Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study / Elizabeth A. LI ; Christopher H. LEGERE ; Jared M. SALETIN ; Noah S. PHILIP ; Daniel P. DICKSTEIN in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1182-1186 Titre : Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth A. LI, Auteur ; Christopher H. LEGERE, Auteur ; Jared M. SALETIN, Auteur ; Noah S. PHILIP, Auteur ; Daniel P. DICKSTEIN, Auteur Article en page(s) : p.1182-1186 Langues : Anglais (eng) Mots-clés : ABCD (adolescent brain cognitive development) study  autism  CBCL (child behavior checklist)  macronutrients  micronutrients  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often consume less varied diets, experience sleep difficulties, and have higher rates of mental health problems as compared to neurotypical peers. Yet, the direct relationship between all of these domains is not well characterized. We leveraged the Adolescent Brain Cognitive DevelopmentSM study (ABCD study) dataset to explore whether estimated levels of consumption of specific macro- and micronutrients correlated with the severity of mental health and sleep problems in autistic youth. We found that low vitamin B3, B6, C, and iron intake was associated with more severe psychiatric problems in autistic children in the ABCD cohort, though these findings did not reach statistical significance after correction for multiple comparisons. In a post hoc analysis, we found that the severity of sleep difficulties was correlated with estimated levels of Vitamins B3, B6, C, and iron intake and with the severity of anxiety/depressive symptoms and/or thought problems. Our analysis on a large number of nutrients, psychiatric symptoms, and sleep serves as an exploratory, initial analysis to identify specific nutrients and psychiatric symptoms that could be the focus of future (confirmatory) studies on the relationship between nutrition, sleep, and mental health in autistic individuals. En ligne : https://doi.org/10.1002/aur.70040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study [Texte imprimé et/ou numérique] / Elizabeth A. LI, Auteur ; Christopher H. LEGERE, Auteur ; Jared M. SALETIN, Auteur ; Noah S. PHILIP, Auteur ; Daniel P. DICKSTEIN, Auteur . - p.1182-1186. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1182-1186 Mots-clés : ABCD (adolescent brain cognitive development) study  autism  CBCL (child behavior checklist)  macronutrients  micronutrients  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often consume less varied diets, experience sleep difficulties, and have higher rates of mental health problems as compared to neurotypical peers. Yet, the direct relationship between all of these domains is not well characterized. We leveraged the Adolescent Brain Cognitive DevelopmentSM study (ABCD study) dataset to explore whether estimated levels of consumption of specific macro- and micronutrients correlated with the severity of mental health and sleep problems in autistic youth. We found that low vitamin B3, B6, C, and iron intake was associated with more severe psychiatric problems in autistic children in the ABCD cohort, though these findings did not reach statistical significance after correction for multiple comparisons. In a post hoc analysis, we found that the severity of sleep difficulties was correlated with estimated levels of Vitamins B3, B6, C, and iron intake and with the severity of anxiety/depressive symptoms and/or thought problems. Our analysis on a large number of nutrients, psychiatric symptoms, and sleep serves as an exploratory, initial analysis to identify specific nutrients and psychiatric symptoms that could be the focus of future (confirmatory) studies on the relationship between nutrition, sleep, and mental health in autistic individuals. En ligne : https://doi.org/10.1002/aur.70040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study / Maria Elisabeth KOOPMAN-VERHOEFF in Journal of Child Psychology and Psychiatry, 61-10 (October 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1061-1069 Titre : Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study Type de document : Texte imprimé et/ou numérique Auteurs : Maria Elisabeth KOOPMAN-VERHOEFF, Auteur ; Rosa H. MULDER, Auteur ; Jared M. SALETIN, Auteur ; Irwin REISS, Auteur ; Gijsbertus T. J. VAN DER HORST, Auteur ; Janine F. FELIX, Auteur ; Mary A. CARSKADON, Auteur ; Henning TIEMEIER, Auteur ; Charlotte A. M. CECIL, Auteur Article en page(s) : p.1061-1069 Langues : Anglais (eng) Mots-clés : DNA methylation  accelerometer  epigenetics  epigenome  psychopathology  sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population. METHODS: This cross-sectional study included 465 10-year-old children (51.3% female) from the Generation R Study. Genome-wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self-report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11-year-old children to calculate sleep duration and midpoint sleep. Weighted gene co-expression network analysis was used to identify highly comethylated DNAm 'modules', which were tested for associations with sleep and mental health outcomes. RESULTS: We identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT - a key regulator of Tau proteins in the brain involved in neuronal function - as well as genes previously implicated in sleep duration. Follow-up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood-brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health. CONCLUSIONS: We identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep. En ligne : http://dx.doi.org/10.1111/jcpp.13252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432 [article] Genome-wide DNA methylation patterns associated with sleep and mental health in children: a population-based study [Texte imprimé et/ou numérique] / Maria Elisabeth KOOPMAN-VERHOEFF, Auteur ; Rosa H. MULDER, Auteur ; Jared M. SALETIN, Auteur ; Irwin REISS, Auteur ; Gijsbertus T. J. VAN DER HORST, Auteur ; Janine F. FELIX, Auteur ; Mary A. CARSKADON, Auteur ; Henning TIEMEIER, Auteur ; Charlotte A. M. CECIL, Auteur . - p.1061-1069. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-10 (October 2020) . - p.1061-1069 Mots-clés : DNA methylation  accelerometer  epigenetics  epigenome  psychopathology  sleep Index. décimale : PER Périodiques Résumé : BACKGROUND: DNA methylation (DNAm) has been implicated in the biology of sleep. Yet, how DNAm patterns across the genome relate to different sleep outcomes, and whether these associations overlap with mental health is currently unknown. Here, we investigated associations of DNAm with sleep and mental health in a pediatric population. METHODS: This cross-sectional study included 465 10-year-old children (51.3% female) from the Generation R Study. Genome-wide DNAm levels were measured using the Illumina 450K array (peripheral blood). Sleep problems were assessed from self-report and mental health outcomes from maternal questionnaires. Wrist actigraphy was used in 188 11-year-old children to calculate sleep duration and midpoint sleep. Weighted gene co-expression network analysis was used to identify highly comethylated DNAm 'modules', which were tested for associations with sleep and mental health outcomes. RESULTS: We identified 64 DNAm modules, one of which associated with sleep duration after covariate and multiple testing adjustment. This module included CpG sites spanning 9 genes on chromosome 17, including MAPT - a key regulator of Tau proteins in the brain involved in neuronal function - as well as genes previously implicated in sleep duration. Follow-up analyses suggested that DNAm variation in this region is under considerable genetic control and shows strong blood-brain concordance. DNAm modules associated with sleep did not overlap with those associated with mental health. CONCLUSIONS: We identified one DNAm region associated with sleep duration, including genes previously reported by recent GWAS studies. Further research is warranted to examine the functional role of this region and its longitudinal association with sleep. En ligne : http://dx.doi.org/10.1111/jcpp.13252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=432

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