Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates / Elyse L. MORIN in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1579-1596 Titre : Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates Type de document : texte imprimé Auteurs : Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric A. EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur Article en page(s) : p.1579-1596 Langues : Anglais (eng) Mots-clés : Adolescent  *Amygdala/diagnostic imaging  Animals  Brain  Child  Female  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  *Prefrontal Cortex/diagnostic imaging  Pregnancy  Primates  *amygdala functional connectivity  *childhood maltreatment  *early life stress  *prefrontal cortex  *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Developmental outcomes of early adverse care on amygdala functional connectivity in nonhuman primates [texte imprimé] / Elyse L. MORIN, Auteur ; Brittany R. HOWELL, Auteur ; Eric FECZKO, Auteur ; Eric A. EARL, Auteur ; Melanie PINCUS, Auteur ; Katherine REDING, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Jerrold S. MEYER, Auteur ; Martin STYNER, Auteur ; Damien A. FAIR, Auteur ; Mar M. SANCHEZ, Auteur . - p.1579-1596. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1579-1596 Mots-clés : Adolescent  *Amygdala/diagnostic imaging  Animals  Brain  Child  Female  Humans  Magnetic Resonance Imaging  Neural Pathways/diagnostic imaging  *Prefrontal Cortex/diagnostic imaging  Pregnancy  Primates  *amygdala functional connectivity  *childhood maltreatment  *early life stress  *prefrontal cortex  *rhesus monkey Index. décimale : PER Périodiques Résumé : Despite the strong link between childhood maltreatment and psychopathology, the underlying neurodevelopmental mechanisms are poorly understood and difficult to disentangle from heritable and prenatal factors. This study used a translational macaque model of infant maltreatment in which the adverse experience occurs in the first months of life, during intense maturation of amygdala circuits important for stress and emotional regulation. Thus, we examined the developmental impact of maltreatment on amygdala functional connectivity (FC) longitudinally, from infancy through the juvenile period. Using resting state functional magnetic resonance imaging (MRI) we performed amygdala-prefrontal cortex (PFC) region-of-interest and exploratory whole-brain amygdala FC analyses. The latter showed (a) developmental increases in amygdala FC with many regions, likely supporting increased processing of socioemotional-relevant stimuli with age; and (b) maltreatment effects on amygdala coupling with arousal and stress brain regions (locus coeruleus, laterodorsal tegmental area) that emerged with age. Maltreated juveniles showed weaker FC than controls, which was negatively associated with infant hair cortisol concentrations. Findings from the region-of-interest analysis also showed weaker amygdala FC with PFC regions in maltreated animals than controls since infancy, whereas bilateral amygdala FC was stronger in maltreated animals. These effects on amygdala FC development may underlie the poor behavioral outcomes associated with this adverse experience. En ligne : http://dx.doi.org/10.1017/s0954579420001133 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study / Chris GUNTER in Autism Research, 15-3 (March 2022)  

Public ISBD [article]  inAutism Research > 15-3 (March 2022) . - p.447-463 Titre : Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study Type de document : texte imprimé Auteurs : Chris GUNTER, Auteur ; R. Alan HARRIS, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Muthuswamy RAVEENDRAN, Auteur ; Vasiliki MICHOPOULOS, Auteur ; Jocelyne BACHEVALIER, Auteur ; Jessica RAPER, Auteur ; Mar M. SANCHEZ, Auteur ; Jeffrey ROGERS, Auteur Article en page(s) : p.447-463 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our understanding of influences on atypical human social behavior, such as that observed in autism spectrum disorders (ASD), many significant questions remain. Improved understanding of the relationships among variation in specific genes and variation in expressed social behavior in a nonhuman primate would benefit efforts to investigate risk factors, developmental mechanisms, and potential therapies for behavioral disorders including ASD. To study genetic influences on key aspects of social behavior and interactions?individual competence and/or motivation for specific aspects of social behavior?we quantified individual variation in social interactions among juvenile rhesus macaques using both a standard macaque ethogram and a macaque-relevant modification of the human Social Responsiveness Scale. Our analyses demonstrate that various aspects of juvenile social behavior exhibit significant genetic heritability, with estimated quantitative genetic effects similar to that described for ASD in human children. We also performed exome sequencing and analyzed variants in 143 genes previously suggested to influence risk for human ASD. We find preliminary evidence for genetic association between specific variants and both individual behaviors and multi-behavioral factor scores. To our knowledge, this is the first demonstration that spontaneous social behaviors performed by free-ranging juvenile rhesus macaques display significant genetic heritability and then to use exome sequencing data to examine potential macaque genetic associations in genes associated with human ASD. En ligne : https://doi.org/10.1002/aur.2675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Heritability of social behavioral phenotypes and preliminary associations with autism spectrum disorder risk genes in rhesus macaques: A whole exome sequencing study [texte imprimé] / Chris GUNTER, Auteur ; R. Alan HARRIS, Auteur ; Zsofia A. KOVACS-BALINT, Auteur ; Muthuswamy RAVEENDRAN, Auteur ; Vasiliki MICHOPOULOS, Auteur ; Jocelyne BACHEVALIER, Auteur ; Jessica RAPER, Auteur ; Mar M. SANCHEZ, Auteur ; Jeffrey ROGERS, Auteur . - p.447-463. Langues : Anglais (eng) in Autism Research > 15-3 (March 2022) . - p.447-463 Index. décimale : PER Périodiques Résumé : Abstract Nonhuman primates and especially rhesus macaques (Macaca mulatta) have been indispensable animal models for studies of various aspects of neurobiology, developmental psychology, and other aspects of neuroscience. While remarkable progress has been made in our understanding of influences on atypical human social behavior, such as that observed in autism spectrum disorders (ASD), many significant questions remain. Improved understanding of the relationships among variation in specific genes and variation in expressed social behavior in a nonhuman primate would benefit efforts to investigate risk factors, developmental mechanisms, and potential therapies for behavioral disorders including ASD. To study genetic influences on key aspects of social behavior and interactions?individual competence and/or motivation for specific aspects of social behavior?we quantified individual variation in social interactions among juvenile rhesus macaques using both a standard macaque ethogram and a macaque-relevant modification of the human Social Responsiveness Scale. Our analyses demonstrate that various aspects of juvenile social behavior exhibit significant genetic heritability, with estimated quantitative genetic effects similar to that described for ASD in human children. We also performed exome sequencing and analyzed variants in 143 genes previously suggested to influence risk for human ASD. We find preliminary evidence for genetic association between specific variants and both individual behaviors and multi-behavioral factor scores. To our knowledge, this is the first demonstration that spontaneous social behaviors performed by free-ranging juvenile rhesus macaques display significant genetic heritability and then to use exome sequencing data to examine potential macaque genetic associations in genes associated with human ASD. En ligne : https://doi.org/10.1002/aur.2675 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

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