Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury / Zeynep BAÅžGÖZE in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Titre : Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury Type de document : texte imprimé Auteurs : Zeynep BAÅžGÖZE, Auteur ; Salahudeen MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur Article en page(s) : p.1774-1792 Langues : Anglais (eng) Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Multimodal assessment of sustained threat in adolescents with nonsuicidal self-injury [texte imprimé] / Zeynep BAÅžGÖZE, Auteur ; Salahudeen MIRZA, Auteur ; Thanharat SILAMONGKOL, Auteur ; Dawson HILL, Auteur ; Conner FALKE, Auteur ; Michelle THAI, Auteur ; Melinda WESTLUND SCHREINER, Auteur ; Anna M. PARENTEAU, Auteur ; Donovan J. ROEDIGER, Auteur ; Timothy J. HENDRICKSON, Auteur ; Bryon A. MUELLER, Auteur ; Mark B. FIECAS, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Kathryn R. CULLEN, Auteur . - p.1774-1792. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1774-1792 Mots-clés : adolescents  nonsuicidal self-injury  RDoC  sustained threat Index. décimale : PER Périodiques Résumé : Nonsuicidal self-injury (NSSI) is a common but poorly understood phenomenon in adolescents. This study examined the Sustained Threat domain in female adolescents with a continuum of NSSI severity (N = 142). Across NSSI lifetime frequency and NSSI severity groups (No + Mild NSSI, Moderate NSSI, Severe NSSI), we examined physiological, self-reported and observed stress during the Trier Social Stress Test; amygdala volume; amygdala responses to threat stimuli; and resting-state functional connectivity (RSFC) between amygdala and medial prefrontal cortex (mPFC). Severe NSSI showed a blunted pattern of cortisol response, despite elevated reported and observed stress during TSST. Severe NSSI showed lower amygdala–mPFC RSFC; follow-up analyses suggested that this was more pronounced in those with a history of suicide attempt for both moderate and severe NSSI. Moderate NSSI showed elevated right amygdala activation to threat; multiple regressions showed that, when considered together with low amygdala–mPFC RSFC, higher right but lower left amygdala activation predicted NSSI severity. Patterns of interrelationships among Sustained Threat measures varied substantially across NSSI severity groups, and further by suicide attempt history. Study limitations include the cross-sectional design, missing data, and sampling biases. Our findings highlight the value of multilevel approaches in understanding the complexity of neurobiological mechanisms in adolescent NSSI. En ligne : http://dx.doi.org/10.1017/S0954579421000754 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence / Jessica BUTTS ; Katherine A. CAROSELLA ; Kathryn R. CULLEN ; Bonnie KLIMES-DOUGAN ; Salahudeen MIRZA ; Victoria PAPKE ; Andrea WIGLESWORTH in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2384-2401 Titre : Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence Type de document : texte imprimé Auteurs : Jessica BUTTS, Auteur ; Katherine A. CAROSELLA, Auteur ; Kathryn R. CULLEN, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Salahudeen MIRZA, Auteur ; Victoria PAPKE, Auteur ; Andrea WIGLESWORTH, Auteur Article en page(s) : p.2384-2401 Mots-clés : adolescence  depressive symptoms  resilience  self-worth  stress response Index. décimale : PER Périodiques Résumé : Resilience promotes positive adaptation to challenges and may facilitate recovery for adolescents experiencing psychopathology. This work examined concordance across the experience, expression, and physiological response to stress as a protective factor that may predict longitudinal patterns of psychopathology and well-being that mark resilience. Adolescents aged 14 17 at recruitment (oversampled for histories of non-suicidal self-injury; NSSI) were part of a three-wave (T1, T2, T3) longitudinal study. Multi-trajectory modeling produced four distinct profiles of stress experience, expression, and physiology at T1 (High-High-High, Low-Low-Low, High-Low-Moderate, and High-High-Low, respectively). Linear mixed-effect regressions modeled whether the profiles predicted depressive symptoms, suicide ideation, NSSI engagement, positive affect, satisfaction with life, and self-worth over time. Broadly, concordant stress response profiles (Low-Low-Low, High-High-High) were associated with resilient-like patterns of psychopathology and well-being over time. Adolescents with a concordant High-High-High stress response profile showed a trend of greater reduction in depressive symptoms (B = 0.71, p = 0.052), as well as increased global self-worth (B = 0.88, p = 0.055), from T2 to T3 compared to the discordant High-High-Low profile. Concordance across multi-level stress responses may be protective and promote future resilience, whereas blunted physiological responses in the presence of high perceived and expressed stress may indicate poorer outcomes over time. En ligne : https://dx.doi.org/10.1017/S0954579423000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Stress system concordance as a predictor of longitudinal patterns of resilience in adolescence [texte imprimé] / Jessica BUTTS, Auteur ; Katherine A. CAROSELLA, Auteur ; Kathryn R. CULLEN, Auteur ; Bonnie KLIMES-DOUGAN, Auteur ; Salahudeen MIRZA, Auteur ; Victoria PAPKE, Auteur ; Andrea WIGLESWORTH, Auteur . - p.2384-2401. in Development and Psychopathology > 35-5 (December 2023) . - p.2384-2401 Mots-clés : adolescence  depressive symptoms  resilience  self-worth  stress response Index. décimale : PER Périodiques Résumé : Resilience promotes positive adaptation to challenges and may facilitate recovery for adolescents experiencing psychopathology. This work examined concordance across the experience, expression, and physiological response to stress as a protective factor that may predict longitudinal patterns of psychopathology and well-being that mark resilience. Adolescents aged 14 17 at recruitment (oversampled for histories of non-suicidal self-injury; NSSI) were part of a three-wave (T1, T2, T3) longitudinal study. Multi-trajectory modeling produced four distinct profiles of stress experience, expression, and physiology at T1 (High-High-High, Low-Low-Low, High-Low-Moderate, and High-High-Low, respectively). Linear mixed-effect regressions modeled whether the profiles predicted depressive symptoms, suicide ideation, NSSI engagement, positive affect, satisfaction with life, and self-worth over time. Broadly, concordant stress response profiles (Low-Low-Low, High-High-High) were associated with resilient-like patterns of psychopathology and well-being over time. Adolescents with a concordant High-High-High stress response profile showed a trend of greater reduction in depressive symptoms (B = 0.71, p = 0.052), as well as increased global self-worth (B = 0.88, p = 0.055), from T2 to T3 compared to the discordant High-High-Low profile. Concordance across multi-level stress responses may be protective and promote future resilience, whereas blunted physiological responses in the presence of high perceived and expressed stress may indicate poorer outcomes over time. En ligne : https://dx.doi.org/10.1017/S0954579423000731 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022) / Salahudeen MIRZA in Journal of Child Psychology and Psychiatry, 64-6 (June 2023)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.968-971 Titre : Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022) Type de document : texte imprimé Auteurs : Salahudeen MIRZA, Auteur ; Anna R. DOCHERTY, Auteur ; Eric T. MONSON, Auteur ; Hilary H. COON, Auteur ; Brooks R. KEESHIN, Auteur ; Gabriel R. FRIES, Auteur Article en page(s) : p.968-971 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Preventing suicidal thoughts and behaviours (STB) among youth is a global public health priority. STB are known to have a heritable basis, and the development of risk for STB likely arises from complex gene-environment interactions across the life course. Lannoy et al. (Journal of Child Psychology and Psychiatry, 63, 2022 and 1164) describe a study in which polygenic risk for suicide attempt, as well as recent negative life events, were related to recent suicidal ideation in adolescents of about 17 years old. Building on this important work, we highlight several critical areas of focus for research in suicide genetics, including problems of measurement, as well as priorities for better uncovering the specific aetiological pathways to STB. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13778 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504 [article] Understanding heterogeneity in suicidal thoughts and behaviours and the implications for genetic studies - a commentary on Lannoy et al. (2022) [texte imprimé] / Salahudeen MIRZA, Auteur ; Anna R. DOCHERTY, Auteur ; Eric T. MONSON, Auteur ; Hilary H. COON, Auteur ; Brooks R. KEESHIN, Auteur ; Gabriel R. FRIES, Auteur . - p.968-971. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 64-6 (June 2023) . - p.968-971 Index. décimale : PER Périodiques Résumé : Preventing suicidal thoughts and behaviours (STB) among youth is a global public health priority. STB are known to have a heritable basis, and the development of risk for STB likely arises from complex gene-environment interactions across the life course. Lannoy et al. (Journal of Child Psychology and Psychiatry, 63, 2022 and 1164) describe a study in which polygenic risk for suicide attempt, as well as recent negative life events, were related to recent suicidal ideation in adolescents of about 17 years old. Building on this important work, we highlight several critical areas of focus for research in suicide genetics, including problems of measurement, as well as priorities for better uncovering the specific aetiological pathways to STB. En ligne : http://dx.doi.org/https://doi.org/10.1111/jcpp.13778 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=504

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