Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD / Agatha LENARTOWICZ in Journal of Child Psychology and Psychiatry, 60-8 (August 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.917-926 Titre : Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD Type de document : texte imprimé Auteurs : Agatha LENARTOWICZ, Auteur ; Holly TRUONG, Auteur ; Giulia C. SALGARI, Auteur ; Robert M. BILDER, Auteur ; James MCGOUGH, Auteur ; James T. MCCRACKEN, Auteur ; Sandra K. LOO, Auteur Article en page(s) : p.917-926 Langues : Anglais (eng) Mots-clés : Adhd  Eeg  academic achievement  alpha oscillations  maintenance  visual attention  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in ADHD unresolved. In this study, we aim to replicate, in an independent sample, previously reported deficits in component processes of WM deficits in ADHD and expand to consider their implications for neurocognitive outcomes. METHODS: In 119 children (7-14 years old, 85 with ADHD), we used electroencephalography measures to quantify component processes during performance of a spatial working memory task. We quantified stimulus encoding using alpha range (8-12 Hz) power; vigilance by the P2 event-related potential to cues; and WMmaintenance by occipital-alpha and frontal-theta (4-7 Hz) power. These measures were evaluated against metrics of executive function, ADHD symptoms, and academic achievement. RESULTS: Encoding alpha-power decreases and cue P2 amplitude were attenuated in ADHD, whereas occipital-alpha power during maintenance was significantly greater in ADHD, consistent with a compensatory response to weak encoding. Weak alpha modulation during encoding was associated with poorer reading comprehension and executive function, as well as enhanced ADHD symptoms. Previously reported effects in frontal-theta power failed to replicate. CONCLUSIONS: Stimulus encoding, a component process of WM coupled to alpha modulation, is impaired in ADHD, and, unlike WM maintenance or vigilance processes, has implications outside of the laboratory via a relationship with executive function, and, to a weaker extent, reading comprehension. En ligne : http://dx.doi.org/10.1111/jcpp.13042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404 [article] Alpha modulation during working memory encoding predicts neurocognitive impairment in ADHD [texte imprimé] / Agatha LENARTOWICZ, Auteur ; Holly TRUONG, Auteur ; Giulia C. SALGARI, Auteur ; Robert M. BILDER, Auteur ; James MCGOUGH, Auteur ; James T. MCCRACKEN, Auteur ; Sandra K. LOO, Auteur . - p.917-926. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-8 (August 2019) . - p.917-926 Mots-clés : Adhd  Eeg  academic achievement  alpha oscillations  maintenance  visual attention  working memory Index. décimale : PER Périodiques Résumé : BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is associated with working memory (WM) deficits. However, WM is a multiprocess construct that can be impaired through several pathways, leaving the source of WM impairments in ADHD unresolved. In this study, we aim to replicate, in an independent sample, previously reported deficits in component processes of WM deficits in ADHD and expand to consider their implications for neurocognitive outcomes. METHODS: In 119 children (7-14 years old, 85 with ADHD), we used electroencephalography measures to quantify component processes during performance of a spatial working memory task. We quantified stimulus encoding using alpha range (8-12 Hz) power; vigilance by the P2 event-related potential to cues; and WMmaintenance by occipital-alpha and frontal-theta (4-7 Hz) power. These measures were evaluated against metrics of executive function, ADHD symptoms, and academic achievement. RESULTS: Encoding alpha-power decreases and cue P2 amplitude were attenuated in ADHD, whereas occipital-alpha power during maintenance was significantly greater in ADHD, consistent with a compensatory response to weak encoding. Weak alpha modulation during encoding was associated with poorer reading comprehension and executive function, as well as enhanced ADHD symptoms. Previously reported effects in frontal-theta power failed to replicate. CONCLUSIONS: Stimulus encoding, a component process of WM coupled to alpha modulation, is impaired in ADHD, and, unlike WM maintenance or vigilance processes, has implications outside of the laboratory via a relationship with executive function, and, to a weaker extent, reading comprehension. En ligne : http://dx.doi.org/10.1111/jcpp.13042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=404

Cognitive control processes in behavior therapy for youth with Tourette's disorder / Joseph F. MCGUIRE in Journal of Child Psychology and Psychiatry, 63-3 (March 2022)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.296-304 Titre : Cognitive control processes in behavior therapy for youth with Tourette's disorder Type de document : texte imprimé Auteurs : Joseph F. MCGUIRE, Auteur ; Alexandra STURM, Auteur ; Emily J. RICKETTS, Auteur ; Gabrielle E. MONTALBANO, Auteur ; Susanna CHANG, Auteur ; Sandra K. LOO, Auteur ; Douglas W. WOODS, Auteur ; James T. MCCRACKEN, Auteur ; John PIACENTINI, Auteur Article en page(s) : p.296-304 Langues : Anglais (eng) Mots-clés : Cognitive control  behavior therapy  inhibition  inhibitory control  tic suppression Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive control processes are implicated in the behavioral treatment of Tourette's disorder (TD). However, the influence of these processes on treatment outcomes has received minimal attention. This study examined whether cognitive control processes and/or tic suppression predicted reductions in tic severity and treatment response to behavior therapy. METHOD: Fifty-three youth with TD or a pervasive tic disorder participated in a randomized wait list-controlled trial of behavior therapy. Following a baseline assessment to evaluate psychiatric diagnoses, tic severity, and cognitive control processes (e.g., response selection, inhibition, and suppression), youth were randomly assigned to receive eight sessions of behavior therapy (n = 23) or a wait list of equal duration (n = 28). Youth receiving immediate treatment completed a post-treatment assessment to determine improvement in tic severity. Meanwhile, youth in the wait list condition completed another assessment to re-evaluate tic severity and cognitive control processes, and subsequently received 8 sessions of behavior therapy followed by a post-treatment assessment to determine improvement. RESULTS: A multiple linear regression model found that pretreatment inhibition/switching on the Delis-Kaplan Executive Function System Color-Word Interference Test predicted reductions in tic severity after behavior therapy (β = -.36, t = -2.35, p = .025, ƞ(2)  = .15). However, other cognitive control processes and tic suppression did not predict treatment response and/or reductions in tic severity. Small nonsignificant effects were observed in cognitive control processes after behavior therapy. CONCLUSION: Cognitive control processes may influence tic severity reductions in behavior therapy. Notably, even when other cognitive control processes are impaired and youth are initially unable to voluntarily suppress their tics, youth with TD can still benefit from behavior therapy. Findings offer implications for clinical practice and research for TD. En ligne : http://dx.doi.org/10.1111/jcpp.13470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457 [article] Cognitive control processes in behavior therapy for youth with Tourette's disorder [texte imprimé] / Joseph F. MCGUIRE, Auteur ; Alexandra STURM, Auteur ; Emily J. RICKETTS, Auteur ; Gabrielle E. MONTALBANO, Auteur ; Susanna CHANG, Auteur ; Sandra K. LOO, Auteur ; Douglas W. WOODS, Auteur ; James T. MCCRACKEN, Auteur ; John PIACENTINI, Auteur . - p.296-304. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 63-3 (March 2022) . - p.296-304 Mots-clés : Cognitive control  behavior therapy  inhibition  inhibitory control  tic suppression Index. décimale : PER Périodiques Résumé : BACKGROUND: Cognitive control processes are implicated in the behavioral treatment of Tourette's disorder (TD). However, the influence of these processes on treatment outcomes has received minimal attention. This study examined whether cognitive control processes and/or tic suppression predicted reductions in tic severity and treatment response to behavior therapy. METHOD: Fifty-three youth with TD or a pervasive tic disorder participated in a randomized wait list-controlled trial of behavior therapy. Following a baseline assessment to evaluate psychiatric diagnoses, tic severity, and cognitive control processes (e.g., response selection, inhibition, and suppression), youth were randomly assigned to receive eight sessions of behavior therapy (n = 23) or a wait list of equal duration (n = 28). Youth receiving immediate treatment completed a post-treatment assessment to determine improvement in tic severity. Meanwhile, youth in the wait list condition completed another assessment to re-evaluate tic severity and cognitive control processes, and subsequently received 8 sessions of behavior therapy followed by a post-treatment assessment to determine improvement. RESULTS: A multiple linear regression model found that pretreatment inhibition/switching on the Delis-Kaplan Executive Function System Color-Word Interference Test predicted reductions in tic severity after behavior therapy (β = -.36, t = -2.35, p = .025, ƞ(2)  = .15). However, other cognitive control processes and tic suppression did not predict treatment response and/or reductions in tic severity. Small nonsignificant effects were observed in cognitive control processes after behavior therapy. CONCLUSION: Cognitive control processes may influence tic severity reductions in behavior therapy. Notably, even when other cognitive control processes are impaired and youth are initially unable to voluntarily suppress their tics, youth with TD can still benefit from behavior therapy. Findings offer implications for clinical practice and research for TD. En ligne : http://dx.doi.org/10.1111/jcpp.13470 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=457

Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Titre : Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes Type de document : texte imprimé Auteurs : Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2008 Article en page(s) : p.950-957 Langues : Anglais (eng) Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes [texte imprimé] / Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur . - 2008 . - p.950-957. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Editorial Perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor / Martijn ARNS in Journal of Child Psychology and Psychiatry, 57-5 (May 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.656-658 Titre : Editorial Perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor Type de document : texte imprimé Auteurs : Martijn ARNS, Auteur ; Sandra K. LOO, Auteur ; M. Barry STERMAN, Auteur ; Hartmut HEINRICH, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur Article en page(s) : p.656-658 Langues : Anglais (eng) Mots-clés : Attention deficit hyperactivity disorder  electroencephalogram  Electroencephalogram-Based Attention Deficit Hyperactivity Disorder Assessment Aid  theta-to-beta ratio  Federal Drug Administration  diagnostic test Index. décimale : PER Périodiques Résumé : Recently several new tests have received US Federal Drug Administration (FDA) marketing approval as aids in the diagnostic process for attention deficit hyperactivity disorder (ADHD), including the Neuropsychiatric electroencephalogram (EEG)-Based ADHD Assessment Aid (NEBA) Health test. The NEBA test relies upon an EEG-based measure, called the theta to beta ratio (TBR). Although this measure has yielded large differences between ADHD and non-ADHD groups in studies prior to 2009, recent studies and a meta-analysis could not replicate these findings. In this article, we have used the NEBA device as an exemplar for a discussion that distinguishes between FDA de novo marketing approval for a device and any claims that that device is empirically supported, scientifically validated with replicated findings. It is understood that the aims of each differ; however, for many, including the lay public as well as some mental health professionals, these terms may be confused and treated as though they are synonymous. With regard to the TBR measure, there is no reliable association or replication for its clinical usage in the ADHD diagnostic process. The recommendation for potential consumers of the NEBA Health test (as well as perhaps for other existing FDA-approved diagnostic tests) is caveat emptor (let the buyer beware!). En ligne : http://dx.doi.org/10.1111/jcpp.12524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Editorial Perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor [texte imprimé] / Martijn ARNS, Auteur ; Sandra K. LOO, Auteur ; M. Barry STERMAN, Auteur ; Hartmut HEINRICH, Auteur ; Jonna KUNTSI, Auteur ; Philip ASHERSON, Auteur ; Tobias BANASCHEWSKI, Auteur ; Daniel BRANDEIS, Auteur . - p.656-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-5 (May 2016) . - p.656-658 Mots-clés : Attention deficit hyperactivity disorder  electroencephalogram  Electroencephalogram-Based Attention Deficit Hyperactivity Disorder Assessment Aid  theta-to-beta ratio  Federal Drug Administration  diagnostic test Index. décimale : PER Périodiques Résumé : Recently several new tests have received US Federal Drug Administration (FDA) marketing approval as aids in the diagnostic process for attention deficit hyperactivity disorder (ADHD), including the Neuropsychiatric electroencephalogram (EEG)-Based ADHD Assessment Aid (NEBA) Health test. The NEBA test relies upon an EEG-based measure, called the theta to beta ratio (TBR). Although this measure has yielded large differences between ADHD and non-ADHD groups in studies prior to 2009, recent studies and a meta-analysis could not replicate these findings. In this article, we have used the NEBA device as an exemplar for a discussion that distinguishes between FDA de novo marketing approval for a device and any claims that that device is empirically supported, scientifically validated with replicated findings. It is understood that the aims of each differ; however, for many, including the lay public as well as some mental health professionals, these terms may be confused and treated as though they are synonymous. With regard to the TBR measure, there is no reliable association or replication for its clinical usage in the ADHD diagnostic process. The recommendation for potential consumers of the NEBA Health test (as well as perhaps for other existing FDA-approved diagnostic tests) is caveat emptor (let the buyer beware!). En ligne : http://dx.doi.org/10.1111/jcpp.12524 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Ethnic Variations in Children's Problem Behaviors: A Cross-sectional, Developmental Study of Hawaii School Children / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 39-4 (May 1998)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 39-4 (May 1998) . - p.567-575 Titre : Ethnic Variations in Children's Problem Behaviors: A Cross-sectional, Developmental Study of Hawaii School Children Type de document : texte imprimé Auteurs : Sandra K. LOO, Auteur ; Mark D. RAPPORT, Auteur Année de publication : 1998 Article en page(s) : p.567-575 Langues : Anglais (eng) Mots-clés : Behavior problems  cross-cultural  epidemiology  ethnicity  school  school children Index. décimale : PER Périodiques Résumé : Variations in children's problem behaviors associated with ethnicity and other demographic variables were examined in 6–18-year-old children (N= 804) residing in a multicultural environment. The Child Behavior Checklist-Teacher's Report Form was used to compare the frequency of behavior problems among clinic-referred and nonreferred children of Hawaiian, Asian, and Caucasian ethnicities. Children who were male, clinic-referred, or of Caucasian or Hawaiian ancestry experienced greater levels of behavioral problems. Explanations concerning ethnic variations in children's problem behaviors include: teacher's perceptual bias, differences in teacher threshold to report problem behaviors, and/or true variations in children's behavior. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=123 [article] Ethnic Variations in Children's Problem Behaviors: A Cross-sectional, Developmental Study of Hawaii School Children [texte imprimé] / Sandra K. LOO, Auteur ; Mark D. RAPPORT, Auteur . - 1998 . - p.567-575. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 39-4 (May 1998) . - p.567-575 Mots-clés : Behavior problems  cross-cultural  epidemiology  ethnicity  school  school children Index. décimale : PER Périodiques Résumé : Variations in children's problem behaviors associated with ethnicity and other demographic variables were examined in 6–18-year-old children (N= 804) residing in a multicultural environment. The Child Behavior Checklist-Teacher's Report Form was used to compare the frequency of behavior problems among clinic-referred and nonreferred children of Hawaiian, Asian, and Caucasian ethnicities. Children who were male, clinic-referred, or of Caucasian or Hawaiian ancestry experienced greater levels of behavioral problems. Explanations concerning ethnic variations in children's problem behaviors include: teacher's perceptual bias, differences in teacher threshold to report problem behaviors, and/or true variations in children's behavior. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=123

Parsing heterogeneity in attention‐deficit hyperactivity disorder using EEG‐based subgroups / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 59-3 (March 2018)  

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Research Review: Use of EEG biomarkers in child psychiatry research – current state and future directions / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 57-1 (January 2016)  

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