaque Social Responsiveness Scale-Revised scores, such that monkeys with the lowest cerebrospinal fluid arginine vasopressin concentration exhibited the greatest social impairment. Finally, we confirmed that this result held in the larger study sample (in which cerebrospinal fluid arginine vasopressin values were available from n = 75 of the subjects). CONCLUSIONS: These findings indicate that cerebrospinal fluid arginine vasopressin concentration is a stable trait-like measure and that it is linked to quantitative social trait variation in male rhesus monkeys. En ligne : http://dx.doi.org/10.1186/s13229-021-00442-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459

Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not? / Ozge OZTAN in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 8p. Titre : Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not? Type de document : texte imprimé Auteurs : Ozge OZTAN, Auteur ; Laura A. DEL ROSSO, Auteur ; Sierra M. SIMMONS, Auteur ; Duyen K.K. NGUYEN, Auteur ; Catherine F. TALBOT, Auteur ; John P. CAPITANIO, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur Article en page(s) : 8p. Langues : Anglais (eng) Mots-clés : Child  Animals  Humans  Male  Female  Autistic Disorder  Autism Spectrum Disorder  Macaca mulatta  Social Behavior  Arginine Vasopressin/cerebrospinal fluid  Oxytocin  Animal model  Arginine vasopressin  Autism spectrum disorder  Cerebrospinal fluid  Dominance rank  Rhesus macaque  Social functioning  Social responsiveness scale  applications related to data reviewed herein: PCT/US2019/019029 ("Methods for  diagnosing and determining severity of an autism spectrum disorder") and  PCT/US2019/041250 ("Intranasal Vasopressin Treatment for Social Deficits in  Children with Autism"). These patents have not been granted or licensed, and no  study author is receiving any financial compensation at this time. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by persistent social interaction impairments and is male-biased in prevalence. We have established naturally occurring low sociality in male rhesus monkeys as a model for the social features of ASD. Low-social male monkeys exhibit reduced social interactions and increased autistic-like trait burden, with both measures highly correlated and strongly linked to low cerebrospinal fluid (CSF) arginine vasopressin (AVP) concentration. Little is known, however, about the behavioral and neurochemical profiles of female rhesus monkeys, and whether low sociality in females is a tractable model for ASD. METHODS: Social behavior assessments (ethological observations; a reverse-translated autistic trait measurement scale, the macaque Social Responsiveness Scale-Revised [mSRS-R]) were completed on N = 88 outdoor-housed female rhesus monkeys during the non-breeding season. CSF and blood samples were collected from a subset of N = 16 monkeys across the frequency distribution of non-social behavior, and AVP and oxytocin (OXT) concentrations were quantified. Data were analyzed using general linear models. RESULTS: Non-social behavior frequency and mSRS-R scores were continuously distributed across the general female monkey population, as previously found for male monkeys. However, dominance rank significantly predicted mSRS-R scores in females, with higher-ranking individuals showing fewer autistic-like traits, a relationship not previously observed in males from this colony. Females differed from males in several other respects: Social behavior frequencies were unrelated to mSRS-R scores, and AVP concentration was unrelated to any social behavior measure. Blood and CSF concentrations of AVP were positively correlated in females; no significant relationship involving any OXT measure was found. LIMITATIONS: This study sample was small, and did not consider genetic, environmental, or other neurochemical measures that may be related to female mSRS-R scores. CONCLUSIONS: Dominance rank is the most significant predictor of autistic-like traits in female rhesus monkeys, and CSF neuropeptide concentrations are unrelated to measures of female social functioning (in contrast to prior CSF AVP findings in male rhesus monkeys and male and female autistic children). Although preliminary, this evidence suggests that the strong matrilineal organization of this species may limit the usefulness of low sociality in female rhesus monkeys as a tractable model for ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00588-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Naturally occurring low sociality in female rhesus monkeys: A tractable model for autism or not? [texte imprimé] / Ozge OZTAN, Auteur ; Laura A. DEL ROSSO, Auteur ; Sierra M. SIMMONS, Auteur ; Duyen K.K. NGUYEN, Auteur ; Catherine F. TALBOT, Auteur ; John P. CAPITANIO, Auteur ; Joseph P. GARNER, Auteur ; Karen J. PARKER, Auteur . - 8p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 8p. Mots-clés : Child  Animals  Humans  Male  Female  Autistic Disorder  Autism Spectrum Disorder  Macaca mulatta  Social Behavior  Arginine Vasopressin/cerebrospinal fluid  Oxytocin  Animal model  Arginine vasopressin  Autism spectrum disorder  Cerebrospinal fluid  Dominance rank  Rhesus macaque  Social functioning  Social responsiveness scale  applications related to data reviewed herein: PCT/US2019/019029 ("Methods for  diagnosing and determining severity of an autism spectrum disorder") and  PCT/US2019/041250 ("Intranasal Vasopressin Treatment for Social Deficits in  Children with Autism"). These patents have not been granted or licensed, and no  study author is receiving any financial compensation at this time. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism spectrum disorder (ASD) is characterized by persistent social interaction impairments and is male-biased in prevalence. We have established naturally occurring low sociality in male rhesus monkeys as a model for the social features of ASD. Low-social male monkeys exhibit reduced social interactions and increased autistic-like trait burden, with both measures highly correlated and strongly linked to low cerebrospinal fluid (CSF) arginine vasopressin (AVP) concentration. Little is known, however, about the behavioral and neurochemical profiles of female rhesus monkeys, and whether low sociality in females is a tractable model for ASD. METHODS: Social behavior assessments (ethological observations; a reverse-translated autistic trait measurement scale, the macaque Social Responsiveness Scale-Revised [mSRS-R]) were completed on N = 88 outdoor-housed female rhesus monkeys during the non-breeding season. CSF and blood samples were collected from a subset of N = 16 monkeys across the frequency distribution of non-social behavior, and AVP and oxytocin (OXT) concentrations were quantified. Data were analyzed using general linear models. RESULTS: Non-social behavior frequency and mSRS-R scores were continuously distributed across the general female monkey population, as previously found for male monkeys. However, dominance rank significantly predicted mSRS-R scores in females, with higher-ranking individuals showing fewer autistic-like traits, a relationship not previously observed in males from this colony. Females differed from males in several other respects: Social behavior frequencies were unrelated to mSRS-R scores, and AVP concentration was unrelated to any social behavior measure. Blood and CSF concentrations of AVP were positively correlated in females; no significant relationship involving any OXT measure was found. LIMITATIONS: This study sample was small, and did not consider genetic, environmental, or other neurochemical measures that may be related to female mSRS-R scores. CONCLUSIONS: Dominance rank is the most significant predictor of autistic-like traits in female rhesus monkeys, and CSF neuropeptide concentrations are unrelated to measures of female social functioning (in contrast to prior CSF AVP findings in male rhesus monkeys and male and female autistic children). Although preliminary, this evidence suggests that the strong matrilineal organization of this species may limit the usefulness of low sociality in female rhesus monkeys as a tractable model for ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00588-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

Evidence of neuroinflammation and immunotherapy responsiveness in individuals with down syndrome regression disorder / Jonathan D. SANTORO in Journal of Neurodevelopmental Disorders, 14 (2022)  

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The effect of gender on the neuroanatomy of children with autism spectrum disorders: a support vector machine case-control study / Alessandra RETICO in Molecular Autism, 7 (2016)  

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