Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability / O. EYRE in Journal of Child Psychology and Psychiatry, 60-8 (August 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.866-874 Titre : Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability Type de document : Texte imprimé et/ou numérique Auteurs : O. EYRE, Auteur ; R. A. HUGHES, Auteur ; Ajay K. THAPAR, Auteur ; E. LEIBENLUFT, Auteur ; A. STRINGARIS, Auteur ; George DAVEY SMITH, Auteur ; E. STERGIAKOULI, Auteur ; S. COLLISHAW, Auteur ; A. THAPAR, Auteur Article en page(s) : p.866-874 Langues : Anglais (eng) Mots-clés : Alspac  attention-deficit/hyperactivity disorder  autism  depression  irritability  neurodevelopmental Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with neurodevelopmental disorders are at increased risk of developing depression. Irritability predicts depression in the general population and is common in children with neurodevelopmental disorders. Thus, it is possible that irritability in children with neurodevelopmental disorders contributes to the link with later depression. This study aimed to (a) examine the association between childhood neurodevelopmental difficulties and adolescent depression and (b) test whether irritability explains this association. METHODS: Children with any neurodevelopmental difficulty at the age of 7-9 (n = 1,697) and a selected, comparison group without any neurodevelopmental difficulty (n = 3,177) were identified from a prospective, UK population-based cohort, the Avon Longitudinal Study of Parents and Children. Neurodevelopmental difficulties were defined as a score in the bottom 5% of the sample on at least one measure of cognitive ability, communication, autism spectrum symptoms, attention-deficit/hyperactivity symptoms, reading or motor coordination. The Development and Well-Being Assessment measured parent-reported child irritability at the age of 7, parent-reported adolescent depression at the age of 10 and 13, and self-reported depression at the age of 15. Depression measures were combined, deriving an outcome of major depressive disorder (MDD) in adolescence. Logistic regression examined the association between childhood neurodevelopmental difficulties and adolescent MDD, controlling for gender. Path analysis estimated the proportion of this association explained by irritability. Analyses were repeated for individual neurodevelopmental problems. RESULTS: Childhood neurodevelopmental difficulties were associated with adolescent MDD (OR = 2.11, 95% CI = 1.24, 3.60, p = .006). Childhood irritability statistically accounted for 42% of this association. On examining each neurodevelopmental difficulty separately, autistic, communication and ADHD problems were each associated with depression, with irritability explaining 29%-51% of these links. CONCLUSIONS: Childhood irritability appears to be a key contributor to the link between childhood neurodevelopmental difficulties and adolescent MDD. High rates of irritability in children with autistic and ADHD difficulties may explain elevated rates of depression in the neurodevelopmental group. En ligne : http://dx.doi.org/10.1111/jcpp.13053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 [article] Childhood neurodevelopmental difficulties and risk of adolescent depression: the role of irritability [Texte imprimé et/ou numérique] / O. EYRE, Auteur ; R. A. HUGHES, Auteur ; Ajay K. THAPAR, Auteur ; E. LEIBENLUFT, Auteur ; A. STRINGARIS, Auteur ; George DAVEY SMITH, Auteur ; E. STERGIAKOULI, Auteur ; S. COLLISHAW, Auteur ; A. THAPAR, Auteur . - p.866-874. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.866-874 Mots-clés : Alspac  attention-deficit/hyperactivity disorder  autism  depression  irritability  neurodevelopmental Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with neurodevelopmental disorders are at increased risk of developing depression. Irritability predicts depression in the general population and is common in children with neurodevelopmental disorders. Thus, it is possible that irritability in children with neurodevelopmental disorders contributes to the link with later depression. This study aimed to (a) examine the association between childhood neurodevelopmental difficulties and adolescent depression and (b) test whether irritability explains this association. METHODS: Children with any neurodevelopmental difficulty at the age of 7-9 (n = 1,697) and a selected, comparison group without any neurodevelopmental difficulty (n = 3,177) were identified from a prospective, UK population-based cohort, the Avon Longitudinal Study of Parents and Children. Neurodevelopmental difficulties were defined as a score in the bottom 5% of the sample on at least one measure of cognitive ability, communication, autism spectrum symptoms, attention-deficit/hyperactivity symptoms, reading or motor coordination. The Development and Well-Being Assessment measured parent-reported child irritability at the age of 7, parent-reported adolescent depression at the age of 10 and 13, and self-reported depression at the age of 15. Depression measures were combined, deriving an outcome of major depressive disorder (MDD) in adolescence. Logistic regression examined the association between childhood neurodevelopmental difficulties and adolescent MDD, controlling for gender. Path analysis estimated the proportion of this association explained by irritability. Analyses were repeated for individual neurodevelopmental problems. RESULTS: Childhood neurodevelopmental difficulties were associated with adolescent MDD (OR = 2.11, 95% CI = 1.24, 3.60, p = .006). Childhood irritability statistically accounted for 42% of this association. On examining each neurodevelopmental difficulty separately, autistic, communication and ADHD problems were each associated with depression, with irritability explaining 29%-51% of these links. CONCLUSIONS: Childhood irritability appears to be a key contributor to the link between childhood neurodevelopmental difficulties and adolescent MDD. High rates of irritability in children with autistic and ADHD difficulties may explain elevated rates of depression in the neurodevelopmental group. En ligne : http://dx.doi.org/10.1111/jcpp.13053 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404

Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents / Alice STEPHENS in Journal of Child Psychology and Psychiatry, 64-3 (March 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.367-375 Titre : Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents Type de document : Texte imprimé et/ou numérique Auteurs : Alice STEPHENS, Auteur ; Judith ALLARDYCE, Auteur ; Bryony WEAVERS, Auteur ; Jessica LENNON, Auteur ; Rhys BEVAN JONES, Auteur ; Victoria POWELL, Auteur ; Olga EYRE, Auteur ; Robert POTTER, Auteur ; Valentina ESCOTT PRICE, Auteur ; David OSBORN, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur ; Ajay K. THAPAR, Auteur ; Jon HERON, Auteur ; Frances RICE, Auteur Article en page(s) : p.367-375 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background Parental depression is common and is a major risk factor for depression in adolescents. Early identification of adolescents at elevated risk of developing major depressive disorder (MDD) in this group could improve early access to preventive interventions. Methods Using longitudinal data from 337 adolescents at high familial risk of depression, we developed a risk prediction model for adolescent MDD. The model was externally validated in an independent cohort of 1,384 adolescents at high familial risk. We assessed predictors at baseline and MDD at follow-up (a median of 2-3 years later). We compared the risk prediction model to a simple comparison model based on screening for depressive symptoms. Decision curve analysis was used to identify which model-predicted risk score thresholds were associated with the greatest clinical benefit. Results The MDD risk prediction model discriminated between those adolescents who did and did not develop MDD in the development (C-statistic=.783, IQR (interquartile range)=.779, .778) and the validation samples (C-statistic=.722, IQR=â’.694, .741). Calibration in the validation sample was good to excellent (calibration intercept=.011, C-slope=.851). The MDD risk prediction model was superior to the simple comparison model where discrimination was no better than chance (C-statistic=.544, IQR=.536, .572). Decision curve analysis found that the highest clinical utility was at the lowest risk score thresholds (0.01-0.05). Conclusions The developed risk prediction model successfully discriminated adolescents who developed MDD from those who did not. In practice, this model could be further developed with user involvement into a tool to target individuals for low-intensity, selective preventive intervention. En ligne : https://doi.org/10.1111/jcpp.13704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493 [article] Developing and validating a prediction model of adolescent major depressive disorder in the offspring of depressed parents [Texte imprimé et/ou numérique] / Alice STEPHENS, Auteur ; Judith ALLARDYCE, Auteur ; Bryony WEAVERS, Auteur ; Jessica LENNON, Auteur ; Rhys BEVAN JONES, Auteur ; Victoria POWELL, Auteur ; Olga EYRE, Auteur ; Robert POTTER, Auteur ; Valentina ESCOTT PRICE, Auteur ; David OSBORN, Auteur ; Anita THAPAR, Auteur ; Stephan COLLISHAW, Auteur ; Ajay K. THAPAR, Auteur ; Jon HERON, Auteur ; Frances RICE, Auteur . - p.367-375. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-3 (March 2023) . - p.367-375 Index. décimale : PER Périodiques Résumé : Background Parental depression is common and is a major risk factor for depression in adolescents. Early identification of adolescents at elevated risk of developing major depressive disorder (MDD) in this group could improve early access to preventive interventions. Methods Using longitudinal data from 337 adolescents at high familial risk of depression, we developed a risk prediction model for adolescent MDD. The model was externally validated in an independent cohort of 1,384 adolescents at high familial risk. We assessed predictors at baseline and MDD at follow-up (a median of 2-3 years later). We compared the risk prediction model to a simple comparison model based on screening for depressive symptoms. Decision curve analysis was used to identify which model-predicted risk score thresholds were associated with the greatest clinical benefit. Results The MDD risk prediction model discriminated between those adolescents who did and did not develop MDD in the development (C-statistic=.783, IQR (interquartile range)=.779, .778) and the validation samples (C-statistic=.722, IQR=â’.694, .741). Calibration in the validation sample was good to excellent (calibration intercept=.011, C-slope=.851). The MDD risk prediction model was superior to the simple comparison model where discrimination was no better than chance (C-statistic=.544, IQR=.536, .572). Decision curve analysis found that the highest clinical utility was at the lowest risk score thresholds (0.01-0.05). Conclusions The developed risk prediction model successfully discriminated adolescents who developed MDD from those who did not. In practice, this model could be further developed with user involvement into a tool to target individuals for low-intensity, selective preventive intervention. En ligne : https://doi.org/10.1111/jcpp.13704 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=493

Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls / Lucy RIGLIN in Development and Psychopathology, 28-1 (February 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-1 (February 2016) . - p.97-109 Titre : Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls Type de document : Texte imprimé et/ou numérique Auteurs : Lucy RIGLIN, Auteur ; Stephan COLLISHAW, Auteur ; Katherine H. SHELTON, Auteur ; I. C. MCMANUS, Auteur ; Terry NG-KNIGHT, Auteur ; Ruth SELLERS, Auteur ; Ajay K. THAPAR, Auteur ; Norah FREDERICKSON, Auteur ; Frances RICE, Auteur Article en page(s) : p.97-109 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Stress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology. En ligne : http://dx.doi.org/10.1017/S0954579415000310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls [Texte imprimé et/ou numérique] / Lucy RIGLIN, Auteur ; Stephan COLLISHAW, Auteur ; Katherine H. SHELTON, Auteur ; I. C. MCMANUS, Auteur ; Terry NG-KNIGHT, Auteur ; Ruth SELLERS, Auteur ; Ajay K. THAPAR, Auteur ; Norah FREDERICKSON, Auteur ; Frances RICE, Auteur . - p.97-109. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.97-109 Index. décimale : PER Périodiques Résumé : Stress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology. En ligne : http://dx.doi.org/10.1017/S0954579415000310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? / Lucy RIGLIN in Journal of Child Psychology and Psychiatry, 62-4 (April 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.449-457 Titre : Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? Type de document : Texte imprimé et/ou numérique Auteurs : Lucy RIGLIN, Auteur ; Beate LEPPERT, Auteur ; Kate LANGLEY, Auteur ; Ajay K. THAPAR, Auteur ; Michael C. O'DONOVAN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur Article en page(s) : p.449-457 Langues : Anglais (eng) Mots-clés : Avon Longitudinal Study of Parents and Children  Neurodevelopmental  adult  attention-deficit hyperactivity disorder  autism spectrum disorder  genetic Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are generally considered early-onset disorders so most research has therefore tended to focus on children. Differences between ADHD/ASD in adult life and childhood have been noted, but few population-based studies have examined them in adulthood. Furthermore, the interpretation of findings is hampered by changes in measure and from parent report to self-report. METHOD: We examined continuous/trait measures of parent- and self-rated ADHD and ASD in adulthood (age 25 years) in a UK prospective longitudinal sample ALPSAC (the Avon Longitudinal Study of Parents and Children), using many of the same measures that parents reported on in childhood (N = 6,064). Our aim was to investigate these traits in this population for mean-level sex differences, overlaps with other cognitive, learning and communication problems and their associations with polygenic risk scores (PRS) for neuropsychiatric disorders (ADHD, ASD, schizophrenia, depression and anxiety). RESULTS: ADHD and ASD traits in adulthood, as in childhood, showed associations with childhood cognitive, learning and communication problems and adult communication/language measures, although less so for self-ratings than parent-ratings. Males had higher ADHD and ASD trait levels, but this was not as marked as in childhood. In adulthood, ADHD (both parent- and self-rated) and ASD (parent-rated) symptoms showed associations with ADHD PRS; self-reported ADHD also showed association with depression PRS, whereas self-reported ASD did not show strong PRS associations. CONCLUSIONS: Our findings suggest that in young adults, ADHD and ASD symptoms have similar characteristics as they do in childhood. Associations with other cognitive, learning and communication problems, and ADHD PRS were somewhat less pronounced for self-reported adult ADHD and ASD symptoms, suggesting that even at age 25, parent reports, where available, could be clinically useful. En ligne : http://dx.doi.org/10.1111/jcpp.13297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445 [article] Investigating attention-deficit hyperactivity disorder and autism spectrum disorder traits in the general population: What happens in adult life? [Texte imprimé et/ou numérique] / Lucy RIGLIN, Auteur ; Beate LEPPERT, Auteur ; Kate LANGLEY, Auteur ; Ajay K. THAPAR, Auteur ; Michael C. O'DONOVAN, Auteur ; George DAVEY SMITH, Auteur ; Evie STERGIAKOULI, Auteur ; Kate TILLING, Auteur ; Anita THAPAR, Auteur . - p.449-457. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-4 (April 2021) . - p.449-457 Mots-clés : Avon Longitudinal Study of Parents and Children  Neurodevelopmental  adult  attention-deficit hyperactivity disorder  autism spectrum disorder  genetic Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are generally considered early-onset disorders so most research has therefore tended to focus on children. Differences between ADHD/ASD in adult life and childhood have been noted, but few population-based studies have examined them in adulthood. Furthermore, the interpretation of findings is hampered by changes in measure and from parent report to self-report. METHOD: We examined continuous/trait measures of parent- and self-rated ADHD and ASD in adulthood (age 25 years) in a UK prospective longitudinal sample ALPSAC (the Avon Longitudinal Study of Parents and Children), using many of the same measures that parents reported on in childhood (N = 6,064). Our aim was to investigate these traits in this population for mean-level sex differences, overlaps with other cognitive, learning and communication problems and their associations with polygenic risk scores (PRS) for neuropsychiatric disorders (ADHD, ASD, schizophrenia, depression and anxiety). RESULTS: ADHD and ASD traits in adulthood, as in childhood, showed associations with childhood cognitive, learning and communication problems and adult communication/language measures, although less so for self-ratings than parent-ratings. Males had higher ADHD and ASD trait levels, but this was not as marked as in childhood. In adulthood, ADHD (both parent- and self-rated) and ASD (parent-rated) symptoms showed associations with ADHD PRS; self-reported ADHD also showed association with depression PRS, whereas self-reported ASD did not show strong PRS associations. CONCLUSIONS: Our findings suggest that in young adults, ADHD and ASD symptoms have similar characteristics as they do in childhood. Associations with other cognitive, learning and communication problems, and ADHD PRS were somewhat less pronounced for self-reported adult ADHD and ASD symptoms, suggesting that even at age 25, parent reports, where available, could be clinically useful. En ligne : http://dx.doi.org/10.1111/jcpp.13297 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=445

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