Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder / Peng QING in Molecular Autism, 15 (2024)  

Public ISBD [article]  inMolecular Autism > 15 (2024) . - 43p. Titre : Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Peng QING, Auteur ; Xiaodong ZHANG, Auteur ; Qi LIU, Auteur ; Linghong HUANG, Auteur ; Dan XU, Auteur ; Jiao LE, Auteur ; Keith M. KENDRICK, Auteur ; Hua LAI, Auteur ; Weihua ZHAO, Auteur Article en page(s) : 43p. Langues : Anglais (eng) Mots-clés : Humans  White Matter/diagnostic imaging/pathology/physiopathology  Autism Spectrum Disorder/physiopathology/diagnostic imaging  Male  Female  Diffusion Tensor Imaging  Adolescent  Child  Adult  Young Adult  Structure-Activity Relationship  Magnetic Resonance Imaging  Autism spectrum disorder  Diffusion tensor  Functional connectivity tensor  Structure-function coupling  White matter tracts Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder associated with alterations in structural and functional coupling in gray matter. However, despite the detectability and modulation of brain signals in white matter, the structure-function coupling in white matter in autism remains less explored. METHODS: In this study, we investigated structural-functional coupling in white matter (WM) regions, by integrating diffusion tensor data that contain fiber orientation information from WM tracts, with functional connectivity tensor data that reflect local functional anisotropy information. Using functional and diffusion magnetic resonance images, we analyzed a cohort of 89 ASD and 63 typically developing (TD) individuals from the Autism Brain Imaging Data Exchange II (ABIDE-II). Subsequently, the associations between structural-functional coupling in WM regions and ASD severity symptoms assessed by Autism Diagnostic Observation Schedule-2 were examined via supervised machine learning in an independent test cohort of 29 ASD individuals. Furthermore, we also compared the performance of multi-model features (i.e. structural-functional coupling) with single-model features (i.e. functional or structural models alone). RESULTS: In the discovery cohort (ABIDE-II), individuals with ASD exhibited widespread reductions in structural-functional coupling in WM regions compared to TD individuals, particularly in commissural tracts (e.g. corpus callosum), association tracts (sagittal stratum), and projection tracts (e.g. internal capsule). Notably, supervised machine learning analysis in the independent test cohort revealed a significant correlation between these alterations in structural-functional coupling and ASD severity scores. Furthermore, compared to single-model features, the integration of multi-model features (i.e., structural-functional coupling) performed best in predicting ASD severity scores. CONCLUSION: This work provides novel evidence for atypical structural-functional coupling in ASD in white matter regions, further refining our understanding of the critical role of WM networks in the pathophysiology of ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00620-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538 [article] Structure-function coupling in white matter uncovers the hypoconnectivity in autism spectrum disorder [Texte imprimé et/ou numérique] / Peng QING, Auteur ; Xiaodong ZHANG, Auteur ; Qi LIU, Auteur ; Linghong HUANG, Auteur ; Dan XU, Auteur ; Jiao LE, Auteur ; Keith M. KENDRICK, Auteur ; Hua LAI, Auteur ; Weihua ZHAO, Auteur . - 43p. Langues : Anglais (eng) in Molecular Autism > 15 (2024) . - 43p. Mots-clés : Humans  White Matter/diagnostic imaging/pathology/physiopathology  Autism Spectrum Disorder/physiopathology/diagnostic imaging  Male  Female  Diffusion Tensor Imaging  Adolescent  Child  Adult  Young Adult  Structure-Activity Relationship  Magnetic Resonance Imaging  Autism spectrum disorder  Diffusion tensor  Functional connectivity tensor  Structure-function coupling  White matter tracts Index. décimale : PER Périodiques Résumé : BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder associated with alterations in structural and functional coupling in gray matter. However, despite the detectability and modulation of brain signals in white matter, the structure-function coupling in white matter in autism remains less explored. METHODS: In this study, we investigated structural-functional coupling in white matter (WM) regions, by integrating diffusion tensor data that contain fiber orientation information from WM tracts, with functional connectivity tensor data that reflect local functional anisotropy information. Using functional and diffusion magnetic resonance images, we analyzed a cohort of 89 ASD and 63 typically developing (TD) individuals from the Autism Brain Imaging Data Exchange II (ABIDE-II). Subsequently, the associations between structural-functional coupling in WM regions and ASD severity symptoms assessed by Autism Diagnostic Observation Schedule-2 were examined via supervised machine learning in an independent test cohort of 29 ASD individuals. Furthermore, we also compared the performance of multi-model features (i.e. structural-functional coupling) with single-model features (i.e. functional or structural models alone). RESULTS: In the discovery cohort (ABIDE-II), individuals with ASD exhibited widespread reductions in structural-functional coupling in WM regions compared to TD individuals, particularly in commissural tracts (e.g. corpus callosum), association tracts (sagittal stratum), and projection tracts (e.g. internal capsule). Notably, supervised machine learning analysis in the independent test cohort revealed a significant correlation between these alterations in structural-functional coupling and ASD severity scores. Furthermore, compared to single-model features, the integration of multi-model features (i.e., structural-functional coupling) performed best in predicting ASD severity scores. CONCLUSION: This work provides novel evidence for atypical structural-functional coupling in ASD in white matter regions, further refining our understanding of the critical role of WM networks in the pathophysiology of ASD. En ligne : https://dx.doi.org/10.1186/s13229-024-00620-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=538

The salience of competing nonsocial objects reduces gaze toward social stimuli, but not the eyes, more in typically developing than autistic boys / Xiao-E. CAI in Autism Research, 15-6 (June 2022)  

Public ISBD [article]  inAutism Research > 15-6 (June 2022) . - p.1043-1055 Titre : The salience of competing nonsocial objects reduces gaze toward social stimuli, but not the eyes, more in typically developing than autistic boys Type de document : Texte imprimé et/ou numérique Auteurs : Xiao-E. CAI, Auteur ; Jiao LE, Auteur ; Xiao-Jing SHOU, Auteur ; Gao-Wa WU-YUN, Auteur ; Xiao-Xi WANG, Auteur ; Song-Ping HAN, Auteur ; Ji-Sheng HAN, Auteur ; Keith M. KENDRICK, Auteur ; Rong ZHANG, Auteur Article en page(s) : p.1043-1055 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/psychology  Autistic Disorder  Child  Child, Preschool  Eye Movements  Eye-Tracking Technology  Humans  Male  Oxytocin  arginine-vasopressin  autism spectrum disorder  eye-tracking  salience Index. décimale : PER Périodiques Résumé : Decreased attention to social information is considered an early emerging symptom of autism spectrum disorder (ASD), although the underlying causes remain controversial. Here we explored the impact of nonsocial object salience on reduced attention to social stimuli in male ASD compared with typically developing (TD) children. Correlations with blood concentrations of neuropeptides linked with social cognition were also investigated. Eye-tracking was performed in 102 preschool-aged boys (50 ASD, 52 TD) using a paradigm with social (faces) versus nonsocial (objects) stimuli presented in pairs in two conditions where nonsocial stimulus salience was varied. Basal oxytocin (OXT) and vasopressin concentrations were measured in blood. Compared with TD boys those with ASD viewed social stimuli less only when they were paired with low-salience nonsocial objects. Additionally, boys with ASD spent less time than TD ones viewing facial features, particularly the eyes. In TD boys, OXT concentrations and cognitive development scores were positively associated with time spent viewing the eye region, whereas for boys with ASD associations with time spent viewing faces were negative. Reduced gaze toward social stimuli in ASD relative to TD individuals may therefore be influenced by how salient the paired nonsocial objects are for the latter. On the other hand, reduced interest in the eyes of faces in boys with ASD is not influenced by how salient competing nonsocial stimuli are. Basal OXT concentrations and cognitive development scores are predictive of time spent viewing social stimuli in TD boys (eyes) and those with ASD (faces) but in the opposite direction. LAY SUMMARY: Children with autism exhibit reduced attention to social paired with nonsocial stimuli compared to typically developing children. Using eye-tracking we show this difference is due to typically developing rather than autistic boys being more influenced by how interesting competing nonsocial objects are. On the other hand, reduced time looking at the eyes in autistic relative to typically developing boys is unaffected by nonsocial object salience. Time spent viewing social stimuli is associated with cognitive development and blood levels of oxytocin. En ligne : http://dx.doi.org/10.1002/aur.2714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] The salience of competing nonsocial objects reduces gaze toward social stimuli, but not the eyes, more in typically developing than autistic boys [Texte imprimé et/ou numérique] / Xiao-E. CAI, Auteur ; Jiao LE, Auteur ; Xiao-Jing SHOU, Auteur ; Gao-Wa WU-YUN, Auteur ; Xiao-Xi WANG, Auteur ; Song-Ping HAN, Auteur ; Ji-Sheng HAN, Auteur ; Keith M. KENDRICK, Auteur ; Rong ZHANG, Auteur . - p.1043-1055. Langues : Anglais (eng) in Autism Research > 15-6 (June 2022) . - p.1043-1055 Mots-clés : Autism Spectrum Disorder/psychology  Autistic Disorder  Child  Child, Preschool  Eye Movements  Eye-Tracking Technology  Humans  Male  Oxytocin  arginine-vasopressin  autism spectrum disorder  eye-tracking  salience Index. décimale : PER Périodiques Résumé : Decreased attention to social information is considered an early emerging symptom of autism spectrum disorder (ASD), although the underlying causes remain controversial. Here we explored the impact of nonsocial object salience on reduced attention to social stimuli in male ASD compared with typically developing (TD) children. Correlations with blood concentrations of neuropeptides linked with social cognition were also investigated. Eye-tracking was performed in 102 preschool-aged boys (50 ASD, 52 TD) using a paradigm with social (faces) versus nonsocial (objects) stimuli presented in pairs in two conditions where nonsocial stimulus salience was varied. Basal oxytocin (OXT) and vasopressin concentrations were measured in blood. Compared with TD boys those with ASD viewed social stimuli less only when they were paired with low-salience nonsocial objects. Additionally, boys with ASD spent less time than TD ones viewing facial features, particularly the eyes. In TD boys, OXT concentrations and cognitive development scores were positively associated with time spent viewing the eye region, whereas for boys with ASD associations with time spent viewing faces were negative. Reduced gaze toward social stimuli in ASD relative to TD individuals may therefore be influenced by how salient the paired nonsocial objects are for the latter. On the other hand, reduced interest in the eyes of faces in boys with ASD is not influenced by how salient competing nonsocial stimuli are. Basal OXT concentrations and cognitive development scores are predictive of time spent viewing social stimuli in TD boys (eyes) and those with ASD (faces) but in the opposite direction. LAY SUMMARY: Children with autism exhibit reduced attention to social paired with nonsocial stimuli compared to typically developing children. Using eye-tracking we show this difference is due to typically developing rather than autistic boys being more influenced by how interesting competing nonsocial objects are. On the other hand, reduced time looking at the eyes in autistic relative to typically developing boys is unaffected by nonsocial object salience. Time spent viewing social stimuli is associated with cognitive development and blood levels of oxytocin. En ligne : http://dx.doi.org/10.1002/aur.2714 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

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