Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study / Linyan FU in Autism Research, 15-4 (April 2022)  

Public ISBD [article]  inAutism Research > 15-4 (April 2022) . - p.628-640 Titre : Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study Type de document : Texte imprimé et/ou numérique Auteurs : Linyan FU, Auteur ; Chunyan LI, Auteur ; Yun LI, Auteur ; Xin CHENG, Auteur ; Xiwen CUI, Auteur ; Jiying JIANG, Auteur ; Ning DING, Auteur ; Hui FANG, Auteur ; Tianyu TANG, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.628-640 Langues : Anglais (eng) Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/genetics  Child  Child, Preschool  Diffusion Magnetic Resonance Imaging  Diffusion Tensor Imaging/methods  Humans  White Matter  autism spectrum disorder  environmental effects  genetic factors  limbic tracts  twins Index. décimale : PER Périodiques Résumé : Although the limbic system is closely related to emotion and social behaviors, little is known about the integrity of limbic pathways and how genetics influence the anatomical abnormalities of limbic networks in children with autism spectrum disorder (ASD). Therefore, we used an ASD twin study design to evaluate the microstructural integrity and autism-related differences in limbic pathways of young children with ASD and to estimate the heritability of limbic tracts microstructure variance. We obtained diffusion tensor imaging scans from 33 pairs of twins with ASD aged 2-9?years and 20 age-matched typically developing children. The ACE model was used to estimate the relative effects of additive genetic factors (A), shared environmental factors (C) and specific environmental factors (E) on the variability of diffusivity measurements. We found a significant decrease in fractional anisotropy (FA) in the bilateral fornix and uncinate fasciculus (UF), as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the bilateral fornix and right UF of ASD children. Correlation analysis showed that FA, MD, and lateralization indices of UF were correlated with autism diagnostic observation schedule scores. The ACE model revealed that genetic effects may drive some of the variability of microstructure in the bilateral fornix, cingulum, and left UF. In conclusion, in children with ASD, there are abnormalities in the white matter microstructure of the limbic system, which is related to the core symptoms; these abnormalities may be related to the relative contribution of genetic and environmental effects on specific tracts. LAY SUMMARY: Autism spectrum disorder (ASD) children have abnormal white matter structure in limbic system related to ASD symptoms, and genetic factors play an important role in the development of limbic tracts. En ligne : https://dx.doi.org/10.1002/aur.2686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473 [article] Heritability of abnormalities in limbic networks of autism spectrum disorder children: Evidence from an autism spectrum disorder twin study [Texte imprimé et/ou numérique] / Linyan FU, Auteur ; Chunyan LI, Auteur ; Yun LI, Auteur ; Xin CHENG, Auteur ; Xiwen CUI, Auteur ; Jiying JIANG, Auteur ; Ning DING, Auteur ; Hui FANG, Auteur ; Tianyu TANG, Auteur ; Xiaoyan KE, Auteur . - p.628-640. Langues : Anglais (eng) in Autism Research > 15-4 (April 2022) . - p.628-640 Mots-clés : Anisotropy  Autism Spectrum Disorder/diagnostic imaging/genetics  Child  Child, Preschool  Diffusion Magnetic Resonance Imaging  Diffusion Tensor Imaging/methods  Humans  White Matter  autism spectrum disorder  environmental effects  genetic factors  limbic tracts  twins Index. décimale : PER Périodiques Résumé : Although the limbic system is closely related to emotion and social behaviors, little is known about the integrity of limbic pathways and how genetics influence the anatomical abnormalities of limbic networks in children with autism spectrum disorder (ASD). Therefore, we used an ASD twin study design to evaluate the microstructural integrity and autism-related differences in limbic pathways of young children with ASD and to estimate the heritability of limbic tracts microstructure variance. We obtained diffusion tensor imaging scans from 33 pairs of twins with ASD aged 2-9?years and 20 age-matched typically developing children. The ACE model was used to estimate the relative effects of additive genetic factors (A), shared environmental factors (C) and specific environmental factors (E) on the variability of diffusivity measurements. We found a significant decrease in fractional anisotropy (FA) in the bilateral fornix and uncinate fasciculus (UF), as well as increased mean diffusivity (MD) and radial diffusivity (RD) in the bilateral fornix and right UF of ASD children. Correlation analysis showed that FA, MD, and lateralization indices of UF were correlated with autism diagnostic observation schedule scores. The ACE model revealed that genetic effects may drive some of the variability of microstructure in the bilateral fornix, cingulum, and left UF. In conclusion, in children with ASD, there are abnormalities in the white matter microstructure of the limbic system, which is related to the core symptoms; these abnormalities may be related to the relative contribution of genetic and environmental effects on specific tracts. LAY SUMMARY: Autism spectrum disorder (ASD) children have abnormal white matter structure in limbic system related to ASD symptoms, and genetic factors play an important role in the development of limbic tracts. En ligne : https://dx.doi.org/10.1002/aur.2686 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=473

High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study / Yonglu WANG in Autism Research, 16-10 (October 2023)  

Public ISBD [article]  inAutism Research > 16-10 (October 2023) . - p.2035-2048 Titre : High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study Type de document : Texte imprimé et/ou numérique Auteurs : Yonglu WANG, Auteur ; Fei WANG, Auteur ; Yue KONG, Auteur ; Tianshu GAO, Auteur ; Qingyao ZHU, Auteur ; Lu HAN, Auteur ; Bei SUN, Auteur ; Luyang GUAN, Auteur ; Ziyi ZHANG, Auteur ; Yuxin QIAN, Auteur ; Lingxi XU, Auteur ; Yun LI, Auteur ; Hui FANG, Auteur ; Gongkai JIAO, Auteur ; Xiaoyan KE, Auteur Article en page(s) : p.2035-2048 Index. décimale : PER Périodiques Résumé : Abstract The purpose of this study was to determine the effect of the Cz of high-definition 5-channel tDCS (HD-tDCS) on social function in 4-12 years-old children with autism spectrum disorder (ASD). This study was a randomized, double-blind, pseudo-controlled trial in which 45 ASD children were recruited and divided into three groups with sex, age, and rehabilitation treatment as control variables. Each group of 15 children with ASD was randomly administered active HD-tDCS with the Cz as the central anode, active HD-tDCS with the left dorsolateral prefrontal cortex (F3) as the central anode, and sham HD-tDCS with the Cz as the central anode with 14 daily sessions in 3?weeks. The Social Responsiveness Scale Chinese Version (SRS-Chinese Version) was compared 1?week after stimulation with values recorded 1?week prior to stimulation. At the end of treatment, both the anodal Cz and anodal left DLFPC tDCS decreased the measures of SRS-Chinese Version. The total score of SRS-Chinese Version decreased by 13.08%, social cognition decreased by 18.33%, and social communication decreased by 10.79%, which were significantly improved over the Cz central anode active stimulation group, especially in children with young age, and middle and low function. There was no significant change in the total score and subscale score of SRS-Chinese Version over the Cz central anode sham stimulation group. In the F3 central anode active stimulation group, the total score of SRS-Chinese Version decreased by 13%, autistic behavior decreased by 19.39%, and social communication decreased by 14.39%, which were all significantly improved. However, there was no significant difference in effect between the Cz and left DLPFC stimulation conditions. HD-tDCS of the Cz central anode may be an effective treatment for social dysfunction in children with ASD. En ligne : https://doi.org/10.1002/aur.3018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 [article] High definition transcranial direct current stimulation of the Cz improves social dysfunction in children with autism spectrum disorder: A randomized, sham, controlled study [Texte imprimé et/ou numérique] / Yonglu WANG, Auteur ; Fei WANG, Auteur ; Yue KONG, Auteur ; Tianshu GAO, Auteur ; Qingyao ZHU, Auteur ; Lu HAN, Auteur ; Bei SUN, Auteur ; Luyang GUAN, Auteur ; Ziyi ZHANG, Auteur ; Yuxin QIAN, Auteur ; Lingxi XU, Auteur ; Yun LI, Auteur ; Hui FANG, Auteur ; Gongkai JIAO, Auteur ; Xiaoyan KE, Auteur . - p.2035-2048. in Autism Research > 16-10 (October 2023) . - p.2035-2048 Index. décimale : PER Périodiques Résumé : Abstract The purpose of this study was to determine the effect of the Cz of high-definition 5-channel tDCS (HD-tDCS) on social function in 4-12 years-old children with autism spectrum disorder (ASD). This study was a randomized, double-blind, pseudo-controlled trial in which 45 ASD children were recruited and divided into three groups with sex, age, and rehabilitation treatment as control variables. Each group of 15 children with ASD was randomly administered active HD-tDCS with the Cz as the central anode, active HD-tDCS with the left dorsolateral prefrontal cortex (F3) as the central anode, and sham HD-tDCS with the Cz as the central anode with 14 daily sessions in 3?weeks. The Social Responsiveness Scale Chinese Version (SRS-Chinese Version) was compared 1?week after stimulation with values recorded 1?week prior to stimulation. At the end of treatment, both the anodal Cz and anodal left DLFPC tDCS decreased the measures of SRS-Chinese Version. The total score of SRS-Chinese Version decreased by 13.08%, social cognition decreased by 18.33%, and social communication decreased by 10.79%, which were significantly improved over the Cz central anode active stimulation group, especially in children with young age, and middle and low function. There was no significant change in the total score and subscale score of SRS-Chinese Version over the Cz central anode sham stimulation group. In the F3 central anode active stimulation group, the total score of SRS-Chinese Version decreased by 13%, autistic behavior decreased by 19.39%, and social communication decreased by 14.39%, which were all significantly improved. However, there was no significant difference in effect between the Cz and left DLPFC stimulation conditions. HD-tDCS of the Cz central anode may be an effective treatment for social dysfunction in children with ASD. En ligne : https://doi.org/10.1002/aur.3018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513

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