Maternal and cord plasma branched-chain amino acids and child risk of attention-deficit hyperactivity disorder: a prospective birth cohort study / N. S. ANAND in Journal of Child Psychology and Psychiatry, 62-7 (July 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.868-875 Titre : Maternal and cord plasma branched-chain amino acids and child risk of attention-deficit hyperactivity disorder: a prospective birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : N. S. ANAND, Auteur ; Y. JI, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; M. VAN DER RIJN, Auteur ; A. RILEY, Auteur ; C. PEARSON, Auteur ; Barry S. ZUCKERMAN, Auteur ; X. WANG, Auteur Article en page(s) : p.868-875 Langues : Anglais (eng) Mots-clés : Amino Acids, Branched-Chain  Attention Deficit Disorder with Hyperactivity/epidemiology  Child  Cohort Studies  Female  Humans  Infant, Newborn  Pregnancy  Premature Birth  Prospective Studies  Attention-Deficit Hyperactivity Disorder  branched-chain amino acids  cord blood  metabolome Index. décimale : PER Périodiques Résumé : BACKGROUND: Branched-chain amino acids (BCAA: leucine, isoleucine, and valine) are essential amino acids involved in biological functions of brain development and recently linked with autism. However, their role in attention-deficit hyperactivity disorder (ADHD) is not well-studied. We investigated individual and combined relationships of maternal plasma and newborn cord plasma BCAAs with childhood development of ADHD. METHODS: We utilized the Boston Birth Cohort, a predominantly urban, low-income, US minority population. Child developmental outcomes were defined in three mutually exclusive groups - ADHD, neurotypical (NT), or other developmental disabilities based on physician diagnoses per ICD-9 or 10 in medical records. The final sample included 626 children (299 ADHD, 327 NT) excluding other developmental disabilities. BCAAs were measured by liquid chromatography-tandem mass spectrometry. We used factor analysis to create composite scores of maternal and cord BCAA, which we divided into tertiles. Logistic regressions analyzed relationships between maternal or cord BCAA tertiles with child ADHD risk, controlling for maternal race, age, parity, smoking, education, low birth weight, preterm birth, and child sex. Additionally, we analyzed maternal and cord plasma BCAAs jointly on child ADHD risk. RESULTS: Adjusted logistic regression found significantly increased odds of child ADHD diagnosis for the second (OR 1.63, 95% CI: 1.04, 2.54, p = .032) and third tertiles (OR 2.01, 95% CI: 1.28, 3.15, p = .002) of cord BCAA scores compared to the first tertile. This finding held for the third tertile when further adjusting for maternal BCAA score. There was no significant association between maternal BCAA score and child ADHD risk, nor a significant interaction between maternal and cord BCAA scores. CONCLUSIONS: In this prospective US birth cohort, higher cord BCAA levels were associated with a greater risk of developing ADHD in childhood. These results have implications for further research into mechanisms of ADHD development and possible early life screening and interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Maternal and cord plasma branched-chain amino acids and child risk of attention-deficit hyperactivity disorder: a prospective birth cohort study [Texte imprimé et/ou numérique] / N. S. ANAND, Auteur ; Y. JI, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; M. VAN DER RIJN, Auteur ; A. RILEY, Auteur ; C. PEARSON, Auteur ; Barry S. ZUCKERMAN, Auteur ; X. WANG, Auteur . - p.868-875. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-7 (July 2021) . - p.868-875 Mots-clés : Amino Acids, Branched-Chain  Attention Deficit Disorder with Hyperactivity/epidemiology  Child  Cohort Studies  Female  Humans  Infant, Newborn  Pregnancy  Premature Birth  Prospective Studies  Attention-Deficit Hyperactivity Disorder  branched-chain amino acids  cord blood  metabolome Index. décimale : PER Périodiques Résumé : BACKGROUND: Branched-chain amino acids (BCAA: leucine, isoleucine, and valine) are essential amino acids involved in biological functions of brain development and recently linked with autism. However, their role in attention-deficit hyperactivity disorder (ADHD) is not well-studied. We investigated individual and combined relationships of maternal plasma and newborn cord plasma BCAAs with childhood development of ADHD. METHODS: We utilized the Boston Birth Cohort, a predominantly urban, low-income, US minority population. Child developmental outcomes were defined in three mutually exclusive groups - ADHD, neurotypical (NT), or other developmental disabilities based on physician diagnoses per ICD-9 or 10 in medical records. The final sample included 626 children (299 ADHD, 327 NT) excluding other developmental disabilities. BCAAs were measured by liquid chromatography-tandem mass spectrometry. We used factor analysis to create composite scores of maternal and cord BCAA, which we divided into tertiles. Logistic regressions analyzed relationships between maternal or cord BCAA tertiles with child ADHD risk, controlling for maternal race, age, parity, smoking, education, low birth weight, preterm birth, and child sex. Additionally, we analyzed maternal and cord plasma BCAAs jointly on child ADHD risk. RESULTS: Adjusted logistic regression found significantly increased odds of child ADHD diagnosis for the second (OR 1.63, 95% CI: 1.04, 2.54, p = .032) and third tertiles (OR 2.01, 95% CI: 1.28, 3.15, p = .002) of cord BCAA scores compared to the first tertile. This finding held for the third tertile when further adjusting for maternal BCAA score. There was no significant association between maternal BCAA score and child ADHD risk, nor a significant interaction between maternal and cord BCAA scores. CONCLUSIONS: In this prospective US birth cohort, higher cord BCAA levels were associated with a greater risk of developing ADHD in childhood. These results have implications for further research into mechanisms of ADHD development and possible early life screening and interventions. En ligne : http://dx.doi.org/10.1111/jcpp.13332 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study / A. S. E. LEE in Autism Research, 14-12 (December 2021)  

Public ISBD [article]  inAutism Research > 14-12 (December 2021) . - p.2533-2543 Titre : Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study Type de document : Texte imprimé et/ou numérique Auteurs : A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur Article en page(s) : p.2533-2543 Langues : Anglais (eng) Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Birth Cohort  Cohort Studies  Female  Humans  Neurodevelopmental Disorders/epidemiology  Pregnancy  Prenatal Exposure Delayed Effects  Prospective Studies  Selenium  attention deficit-hyperactivity disorder  children  environmental risk factors  epigenetics  gene-environment interaction  pediatrics  pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Maternal prenatal selenium levels and child risk of neurodevelopmental disorders: A prospective birth cohort study [Texte imprimé et/ou numérique] / A. S. E. LEE, Auteur ; Y. JI, Auteur ; R. RAGHAVAN, Auteur ; G. WANG, Auteur ; X. HONG, Auteur ; C. PEARSON, Auteur ; G. MIROLLI, Auteur ; E. BIND, Auteur ; A. STEFFENS, Auteur ; J. MUKHERJEE, Auteur ; D. HALTMEIER, Auteur ; Z. T. FAN, Auteur ; X. WANG, Auteur . - p.2533-2543. Langues : Anglais (eng) in Autism Research > 14-12 (December 2021) . - p.2533-2543 Mots-clés : Attention Deficit Disorder with Hyperactivity  Autism Spectrum Disorder/epidemiology  Birth Cohort  Cohort Studies  Female  Humans  Neurodevelopmental Disorders/epidemiology  Pregnancy  Prenatal Exposure Delayed Effects  Prospective Studies  Selenium  attention deficit-hyperactivity disorder  children  environmental risk factors  epigenetics  gene-environment interaction  pediatrics  pre- and perinatal risk factors Index. décimale : PER Périodiques Résumé : Selenium (Se) is an essential trace element involved in various biological processes, including neurodevelopment. Available literature indicates that both Se deficiency and excess may be detrimental to health. It is also known that Se can cross the placenta from maternal to fetal circulation. To date, the role of maternal Se status in child long-term neurodevelopment is largely unexplored. This study investigated the temporal and dose-response associations between maternal Se status and child risk of neurodevelopmental disorders including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD). It consisted of 1550 mother-infant dyads from the Boston Birth Cohort. Maternal red blood cell (RBC) Se levels were measured in samples collected within 72?h of delivery (biomarker of third trimester Se status). Pediatric neurodevelopmental diagnoses were obtained from electronic medical records. Data analyses showed that maternal RBC Se levels were positively associated with child risk of developing ASD, with an adjusted odds ratio of 1.49 for ASD (95% CI: 1.09, 2.02) per IQR increase in Se. There was also a positive association between maternal Se and ADHD (OR: 1.29; 95% CI: 1.04, 1.56, per IQR increase in Se). These associations remained robust even after adjusting for pertinent covariables; and there was no significant interaction between Se and these covariables. Our findings suggest that prenatal exposure to high maternal Se levels may adversely affect child neurodevelopment. Our findings warrant further investigation; if confirmed, optimizing maternal prenatal Se levels may be necessary to maximize its health benefits while preventing undue risk. LAY SUMMARY: Selenium (Se) is an essential nutrient for the health of the pregnant mother and her baby. While Se can readily cross the placenta from maternal to fetal circulation, little is known about maternal Se status on her child's neurodevelopmental outcomes. We studied over 1500 mother-child dyads from birth to school age of the child. We found that babies born from mothers with high blood Se levels may be at increased risk of developing autism spectrum disorder or attention deficit hyperactivity disorder. Given this is the first study of the kind, more study is needed to confirm our findings. En ligne : http://dx.doi.org/10.1002/aur.2617 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

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