Diagnostic validity of Autism Diagnostic Observation Schedule, second edition (K-ADOS-2) in the Korean population / So Yoon KIM in Molecular Autism, 13 (2022)  

Public ISBD [article]  inMolecular Autism > 13 (2022) . - 30 p. Titre : Diagnostic validity of Autism Diagnostic Observation Schedule, second edition (K-ADOS-2) in the Korean population Type de document : Texte imprimé et/ou numérique Auteurs : So Yoon KIM, Auteur ; Miae OH, Auteur ; Guiyoung BONG, Auteur ; Da-Yea SONG, Auteur ; Nan-He YOON, Auteur ; Joo Hyun KIM, Auteur ; Hee Jeong YOO, Auteur Article en page(s) : 30 p. Langues : Anglais (eng) Mots-clés : Adolescent  Adult  Asian People  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Female  Humans  Male  ROC Curve  Reproducibility of Results  Ados-2  Autism  Diagnosis  Validity Index. décimale : PER Périodiques Résumé : BACKGROUND: Although the Korean version of the Autism Diagnostic Observation Schedule-2 (K-ADOS-2) is widely being used to diagnose autism spectrum disorder (ASD) in South Korea, no previous study has examined the validity and reliability of all modules of K-ADOS-2 across a wide age range, particularly older children, adolescents, and adults. METHOD: Data from 2,158 participants were included (mean age=79.7 months; 73.6% male): 1473 participants with ASD and 685 participants without ASD (Toddler Module, n=289; Module 1, n=642; Module 2 n=574; Module 3 n=411; Module 4, n=242). Participants completed a battery of tests, including the K-ADOS or K-ADOS-2 and other existing diagnostic instruments. Sensitivity, specificity, area under the receiver operating characteristic (ROC) curve, positive predictive value (PPV), negative predictive value (NPV), Cohen's kappa (k), and agreement with existing diagnostic instruments were computed. Cronbach's Î+ values were also calculated. RESULTS: All developmental cells of the K-ADOS-2 showed sufficient ranges of sensitivity 85.4-100.0%; specificity, 80.4-96.8%; area under the ROC curve, .90-.97; PPV, 77.8-99.3%; NPV, 80.6-100.0%; and k values, .83-.92. The kappa agreements of developmental cells with existing diagnostic instruments ranged from .20 to .90. Cronbach's Î+ values ranged from .82 to .91 across all developmental cells. LIMITATION: The best-estimate clinical diagnoses made in this study were not independent of the K-ADOS-2 scores. Some modules did not include balanced numbers of participants in terms of gender and diagnostic status. CONCLUSION: The K-ADOS-2 is a valid and reliable instrument in diagnosing ASD in South Korea. Future studies exploring the effectiveness of the K-ADOS-2 in capturing restricted, repetitive behaviors and differentiating ASD from other developmental disabilities are needed. En ligne : http://dx.doi.org/10.1186/s13229-022-00506-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491 [article] Diagnostic validity of Autism Diagnostic Observation Schedule, second edition (K-ADOS-2) in the Korean population [Texte imprimé et/ou numérique] / So Yoon KIM, Auteur ; Miae OH, Auteur ; Guiyoung BONG, Auteur ; Da-Yea SONG, Auteur ; Nan-He YOON, Auteur ; Joo Hyun KIM, Auteur ; Hee Jeong YOO, Auteur . - 30 p. Langues : Anglais (eng) in Molecular Autism > 13 (2022) . - 30 p. Mots-clés : Adolescent  Adult  Asian People  Autism Spectrum Disorder/diagnosis  Autistic Disorder  Child  Female  Humans  Male  ROC Curve  Reproducibility of Results  Ados-2  Autism  Diagnosis  Validity Index. décimale : PER Périodiques Résumé : BACKGROUND: Although the Korean version of the Autism Diagnostic Observation Schedule-2 (K-ADOS-2) is widely being used to diagnose autism spectrum disorder (ASD) in South Korea, no previous study has examined the validity and reliability of all modules of K-ADOS-2 across a wide age range, particularly older children, adolescents, and adults. METHOD: Data from 2,158 participants were included (mean age=79.7 months; 73.6% male): 1473 participants with ASD and 685 participants without ASD (Toddler Module, n=289; Module 1, n=642; Module 2 n=574; Module 3 n=411; Module 4, n=242). Participants completed a battery of tests, including the K-ADOS or K-ADOS-2 and other existing diagnostic instruments. Sensitivity, specificity, area under the receiver operating characteristic (ROC) curve, positive predictive value (PPV), negative predictive value (NPV), Cohen's kappa (k), and agreement with existing diagnostic instruments were computed. Cronbach's Î+ values were also calculated. RESULTS: All developmental cells of the K-ADOS-2 showed sufficient ranges of sensitivity 85.4-100.0%; specificity, 80.4-96.8%; area under the ROC curve, .90-.97; PPV, 77.8-99.3%; NPV, 80.6-100.0%; and k values, .83-.92. The kappa agreements of developmental cells with existing diagnostic instruments ranged from .20 to .90. Cronbach's Î+ values ranged from .82 to .91 across all developmental cells. LIMITATION: The best-estimate clinical diagnoses made in this study were not independent of the K-ADOS-2 scores. Some modules did not include balanced numbers of participants in terms of gender and diagnostic status. CONCLUSION: The K-ADOS-2 is a valid and reliable instrument in diagnosing ASD in South Korea. Future studies exploring the effectiveness of the K-ADOS-2 in capturing restricted, repetitive behaviors and differentiating ASD from other developmental disabilities are needed. En ligne : http://dx.doi.org/10.1186/s13229-022-00506-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=491

Exploring sex differences in the manifestation of autistic traits in young children / Da-Yea SONG in Research in Autism Spectrum Disorders, 88 (October 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 88 (October 2021) . - 101848 Titre : Exploring sex differences in the manifestation of autistic traits in young children Type de document : Texte imprimé et/ou numérique Auteurs : Da-Yea SONG, Auteur ; So Yoon KIM, Auteur ; Guiyoung BONG, Auteur ; Young Ah KIM, Auteur ; Joo Hyun KIM, Auteur ; Jong-Myeong KIM, Auteur ; Hee Jeong YOO, Auteur Article en page(s) : 101848 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Sex differences  Phenotype  Social communication  Restricted repetitive behaviors Index. décimale : PER Périodiques Résumé : Background Previous works attempting to document sex differences in younger children with autism spectrum disorder (ASD) have yielded inconsistent results. Therefore, this study aimed to investigate potential sex differences in the manifestation of ASD-related features in toddlers and preschoolers with ASD, typical development (TD), and other developmental disorders (OD). Method Analyses were conducted using a sample of 557 young children, aged 18?42 months, composed of 261 participants with ASD (n = 207 males; n = 54 females), 223 TD (n = 133 males; n = 90 females), and 73 with OD (n = 45 males; n = 28 females). A battery of tests, including the gold standard ASD diagnostic assessments and caregiver questionnaires, were used to measure symptomatology. We implemented ANCOVA while covarying for adaptive skills to detect sex differences in ASD trait presentation. Results The ASD group demonstrated significant differences in the parent-report social interaction domain with more deficits in females than males, while the TD and OD groups found that males exhibited more restricted or repetitive behaviors (RRB) than females. When the participants were limited to children over 24 months to ensure good diagnostic validity, the same patterns in traits by sex were observed, except in the OD group, suggesting that the younger children might have driven the significant findings. Conclusion Sex differences in the social interaction domain were reported by parents of children with ASD, while children in the non-ASD groups exhibited differences in RRBs. Therefore, healthcare professionals should become aware of the different presentational profiles in young children to prevent over or under detection of ASD. En ligne : https://doi.org/10.1016/j.rasd.2021.101848 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Exploring sex differences in the manifestation of autistic traits in young children [Texte imprimé et/ou numérique] / Da-Yea SONG, Auteur ; So Yoon KIM, Auteur ; Guiyoung BONG, Auteur ; Young Ah KIM, Auteur ; Joo Hyun KIM, Auteur ; Jong-Myeong KIM, Auteur ; Hee Jeong YOO, Auteur . - 101848. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 88 (October 2021) . - 101848 Mots-clés : Autism spectrum disorder  Sex differences  Phenotype  Social communication  Restricted repetitive behaviors Index. décimale : PER Périodiques Résumé : Background Previous works attempting to document sex differences in younger children with autism spectrum disorder (ASD) have yielded inconsistent results. Therefore, this study aimed to investigate potential sex differences in the manifestation of ASD-related features in toddlers and preschoolers with ASD, typical development (TD), and other developmental disorders (OD). Method Analyses were conducted using a sample of 557 young children, aged 18?42 months, composed of 261 participants with ASD (n = 207 males; n = 54 females), 223 TD (n = 133 males; n = 90 females), and 73 with OD (n = 45 males; n = 28 females). A battery of tests, including the gold standard ASD diagnostic assessments and caregiver questionnaires, were used to measure symptomatology. We implemented ANCOVA while covarying for adaptive skills to detect sex differences in ASD trait presentation. Results The ASD group demonstrated significant differences in the parent-report social interaction domain with more deficits in females than males, while the TD and OD groups found that males exhibited more restricted or repetitive behaviors (RRB) than females. When the participants were limited to children over 24 months to ensure good diagnostic validity, the same patterns in traits by sex were observed, except in the OD group, suggesting that the younger children might have driven the significant findings. Conclusion Sex differences in the social interaction domain were reported by parents of children with ASD, while children in the non-ASD groups exhibited differences in RRBs. Therefore, healthcare professionals should become aware of the different presentational profiles in young children to prevent over or under detection of ASD. En ligne : https://doi.org/10.1016/j.rasd.2021.101848 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

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