Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder / Jiang ZHU in Journal of Autism and Developmental Disorders, 52-7 (July 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128 Titre : Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.3116-3128 Langues : Anglais (eng) Mots-clés : Amino Acids/metabolism  Autism Spectrum Disorder/diagnosis  Child  Humans  Intestines  Metabolome  Metabolomics/methods  Vitamins  Autism  Children  Metabolism  Metabolomics  Symptoms  Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477 [article] Alterations in Gut Vitamin and Amino Acid Metabolism are Associated with Symptoms and Neurodevelopment in Children with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Jiang ZHU, Auteur ; Xueying HUA, Auteur ; Ting YANG, Auteur ; Min GUO, Auteur ; Qiu LI, Auteur ; Lu XIAO, Auteur ; Ling LI, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur . - p.3116-3128. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-7 (July 2022) . - p.3116-3128 Mots-clés : Amino Acids/metabolism  Autism Spectrum Disorder/diagnosis  Child  Humans  Intestines  Metabolome  Metabolomics/methods  Vitamins  Autism  Children  Metabolism  Metabolomics  Symptoms  Vitamin Index. décimale : PER Périodiques Résumé : Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and neurodevelopment levels were assessed. Fecal samples were analyzed using untargeted liquid chromatography-tandem mass spectrometry methods. Our results showed the metabolic disturbances of autistic children involved in multiple vitamin and amino acid metabolism pathways, with the strongest enrichment identified for tryptophan metabolism, retinol metabolism, cysteine-methionine metabolism, and vitamin digestion and absorption. Differential gut metabolites were correlated to autistic symptoms and neurodevelopment levels. Our findings improved the understanding of the perturbations of metabolome networks in autism. En ligne : http://dx.doi.org/10.1007/s10803-021-05066-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=477

Developmental Language Differences in Children with Autism Spectrum Disorders and Possible Sex Difference / Haiyi XIONG in Journal of Autism and Developmental Disorders, 54-3 (March 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.841-851 Titre : Developmental Language Differences in Children with Autism Spectrum Disorders and Possible Sex Difference Type de document : Texte imprimé et/ou numérique Auteurs : Haiyi XIONG, Auteur ; Xiao LIU, Auteur ; Feng YANG, Auteur ; Ting YANG, Auteur ; Jinjin CHEN, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.841-851 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Developmental difference is a common characteristic of autism spectrum disorder (ASD) with unclear sex differences. The current study included 610 children with ASD, aged between 2 and 7 years, with completed language profiles. We used a nonparametric item response theory model called Mokken scale analysis to examine the order of acquisition of developmental language milestones in children with ASD. Our results demonstrated the developmental language differences in the expressive and receptive language dimensions in children with ASD compared with typical developmental sequences. Furthermore, The acquisition of gestures and pragmatics was more impaired in the female subgroup than in the male subgroup. The identified developmental language sequence could help provide a more comprehensive ASD developmental profile. En ligne : https://doi.org/10.1007/s10803-022-05806-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524 [article] Developmental Language Differences in Children with Autism Spectrum Disorders and Possible Sex Difference [Texte imprimé et/ou numérique] / Haiyi XIONG, Auteur ; Xiao LIU, Auteur ; Feng YANG, Auteur ; Ting YANG, Auteur ; Jinjin CHEN, Auteur ; Jie CHEN, Auteur ; Tingyu LI, Auteur . - p.841-851. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-3 (March 2024) . - p.841-851 Index. décimale : PER Périodiques Résumé : Developmental difference is a common characteristic of autism spectrum disorder (ASD) with unclear sex differences. The current study included 610 children with ASD, aged between 2 and 7 years, with completed language profiles. We used a nonparametric item response theory model called Mokken scale analysis to examine the order of acquisition of developmental language milestones in children with ASD. Our results demonstrated the developmental language differences in the expressive and receptive language dimensions in children with ASD compared with typical developmental sequences. Furthermore, The acquisition of gestures and pragmatics was more impaired in the female subgroup than in the male subgroup. The identified developmental language sequence could help provide a more comprehensive ASD developmental profile. En ligne : https://doi.org/10.1007/s10803-022-05806-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=524

Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China / Ting YANG in Journal of Autism and Developmental Disorders, 54-11 (November)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-11 (November) . - p.4302-4310 Titre : Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China Type de document : Texte imprimé et/ou numérique Auteurs : Ting YANG, Auteur ; Qian ZHANG, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Fei-Yong JIA, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Li-Jie WU, Auteur ; Xiao-Yan KE, Auteur ; Ming-Ji YI, Auteur ; Qi HONG, Auteur ; Jin-Jin CHEN, Auteur ; Shuan-Feng FANG, Auteur ; Yi-Chao WANG, Auteur ; Qi WANG, Auteur ; Chun-Hua JIN, Auteur ; Jie CHEN, Auteur ; Ting-Yu LI, Auteur Article en page(s) : p.4302-4310 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD. En ligne : https://doi.org/10.1007/s10803-023-06122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537 [article] Intestinal Symptoms Among Children aged 2-7 Years with Autism Spectrum Disorder in 13 Cities of China [Texte imprimé et/ou numérique] / Ting YANG, Auteur ; Qian ZHANG, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Fei-Yong JIA, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Li-Jie WU, Auteur ; Xiao-Yan KE, Auteur ; Ming-Ji YI, Auteur ; Qi HONG, Auteur ; Jin-Jin CHEN, Auteur ; Shuan-Feng FANG, Auteur ; Yi-Chao WANG, Auteur ; Qi WANG, Auteur ; Chun-Hua JIN, Auteur ; Jie CHEN, Auteur ; Ting-Yu LI, Auteur . - p.4302-4310. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-11 (November) . - p.4302-4310 Index. décimale : PER Périodiques Résumé : Background: Autism spectrum disorder (ASD) is a multifactorial, pervasive, neurodevelopmental disorder, of which intestinal symptoms collectively represent one of the most common comorbidities. Methods: In this study, 1,222 children with ASD and 1,206 typically developing (TD) children aged 2-7 years were enrolled from 13 cities in China. Physical measurement and basic information questionnaires were conducted in ASD and TD children. The Childhood Autism Rating Scale (CARS), Social Responsiveness Scale (SRS), and Autism Behavior Checklist (ABC) were used to evaluate the clinical symptoms of children with ASD. The six-item Gastrointestinal Severity Index (6-GSI) was used to evaluate the prevalence of intestinal symptoms in two groups. Results: The detection rates of constipation, stool odor, and total intestinal symptoms in ASD children were significantly higher than those in TD children (40.098% vs. 25.622%, 17.021% vs. 9.287%, and 53.601% vs. 41.294%, respectively). Autistic children presenting with intestinal comorbidity had significantly higher scores on the ABC, SRS, CARS, and multiple subscales than autistic children without intestinal symptoms, suggesting that intestinal comorbidity may exacerbates the core symptoms of ASD children. Conclusion: Intestinal dysfunction was significantly more common in autistic than in TD children. This dysfunction may aggravate the core symptoms of children with ASD. En ligne : https://doi.org/10.1007/s10803-023-06122-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=537

Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China / Ting YANG ; Jie CHEN ; Li CHEN ; Ying DAI ; Hua WEI ; Feiyong JIA ; Lijie WU ; Yan HAO ; Ling LI ; Jie ZHANG ; Xiaoyan KE ; Mingji YI ; Qi HONG ; Jinjin CHEN ; Shuanfeng FANG ; Yichao WANG ; Qi WANG ; Chunhua JIN ; Tingyu LI in Research in Autism Spectrum Disorders, 111 (March 2024)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Titre : Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China Type de document : Texte imprimé et/ou numérique Auteurs : Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur Article en page(s) : p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521 [article] Maternal multivitamin supplementation is associated with symptoms in offspring with autism spectrum disorder: A multi-center study in China [Texte imprimé et/ou numérique] / Ting YANG, Auteur ; Jie CHEN, Auteur ; Li CHEN, Auteur ; Ying DAI, Auteur ; Hua WEI, Auteur ; Feiyong JIA, Auteur ; Lijie WU, Auteur ; Yan HAO, Auteur ; Ling LI, Auteur ; Jie ZHANG, Auteur ; Xiaoyan KE, Auteur ; Mingji YI, Auteur ; Qi HONG, Auteur ; Jinjin CHEN, Auteur ; Shuanfeng FANG, Auteur ; Yichao WANG, Auteur ; Qi WANG, Auteur ; Chunhua JIN, Auteur ; Tingyu LI, Auteur . - p.102309. in Research in Autism Spectrum Disorders > 111 (March 2024) . - p.102309 Mots-clés : Vitamin D  Multivitamin  Pregnancy  Autism spectrum disorder  Symptom  Children Index. décimale : PER Périodiques Résumé : Background We aimed to investigate the relationship between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of autism spectrum disorder (ASD) and symptoms in offspring with ASD. Methods This study enrolled 1321 children with ASD and 1200 typically developing (TD) children under 7 years old in China. Maternal vitamin supplements were classified for vitamin D, multivitamin (with or without vitamin D), and none (no use of vitamin D or multivitamin). For children with ASD, symptoms were assessed with the Autism Behavior Checklist (ABC), Social Responsiveness Scale (SRS) and Childhood Autism Rating Scale (CARS), and neurodevelopmental levels were evaluated with the Children Neuropsychological and Behavior Scale-Revision 2016 (CNBS-R2016). Results Maternal vitamin D and multivitamin supplementation during pregnancy were both significantly associated with a decreased risk of ASD in offspring (P = 0.024 and P < 0.001). The ASD children born to mothers with gestational multivitamin supplementation had lower CARS [? = ?1.342 (?2.275, ?0.409), P = 0.005] and communication warning behavior [? = ?6.631 (?9.899, ?3.363), P < 0.001] scores and higher personal-social quotient [? = 3.347 (0.190, 6.504), P = 0.038] than children born to mothers without supplementation. Maternal vitamin D supplementation was not associated with symptoms and development quotients in ASD children (P > 0.05). Conclusions This study supports a protective association between maternal vitamin D and multivitamin supplementation during pregnancy and the risk of ASD in offspring. Maternal multivitamin supplementation may potentially moderate the symptoms and personal-social ability in ASD children. Further studies are needed on the role of maternal nutrition in the etiology and autistic symptoms and the underlying molecular mechanisms. En ligne : https://doi.org/10.1016/j.rasd.2023.102309 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=521

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