Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder / James BARTOLOTTI in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1273-1286 Titre : Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder Type de document : texte imprimé Auteurs : James BARTOLOTTI, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur Article en page(s) : p.1273-1286 Langues : Anglais (eng) Mots-clés : amygdala  anxiety  autism  comorbid disorders  functional connectivity Index. décimale : PER Périodiques Résumé : Anxiety disorders are common in autism spectrum disorder (ASD) and associated with social-communication impairment and repetitive behavior symptoms. The neurobiology of anxiety in ASD is unknown, but amygdala dysfunction has been implicated in both ASD and anxiety disorders. Using resting-state functional magnetic resonance imaging, we compared amygdala-prefrontal and amygdala-striatal connections across three demographically matched groups studied in the Autism Brain Imaging Data Exchange (ABIDE): ASD with a comorbid anxiety disorder (N = 25; ASD + Anxiety), ASD without a comorbid disorder (N = 68; ASD-NoAnx), and typically developing controls (N = 139; TD). Relative to ASD-NoAnx and TD controls, ASD + Anxiety individuals had decreased connectivity between the amygdala and dorsal/rostral anterior cingulate cortex (dACC/rACC). The functional connectivity of these connections was not affected in ASD-NoAnx, and amygdala connectivity with ventral ACC/medial prefrontal cortex (mPFC) circuits was not different in ASD + Anxiety or ASD-NoAnx relative to TD. Decreased amygdala-dorsomedial prefrontal cortex (dmPFC)/rACC connectivity was associated with more severe social impairment in ASD + Anxiety; amygdala-striatal connectivity was associated with restricted, repetitive behavior (RRB) symptom severity in ASD-NoAnx individuals. These findings suggest comorbid anxiety in ASD is associated with disrupted emotion-monitoring processes supported by amygdala-dACC/mPFC pathways, whereas emotion regulation systems involving amygdala-ventromedial prefrontal cortex (vmPFC) are relatively spared. Our results highlight the importance of accounting for comorbid anxiety for parsing ASD neurobiological heterogeneity. En ligne : http://dx.doi.org/10.1017/s0954579420000772 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Functional brain abnormalities associated with comorbid anxiety in autism spectrum disorder [texte imprimé] / James BARTOLOTTI, Auteur ; John A. SWEENEY, Auteur ; Matthew W. MOSCONI, Auteur . - p.1273-1286. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1273-1286 Mots-clés : amygdala  anxiety  autism  comorbid disorders  functional connectivity Index. décimale : PER Périodiques Résumé : Anxiety disorders are common in autism spectrum disorder (ASD) and associated with social-communication impairment and repetitive behavior symptoms. The neurobiology of anxiety in ASD is unknown, but amygdala dysfunction has been implicated in both ASD and anxiety disorders. Using resting-state functional magnetic resonance imaging, we compared amygdala-prefrontal and amygdala-striatal connections across three demographically matched groups studied in the Autism Brain Imaging Data Exchange (ABIDE): ASD with a comorbid anxiety disorder (N = 25; ASD + Anxiety), ASD without a comorbid disorder (N = 68; ASD-NoAnx), and typically developing controls (N = 139; TD). Relative to ASD-NoAnx and TD controls, ASD + Anxiety individuals had decreased connectivity between the amygdala and dorsal/rostral anterior cingulate cortex (dACC/rACC). The functional connectivity of these connections was not affected in ASD-NoAnx, and amygdala connectivity with ventral ACC/medial prefrontal cortex (mPFC) circuits was not different in ASD + Anxiety or ASD-NoAnx relative to TD. Decreased amygdala-dorsomedial prefrontal cortex (dmPFC)/rACC connectivity was associated with more severe social impairment in ASD + Anxiety; amygdala-striatal connectivity was associated with restricted, repetitive behavior (RRB) symptom severity in ASD-NoAnx individuals. These findings suggest comorbid anxiety in ASD is associated with disrupted emotion-monitoring processes supported by amygdala-dACC/mPFC pathways, whereas emotion regulation systems involving amygdala-ventromedial prefrontal cortex (vmPFC) are relatively spared. Our results highlight the importance of accounting for comorbid anxiety for parsing ASD neurobiological heterogeneity. En ligne : http://dx.doi.org/10.1017/s0954579420000772 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

Visual and somatosensory feedback mechanisms of precision manual motor control in autism spectrum disorder / Robin L. SHAFER in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : Visual and somatosensory feedback mechanisms of precision manual motor control in autism spectrum disorder Type de document : texte imprimé Auteurs : Robin L. SHAFER, Auteur ; Zheng WANG, Auteur ; James BARTOLOTTI, Auteur ; Matthew W. MOSCONI, Auteur Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Feedback  Hand Strength  Humans  Young Adult  Autism spectrum disorders  Entropy  Fine motor control  Grip force  Proprioception  Sensorimotor  Sensory reweighting  Visual gain Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) show deficits processing sensory feedback to reactively adjust ongoing motor behaviors. Atypical reliance on visual and somatosensory feedback each have been reported during motor behaviors in ASD suggesting that impairments are not specific to one sensory domain but may instead reflect a deficit in multisensory processing, resulting in reliance on unimodal feedback. The present study tested this hypothesis by examining motor behavior across different visual and somatosensory feedback conditions during a visually guided precision grip force test. METHODS: Participants with ASD (N = 43) and age-matched typically developing (TD) controls (N = 23), ages 10-20 years, completed a test of precision gripping. They pressed on force transducers with their index finger and thumb while receiving visual feedback on a computer screen in the form of a horizontal bar that moved upwards with increased force. They were instructed to press so that the bar reached the level of a static target bar and then to hold their grip force as steadily as possible. Visual feedback was manipulated by changing the gain of the force bar. Somatosensory feedback was manipulated by applying 80 Hz tendon vibration at the wrist to disrupt the somatosensory percept. Force variability (standard deviation) and irregularity (sample entropy) were examined using multilevel linear models. RESULTS: While TD controls showed increased force variability with the tendon vibration on compared to off, individuals with ASD showed similar levels of force variability across tendon vibration conditions. Individuals with ASD showed stronger age-associated reductions in force variability relative to controls across conditions. The ASD group also showed greater age-associated increases in force irregularity relative to controls, especially at higher gain levels and when the tendon vibrator was turned on. CONCLUSIONS: Our findings that disrupting somatosensory feedback did not contribute to changes in force variability or regularity among individuals with ASD suggests a reduced ability to integrate somatosensory feedback information to guide ongoing precision manual motor behavior. We also document stronger age-associated gains in force control in ASD relative to TD suggesting delayed development of multisensory feedback control of motor behavior. En ligne : https://dx.doi.org/10.1186/s11689-021-09381-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] Visual and somatosensory feedback mechanisms of precision manual motor control in autism spectrum disorder [texte imprimé] / Robin L. SHAFER, Auteur ; Zheng WANG, Auteur ; James BARTOLOTTI, Auteur ; Matthew W. MOSCONI, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Adolescent  Adult  Autism Spectrum Disorder  Child  Feedback  Hand Strength  Humans  Young Adult  Autism spectrum disorders  Entropy  Fine motor control  Grip force  Proprioception  Sensorimotor  Sensory reweighting  Visual gain Index. décimale : PER Périodiques Résumé : BACKGROUND: Individuals with autism spectrum disorder (ASD) show deficits processing sensory feedback to reactively adjust ongoing motor behaviors. Atypical reliance on visual and somatosensory feedback each have been reported during motor behaviors in ASD suggesting that impairments are not specific to one sensory domain but may instead reflect a deficit in multisensory processing, resulting in reliance on unimodal feedback. The present study tested this hypothesis by examining motor behavior across different visual and somatosensory feedback conditions during a visually guided precision grip force test. METHODS: Participants with ASD (N = 43) and age-matched typically developing (TD) controls (N = 23), ages 10-20 years, completed a test of precision gripping. They pressed on force transducers with their index finger and thumb while receiving visual feedback on a computer screen in the form of a horizontal bar that moved upwards with increased force. They were instructed to press so that the bar reached the level of a static target bar and then to hold their grip force as steadily as possible. Visual feedback was manipulated by changing the gain of the force bar. Somatosensory feedback was manipulated by applying 80 Hz tendon vibration at the wrist to disrupt the somatosensory percept. Force variability (standard deviation) and irregularity (sample entropy) were examined using multilevel linear models. RESULTS: While TD controls showed increased force variability with the tendon vibration on compared to off, individuals with ASD showed similar levels of force variability across tendon vibration conditions. Individuals with ASD showed stronger age-associated reductions in force variability relative to controls across conditions. The ASD group also showed greater age-associated increases in force irregularity relative to controls, especially at higher gain levels and when the tendon vibrator was turned on. CONCLUSIONS: Our findings that disrupting somatosensory feedback did not contribute to changes in force variability or regularity among individuals with ASD suggests a reduced ability to integrate somatosensory feedback information to guide ongoing precision manual motor behavior. We also document stronger age-associated gains in force control in ASD relative to TD suggesting delayed development of multisensory feedback control of motor behavior. En ligne : https://dx.doi.org/10.1186/s11689-021-09381-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

Visual feedback and motor memory contributions to sustained motor control deficits in autism spectrum disorder across childhood and into adulthood / Robin L. SHAFER in Journal of Neurodevelopmental Disorders, 17 (2025)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 17 (2025) Titre : Visual feedback and motor memory contributions to sustained motor control deficits in autism spectrum disorder across childhood and into adulthood Type de document : texte imprimé Auteurs : Robin L. SHAFER, Auteur ; James BARTOLOTTI, Auteur ; Abigail DRIGGERS, Auteur ; Erin BOJANEK, Auteur ; Zheng WANG, Auteur ; Matthew W. MOSCONI, Auteur Langues : Anglais (eng) Mots-clés : Humans  Adolescent  Child  Autism Spectrum Disorder/physiopathology/complications  Male  Young Adult  Feedback, Sensory/physiology  Adult  Female  Psychomotor Performance/physiology  Memory/physiology  Motor Skills/physiology  Hand Strength/physiology  Autism spectrum disorders  Entropy  Fine motor control  Grip force  Motor memory  Sensorimotor  Sensory integration  Visual feedback  Visuomotor  provided written informed consent after a complete description of the study, in  accordance with the Declaration of Helsinki. For participants under the age of 18  and adults who were under legal guardianship, a parent or legal guardian provided  written informed consent on behalf of the participant, and the participant  provided written assent. All study procedures were approved by the University of  Kansas Medical Center Institutional Review Board (IRB#: STUDY00140269). Consent  for publication: Not applicable. Competing interests: MWM is PI on an  investigator initiated clinical trial of behavioral inflexibility in autism  funded by Acadia Pharmaceuticals. MWM and ZW received funding from Novartis  Pharmaceuticals Corporation for an investigator-initiated study of Phelan  McDermid Syndrome. The other authors declare that they have no competing  interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals show deficits in sustained fine motor control which are associated with an over-reliance on visual feedback. Motor memory deficits also have been reported during sustained fine motor control in autism spectrum disorders (ASD). The development of motor memory and visuomotor feedback processes contributing to sustained motor control issues in ASD are not known. The present study aimed to characterize age-related changes in visual feedback and motor memory processes contributing to sustained fine motor control issues in ASD. METHODS: Fifty-four autistic participants and 31 neurotypical (NT) controls ages 10-25 years completed visually guided and memory guided sustained precision gripping tests by pressing on force sensors with their dominant hand index finger and thumb. For visually guided trials, participants viewed a stationary target bar and a force bar that moved upwards with increased force for 15s. During memory guided trials, the force bar was visible for 3s, after which participants attempted to maintain their force output without visual feedback for another 12s. To assess visual feedback processing, force accuracy, variability (standard deviation), and regularity (sample entropy) were examined. To assess motor memory, force decay latency, slope, and magnitude were examined during epochs without visual feedback. RESULTS: Relative to NT controls, autistic individuals showed a greater magnitude and a trend for a steeper slope of force decay during memory guided trials. Across conditions, the ASD group showed reduced force accuracy (β = 0.41, R(2) = 0.043, t(79.3)=2.36, p = .021) and greater force variability (β=-2.16, R(2) = 0.143, t(77.1)=-4.04, p = .0001) and regularity (β=-0.52, R(2) = 0.021, t(77.4)=-2.21, p = .030) relative to NT controls at younger ages, but these differences normalized by adolescence (age x group interactions). Lower force accuracy and greater force variability during visually guided trials and steeper decay slope during memory guided trials were associated with overall autism severity. CONCLUSIONS: Our findings that autistic individuals show a greater magnitude and tendency for a greater rate of force decay than NT individuals following the removal of visual feedback indicate that motor memory deficits contribute to fine motor control issues in ASD. Findings that sensorimotor differences in ASD were specific to younger ages suggest delayed development across multiple motor control processes. En ligne : https://dx.doi.org/10.1186/s11689-025-09607-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576 [article] Visual feedback and motor memory contributions to sustained motor control deficits in autism spectrum disorder across childhood and into adulthood [texte imprimé] / Robin L. SHAFER, Auteur ; James BARTOLOTTI, Auteur ; Abigail DRIGGERS, Auteur ; Erin BOJANEK, Auteur ; Zheng WANG, Auteur ; Matthew W. MOSCONI, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 17 (2025) Mots-clés : Humans  Adolescent  Child  Autism Spectrum Disorder/physiopathology/complications  Male  Young Adult  Feedback, Sensory/physiology  Adult  Female  Psychomotor Performance/physiology  Memory/physiology  Motor Skills/physiology  Hand Strength/physiology  Autism spectrum disorders  Entropy  Fine motor control  Grip force  Motor memory  Sensorimotor  Sensory integration  Visual feedback  Visuomotor  provided written informed consent after a complete description of the study, in  accordance with the Declaration of Helsinki. For participants under the age of 18  and adults who were under legal guardianship, a parent or legal guardian provided  written informed consent on behalf of the participant, and the participant  provided written assent. All study procedures were approved by the University of  Kansas Medical Center Institutional Review Board (IRB#: STUDY00140269). Consent  for publication: Not applicable. Competing interests: MWM is PI on an  investigator initiated clinical trial of behavioral inflexibility in autism  funded by Acadia Pharmaceuticals. MWM and ZW received funding from Novartis  Pharmaceuticals Corporation for an investigator-initiated study of Phelan  McDermid Syndrome. The other authors declare that they have no competing  interests. Index. décimale : PER Périodiques Résumé : BACKGROUND: Autistic individuals show deficits in sustained fine motor control which are associated with an over-reliance on visual feedback. Motor memory deficits also have been reported during sustained fine motor control in autism spectrum disorders (ASD). The development of motor memory and visuomotor feedback processes contributing to sustained motor control issues in ASD are not known. The present study aimed to characterize age-related changes in visual feedback and motor memory processes contributing to sustained fine motor control issues in ASD. METHODS: Fifty-four autistic participants and 31 neurotypical (NT) controls ages 10-25 years completed visually guided and memory guided sustained precision gripping tests by pressing on force sensors with their dominant hand index finger and thumb. For visually guided trials, participants viewed a stationary target bar and a force bar that moved upwards with increased force for 15s. During memory guided trials, the force bar was visible for 3s, after which participants attempted to maintain their force output without visual feedback for another 12s. To assess visual feedback processing, force accuracy, variability (standard deviation), and regularity (sample entropy) were examined. To assess motor memory, force decay latency, slope, and magnitude were examined during epochs without visual feedback. RESULTS: Relative to NT controls, autistic individuals showed a greater magnitude and a trend for a steeper slope of force decay during memory guided trials. Across conditions, the ASD group showed reduced force accuracy (β = 0.41, R(2) = 0.043, t(79.3)=2.36, p = .021) and greater force variability (β=-2.16, R(2) = 0.143, t(77.1)=-4.04, p = .0001) and regularity (β=-0.52, R(2) = 0.021, t(77.4)=-2.21, p = .030) relative to NT controls at younger ages, but these differences normalized by adolescence (age x group interactions). Lower force accuracy and greater force variability during visually guided trials and steeper decay slope during memory guided trials were associated with overall autism severity. CONCLUSIONS: Our findings that autistic individuals show a greater magnitude and tendency for a greater rate of force decay than NT individuals following the removal of visual feedback indicate that motor memory deficits contribute to fine motor control issues in ASD. Findings that sensorimotor differences in ASD were specific to younger ages suggest delayed development across multiple motor control processes. En ligne : https://dx.doi.org/10.1186/s11689-025-09607-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=576

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