Altered task?related modulation of long?range connectivity in children with autism / Ajay S. PILLAI in Autism Research, 11-2 (February 2018)  

Public ISBD [article]  inAutism Research > 11-2 (February 2018) . - p.245-257 Titre : Altered task?related modulation of long?range connectivity in children with autism Type de document : Texte imprimé et/ou numérique Auteurs : Ajay S. PILLAI, Auteur ; Danielle MCAULIFFE, Auteur ; Balaji M. LAKSHMANAN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nathan E. CRONE, Auteur ; Joshua B. EWEN, Auteur Année de publication : 2018 Article en page(s) : p.245-257 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task?related changes in connectivity in disorder?relevant behavioral paradigms. In this paper, we examined the task?related changes in functional connectivity using EEG and a movement?based paradigm that has behavioral relevance to ASD. Resting?state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor?control task. Contrary to our initial hypothesis, however, we observed that task?related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task?related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Decreased connectivity between brain regions is thought to cause the symptoms of autism. Because most of our knowledge comes from data in which children are at rest, we do not know how connectivity changes directly lead to autistic behaviors, such as impaired gestures. When typically developing children produced complex movements, connectivity decreased between brain regions. In children with autism, connectivity increased. It may be that behavior?related changes in brain connectivity are more important than absolute differences in connectivity in autism. En ligne : https://doi.org/10.1002/aur.1858 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334 [article] Altered task?related modulation of long?range connectivity in children with autism [Texte imprimé et/ou numérique] / Ajay S. PILLAI, Auteur ; Danielle MCAULIFFE, Auteur ; Balaji M. LAKSHMANAN, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Nathan E. CRONE, Auteur ; Joshua B. EWEN, Auteur . - 2018 . - p.245-257. Langues : Anglais (eng) in Autism Research > 11-2 (February 2018) . - p.245-257 Index. décimale : PER Périodiques Résumé : Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task?related changes in connectivity in disorder?relevant behavioral paradigms. In this paper, we examined the task?related changes in functional connectivity using EEG and a movement?based paradigm that has behavioral relevance to ASD. Resting?state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor?control task. Contrary to our initial hypothesis, however, we observed that task?related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task?related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Decreased connectivity between brain regions is thought to cause the symptoms of autism. Because most of our knowledge comes from data in which children are at rest, we do not know how connectivity changes directly lead to autistic behaviors, such as impaired gestures. When typically developing children produced complex movements, connectivity decreased between brain regions. In children with autism, connectivity increased. It may be that behavior?related changes in brain connectivity are more important than absolute differences in connectivity in autism. En ligne : https://doi.org/10.1002/aur.1858 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=334

Automated and scalable Computerized Assessment of Motor Imitation (CAMI) in children with Autism Spectrum Disorder using a single 2D camera: A pilot study / Daniel E. LIDSTONE in Research in Autism Spectrum Disorders, 87 (September 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 87 (September 2021) . - 101840 Titre : Automated and scalable Computerized Assessment of Motor Imitation (CAMI) in children with Autism Spectrum Disorder using a single 2D camera: A pilot study Type de document : Texte imprimé et/ou numérique Auteurs : Daniel E. LIDSTONE, Auteur ; Rebecca ROCHOWIAK, Auteur ; Carolina PACHECO, Auteur ; Bahar TUNÇGENÇ, Auteur ; Rene VIDAL, Auteur ; Stewart H. MOSTOFSKY, Auteur Article en page(s) : 101840 Langues : Anglais (eng) Mots-clés : Autism  Imitation  Intervention  Social behavior  OpenPose Index. décimale : PER Périodiques Résumé : Background Motor imitation difficulties are pervasive in children with Autism Spectrum Disorder (ASD). Previous research demonstrated the validity and reliability of an algorithm called Computerized Assessment of Motor Imitation (CAMI) using 3D depth cameras. However, incorporating CAMI into serious games and making it accessible in clinic and home settings requires a more scalable approach that uses “off-the-shelf” 2D cameras. Method In a brief (one-minute) task, children (23 ASD, 17 typically developing [TD]) imitated a model’s dance movements while simultaneously being recorded using Kinect Xbox motion tracking technology (Kinect 3D) and a single 2D camera. Pose-estimation software (OpenPose 2D) was used on the 2D camera video to fit a skeleton to the imitating child. Motor imitation scores computed from the fully automated OpenPose 2D CAMI method were compared to scores computed from the Kinect 3D CAMI and Human Observation Coding (HOC) methods. Results Motor imitation scores obtained from the OpenPose 2D CAMI method were significantly correlated with scores obtained from the Kinect 3D CAMI method (r40 = 0.82, p < 0.001) and the HOC method (r40 = 0.80, p < 0.001). Both 2D and 3D CAMI methods showed better discriminative ability than the HOC, with the Kinect 3D CAMI method outperforming the OpenPose 2D CAMI method (area under ROC curve (AUC): AUCHOC = 0.799, AUC2D-CAMI = 0.876, AUC3D-CAMI = 0.94). Finally, all motor imitation scores were significantly associated with the social-communication impairment (all p ? 0.003). Conclusions This pilot-study demonstrated that motor imitation can be automatically quantified using a single 2D camera. En ligne : https://doi.org/10.1016/j.rasd.2021.101840 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Automated and scalable Computerized Assessment of Motor Imitation (CAMI) in children with Autism Spectrum Disorder using a single 2D camera: A pilot study [Texte imprimé et/ou numérique] / Daniel E. LIDSTONE, Auteur ; Rebecca ROCHOWIAK, Auteur ; Carolina PACHECO, Auteur ; Bahar TUNÇGENÇ, Auteur ; Rene VIDAL, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 101840. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 87 (September 2021) . - 101840 Mots-clés : Autism  Imitation  Intervention  Social behavior  OpenPose Index. décimale : PER Périodiques Résumé : Background Motor imitation difficulties are pervasive in children with Autism Spectrum Disorder (ASD). Previous research demonstrated the validity and reliability of an algorithm called Computerized Assessment of Motor Imitation (CAMI) using 3D depth cameras. However, incorporating CAMI into serious games and making it accessible in clinic and home settings requires a more scalable approach that uses “off-the-shelf” 2D cameras. Method In a brief (one-minute) task, children (23 ASD, 17 typically developing [TD]) imitated a model’s dance movements while simultaneously being recorded using Kinect Xbox motion tracking technology (Kinect 3D) and a single 2D camera. Pose-estimation software (OpenPose 2D) was used on the 2D camera video to fit a skeleton to the imitating child. Motor imitation scores computed from the fully automated OpenPose 2D CAMI method were compared to scores computed from the Kinect 3D CAMI and Human Observation Coding (HOC) methods. Results Motor imitation scores obtained from the OpenPose 2D CAMI method were significantly correlated with scores obtained from the Kinect 3D CAMI method (r40 = 0.82, p < 0.001) and the HOC method (r40 = 0.80, p < 0.001). Both 2D and 3D CAMI methods showed better discriminative ability than the HOC, with the Kinect 3D CAMI method outperforming the OpenPose 2D CAMI method (area under ROC curve (AUC): AUCHOC = 0.799, AUC2D-CAMI = 0.876, AUC3D-CAMI = 0.94). Finally, all motor imitation scores were significantly associated with the social-communication impairment (all p ? 0.003). Conclusions This pilot-study demonstrated that motor imitation can be automatically quantified using a single 2D camera. En ligne : https://doi.org/10.1016/j.rasd.2021.101840 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Brain glutathione and GABA+ levels in autistic children / Yulu SONG in Autism Research, 17-3 (March 2024)  

Public ISBD [article]  inAutism Research > 17-3 (March 2024) . - p.512-528 Titre : Brain glutathione and GABA+ levels in autistic children Type de document : Texte imprimé et/ou numérique Auteurs : Yulu SONG, Auteur ; Kathleen E. HUPFELD, Auteur ; Christopher W. DAVIES-JENKINS, Auteur ; Helge J. ZÖLLNER, Auteur ; Saipavitra MURALI-MANOHAR, Auteur ; Abdul Nashirudeen MUMUNI, Auteur ; Deana CROCETTI, Auteur ; Vivek YEDAVALLI, Auteur ; Georg OELTZSCHNER, Auteur ; Natalie ALESSI, Auteur ; Mitchell A. BATSCHELETT, Auteur ; Nicolaas A. J. PUTS, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur Article en page(s) : p.512-528 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA), have been proposed as potential contributors to the biology underlying ASD. This study investigated whether cerebral GSH or GABA levels differ between a cohort of children aged 8-12?years with ASD (n = 52) and typically developing children (TDC, n = 49). A comprehensive analysis of GSH and GABA levels in multiple brain regions, including the primary motor cortex (SM1), thalamus (Thal), medial prefrontal cortex (mPFC), and supplementary motor area (SMA), was conducted using single-voxel HERMES MR spectroscopy at 3T. The results revealed no significant differences in cerebral GSH or GABA levels between the ASD and TDC groups across all examined regions. These findings suggest that the concentrations of GSH (an important antioxidant and neuromodulator) and GABA (a major inhibitory neurotransmitter) do not exhibit marked alterations in children with ASD compared to TDC. A statistically significant positive correlation was observed between GABA levels in the SM1 and Thal regions with ADHD inattention scores. No significant correlation was found between metabolite levels and hyper/impulsive scores of ADHD, measures of core ASD symptoms (ADOS-2, SRS-P) or adaptive behavior (ABAS-2). While both GSH and GABA have been implicated in various neurological disorders, the current study provides valuable insights into the specific context of ASD and highlights the need for further research to explore other neurochemical alterations that may contribute to the pathophysiology of this complex disorder. En ligne : https://doi.org/10.1002/aur.3097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525 [article] Brain glutathione and GABA+ levels in autistic children [Texte imprimé et/ou numérique] / Yulu SONG, Auteur ; Kathleen E. HUPFELD, Auteur ; Christopher W. DAVIES-JENKINS, Auteur ; Helge J. ZÖLLNER, Auteur ; Saipavitra MURALI-MANOHAR, Auteur ; Abdul Nashirudeen MUMUNI, Auteur ; Deana CROCETTI, Auteur ; Vivek YEDAVALLI, Auteur ; Georg OELTZSCHNER, Auteur ; Natalie ALESSI, Auteur ; Mitchell A. BATSCHELETT, Auteur ; Nicolaas A. J. PUTS, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Richard A. E. EDDEN, Auteur . - p.512-528. Langues : Anglais (eng) in Autism Research > 17-3 (March 2024) . - p.512-528 Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered neurometabolite levels, including glutathione (GSH) and gamma-aminobutyric acid (GABA), have been proposed as potential contributors to the biology underlying ASD. This study investigated whether cerebral GSH or GABA levels differ between a cohort of children aged 8-12?years with ASD (n = 52) and typically developing children (TDC, n = 49). A comprehensive analysis of GSH and GABA levels in multiple brain regions, including the primary motor cortex (SM1), thalamus (Thal), medial prefrontal cortex (mPFC), and supplementary motor area (SMA), was conducted using single-voxel HERMES MR spectroscopy at 3T. The results revealed no significant differences in cerebral GSH or GABA levels between the ASD and TDC groups across all examined regions. These findings suggest that the concentrations of GSH (an important antioxidant and neuromodulator) and GABA (a major inhibitory neurotransmitter) do not exhibit marked alterations in children with ASD compared to TDC. A statistically significant positive correlation was observed between GABA levels in the SM1 and Thal regions with ADHD inattention scores. No significant correlation was found between metabolite levels and hyper/impulsive scores of ADHD, measures of core ASD symptoms (ADOS-2, SRS-P) or adaptive behavior (ABAS-2). While both GSH and GABA have been implicated in various neurological disorders, the current study provides valuable insights into the specific context of ASD and highlights the need for further research to explore other neurochemical alterations that may contribute to the pathophysiology of this complex disorder. En ligne : https://doi.org/10.1002/aur.3097 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=525

Brief Report: Enhanced Picture Naming in Autism / Matthew WALENSKI in Journal of Autism and Developmental Disorders, 38-7 (August 2008)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 38-7 (August 2008) . - p.1395-1399 Titre : Brief Report: Enhanced Picture Naming in Autism Type de document : Texte imprimé et/ou numérique Auteurs : Matthew WALENSKI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Jennifer C. GIDLEY-LARSON, Auteur ; Michael T. ULLMAN, Auteur Année de publication : 2008 Article en page(s) : p.1395-1399 Langues : Anglais (eng) Mots-clés : Autism Language Memory Sex-difference Index. décimale : PER Périodiques Résumé : Language and communication deficits are key diagnostic criteria for autism. However, not all aspects of language are equally affected. Here we present evidence of enhanced performance of a critical aspect of language—word processing—in children with autism. The results have implications for explanatory theories of autism and language, and for the development of therapeutic approaches. En ligne : http://dx.doi.org/10.1007/s10803-007-0513-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Brief Report: Enhanced Picture Naming in Autism [Texte imprimé et/ou numérique] / Matthew WALENSKI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Jennifer C. GIDLEY-LARSON, Auteur ; Michael T. ULLMAN, Auteur . - 2008 . - p.1395-1399. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 38-7 (August 2008) . - p.1395-1399 Mots-clés : Autism Language Memory Sex-difference Index. décimale : PER Périodiques Résumé : Language and communication deficits are key diagnostic criteria for autism. However, not all aspects of language are equally affected. Here we present evidence of enhanced performance of a critical aspect of language—word processing—in children with autism. The results have implications for explanatory theories of autism and language, and for the development of therapeutic approaches. En ligne : http://dx.doi.org/10.1007/s10803-007-0513-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Cerebellar gray matter differentiates children with early language delay in autism / Anila M. D'MELLO in Autism Research, 9-11 (November 2016)  

Public ISBD [article]  inAutism Research > 9-11 (November 2016) . - p.1191-1204 Titre : Cerebellar gray matter differentiates children with early language delay in autism Type de document : Texte imprimé et/ou numérique Auteurs : Anila M. D'MELLO, Auteur ; Dorothea M. MOORE, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Catherine J. STOODLEY, Auteur Article en page(s) : p.1191-1204 Langues : Anglais (eng) Mots-clés : autism  cerebellum  early language delay  voxel-based morphometry  ADOS  imaging Index. décimale : PER Périodiques Résumé : Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8–13 year old children with autism (n?=?13 ELD; n?=?22 non-ELD) and 35 age-matched typically developing (TD) children. Multiple regression analyses examined the relationships between GM, age of first word/phrase, and autism diagnostic observation schedule (ADOS) scores. Composite age of first word/phrase negatively correlated with GM throughout the cerebellum. Both ASD groups (ELD and non-ELD) had reduced GM in right cerebellar Crus I/II when compared to TD children. Left cerebellar Crus I/II was the only region in the brain that differentiated ELD and non-ELD children, with ELD children showing reduced GM relative to both non-ELD and TD groups. Group×score interactions converged in left Crus I/II, such that the non-ELD group showed poorer ADOS scores with increasing GM, whereas the ELD group showed poorer ADOS scores as GM decreased. Reduced GM in right cerebellar Crus I/I was related ASD diagnosis, while children with ELD showed additional reduced GM in left Crus I/II. These findings highlight the importance of specific cerebellar networks in both ASD and early language development, and suggest that bilateral disruption in cerebellar regions that interconnect with fronto-parietal networks could impact language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 [article] Cerebellar gray matter differentiates children with early language delay in autism [Texte imprimé et/ou numérique] / Anila M. D'MELLO, Auteur ; Dorothea M. MOORE, Auteur ; Deana CROCETTI, Auteur ; Stewart H. MOSTOFSKY, Auteur ; Catherine J. STOODLEY, Auteur . - p.1191-1204. Langues : Anglais (eng) in Autism Research > 9-11 (November 2016) . - p.1191-1204 Mots-clés : autism  cerebellum  early language delay  voxel-based morphometry  ADOS  imaging Index. décimale : PER Périodiques Résumé : Early language delay (ELD) is one of the earliest indicators of autism spectrum disorder (ASD), and predicts later cognitive and behavioral outcomes. We aimed to determine the neural correlates of ELD in autism, and examine the relationships between gray matter (GM), age of first word/phrase, and core ASD symptoms. We used voxel-based morphometry to examine whole-brain differences in GM in 8–13 year old children with autism (n?=?13 ELD; n?=?22 non-ELD) and 35 age-matched typically developing (TD) children. Multiple regression analyses examined the relationships between GM, age of first word/phrase, and autism diagnostic observation schedule (ADOS) scores. Composite age of first word/phrase negatively correlated with GM throughout the cerebellum. Both ASD groups (ELD and non-ELD) had reduced GM in right cerebellar Crus I/II when compared to TD children. Left cerebellar Crus I/II was the only region in the brain that differentiated ELD and non-ELD children, with ELD children showing reduced GM relative to both non-ELD and TD groups. Group×score interactions converged in left Crus I/II, such that the non-ELD group showed poorer ADOS scores with increasing GM, whereas the ELD group showed poorer ADOS scores as GM decreased. Reduced GM in right cerebellar Crus I/I was related ASD diagnosis, while children with ELD showed additional reduced GM in left Crus I/II. These findings highlight the importance of specific cerebellar networks in both ASD and early language development, and suggest that bilateral disruption in cerebellar regions that interconnect with fronto-parietal networks could impact language acquisition in ASD. En ligne : http://dx.doi.org/10.1002/aur.1622 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297

Could Sensory Differences Be a Sex-Indifferent Biomarker of Autism? Early Investigation Comparing Tactile Sensitivity Between Autistic Males and Females / Ericka L. WODKA ; Richard A. E. EDDEN ; Stewart H. MOSTOFSKY ; Nicolaas A. J. PUTS ; Jason L. HE in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

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Developmental deviation in delay discounting as a transdiagnostic indicator of risk for child psychopathology / Keri S. ROSCH ; Stewart H. MOSTOFSKY ; Aki NIKOLAIDIS in Journal of Child Psychology and Psychiatry, 65-2 (February 2024)  

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Dyspraxia in ASD: Impaired coordination of movement elements / Danielle MCAULIFFE in Autism Research, 10-4 (April 2017)  

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Evidence for Impairments in Using Static Line Drawings of Eye Gaze Cues to Orient Visual-Spatial Attention in Children with High Functioning Autism / Melissa C. GOLDBERG in Journal of Autism and Developmental Disorders, 38-8 (September 2008)  

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Evidence that the pattern of visuomotor sequence learning is altered in children with autism / Jennifer C. GIDLEY-LARSON in Autism Research, 1-6 (December 2008)  

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Examining the latent structure and correlates of sensory reactivity in autism: a multi-site integrative data analysis by the autism sensory research consortium / Roseann SCHAAF ; Karla K. AUSDERAU ; Grace T. BARANEK ; D Jonah BARRETT ; Carissa J. CASCIO ; Rachel L. DUMONT ; Ekomobong E. Eyoh ; Michelle D. FAILLA ; Jacob I. FELDMAN ; Jennifer H. FOSS-FEIG ; Heather L. GREEN ; Shulamite A. GREEN ; Jason L. HE ; Elizabeth A. KAPLAN-KAHN ; Bahar KEÇELI-KAYS?L? ; Keren MACLENNAN ; Zoe MAILLOUX ; Elysa J. MARCO ; Lisa E. MASH ; Elizabeth P. MCKERNAN ; Sophie MOLHOLM ; Stewart H. MOSTOFSKY ; Nicolaas A. J. PUTS ; Caroline E. ROBERTSON ; Natalie RUSSO ; Nicole SHEA ; John SIDERIS ; James S. SUTCLIFFE ; Teresa TAVASSOLI ; Mark T. WALLACE ; Ericka L. WODKA ; Tiffany G. WOYNAROSKI in Molecular Autism, 14 (2023)  

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Examining the reinforcing value of stimuli within social and non-social contexts in children with and without high-functioning autism / Melissa C. GOLDBERG in Autism, 21-7 (October 2017)  

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Exploring the Symptom Profiles of Intolerance of Uncertainty in Autistic Children / Vini SINGH ; Yeon Sik JANG ; Leigh ALON ; Madison SURMACZ ; Calliope HOLINGUE ; Stewart H. MOSTOFSKY ; Roma A. VASA in Journal of Autism and Developmental Disorders, 54-1 (January 2024)  

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Inflectional morphology in high-functioning autism: Evidence for speeded grammatical processing / Matthew WALENSKI in Research in Autism Spectrum Disorders, 8-11 (November 2014)  

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Isolating Visual and Proprioceptive Components of Motor Sequence Learning in ASD / Elizabeth A. SHARER in Autism Research, 9-5 (May 2016)  

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