Examining the bidirectional association between emotion recognition and social autistic traits using observational and genetic analyses / Zoe E. REED in Journal of Child Psychology and Psychiatry, 62-11 (November 2021)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1330-1338 Titre : Examining the bidirectional association between emotion recognition and social autistic traits using observational and genetic analyses Type de document : texte imprimé Auteurs : Zoe E. REED, Auteur ; L. MAHEDY, Auteur ; Abigail JACKSON, Auteur ; George DAVEY SMITH, Auteur ; Ian S. PENTON-VOAK, Auteur ; A.S. ATTWOOD, Auteur ; Marcus R. MUNAFO, Auteur Article en page(s) : p.1330-1338 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/genetics  Autistic Disorder  Child  Emotions  Humans  Longitudinal Studies  Parents  Young Adult  Alspac  Autism spectrum disorder  emotion recognition  polygenic risk score  social autistic traits Index. décimale : PER Périodiques Résumé : BACKGROUND: There is mixed evidence for an association between autism spectrum disorder (ASD) and emotion recognition deficits. We sought to assess the bidirectionality of this association using phenotypic and genetic data in a large community sample. METHODS: Analyses were conducted in three stages. First, we examined the bidirectional association between social autistic traits at age 8 years and emotion recognition task (ERT) responses at age 24 years (Study 1; N = 3,562); and between Diagnostic Analysis of Non-Verbal Accuracy (DANVA) emotion recognition responses at age 8 years and social autistic traits at age 10 years (Study 2; N = 9,071). Next, we used genetic analyses (Study 3) to examine the association between polygenic risk scores for ASD and outcomes for the ERT and DANVA. The genetic correlation between ASD and ERT responses at age 24 was also estimated. Analyses were conducted in the Avon Longitudinal Study of Parents and Children. RESULTS: Social autistic traits at age 8 years were negatively associated with later total correct responses on ERT in Study 1 (b = -0.18; 95% CI: -0.27 to -0.09). We also found evidence of an association in Study 2 (b = -0.04; 95% CI: -0.05 to -0.03). We found the opposite association, that is positive, between the ASD polygenic risk score and ERT (b = 0.40; 95% CI: 0.10 to 0.70); however, this association varied across different p-value thresholds and would not survive multiple testing, so should be interpreted with caution. We did not find evidence of a genetic correlation between ASD and ERT. CONCLUSION: We found an observational association between poorer emotion recognition and increased social autistic traits. Our genetic analyses may suggest a shared genetic aetiology between these or a potential causal pathway; however, future research would benefit from using better powered GWAS to examine this further. Our results may inform interventions targeting emotion recognition. En ligne : http://dx.doi.org/10.1111/jcpp.13395 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456 [article] Examining the bidirectional association between emotion recognition and social autistic traits using observational and genetic analyses [texte imprimé] / Zoe E. REED, Auteur ; L. MAHEDY, Auteur ; Abigail JACKSON, Auteur ; George DAVEY SMITH, Auteur ; Ian S. PENTON-VOAK, Auteur ; A.S. ATTWOOD, Auteur ; Marcus R. MUNAFO, Auteur . - p.1330-1338. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 62-11 (November 2021) . - p.1330-1338 Mots-clés : Adult  Autism Spectrum Disorder/genetics  Autistic Disorder  Child  Emotions  Humans  Longitudinal Studies  Parents  Young Adult  Alspac  Autism spectrum disorder  emotion recognition  polygenic risk score  social autistic traits Index. décimale : PER Périodiques Résumé : BACKGROUND: There is mixed evidence for an association between autism spectrum disorder (ASD) and emotion recognition deficits. We sought to assess the bidirectionality of this association using phenotypic and genetic data in a large community sample. METHODS: Analyses were conducted in three stages. First, we examined the bidirectional association between social autistic traits at age 8 years and emotion recognition task (ERT) responses at age 24 years (Study 1; N = 3,562); and between Diagnostic Analysis of Non-Verbal Accuracy (DANVA) emotion recognition responses at age 8 years and social autistic traits at age 10 years (Study 2; N = 9,071). Next, we used genetic analyses (Study 3) to examine the association between polygenic risk scores for ASD and outcomes for the ERT and DANVA. The genetic correlation between ASD and ERT responses at age 24 was also estimated. Analyses were conducted in the Avon Longitudinal Study of Parents and Children. RESULTS: Social autistic traits at age 8 years were negatively associated with later total correct responses on ERT in Study 1 (b = -0.18; 95% CI: -0.27 to -0.09). We also found evidence of an association in Study 2 (b = -0.04; 95% CI: -0.05 to -0.03). We found the opposite association, that is positive, between the ASD polygenic risk score and ERT (b = 0.40; 95% CI: 0.10 to 0.70); however, this association varied across different p-value thresholds and would not survive multiple testing, so should be interpreted with caution. We did not find evidence of a genetic correlation between ASD and ERT. CONCLUSION: We found an observational association between poorer emotion recognition and increased social autistic traits. Our genetic analyses may suggest a shared genetic aetiology between these or a potential causal pathway; however, future research would benefit from using better powered GWAS to examine this further. Our results may inform interventions targeting emotion recognition. En ligne : http://dx.doi.org/10.1111/jcpp.13395 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=456

Mapping associations of polygenic scores with autistic and ADHD traits in a single city region / Zoe E. REED ; Richard THOMAS ; Andy BOYD ; Gareth J. GRIFFITH ; Tim T. MORRIS ; Dheeraj RAI ; David MANLEY ; George DAVEY SMITH ; Oliver S.P. DAVIS in Journal of Child Psychology and Psychiatry, 66-2 (February 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.202-213 Titre : Mapping associations of polygenic scores with autistic and ADHD traits in a single city region : Journal of Child Psychology and Psychiatry Type de document : texte imprimé Auteurs : Zoe E. REED, Auteur ; Richard THOMAS, Auteur ; Andy BOYD, Auteur ; Gareth J. GRIFFITH, Auteur ; Tim T. MORRIS, Auteur ; Dheeraj RAI, Auteur ; David MANLEY, Auteur ; George DAVEY SMITH, Auteur ; Oliver S.P. DAVIS, Auteur Article en page(s) : p.202-213 Langues : Anglais (eng) Mots-clés : Autism  ADHD  polygenic risk score  ALSPAC  spatial Index. décimale : PER Périodiques Résumé : Background The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? Methods We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N 4,255 6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. Results Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. Conclusions These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits. En ligne : https://doi.org/10.1111/jcpp.14047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545 [article] Mapping associations of polygenic scores with autistic and ADHD traits in a single city region : Journal of Child Psychology and Psychiatry [texte imprimé] / Zoe E. REED, Auteur ; Richard THOMAS, Auteur ; Andy BOYD, Auteur ; Gareth J. GRIFFITH, Auteur ; Tim T. MORRIS, Auteur ; Dheeraj RAI, Auteur ; David MANLEY, Auteur ; George DAVEY SMITH, Auteur ; Oliver S.P. DAVIS, Auteur . - p.202-213. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-2 (February 2025) . - p.202-213 Mots-clés : Autism  ADHD  polygenic risk score  ALSPAC  spatial Index. décimale : PER Périodiques Résumé : Background The genetic and environmental aetiology of autistic and Attention Deficit Hyperactivity Disorder (ADHD) traits is known to vary spatially, but does this translate into variation in the association of specific common genetic variants? Methods We mapped associations between polygenic scores for autism and ADHD and their respective traits in the Avon Longitudinal Study of Parents and Children (N 4,255 6,165) across the area surrounding Bristol, UK, and compared them to maps of environments associated with the prevalence of autism and ADHD. Results Our results suggest genetic associations vary spatially, with consistent patterns for autistic traits across polygenic scores constructed at different p-value thresholds. Patterns for ADHD traits were more variable across thresholds. We found that the spatial distributions often correlated with known environmental influences. Conclusions These findings shed light on the factors that contribute to the complex interplay between the environment and genetic influences in autistic and ADHD traits. En ligne : https://doi.org/10.1111/jcpp.14047 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=545

Where you live matters: visualizing environmental effects on reading attainment / Florina ERBELI ; Zoe E. REED ; Rasheda HAUGHBROOK ; Oliver S.P. DAVIS ; Sara A. HART ; Jeanette E. TAYLOR in Journal of Child Psychology and Psychiatry, 65-6 (June 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-6 (June 2024) . - p.798-808 Titre : Where you live matters: visualizing environmental effects on reading attainment Type de document : texte imprimé Auteurs : Florina ERBELI, Auteur ; Zoe E. REED, Auteur ; Rasheda HAUGHBROOK, Auteur ; Oliver S.P. DAVIS, Auteur ; Sara A. HART, Auteur ; Jeanette E. TAYLOR, Auteur Année de publication : 2024 Article en page(s) : p.798-808 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Background The way in which socioeconomic status (SES) moderates the etiology of reading attainment has been explored many times, with past work often finding that genetic influences are suppressed under conditions of socioeconomic deprivation and more fully realized under conditions of socioeconomic advantage: a gene-SES interaction. Additionally, past work has pointed toward the presence of gene-location interactions, with the relative influence of genes and environment varying across geographic regions of the same country/state. Method This study investigates the extent to which SES and geographical location interact to moderate the genetic and environmental components of reading attainment. Utilizing data from 2,135 twin pairs in Florida (mean age 13.82 years, range 10.71-17.77), the study operationalized reading attainment as reading comprehension scores from a statewide test and SES as household income. We applied a spatial twin analysis procedure to investigate how twin genetic and environmental estimates vary by geographic location. We then expanded this analysis to explore how the moderating role of SES on said genetic and environmental influences also varied by geographic location. Results A gene-SES interaction was found, with heritability of reading being suppressed in lower- (23%) versus higher-SES homes (78%). The magnitude of the moderating parameters were not consistent by location, however, and ranged from 0.10 to 0.10 for the moderating effect on genetic influences, and from 0.30 to 0.05 for the moderating effect on environmental influences. For smaller areas and those with less socioeconomic variability, the magnitude of the genetic moderating parameter was high, giving rise to more fully realized genetic influences on reading there. Conclusions SES significantly influences reading variability. However, a child's home location matters in both the overall etiology and how strongly SES moderates said etiologies. These results point toward the presence of multiple significant environmental factors that simultaneously, and inseparably, influence the underlying etiology of reading attainment. En ligne : https://doi.org/10.1111/jcpp.13909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529 [article] Where you live matters: visualizing environmental effects on reading attainment [texte imprimé] / Florina ERBELI, Auteur ; Zoe E. REED, Auteur ; Rasheda HAUGHBROOK, Auteur ; Oliver S.P. DAVIS, Auteur ; Sara A. HART, Auteur ; Jeanette E. TAYLOR, Auteur . - 2024 . - p.798-808. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-6 (June 2024) . - p.798-808 Index. décimale : PER Périodiques Résumé : Background The way in which socioeconomic status (SES) moderates the etiology of reading attainment has been explored many times, with past work often finding that genetic influences are suppressed under conditions of socioeconomic deprivation and more fully realized under conditions of socioeconomic advantage: a gene-SES interaction. Additionally, past work has pointed toward the presence of gene-location interactions, with the relative influence of genes and environment varying across geographic regions of the same country/state. Method This study investigates the extent to which SES and geographical location interact to moderate the genetic and environmental components of reading attainment. Utilizing data from 2,135 twin pairs in Florida (mean age 13.82 years, range 10.71-17.77), the study operationalized reading attainment as reading comprehension scores from a statewide test and SES as household income. We applied a spatial twin analysis procedure to investigate how twin genetic and environmental estimates vary by geographic location. We then expanded this analysis to explore how the moderating role of SES on said genetic and environmental influences also varied by geographic location. Results A gene-SES interaction was found, with heritability of reading being suppressed in lower- (23%) versus higher-SES homes (78%). The magnitude of the moderating parameters were not consistent by location, however, and ranged from 0.10 to 0.10 for the moderating effect on genetic influences, and from 0.30 to 0.05 for the moderating effect on environmental influences. For smaller areas and those with less socioeconomic variability, the magnitude of the genetic moderating parameter was high, giving rise to more fully realized genetic influences on reading there. Conclusions SES significantly influences reading variability. However, a child's home location matters in both the overall etiology and how strongly SES moderates said etiologies. These results point toward the presence of multiple significant environmental factors that simultaneously, and inseparably, influence the underlying etiology of reading attainment. En ligne : https://doi.org/10.1111/jcpp.13909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=529

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