Correction: Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder / Konnor DAVIS in Journal of Autism and Developmental Disorders, 53-3 (March 2023)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 53-3 (March 2023) . - p.1301-1301 Titre : Correction: Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Konnor DAVIS, Auteur ; Ana-Maria IOSIF, Auteur ; Christine Wu NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; Marie K. KRUG, Auteur Article en page(s) : p.1301-1301 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-022-05694-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500 [article] Correction: Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Konnor DAVIS, Auteur ; Ana-Maria IOSIF, Auteur ; Christine Wu NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; Marie K. KRUG, Auteur . - p.1301-1301. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 53-3 (March 2023) . - p.1301-1301 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-022-05694-w Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=500

Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability / Derek S. ANDREWS in Autism Research, 18-3 (March 2025)  

Public ISBD [article]  inAutism Research > 18-3 (March 2025) . - p.486-497 Titre : Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability Type de document : Texte imprimé et/ou numérique Auteurs : Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur Article en page(s) : p.486-497 Langues : Anglais (eng) Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n?=?88, mean age 5.37?years) with a large range of intellectual ability (IQ 19?133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n?=?53, mean age 5.29?years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ???70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550 [article] Cortical Thickness Differences in Autistic Children With and Without Intellectual Disability [Texte imprimé et/ou numérique] / Derek S. ANDREWS, Auteur ; Andrew J. DAKOPOLOS, Auteur ; Joshua K. LEE, Auteur ; Brianna HEATH, Auteur ; Devani CORDERO, Auteur ; Marjorie SOLOMON, Auteur ; David G. AMARAL, Auteur ; Christine Wu NORDAHL, Auteur . - p.486-497. Langues : Anglais (eng) in Autism Research > 18-3 (March 2025) . - p.486-497 Mots-clés : autism  cortical thickness  intellectual disability  IQ  MRI Index. décimale : PER Périodiques Résumé : ABSTRACT Of the 1 in 36 individuals in the United States who are diagnosed with autism spectrum disorder, nearly 40% also have intellectual disability (ID). The cortex has been widely implicated in neural processes underlying autistic behaviors as well as intellectual ability. Thus, neuroimaging features such as cortical thickness are of particular interest as a possible biomarkers of the condition. However, neuroimaging studies often fail to include autistic individuals with ID. As a result, there are few studies of cortical thickness in autistic individuals across the entire range of intellectual abilities. This study used MRI to evaluate cortical thickness in young autistic children (n?=?88, mean age 5.37?years) with a large range of intellectual ability (IQ 19?133) as well as nonautistic, nondevelopmentally delayed (referred to here as typically developing [TD]) peers (n?=?53, mean age 5.29?years). We first investigated associations between full scale IQ and cortical thickness in both autistic and TD children. Autistic children had significant negative associations (i.e., thinner cortex, higher IQ) in bilateral entorhinal cortex, right fusiform gyrus, superior, middle and inferior temporal gyri, and right temporal pole that were not present in TD children. Significantly thicker cortex was also observed in these regions for autistic children with ID (i.e., IQ???70) compared with those without. Last, given the reported correspondence between the severity of autism symptoms and intellectual ability, we compared cortical thickness associations with both IQ and ADOS Calibrated Severity Scores and found these patterns overlapped to a significant degree across the cortex. En ligne : https://doi.org/10.1002/aur.3313 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=550

Hyper-focus, sticky attention, and springy attention in young autistic children: Associations with sensory behaviors and cognitive ability / Andre SILLAS ; Melanie PRIETO ; Emily CAMP ; Christine Wu NORDAHL ; Susan M. RIVERA in Autism Research, 17-8 (August 2024)  

Public ISBD [article]  inAutism Research > 17-8 (August 2024) . - p.1677-1695 Titre : Hyper-focus, sticky attention, and springy attention in young autistic children: Associations with sensory behaviors and cognitive ability Type de document : Texte imprimé et/ou numérique Auteurs : Andre SILLAS, Auteur ; Melanie PRIETO, Auteur ; Emily CAMP, Auteur ; Christine Wu NORDAHL, Auteur ; Susan M. RIVERA, Auteur Article en page(s) : p.1677-1695 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Abstract The autistic-developed monotropism account suggests that atypical, domain-general attentional hyper-focus on interests is a central aspect of autism, but domain-general attention differences in autism can manifest differently. Prior research suggests autistic children are often slow to disengage attention from stimuli-a pattern often called "sticky attention"-and that they can show reduced novelty preference. These attentional patterns could influence sensory experiences and learning. We used eye-tracking to investigate novelty preference and "sticky attention" in young autistic children; we also examined whether attentional patterns were related to cognitive abilities and caregiver-reported sensory responsiveness. A total of 46 autistic and 28 nonautistic participants, aged between 2 and 4?years, provided usable data. We found no evidence that autistic children exhibited greater "sticky attention" than nonautistics, but "sticky attention" in autism was associated with more caregiver-reported sensory hyper-responsiveness, seeking/interests, and enhanced perception. Autistic children also nonsignificantly trended toward exhibiting reduced novelty preference. Unexpectedly, the time-course of this trending novelty preference difference implied it was not driven by reduced orienting to novelty, but increased returning to already-familiarized stimuli: what we call "springy attention." Exploratory analyses of data from the attentional disengagement task suggest autistic participants may have exhibited greater "springy attention," though further research with paradigms optimized for measuring this construct should confirm this. Importantly, "springy attention" was robustly related to reduced cognitive abilities and greater caregiver-reported hypo-responsiveness. Thus, this study illuminates two distinct domain-general attentional patterns, each with distinct correlates in young autistic children, which could have important implications for understanding autistic children's learning, development, and experiences. En ligne : https://doi.org/10.1002/aur.3174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Hyper-focus, sticky attention, and springy attention in young autistic children: Associations with sensory behaviors and cognitive ability [Texte imprimé et/ou numérique] / Andre SILLAS, Auteur ; Melanie PRIETO, Auteur ; Emily CAMP, Auteur ; Christine Wu NORDAHL, Auteur ; Susan M. RIVERA, Auteur . - p.1677-1695. Langues : Anglais (eng) in Autism Research > 17-8 (August 2024) . - p.1677-1695 Index. décimale : PER Périodiques Résumé : Abstract The autistic-developed monotropism account suggests that atypical, domain-general attentional hyper-focus on interests is a central aspect of autism, but domain-general attention differences in autism can manifest differently. Prior research suggests autistic children are often slow to disengage attention from stimuli-a pattern often called "sticky attention"-and that they can show reduced novelty preference. These attentional patterns could influence sensory experiences and learning. We used eye-tracking to investigate novelty preference and "sticky attention" in young autistic children; we also examined whether attentional patterns were related to cognitive abilities and caregiver-reported sensory responsiveness. A total of 46 autistic and 28 nonautistic participants, aged between 2 and 4?years, provided usable data. We found no evidence that autistic children exhibited greater "sticky attention" than nonautistics, but "sticky attention" in autism was associated with more caregiver-reported sensory hyper-responsiveness, seeking/interests, and enhanced perception. Autistic children also nonsignificantly trended toward exhibiting reduced novelty preference. Unexpectedly, the time-course of this trending novelty preference difference implied it was not driven by reduced orienting to novelty, but increased returning to already-familiarized stimuli: what we call "springy attention." Exploratory analyses of data from the attentional disengagement task suggest autistic participants may have exhibited greater "springy attention," though further research with paradigms optimized for measuring this construct should confirm this. Importantly, "springy attention" was robustly related to reduced cognitive abilities and greater caregiver-reported hypo-responsiveness. Thus, this study illuminates two distinct domain-general attentional patterns, each with distinct correlates in young autistic children, which could have important implications for understanding autistic children's learning, development, and experiences. En ligne : https://doi.org/10.1002/aur.3174 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

m6A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly / Nicholas K. HAGHANI ; Gabriana N. LA ; Natasha Ann F. MARIANO ; José M. URIBE-SALAZAR ; Gulhan KAYA ; Melissa REGESTER ; Derek Sayre ANDREWS ; Christine Wu NORDAHL ; David G. AMARAL ; Megan Y. DENNIS in Autism Research, 18-5 (May 2025)  

Public ISBD [article]  inAutism Research > 18-5 (May 2025) . - p.966-982 Titre : m6A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly Type de document : Texte imprimé et/ou numérique Auteurs : Nicholas K. HAGHANI, Auteur ; Gabriana N. LA, Auteur ; Natasha Ann F. MARIANO, Auteur ; José M. URIBE-SALAZAR, Auteur ; Gulhan KAYA, Auteur ; Melissa REGESTER, Auteur ; Derek Sayre ANDREWS, Auteur ; Christine Wu NORDAHL, Auteur ; David G. AMARAL, Auteur ; Megan Y. DENNIS, Auteur Article en page(s) : p.966-982 Langues : Anglais (eng) Mots-clés : autism  disproportionate megalencephaly  genetics  m6A-RNA modification  YTHDF2  zebrafish Index. décimale : PER Périodiques Résumé : ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD-DM) seen at three years of age is associated with co-occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD-DM have yet to be delineated. In this study, we identified additional ASD-DM candidate genes with the aim to better define the genetic etiology of this subphenotype of autism. We expanded the previously studied sample size of ASD-DM individuals ten fold by including probands from the Autism Phenome Project and Simons Simplex Collection, totaling 766 autistic individuals meeting the criteria for megalencephaly or macrocephaly and revealing 154 candidate ASD-DM genes harboring de novo protein-impacting variants. Our findings include 14 high confidence autism genes and seven genes previously associated with DM. Five impacted genes have previously been associated with both autism and DM, including CHD8 and PTEN. By performing functional network analysis, we expanded to additional candidate genes, including one previously implicated in ASD-DM (PIK3CA) as well as 184 additional genes connected with ASD or DM alone. Using zebrafish, we modeled a de novo tandem duplication impacting YTHDF2, encoding an N6-methyladenosine (m6A)-mRNA reader, in an ASD-DM proband. Testing zebrafish CRISPR knockdown led to reduced head/brain size, while overexpressing YTHDF2 resulted in increased head/brain size matching that of the proband. Single-cell transcriptomes of YTHDF2 gain-of-function larvae point to reduced expression of Fragile-X-syndrome-associated FMRP-target genes globally and in the developing brain, providing insight into the mechanism underlying autistic phenotypes. We additionally discovered a variant impacting a different gene encoding an m6A reader, YTHDC1, in our ASD-DM cohort. Though we highlight only two cases to date, our study provides support for the m6A-RNA modification pathway as potentially contributing to this severe form of autism. En ligne : https://doi.org/10.1002/aur.3314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] m6A-mRNA Reader YTHDF2 Identified as a Potential Risk Gene in Autism With Disproportionate Megalencephaly [Texte imprimé et/ou numérique] / Nicholas K. HAGHANI, Auteur ; Gabriana N. LA, Auteur ; Natasha Ann F. MARIANO, Auteur ; José M. URIBE-SALAZAR, Auteur ; Gulhan KAYA, Auteur ; Melissa REGESTER, Auteur ; Derek Sayre ANDREWS, Auteur ; Christine Wu NORDAHL, Auteur ; David G. AMARAL, Auteur ; Megan Y. DENNIS, Auteur . - p.966-982. Langues : Anglais (eng) in Autism Research > 18-5 (May 2025) . - p.966-982 Mots-clés : autism  disproportionate megalencephaly  genetics  m6A-RNA modification  YTHDF2  zebrafish Index. décimale : PER Périodiques Résumé : ABSTRACT Among autistic individuals, a subphenotype of disproportionate megalencephaly (ASD-DM) seen at three years of age is associated with co-occurring intellectual disability and poorer prognoses later in life. However, many of the genes contributing to ASD-DM have yet to be delineated. In this study, we identified additional ASD-DM candidate genes with the aim to better define the genetic etiology of this subphenotype of autism. We expanded the previously studied sample size of ASD-DM individuals ten fold by including probands from the Autism Phenome Project and Simons Simplex Collection, totaling 766 autistic individuals meeting the criteria for megalencephaly or macrocephaly and revealing 154 candidate ASD-DM genes harboring de novo protein-impacting variants. Our findings include 14 high confidence autism genes and seven genes previously associated with DM. Five impacted genes have previously been associated with both autism and DM, including CHD8 and PTEN. By performing functional network analysis, we expanded to additional candidate genes, including one previously implicated in ASD-DM (PIK3CA) as well as 184 additional genes connected with ASD or DM alone. Using zebrafish, we modeled a de novo tandem duplication impacting YTHDF2, encoding an N6-methyladenosine (m6A)-mRNA reader, in an ASD-DM proband. Testing zebrafish CRISPR knockdown led to reduced head/brain size, while overexpressing YTHDF2 resulted in increased head/brain size matching that of the proband. Single-cell transcriptomes of YTHDF2 gain-of-function larvae point to reduced expression of Fragile-X-syndrome-associated FMRP-target genes globally and in the developing brain, providing insight into the mechanism underlying autistic phenotypes. We additionally discovered a variant impacting a different gene encoding an m6A reader, YTHDC1, in our ASD-DM cohort. Though we highlight only two cases to date, our study provides support for the m6A-RNA modification pathway as potentially contributing to this severe form of autism. En ligne : https://doi.org/10.1002/aur.3314 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Trajectories of autism symptom severity for boys and girls across childhood / Emilio FERRER ; Meghan MILLER ; Brianna HEATH ; Derek S ANDREWS ; Sally J ROGERS ; Christine Wu NORDAHL ; Marjorie SOLOMON ; David G AMARAL in Autism, 29-7 (July 2025)  

Public ISBD [article]  inAutism > 29-7 (July 2025) . - p.1782-1794 Titre : Trajectories of autism symptom severity for boys and girls across childhood Type de document : Texte imprimé et/ou numérique Auteurs : Emilio FERRER, Auteur ; Meghan MILLER, Auteur ; Brianna HEATH, Auteur ; Derek S ANDREWS, Auteur ; Sally J ROGERS, Auteur ; Christine Wu NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G AMARAL, Auteur Article en page(s) : p.1782-1794 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  behavioral measurement  communication and language  development  diagnosis  preschool children  repetitive behaviors and interests  social cognition and social behavior  sex differences Index. décimale : PER Périodiques Résumé : Girls, more than boys, experience a decrease in the severity of autism symptoms during childhood. It is unclear, however, which specific autistic behaviors change more for girls than for boys. Trajectories of autism symptoms were evaluated using the Autism Diagnostic Observation Schedule-calibrated severity scores (ADOS-CSS). Change in the specific behavioral characteristics of autism was assessed by studying individual ADOS items for 183 children (55 girls) from age 3-to-11?years. Girls decreased in total autism symptom severity (ADOS-CSS) and restricted/repetitive behavior severity (RRB-CSS) across childhood, while boys remained stable in both. Girls showed decreasing-severity trajectories for seven ADOS items and an increasing-trajectory for one item. Boys showed decreasing-severity trajectories for six items and increasing-severity trajectories for three items. Girls with higher ADOS-CSS at age 3 were more likely to decrease in total symptom severity than other girls. Girls in our study mostly improved or remained stable in autism symptom severity and its specific behaviors during childhood, especially behaviors related to being socially engaged and responsive. Boys" symptom change was variable over time and included both improvement and worsening, especially in social behaviors that are key to interaction. Girls with high early severity levels can potentially decrease substantially in severity during childhood.Lay Abstract The severity of overall autism symptoms tend to decrease more in autistic girls than in autistic boys during childhood, but we do not know which specific behaviors drive this difference. We studied how specific behaviors characteristic of autism change for girls and boys across childhood. We found that girls mostly improve or remain stable in the severity level of their autism symptoms and its specific behaviors during childhood. They improved mostly in behaviors related to being socially engaged and responsive to others. Furthermore, we found that it is possible for girls with high early autism symptoms to show major improvement during childhood. Boys improved in some specific behaviors but worsened in others. Boys worsened in some behaviors that are key to engaging in social interactions. En ligne : https://dx.doi.org/10.1177/13623613251325317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Trajectories of autism symptom severity for boys and girls across childhood [Texte imprimé et/ou numérique] / Emilio FERRER, Auteur ; Meghan MILLER, Auteur ; Brianna HEATH, Auteur ; Derek S ANDREWS, Auteur ; Sally J ROGERS, Auteur ; Christine Wu NORDAHL, Auteur ; Marjorie SOLOMON, Auteur ; David G AMARAL, Auteur . - p.1782-1794. Langues : Anglais (eng) in Autism > 29-7 (July 2025) . - p.1782-1794 Mots-clés : autism spectrum disorders  behavioral measurement  communication and language  development  diagnosis  preschool children  repetitive behaviors and interests  social cognition and social behavior  sex differences Index. décimale : PER Périodiques Résumé : Girls, more than boys, experience a decrease in the severity of autism symptoms during childhood. It is unclear, however, which specific autistic behaviors change more for girls than for boys. Trajectories of autism symptoms were evaluated using the Autism Diagnostic Observation Schedule-calibrated severity scores (ADOS-CSS). Change in the specific behavioral characteristics of autism was assessed by studying individual ADOS items for 183 children (55 girls) from age 3-to-11?years. Girls decreased in total autism symptom severity (ADOS-CSS) and restricted/repetitive behavior severity (RRB-CSS) across childhood, while boys remained stable in both. Girls showed decreasing-severity trajectories for seven ADOS items and an increasing-trajectory for one item. Boys showed decreasing-severity trajectories for six items and increasing-severity trajectories for three items. Girls with higher ADOS-CSS at age 3 were more likely to decrease in total symptom severity than other girls. Girls in our study mostly improved or remained stable in autism symptom severity and its specific behaviors during childhood, especially behaviors related to being socially engaged and responsive. Boys" symptom change was variable over time and included both improvement and worsening, especially in social behaviors that are key to interaction. Girls with high early severity levels can potentially decrease substantially in severity during childhood.Lay Abstract The severity of overall autism symptoms tend to decrease more in autistic girls than in autistic boys during childhood, but we do not know which specific behaviors drive this difference. We studied how specific behaviors characteristic of autism change for girls and boys across childhood. We found that girls mostly improve or remain stable in the severity level of their autism symptoms and its specific behaviors during childhood. They improved mostly in behaviors related to being socially engaged and responsive to others. Furthermore, we found that it is possible for girls with high early autism symptoms to show major improvement during childhood. Boys improved in some specific behaviors but worsened in others. Boys worsened in some behaviors that are key to engaging in social interactions. En ligne : https://dx.doi.org/10.1177/13623613251325317 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Video Game Use, Aggression, and Social Impairment in Adolescents with Autism Spectrum Disorder / Konnor DAVIS in Journal of Autism and Developmental Disorders, 53-9 (September 2023)  

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Why do we need sex-balanced studies of autism? / Christine Wu NORDAHL in Autism Research, 16-9 (September 2023)  

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