Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits / Alexandra HENDRY in Journal of Autism and Developmental Disorders, 50-11 (November 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4085-4105 Titre : Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits Type de document : Texte imprimé et/ou numérique Auteurs : Alexandra HENDRY, Auteur ; Emily J. H. JONES, Auteur ; Rachael BEDFORD, Auteur ; Linn ANDERSSON KONKE, Auteur ; Jannath BEGUM ALI, Auteur ; Sven B?LTE, Auteur ; Karin C. BROCKI, Auteur ; Ellen DEMURIE, Auteur ; Mark H. JOHNSON, Auteur ; Mirjam K. J. PIJL, Auteur ; Herbert ROEYERS, Auteur ; Tony CHARMAN, Auteur Article en page(s) : p.4085-4105 Langues : Anglais (eng) Mots-clés : Adhd  Attention  Atypical development  Autism  Infant  Intermediate phenotype  lecturer for Shire/Takeda, Medice, Roche, Eli Lilly, Prima Psychiatry, and SB  Education and Psychological Consulting AB. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Charman discloses that he  has served as a consultant to F. Hoffmann-La Roche Ltd and has received royalties  from Sage Publications and Guilford Publications. All other authors report no  conflict of interest. Index. décimale : PER Périodiques Résumé : Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals' mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N?=?294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7-9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04465-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Atypical Development of Attentional Control Associates with Later Adaptive Functioning, Autism and ADHD Traits [Texte imprimé et/ou numérique] / Alexandra HENDRY, Auteur ; Emily J. H. JONES, Auteur ; Rachael BEDFORD, Auteur ; Linn ANDERSSON KONKE, Auteur ; Jannath BEGUM ALI, Auteur ; Sven B?LTE, Auteur ; Karin C. BROCKI, Auteur ; Ellen DEMURIE, Auteur ; Mark H. JOHNSON, Auteur ; Mirjam K. J. PIJL, Auteur ; Herbert ROEYERS, Auteur ; Tony CHARMAN, Auteur . - p.4085-4105. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-11 (November 2020) . - p.4085-4105 Mots-clés : Adhd  Attention  Atypical development  Autism  Infant  Intermediate phenotype  lecturer for Shire/Takeda, Medice, Roche, Eli Lilly, Prima Psychiatry, and SB  Education and Psychological Consulting AB. He receives royalties for text books and  diagnostic tools from Huber/Hogrefe, Kohlhammer and UTB. Charman discloses that he  has served as a consultant to F. Hoffmann-La Roche Ltd and has received royalties  from Sage Publications and Guilford Publications. All other authors report no  conflict of interest. Index. décimale : PER Périodiques Résumé : Autism is frequently associated with difficulties with top-down attentional control, which impact on individuals' mental health and quality of life. The developmental processes involved in these attentional difficulties are not well understood. Using a data-driven approach, 2 samples (N?=?294 and 412) of infants at elevated and typical likelihood of autism were grouped according to profiles of parent report of attention at 10, 15 and 25 months. In contrast to the normative profile of increases in attentional control scores between infancy and toddlerhood, a minority (7-9%) showed plateauing attentional control scores between 10 and 25 months. Consistent with pre-registered hypotheses, plateaued growth of attentional control was associated with elevated autism and ADHD traits, and lower adaptive functioning at age 3 years. En ligne : http://dx.doi.org/10.1007/s10803-020-04465-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis / L. A. FISH in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1308-1319 Titre : Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis Type de document : Texte imprimé et/ou numérique Auteurs : L. A. FISH, Auteur ; P. NYSTROM, Auteur ; T. GLIGA, Auteur ; A. GUI, Auteur ; Jannath BEGUM ALI, Auteur ; L. MASON, Auteur ; S. GARG, Auteur ; J. GREEN, Auteur ; M. H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; R. HARRISON, Auteur ; E. MEABURN, Auteur ; T. FALCK-YTTER, Auteur ; E. J. H. JONES, Auteur Article en page(s) : p.1308-1319 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Humans  Infant  Phenotype  Reflex  Autism spectrum disorder  infancy  neurodevelopment  pupillary light reflex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is heritable, the mechanisms through which genes contribute to symptom emergence remain unclear. Investigating candidate intermediate phenotypes such as the pupillary light reflex (PLR) prospectively from early in development could bridge genotype and behavioural phenotype. METHODS: Using eye tracking, we longitudinally measured the PLR at 9, 14 and 24 months in a sample of infants (N = 264) enriched for a family history of ASD; 27 infants received an ASD diagnosis at 3 years. We examined the 9- to 24-month developmental trajectories of PLR constriction latency (onset; ms) and amplitude (%) and explored their relation to categorical 3-year ASD outcome, polygenic liability for ASD and dimensional 3-year social affect (SA) and repetitive/restrictive behaviour (RRB) traits. Polygenic scores for ASD (PGS(ASD) ) were calculated for 190 infants. RESULTS: While infants showed a decrease in latency between 9 and 14 months, higher PGS(ASD) was associated with a smaller decrease in latency in the first year (? = -.16, 95% CI = -0.31, -0.002); infants with later ASD showed a significantly steeper decrease in latency (a putative 'catch-up') between 14 and 24 months relative to those with other outcomes (typical: ? = .54, 95% CI = 0.08, 0.99; other: ? = .53, 95% CI = 0.02, 1.04). Latency development did not associate with later dimensional variation in ASD-related traits. In contrast, change in amplitude was not related to categorical ASD or genetics, but decreasing 9- to 14-month amplitude was associated with higher SA (? = .08, 95% CI = 0.01, 0.14) and RRB (? = .05, 95% CI = 0.004, 0.11) traits. CONCLUSIONS: These findings corroborate PLR development as possible intermediate phenotypes being linked to both genetic liability and phenotypic outcomes. Future work should incorporate alternative measures (e.g. functionally informed structural and genetic measures) to test whether distinct neural mechanisms underpin PLR alterations. En ligne : http://dx.doi.org/10.1111/jcpp.13518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Development of the pupillary light reflex from 9 to 24 months: association with common autism spectrum disorder (ASD) genetic liability and 3-year ASD diagnosis [Texte imprimé et/ou numérique] / L. A. FISH, Auteur ; P. NYSTROM, Auteur ; T. GLIGA, Auteur ; A. GUI, Auteur ; Jannath BEGUM ALI, Auteur ; L. MASON, Auteur ; S. GARG, Auteur ; J. GREEN, Auteur ; M. H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; R. HARRISON, Auteur ; E. MEABURN, Auteur ; T. FALCK-YTTER, Auteur ; E. J. H. JONES, Auteur . - p.1308-1319. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1308-1319 Mots-clés : Autism Spectrum Disorder/diagnosis/genetics  Humans  Infant  Phenotype  Reflex  Autism spectrum disorder  infancy  neurodevelopment  pupillary light reflex Index. décimale : PER Périodiques Résumé : BACKGROUND: Although autism spectrum disorder (ASD) is heritable, the mechanisms through which genes contribute to symptom emergence remain unclear. Investigating candidate intermediate phenotypes such as the pupillary light reflex (PLR) prospectively from early in development could bridge genotype and behavioural phenotype. METHODS: Using eye tracking, we longitudinally measured the PLR at 9, 14 and 24 months in a sample of infants (N = 264) enriched for a family history of ASD; 27 infants received an ASD diagnosis at 3 years. We examined the 9- to 24-month developmental trajectories of PLR constriction latency (onset; ms) and amplitude (%) and explored their relation to categorical 3-year ASD outcome, polygenic liability for ASD and dimensional 3-year social affect (SA) and repetitive/restrictive behaviour (RRB) traits. Polygenic scores for ASD (PGS(ASD) ) were calculated for 190 infants. RESULTS: While infants showed a decrease in latency between 9 and 14 months, higher PGS(ASD) was associated with a smaller decrease in latency in the first year (? = -.16, 95% CI = -0.31, -0.002); infants with later ASD showed a significantly steeper decrease in latency (a putative 'catch-up') between 14 and 24 months relative to those with other outcomes (typical: ? = .54, 95% CI = 0.08, 0.99; other: ? = .53, 95% CI = 0.02, 1.04). Latency development did not associate with later dimensional variation in ASD-related traits. In contrast, change in amplitude was not related to categorical ASD or genetics, but decreasing 9- to 14-month amplitude was associated with higher SA (? = .08, 95% CI = 0.01, 0.14) and RRB (? = .05, 95% CI = 0.004, 0.11) traits. CONCLUSIONS: These findings corroborate PLR development as possible intermediate phenotypes being linked to both genetic liability and phenotypic outcomes. Future work should incorporate alternative measures (e.g. functionally informed structural and genetic measures) to test whether distinct neural mechanisms underpin PLR alterations. En ligne : http://dx.doi.org/10.1111/jcpp.13518 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Early Motor Differences in Infants at Elevated Likelihood of Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder / Jannath BEGUM ALI in Journal of Autism and Developmental Disorders, 50-12 (December 2020)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4367-4384 Titre : Early Motor Differences in Infants at Elevated Likelihood of Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jannath BEGUM ALI, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur Article en page(s) : p.4367-4384 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder  Autism spectrum disorder  Midline crossing  Motor ability  Reaching Index. décimale : PER Périodiques Résumé : We investigated infant's manual motor behaviour; specifically behaviours crossing the body midline. Infants at elevated likelihood of Autism Spectrum Disorder (ASD) and/or Attention Deficit Hyperactivity Disorder (ADHD) produced fewer manual behaviours that cross the midline compared to infants with a typical likelihood of developing these disorders; however this effect was limited to 10-month-olds and not apparent at age 5 and 14 months. Although, midline crossing did not predict ASD traits, it was related to ADHD traits at 2 years of age. We rule out motor ability and hand dominance as possible explanations for this pattern of behaviour, positing that these results may be a consequence of multisensory integration abilities, and the neurobehavioural shift period, in the first year of life. En ligne : http://dx.doi.org/10.1007/s10803-020-04489-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Early Motor Differences in Infants at Elevated Likelihood of Autism Spectrum Disorder and/or Attention Deficit Hyperactivity Disorder [Texte imprimé et/ou numérique] / Jannath BEGUM ALI, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emily J. H. JONES, Auteur . - p.4367-4384. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 50-12 (December 2020) . - p.4367-4384 Mots-clés : Attention deficit hyperactivity disorder  Autism spectrum disorder  Midline crossing  Motor ability  Reaching Index. décimale : PER Périodiques Résumé : We investigated infant's manual motor behaviour; specifically behaviours crossing the body midline. Infants at elevated likelihood of Autism Spectrum Disorder (ASD) and/or Attention Deficit Hyperactivity Disorder (ADHD) produced fewer manual behaviours that cross the midline compared to infants with a typical likelihood of developing these disorders; however this effect was limited to 10-month-olds and not apparent at age 5 and 14 months. Although, midline crossing did not predict ASD traits, it was related to ADHD traits at 2 years of age. We rule out motor ability and hand dominance as possible explanations for this pattern of behaviour, positing that these results may be a consequence of multisensory integration abilities, and the neurobehavioural shift period, in the first year of life. En ligne : http://dx.doi.org/10.1007/s10803-020-04489-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD / Anna GUI in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1303-1322 Titre : Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Anna GUI, Auteur ; Luke MASON, Auteur ; Teodora GLIGA, Auteur ; Alexandra HENDRY, Auteur ; Jannath BEGUM ALI, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Charles CURTIS, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emma MEABURN, Auteur ; Emily J. H. JONES, Auteur Article en page(s) : p.1303-1322 Langues : Anglais (eng) Mots-clés : attention  endophenotypes  eye-tracking  infant siblings  polygenic score Index. décimale : PER Périodiques Résumé : Identifying developmental endophenotypes on the pathway between genetics and behavior is critical to uncovering the mechanisms underlying neurodevelopmental conditions. In this proof-of-principle study, we explored whether early disruptions in visual attention are a unique or shared candidate endophenotype of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). We calculated the duration of the longest look (i.e., peak look) to faces in an array-based eye-tracking task for 335 14-month-old infants with and without first-degree relatives with ASD and/or ADHD. We leveraged parent-report and genotype data available for a proportion of these infants to evaluate the relation of looking behavior to familial (n = 285) and genetic liability (using polygenic scores, n = 185) as well as ASD and ADHD-relevant temperament traits at 2 years of age (shyness and inhibitory control, respectively, n = 272) and ASD and ADHD clinical traits at 6 years of age (n = 94).Results showed that longer peak looks at the face were associated with elevated polygenic scores for ADHD (? = 0.078, p = .023), but not ASD (? = 0.002, p = .944), and with elevated ADHD traits in mid-childhood (F(1,88) = 6.401, p = .013, $\eta _p^2$=0.068; ASD: F (1,88) = 3.218, p = .076), but not in toddlerhood (ps > 0.2). This pattern of results did not emerge when considering mean peak look duration across face and nonface stimuli. Thus, alterations in attention to faces during spontaneous visual exploration may be more consistent with a developmental endophenotype of ADHD than ASD. Our work shows that dissecting paths to neurodevelopmental conditions requires longitudinal data incorporating polygenic contribution, early neurocognitive function, and clinical phenotypic variation. En ligne : http://dx.doi.org/10.1017/s0954579420000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Look duration at the face as a developmental endophenotype: elucidating pathways to autism and ADHD [Texte imprimé et/ou numérique] / Anna GUI, Auteur ; Luke MASON, Auteur ; Teodora GLIGA, Auteur ; Alexandra HENDRY, Auteur ; Jannath BEGUM ALI, Auteur ; Greg PASCO, Auteur ; Elizabeth SHEPHARD, Auteur ; Charles CURTIS, Auteur ; Tony CHARMAN, Auteur ; Mark H. JOHNSON, Auteur ; Emma MEABURN, Auteur ; Emily J. H. JONES, Auteur . - p.1303-1322. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1303-1322 Mots-clés : attention  endophenotypes  eye-tracking  infant siblings  polygenic score Index. décimale : PER Périodiques Résumé : Identifying developmental endophenotypes on the pathway between genetics and behavior is critical to uncovering the mechanisms underlying neurodevelopmental conditions. In this proof-of-principle study, we explored whether early disruptions in visual attention are a unique or shared candidate endophenotype of autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). We calculated the duration of the longest look (i.e., peak look) to faces in an array-based eye-tracking task for 335 14-month-old infants with and without first-degree relatives with ASD and/or ADHD. We leveraged parent-report and genotype data available for a proportion of these infants to evaluate the relation of looking behavior to familial (n = 285) and genetic liability (using polygenic scores, n = 185) as well as ASD and ADHD-relevant temperament traits at 2 years of age (shyness and inhibitory control, respectively, n = 272) and ASD and ADHD clinical traits at 6 years of age (n = 94).Results showed that longer peak looks at the face were associated with elevated polygenic scores for ADHD (? = 0.078, p = .023), but not ASD (? = 0.002, p = .944), and with elevated ADHD traits in mid-childhood (F(1,88) = 6.401, p = .013, $\eta _p^2$=0.068; ASD: F (1,88) = 3.218, p = .076), but not in toddlerhood (ps > 0.2). This pattern of results did not emerge when considering mean peak look duration across face and nonface stimuli. Thus, alterations in attention to faces during spontaneous visual exploration may be more consistent with a developmental endophenotype of ADHD than ASD. Our work shows that dissecting paths to neurodevelopmental conditions requires longitudinal data incorporating polygenic contribution, early neurocognitive function, and clinical phenotypic variation. En ligne : http://dx.doi.org/10.1017/s0954579420000930 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

The roles of sensory hyperreactivity and hyporeactivity in understanding infant fearfulness and emerging autistic traits / Virginia CARTER LENO ; Greg PASCO ; Jannath BEGUM ALI ; Mark H. JOHNSON ; Tony CHARMAN ; Emily J. H. JONES ; The STAARS TEAM in Journal of Child Psychology and Psychiatry, 65-8 (August 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1022-1036 Titre : The roles of sensory hyperreactivity and hyporeactivity in understanding infant fearfulness and emerging autistic traits Type de document : Texte imprimé et/ou numérique Auteurs : Virginia CARTER LENO, Auteur ; Greg PASCO, Auteur ; Jannath BEGUM ALI, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Emily J. H. JONES, Auteur ; The STAARS TEAM, Auteur Article en page(s) : p.1022-1036 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Existing evidence indicates that atypical sensory reactivity is a core characteristic of autism, and has been linked to both anxiety (and its putative infant precursor of fearfulness) and repetitive behaviours. However, most work has used cross-sectional designs and not considered the differential roles of hyperreactivity and hyporeactivity to sensory inputs, and is thus limited in specificity. Methods 161 infants with and without an elevated likelihood of developing autism and attention-deficit hyperactivity disorder (ADHD) were followed from 10 to 36?months of age. Parents rated an infant precursor of later anxiety (fearfulness) using the Infant Behaviour Questionnaire at 10 and 14?months, and the Early Childhood Behavioural Questionnaire at 24?months, and sensory hyperreactivity and hyporeactivity at 10, 14 and 24?months using the Infant Toddler Sensory Profile. Domains of autistic traits (restrictive and repetitive behaviours; RRB, and social communication interaction, SCI) were assessed using the parent-rated Social Responsiveness Scale at 36?months. Cross-lagged models tested (a) paths between fearfulness and hyperreactivity at 10-24?months, and from fearfulness and hyperreactivity to later autism traits, (b) the specificity of hyperreactivity effects by including hyporeactivity as a correlated predictor. Results Hyperreactivity at 14?months was positively associated with fearfulness at 24?months, and hyperreactivity at 24?months was positively associated with SCI and RRB at 36?months. When hyporeactivity was included in the model, paths between hyperreactivity and fearfulness remained, but paths between hyperreactivity and autistic traits became nonsignificant. Conclusions Our findings indicate that alterations in early sensory reactivity may increase the likelihood of showing fearfulness in infancy, and relate to later social interactions and repetitive behaviours, particularly in individuals with a family history of autism or ADHD. En ligne : https://doi.org/10.1111/jcpp.13941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532 [article] The roles of sensory hyperreactivity and hyporeactivity in understanding infant fearfulness and emerging autistic traits [Texte imprimé et/ou numérique] / Virginia CARTER LENO, Auteur ; Greg PASCO, Auteur ; Jannath BEGUM ALI, Auteur ; Mark H. JOHNSON, Auteur ; Tony CHARMAN, Auteur ; Emily J. H. JONES, Auteur ; The STAARS TEAM, Auteur . - p.1022-1036. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-8 (August 2024) . - p.1022-1036 Index. décimale : PER Périodiques Résumé : Background Existing evidence indicates that atypical sensory reactivity is a core characteristic of autism, and has been linked to both anxiety (and its putative infant precursor of fearfulness) and repetitive behaviours. However, most work has used cross-sectional designs and not considered the differential roles of hyperreactivity and hyporeactivity to sensory inputs, and is thus limited in specificity. Methods 161 infants with and without an elevated likelihood of developing autism and attention-deficit hyperactivity disorder (ADHD) were followed from 10 to 36?months of age. Parents rated an infant precursor of later anxiety (fearfulness) using the Infant Behaviour Questionnaire at 10 and 14?months, and the Early Childhood Behavioural Questionnaire at 24?months, and sensory hyperreactivity and hyporeactivity at 10, 14 and 24?months using the Infant Toddler Sensory Profile. Domains of autistic traits (restrictive and repetitive behaviours; RRB, and social communication interaction, SCI) were assessed using the parent-rated Social Responsiveness Scale at 36?months. Cross-lagged models tested (a) paths between fearfulness and hyperreactivity at 10-24?months, and from fearfulness and hyperreactivity to later autism traits, (b) the specificity of hyperreactivity effects by including hyporeactivity as a correlated predictor. Results Hyperreactivity at 14?months was positively associated with fearfulness at 24?months, and hyperreactivity at 24?months was positively associated with SCI and RRB at 36?months. When hyporeactivity was included in the model, paths between hyperreactivity and fearfulness remained, but paths between hyperreactivity and autistic traits became nonsignificant. Conclusions Our findings indicate that alterations in early sensory reactivity may increase the likelihood of showing fearfulness in infancy, and relate to later social interactions and repetitive behaviours, particularly in individuals with a family history of autism or ADHD. En ligne : https://doi.org/10.1111/jcpp.13941 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=532

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