5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study / Robert KUMSTA in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.755-762 Titre : 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study Type de document : Texte imprimé et/ou numérique Auteurs : Robert KUMSTA, Auteur ; Michael RUTTER, Auteur ; Jana KREPPNER, Auteur ; Celia BECKETT, Auteur ; Jenny CASTLE, Auteur ; Suzanne E. STEVENS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wolff SCHLOTZ, Auteur Année de publication : 2010 Article en page(s) : p.755-762 Langues : Anglais (eng) Mots-clés : Early-institutional-deprivation prospective-longitudinal-study gene–environment-interactions 5-HTTLPR depression Index. décimale : PER Périodiques Résumé : Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence. Methods: Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured. Results: There was a significant effect for genotype (p = .003) and a gene × environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05). Conclusions: The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02249.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study [Texte imprimé et/ou numérique] / Robert KUMSTA, Auteur ; Michael RUTTER, Auteur ; Jana KREPPNER, Auteur ; Celia BECKETT, Auteur ; Jenny CASTLE, Auteur ; Suzanne E. STEVENS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wolff SCHLOTZ, Auteur . - 2010 . - p.755-762. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.755-762 Mots-clés : Early-institutional-deprivation prospective-longitudinal-study gene–environment-interactions 5-HTTLPR depression Index. décimale : PER Périodiques Résumé : Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence. Methods: Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured. Results: There was a significant effect for genotype (p = .003) and a gene × environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05). Conclusions: The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02249.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

Adoptees' responses to separation from, and reunion with, their adoptive parent at age 4 years is associated with long-term persistence of autism symptoms following early severe institutional deprivation / Edmund J. S. SONUGA-BARKE in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.631-640 Titre : Adoptees' responses to separation from, and reunion with, their adoptive parent at age 4 years is associated with long-term persistence of autism symptoms following early severe institutional deprivation Type de document : Texte imprimé et/ou numérique Auteurs : Edmund J. S. SONUGA-BARKE, Auteur ; Mark KENNEDY, Auteur ; Dennis GOLM, Auteur ; Nicky KNIGHTS, Auteur ; Hanna KOVSHOFF, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Thomas G. O'CONNOR, Auteur ; Wolff SCHLOTZ, Auteur Article en page(s) : p.631-640 Langues : Anglais (eng) Mots-clés : Romanian adoptees  adversity  insecure other  institutional deprivation  longitudinal Index. décimale : PER Périodiques Résumé : Institutionally deprived young children often display distinctive patterns of attachment, classified as insecure/other (INS/OTH), with their adoptive parents. The associations between INS/OTH and developmental trajectories of mental health and neurodevelopmental symptoms were examined. Age 4 attachment status was determined for 97 Romanian adoptees exposed to up to 24 months of deprivation in Romanian orphanages and 49 nondeprived UK adoptees. Autism, inattention/overactivity and disinhibited-social-engagement symptoms, emotional problems, and IQ were measured at 4, 6, 11, and 15 years and in young adulthood. Romanian adoptees with over 6 months deprivation (Rom>6) were more often classified as INS/OTH than UK and Romanian adoptees with less than 6 months deprivation combined. INS/OTH was associated with cognitive impairment at age 4 years. The interaction between deprivation, attachment status, and age for autism spectrum disorder assessment was significant, with greater symptom persistence in Rom>6 INS/OTH(+) than other groups. This effect was reduced when IQ at age 4 was controlled for. Age 4 INS/OTH in Rom>6 was associated with worse autism spectrum disorder outcomes up to two decades later. Its association with cognitive impairment at age 4 is consistent with INS/OTH being an early marker of this negative developmental trajectory, rather than its cause. En ligne : http://dx.doi.org/10.1017/s0954579419000506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Adoptees' responses to separation from, and reunion with, their adoptive parent at age 4 years is associated with long-term persistence of autism symptoms following early severe institutional deprivation [Texte imprimé et/ou numérique] / Edmund J. S. SONUGA-BARKE, Auteur ; Mark KENNEDY, Auteur ; Dennis GOLM, Auteur ; Nicky KNIGHTS, Auteur ; Hanna KOVSHOFF, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Thomas G. O'CONNOR, Auteur ; Wolff SCHLOTZ, Auteur . - p.631-640. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.631-640 Mots-clés : Romanian adoptees  adversity  insecure other  institutional deprivation  longitudinal Index. décimale : PER Périodiques Résumé : Institutionally deprived young children often display distinctive patterns of attachment, classified as insecure/other (INS/OTH), with their adoptive parents. The associations between INS/OTH and developmental trajectories of mental health and neurodevelopmental symptoms were examined. Age 4 attachment status was determined for 97 Romanian adoptees exposed to up to 24 months of deprivation in Romanian orphanages and 49 nondeprived UK adoptees. Autism, inattention/overactivity and disinhibited-social-engagement symptoms, emotional problems, and IQ were measured at 4, 6, 11, and 15 years and in young adulthood. Romanian adoptees with over 6 months deprivation (Rom>6) were more often classified as INS/OTH than UK and Romanian adoptees with less than 6 months deprivation combined. INS/OTH was associated with cognitive impairment at age 4 years. The interaction between deprivation, attachment status, and age for autism spectrum disorder assessment was significant, with greater symptom persistence in Rom>6 INS/OTH(+) than other groups. This effect was reduced when IQ at age 4 was controlled for. Age 4 INS/OTH in Rom>6 was associated with worse autism spectrum disorder outcomes up to two decades later. Its association with cognitive impairment at age 4 is consistent with INS/OTH being an early marker of this negative developmental trajectory, rather than its cause. En ligne : http://dx.doi.org/10.1017/s0954579419000506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study / Mark KENNEDY in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1113-1125 Titre : Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study Type de document : Texte imprimé et/ou numérique Auteurs : Mark KENNEDY, Auteur ; Jana KREPPNER, Auteur ; Nicky KNIGHTS, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Dennis GOLM, Auteur ; Michael RUTTER, Auteur ; Wolff SCHLOTZ, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur Article en page(s) : p.1113-1125 Langues : Anglais (eng) Mots-clés : Adult attention-deficit/hyperactivity disorder  institutional deprivation  Romanian adoptees  adult onset  longitudinal  adversity Index. décimale : PER Périodiques Résumé : Background Early-life institutional deprivation is associated with attention-deficit/hyperactivity disorder (ADHD) later in childhood and adolescence. In this article, we examine, for the first time, the persistence of deprivation-related ADHD into young adulthood in a sample of individuals adopted as young children by UK families after periods in extremely depriving Romanian orphanages. Methods We estimated rates of ADHD at age 15 years and in young adulthood (ages 22–25 years) in individuals at low (LoDep; nondeprived UK adoptees and Romanian adoptees with less than 6-month institutional exposure) and high deprivation-related risk (HiDep; Romanian adoptees with more than 6-month exposure). Estimates were based on parent report using DSM-5 childhood symptom and impairment criteria. At age 15, data were available for 108 LoDep and 86 HiDep cases, while in young adulthood, the numbers were 83 and 60, respectively. Data on education and employment status, IQ, co-occurring symptoms of young adult disinhibited social engagement (DSE), autism spectrum disorder (ASD), cognitive impairment, conduct disorder (CD), callous-unemotional (CU) traits, anxiety, depression and quality of life (QoL) were also collected. Results ADHD rates in the LoDep group were similar to the general population in adolescence (5.6%) and adulthood (3.8%). HiDep individuals were, respectively, nearly four (19%) and over seven (29.3%) times more likely to meet criteria, than LoDep. Nine ‘onset’ young adult cases emerged, but these had a prior childhood history of elevated ADHD behaviours at ages 6, 11 and 15 years. Young adult ADHD was equally common in males and females, was predominantly inattentive in presentation and co-occurred with high levels of ASD, DSE and CU features. ADHD was associated with high unemployment and low educational attainment. Conclusion We provide the first evidence of a strong persistence into adulthood of a distinctively complex and impairing deprivation-related variant of ADHD. Our results confirm the powerful association of early experience with later development in a way that suggests a role for deep-seated alterations to brain structure and function. En ligne : http://dx.doi.org/10.1111/jcpp.12576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study [Texte imprimé et/ou numérique] / Mark KENNEDY, Auteur ; Jana KREPPNER, Auteur ; Nicky KNIGHTS, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Dennis GOLM, Auteur ; Michael RUTTER, Auteur ; Wolff SCHLOTZ, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur . - p.1113-1125. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1113-1125 Mots-clés : Adult attention-deficit/hyperactivity disorder  institutional deprivation  Romanian adoptees  adult onset  longitudinal  adversity Index. décimale : PER Périodiques Résumé : Background Early-life institutional deprivation is associated with attention-deficit/hyperactivity disorder (ADHD) later in childhood and adolescence. In this article, we examine, for the first time, the persistence of deprivation-related ADHD into young adulthood in a sample of individuals adopted as young children by UK families after periods in extremely depriving Romanian orphanages. Methods We estimated rates of ADHD at age 15 years and in young adulthood (ages 22–25 years) in individuals at low (LoDep; nondeprived UK adoptees and Romanian adoptees with less than 6-month institutional exposure) and high deprivation-related risk (HiDep; Romanian adoptees with more than 6-month exposure). Estimates were based on parent report using DSM-5 childhood symptom and impairment criteria. At age 15, data were available for 108 LoDep and 86 HiDep cases, while in young adulthood, the numbers were 83 and 60, respectively. Data on education and employment status, IQ, co-occurring symptoms of young adult disinhibited social engagement (DSE), autism spectrum disorder (ASD), cognitive impairment, conduct disorder (CD), callous-unemotional (CU) traits, anxiety, depression and quality of life (QoL) were also collected. Results ADHD rates in the LoDep group were similar to the general population in adolescence (5.6%) and adulthood (3.8%). HiDep individuals were, respectively, nearly four (19%) and over seven (29.3%) times more likely to meet criteria, than LoDep. Nine ‘onset’ young adult cases emerged, but these had a prior childhood history of elevated ADHD behaviours at ages 6, 11 and 15 years. Young adult ADHD was equally common in males and females, was predominantly inattentive in presentation and co-occurred with high levels of ASD, DSE and CU features. ADHD was associated with high unemployment and low educational attainment. Conclusion We provide the first evidence of a strong persistence into adulthood of a distinctively complex and impairing deprivation-related variant of ADHD. Our results confirm the powerful association of early experience with later development in a way that suggests a role for deep-seated alterations to brain structure and function. En ligne : http://dx.doi.org/10.1111/jcpp.12576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children / Wolff SCHLOTZ in Journal of Child Psychology and Psychiatry, 49-11 (November 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1228-1236 Titre : Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children Type de document : Texte imprimé et/ou numérique Auteurs : Wolff SCHLOTZ, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur Année de publication : 2008 Article en page(s) : p.1228-1236 Langues : Anglais (eng) Mots-clés : Fetal-growth temperament effortful-control behavioural-problems hyperactivity birth-weight Index. décimale : PER Périodiques Résumé : Background: Inverse associations of fetal growth with behavioural problems in childhood have been repeatedly reported, suggesting long-term effects of the prenatal developmental environment on behaviour later in life. However, no study so far has examined effects on temperament and potential developmental pathways. Temperamental traits may be particularly susceptible to neurodevelopmental alterations, and they are linked to behavioural problems. Therefore, we tested for associations of fetal growth with behavioural problems in children and tested if temperament mediated such effects. Methods: One hundred and thirty-nine mother–child pairs were recruited in early pregnancy. Weight, head circumference and gestational age were measured at birth, and the mother reported on their child's behavioural problems and temperament at age 7 to 9 years. Results: Birth weight and head circumference at birth adjusted for gestational age (i.e., fetal growth) were inversely associated with hyperactivity and total behavioural problems, and positively associated with the temperamental trait Effortful Control. Path analyses showed that Effortful Control mediated the effects of fetal growth on hyperactivity and total behavioural problems. Conclusions: Our results suggest that an adverse fetal environment is associated with behavioural problems in childhood, in particular in those children that show a low capacity for attentional and behavioural regulation. An adverse fetal environment might induce vulnerability for behavioural problems, or it might induce changes in temperament and behavioural problems independently, representing a common cause. Pathways are likely to be based on long-lasting neurodevelopmental alterations due to prenatal adversity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01946.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633 [article] Effortful control mediates associations of fetal growth with hyperactivity and behavioural problems in 7- to 9-year-old children [Texte imprimé et/ou numérique] / Wolff SCHLOTZ, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur . - 2008 . - p.1228-1236. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-11 (November 2008) . - p.1228-1236 Mots-clés : Fetal-growth temperament effortful-control behavioural-problems hyperactivity birth-weight Index. décimale : PER Périodiques Résumé : Background: Inverse associations of fetal growth with behavioural problems in childhood have been repeatedly reported, suggesting long-term effects of the prenatal developmental environment on behaviour later in life. However, no study so far has examined effects on temperament and potential developmental pathways. Temperamental traits may be particularly susceptible to neurodevelopmental alterations, and they are linked to behavioural problems. Therefore, we tested for associations of fetal growth with behavioural problems in children and tested if temperament mediated such effects. Methods: One hundred and thirty-nine mother–child pairs were recruited in early pregnancy. Weight, head circumference and gestational age were measured at birth, and the mother reported on their child's behavioural problems and temperament at age 7 to 9 years. Results: Birth weight and head circumference at birth adjusted for gestational age (i.e., fetal growth) were inversely associated with hyperactivity and total behavioural problems, and positively associated with the temperamental trait Effortful Control. Path analyses showed that Effortful Control mediated the effects of fetal growth on hyperactivity and total behavioural problems. Conclusions: Our results suggest that an adverse fetal environment is associated with behavioural problems in childhood, in particular in those children that show a low capacity for attentional and behavioural regulation. An adverse fetal environment might induce vulnerability for behavioural problems, or it might induce changes in temperament and behavioural problems independently, representing a common cause. Pathways are likely to be based on long-lasting neurodevelopmental alterations due to prenatal adversity. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01946.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=633

Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring / Wolff SCHLOTZ in Journal of Child Psychology and Psychiatry, 51-5 (May 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.594-602 Titre : Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring Type de document : Texte imprimé et/ou numérique Auteurs : Wolff SCHLOTZ, Auteur ; Sian M. ROBINSON, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur ; Catherine GALE, Auteur Année de publication : 2010 Article en page(s) : p.594-602 Langues : Anglais (eng) Mots-clés : Fetal-programming folate behavioural-difficulties fetal-brain-growth hyperactivity peer-problems Index. décimale : PER Périodiques Résumé : Background: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring. Methods: In a prospective cohort study, maternal red blood cell folate (RCF) was measured at 14 weeks of pregnancy and total folate intake (TFI) from food and supplements was assessed in early and late pregnancy. The offspring's head circumference and body weight were measured at birth and in infancy, and 100 mothers reported on children's behavioural difficulties at a mean age of 8.75 years using the Strengths and Difficulties Questionnaire. Results: Lower maternal RCF and TFI in early pregnancy were associated with higher childhood hyperactivity (RCF: beta = −.24; p = .013; TFI: beta = −.24; p = .022) and peer problems scores (RCF: beta = −.28; p = .004; TFI: beta = −.28; p = .009) in the offspring. Maternal gestational RCF was positively associated with head circumference at birth (adjusted for gestational age), and mediation analyses showed significant inverse indirect associations of RCF with hyperactivity/inattention and peer problems via fetal brain growth. Adjustment for mother's smoking and drinking alcohol during pregnancy did not change the results. Conclusions: Although the associations are small and residual confounding is possible, our data provide preliminary support for the hypothesis that lower folate status in early pregnancy might impair fetal brain development and affect hyperactivity/inattention and peer problems in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02182.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] Lower maternal folate status in early pregnancy is associated with childhood hyperactivity and peer problems in offspring [Texte imprimé et/ou numérique] / Wolff SCHLOTZ, Auteur ; Sian M. ROBINSON, Auteur ; Keith M. GODFREY, Auteur ; Alexander JONES, Auteur ; David I.W. PHILLIPS, Auteur ; Catherine GALE, Auteur . - 2010 . - p.594-602. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-5 (May 2010) . - p.594-602 Mots-clés : Fetal-programming folate behavioural-difficulties fetal-brain-growth hyperactivity peer-problems Index. décimale : PER Périodiques Résumé : Background: Maternal nutrition during pregnancy has been linked with fetal brain development and psychopathology in the offspring. We examined for associations of maternal folate status and dietary intake during pregnancy with brain growth and childhood behavioural difficulties in the offspring. Methods: In a prospective cohort study, maternal red blood cell folate (RCF) was measured at 14 weeks of pregnancy and total folate intake (TFI) from food and supplements was assessed in early and late pregnancy. The offspring's head circumference and body weight were measured at birth and in infancy, and 100 mothers reported on children's behavioural difficulties at a mean age of 8.75 years using the Strengths and Difficulties Questionnaire. Results: Lower maternal RCF and TFI in early pregnancy were associated with higher childhood hyperactivity (RCF: beta = −.24; p = .013; TFI: beta = −.24; p = .022) and peer problems scores (RCF: beta = −.28; p = .004; TFI: beta = −.28; p = .009) in the offspring. Maternal gestational RCF was positively associated with head circumference at birth (adjusted for gestational age), and mediation analyses showed significant inverse indirect associations of RCF with hyperactivity/inattention and peer problems via fetal brain growth. Adjustment for mother's smoking and drinking alcohol during pregnancy did not change the results. Conclusions: Although the associations are small and residual confounding is possible, our data provide preliminary support for the hypothesis that lower folate status in early pregnancy might impair fetal brain development and affect hyperactivity/inattention and peer problems in childhood. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2009.02182.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

Neuropsychological correlates of emotional lability in children with ADHD / Tobias BANASCHEWSKI in Journal of Child Psychology and Psychiatry, 53-11 (November 2012)  

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Oily fish intake during pregnancy – association with lower hyperactivity but not with higher full-scale IQ in offspring / Catherine GALE in Journal of Child Psychology and Psychiatry, 49-10 (October 2008)  

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Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model / Dennis GOLM in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

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