Empathy deficits, callous-unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth / Antonia TKALCEC in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.1946-1962 Titre : Empathy deficits, callous-unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth Type de document : Texte imprimé et/ou numérique Auteurs : Antonia TKALCEC, Auteur ; Maria BIERLEIN, Auteur ; Gudrun SEEGER-SCHNEIDER, Auteur ; Susanne WALITZA, Auteur ; Bettina JENNY, Auteur ; Willeke M. MENKS, Auteur ; Lynn V. FELHBAUM, Auteur ; Reka BORBAS, Auteur ; David M. COLE, Auteur ; Nora RASCHLE, Auteur ; Evelyn HERBRECHT, Auteur ; Christina STADLER, Auteur ; Ana CUBILLO, Auteur Article en page(s) : p.1946-1962 Index. décimale : PER Périodiques Résumé : Abstract Distinct empathy deficits are often described in patients with conduct disorder (CD) and autism spectrum disorder (ASD) yet their neural underpinnings and the influence of comorbid Callous-Unemotional (CU) traits are unclear. This study compares the cognitive (CE) and affective empathy (AE) abilities of youth with CD and ASD, their potential neuroanatomical correlates, and the influence of CU traits on empathy. Adolescents and parents/caregivers completed empathy questionnaires (N?=?148 adolescents, mean age?=?15.16?years) and T1 weighted images were obtained from a subsample (N?=?130). Group differences in empathy and the influence of CU traits were investigated using Bayesian analyses and Voxel-Based Morphometry with Threshold-Free Cluster Enhancement focusing on regions involved in AE (insula, amygdala, inferior frontal gyrus and cingulate cortex) and CE processes (ventromedial prefrontal cortex, temporoparietal junction, superior temporal gyrus, and precuneus). The ASD group showed lower parent-reported AE and CE scores and lower self-reported CE scores while the CD group showed lower parent-reported CE scores than controls. When accounting for the influence of CU traits no AE deficits in ASD and CE deficits in CD were found, but CE deficits in ASD remained. Across all participants, CU traits were negatively associated with gray matter volumes in anterior cingulate which extends into the mid cingulate, ventromedial prefrontal cortex, and precuneus. Thus, although co-occurring CU traits have been linked to global empathy deficits in reports and underlying brain structures, its influence on empathy aspects might be disorder-specific. Investigating the subdimensions of empathy may therefore help to identify disorder-specific empathy deficits. En ligne : https://doi.org/10.1002/aur.2993 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] Empathy deficits, callous-unemotional traits and structural underpinnings in autism spectrum disorder and conduct disorder youth [Texte imprimé et/ou numérique] / Antonia TKALCEC, Auteur ; Maria BIERLEIN, Auteur ; Gudrun SEEGER-SCHNEIDER, Auteur ; Susanne WALITZA, Auteur ; Bettina JENNY, Auteur ; Willeke M. MENKS, Auteur ; Lynn V. FELHBAUM, Auteur ; Reka BORBAS, Auteur ; David M. COLE, Auteur ; Nora RASCHLE, Auteur ; Evelyn HERBRECHT, Auteur ; Christina STADLER, Auteur ; Ana CUBILLO, Auteur . - p.1946-1962. in Autism Research > 16-10 (October 2023) . - p.1946-1962 Index. décimale : PER Périodiques Résumé : Abstract Distinct empathy deficits are often described in patients with conduct disorder (CD) and autism spectrum disorder (ASD) yet their neural underpinnings and the influence of comorbid Callous-Unemotional (CU) traits are unclear. This study compares the cognitive (CE) and affective empathy (AE) abilities of youth with CD and ASD, their potential neuroanatomical correlates, and the influence of CU traits on empathy. Adolescents and parents/caregivers completed empathy questionnaires (N?=?148 adolescents, mean age?=?15.16?years) and T1 weighted images were obtained from a subsample (N?=?130). Group differences in empathy and the influence of CU traits were investigated using Bayesian analyses and Voxel-Based Morphometry with Threshold-Free Cluster Enhancement focusing on regions involved in AE (insula, amygdala, inferior frontal gyrus and cingulate cortex) and CE processes (ventromedial prefrontal cortex, temporoparietal junction, superior temporal gyrus, and precuneus). The ASD group showed lower parent-reported AE and CE scores and lower self-reported CE scores while the CD group showed lower parent-reported CE scores than controls. When accounting for the influence of CU traits no AE deficits in ASD and CE deficits in CD were found, but CE deficits in ASD remained. Across all participants, CU traits were negatively associated with gray matter volumes in anterior cingulate which extends into the mid cingulate, ventromedial prefrontal cortex, and precuneus. Thus, although co-occurring CU traits have been linked to global empathy deficits in reports and underlying brain structures, its influence on empathy aspects might be disorder-specific. Investigating the subdimensions of empathy may therefore help to identify disorder-specific empathy deficits. En ligne : https://doi.org/10.1002/aur.2993 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry / Stephane DE BRITO ; Graeme FAIRCHILD ; Christine FREITAG ; Karen GONZALEZ-MADRUGA ; Catherine HAMILTON-GIACHRITSIS ; Gregor KOHLS ; Kerstin KONRAD ; Anne MARTINELLI ; Nora Maria RASCHLE ; Jack ROGERS ; Areti SMARAGDI ; Christina STADLER ; Marlene STAGINNUS ; Nicola TOSCHI in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Titre : Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry Type de document : Texte imprimé et/ou numérique Auteurs : Stephane DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora Maria RASCHLE, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur Article en page(s) : p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9?18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Identifying structural brain markers of resilience to adversity in young people using voxel-based morphometry [Texte imprimé et/ou numérique] / Stephane DE BRITO, Auteur ; Graeme FAIRCHILD, Auteur ; Christine FREITAG, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Catherine HAMILTON-GIACHRITSIS, Auteur ; Gregor KOHLS, Auteur ; Kerstin KONRAD, Auteur ; Anne MARTINELLI, Auteur ; Nora Maria RASCHLE, Auteur ; Jack ROGERS, Auteur ; Areti SMARAGDI, Auteur ; Christina STADLER, Auteur ; Marlene STAGINNUS, Auteur ; Nicola TOSCHI, Auteur . - p.2302-2314. in Development and Psychopathology > 35-5 (December 2023) . - p.2302-2314 Mots-clés : Resilience  adversity  brain structure  voxel-based morphometry  youth Index. décimale : PER Périodiques Résumé : There is increasing evidence that resilience in youth may have a neurobiological basis. However, the existing literature lacks a consistent way of operationalizing resilience, often relying on arbitrary judgments or narrow definitions (e.g., not developing PTSD) to classify individuals as resilient. Therefore, this study used data-driven, continuous resilience scores based on adversity and psychopathology to investigate associations between resilience and brain structure in youth. Structural MRI data from 298 youth aged 9?18 years (Mage = 13.51; 51% female) who participated in the European multisite FemNAT-CD study were preprocessed using SPM12 and analyzed using voxel-based morphometry. Resilience scores were derived by regressing data on adversity exposure against current/lifetime psychopathology and quantifying each individual?s distance from the regression line. General linear models tested for associations between resilience and gray matter volume (GMV) and examined whether associations between resilience and GMV differed by sex. Resilience was positively correlated with GMV in the right inferior frontal and medial frontal gyri. Sex-by-resilience interactions were observed in the middle temporal and middle frontal gyri. These findings demonstrate that resilience in youth is associated with volume in brain regions implicated in executive functioning, emotion regulation, and attention. Our results also provide evidence for sex differences in the neurobiology of resilience. En ligne : https://dx.doi.org/10.1017/S0954579423000718 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits / Ruth PAULI in Development and Psychopathology, 33-3 (August 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-3 (August 2021) . - p.980-991 Titre : Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits Type de document : Texte imprimé et/ou numérique Auteurs : Ruth PAULI, Auteur ; Peter TINO, Auteur ; Jack C. ROGERS, Auteur ; Rosalind BAKER, Auteur ; Roberta CLANTON, Auteur ; Philippa BIRCH, Auteur ; Abigail BROWN, Auteur ; Gemma DANIEL, Auteur ; Lisandra FERREIRA, Auteur ; Liam GRISLEY, Auteur ; Gregor KOHLS, Auteur ; Sarah BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Helen LAZARATOU, Auteur ; Foteini TSIAKOULIA, Auteur ; Panagiota BALI, Auteur ; Helena OLDENHOF, Auteur ; Lucres JANSEN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Maider GONZALEZ DE ARTAZA-LAVESA, Auteur ; Martin STEPPAN, Auteur ; Noortje VRIENDS, Auteur ; Aitana BIGORRA, Auteur ; Reka SIKLOSI, Auteur ; Sreejita GHOSH, Auteur ; Kerstin BUNTE, Auteur ; Roberta DOCHNAL, Auteur ; Amaia HERVAS, Auteur ; Christina STADLER, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Graeme FAIRCHILD, Auteur ; Arne POPMA, Auteur ; Dimitris DIKEOS, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Christine M. FREITAG, Auteur ; Pia ROTSHTEIN, Auteur ; Stephane A. DE BRITO, Auteur Article en page(s) : p.980-991 Langues : Anglais (eng) Mots-clés : angle-based generalized matrix learning vector quantization  callous–unemotional traits  conduct disorder  machine learning  parenting Index. décimale : PER Périodiques Résumé : Less is known about the relationship between conduct disorder (CD), callous–unemotional (CU) traits, and positive and negative parenting in youth compared to early childhood. We combined traditional univariate analyses with a novel machine learning classifier (Angle-based Generalized Matrix Learning Vector Quantization) to classify youth (N = 756; 9–18 years) into typically developing (TD) or CD groups with or without elevated CU traits (CD/HCU, CD/LCU, respectively) using youth- and parent-reports of parenting behavior. At the group level, both CD/HCU and CD/LCU were associated with high negative and low positive parenting relative to TD. However, only positive parenting differed between the CD/HCU and CD/LCU groups. In classification analyses, performance was best when distinguishing CD/HCU from TD groups and poorest when distinguishing CD/HCU from CD/LCU groups. Positive and negative parenting were both relevant when distinguishing CD/HCU from TD, negative parenting was most relevant when distinguishing between CD/LCU and TD, and positive parenting was most relevant when distinguishing CD/HCU from CD/LCU groups. These findings suggest that while positive parenting distinguishes between CD/HCU and CD/LCU, negative parenting is associated with both CD subtypes. These results highlight the importance of considering multiple parenting behaviors in CD with varying levels of CU traits in late childhood/adolescence. En ligne : http://dx.doi.org/10.1017/S0954579420000279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Positive and negative parenting in conduct disorder with high versus low levels of callous–unemotional traits [Texte imprimé et/ou numérique] / Ruth PAULI, Auteur ; Peter TINO, Auteur ; Jack C. ROGERS, Auteur ; Rosalind BAKER, Auteur ; Roberta CLANTON, Auteur ; Philippa BIRCH, Auteur ; Abigail BROWN, Auteur ; Gemma DANIEL, Auteur ; Lisandra FERREIRA, Auteur ; Liam GRISLEY, Auteur ; Gregor KOHLS, Auteur ; Sarah BAUMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Katharina ACKERMANN, Auteur ; Helen LAZARATOU, Auteur ; Foteini TSIAKOULIA, Auteur ; Panagiota BALI, Auteur ; Helena OLDENHOF, Auteur ; Lucres JANSEN, Auteur ; Areti SMARAGDI, Auteur ; Karen GONZALEZ-MADRUGA, Auteur ; Miguel Angel GONZALEZ-TORRES, Auteur ; Maider GONZALEZ DE ARTAZA-LAVESA, Auteur ; Martin STEPPAN, Auteur ; Noortje VRIENDS, Auteur ; Aitana BIGORRA, Auteur ; Reka SIKLOSI, Auteur ; Sreejita GHOSH, Auteur ; Kerstin BUNTE, Auteur ; Roberta DOCHNAL, Auteur ; Amaia HERVAS, Auteur ; Christina STADLER, Auteur ; Aranzazu FERNANDEZ-RIVAS, Auteur ; Graeme FAIRCHILD, Auteur ; Arne POPMA, Auteur ; Dimitris DIKEOS, Auteur ; Kerstin KONRAD, Auteur ; Beate HERPERTZ-DAHLMANN, Auteur ; Christine M. FREITAG, Auteur ; Pia ROTSHTEIN, Auteur ; Stephane A. DE BRITO, Auteur . - p.980-991. Langues : Anglais (eng) in Development and Psychopathology > 33-3 (August 2021) . - p.980-991 Mots-clés : angle-based generalized matrix learning vector quantization  callous–unemotional traits  conduct disorder  machine learning  parenting Index. décimale : PER Périodiques Résumé : Less is known about the relationship between conduct disorder (CD), callous–unemotional (CU) traits, and positive and negative parenting in youth compared to early childhood. We combined traditional univariate analyses with a novel machine learning classifier (Angle-based Generalized Matrix Learning Vector Quantization) to classify youth (N = 756; 9–18 years) into typically developing (TD) or CD groups with or without elevated CU traits (CD/HCU, CD/LCU, respectively) using youth- and parent-reports of parenting behavior. At the group level, both CD/HCU and CD/LCU were associated with high negative and low positive parenting relative to TD. However, only positive parenting differed between the CD/HCU and CD/LCU groups. In classification analyses, performance was best when distinguishing CD/HCU from TD groups and poorest when distinguishing CD/HCU from CD/LCU groups. Positive and negative parenting were both relevant when distinguishing CD/HCU from TD, negative parenting was most relevant when distinguishing between CD/LCU and TD, and positive parenting was most relevant when distinguishing CD/HCU from CD/LCU groups. These findings suggest that while positive parenting distinguishes between CD/HCU and CD/LCU, negative parenting is associated with both CD subtypes. These results highlight the importance of considering multiple parenting behaviors in CD with varying levels of CU traits in late childhood/adolescence. En ligne : http://dx.doi.org/10.1017/S0954579420000279 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

---

1 (1 - 3 / 3)