5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study / Robert KUMSTA in Journal of Child Psychology and Psychiatry, 51-7 (July 2010)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.755-762 Titre : 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study Type de document : Texte imprimé et/ou numérique Auteurs : Robert KUMSTA, Auteur ; Michael RUTTER, Auteur ; Jana KREPPNER, Auteur ; Celia BECKETT, Auteur ; Jenny CASTLE, Auteur ; Suzanne E. STEVENS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wolff SCHLOTZ, Auteur Année de publication : 2010 Article en page(s) : p.755-762 Langues : Anglais (eng) Mots-clés : Early-institutional-deprivation prospective-longitudinal-study gene–environment-interactions 5-HTTLPR depression Index. décimale : PER Périodiques Résumé : Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence. Methods: Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured. Results: There was a significant effect for genotype (p = .003) and a gene × environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05). Conclusions: The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02249.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101 [article] 5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study [Texte imprimé et/ou numérique] / Robert KUMSTA, Auteur ; Michael RUTTER, Auteur ; Jana KREPPNER, Auteur ; Celia BECKETT, Auteur ; Jenny CASTLE, Auteur ; Suzanne E. STEVENS, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur ; Keeley-Joanne BROOKES, Auteur ; Wolff SCHLOTZ, Auteur . - 2010 . - p.755-762. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 51-7 (July 2010) . - p.755-762 Mots-clés : Early-institutional-deprivation prospective-longitudinal-study gene–environment-interactions 5-HTTLPR depression Index. décimale : PER Périodiques Résumé : Background: A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence. Methods: Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured. Results: There was a significant effect for genotype (p = .003) and a gene × environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05). Conclusions: The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02249.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=101

Adoptees' responses to separation from, and reunion with, their adoptive parent at age 4 years is associated with long-term persistence of autism symptoms following early severe institutional deprivation / Edmund J. S. SONUGA-BARKE in Development and Psychopathology, 32-2 (May 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-2 (May 2020) . - p.631-640 Titre : Adoptees' responses to separation from, and reunion with, their adoptive parent at age 4 years is associated with long-term persistence of autism symptoms following early severe institutional deprivation Type de document : Texte imprimé et/ou numérique Auteurs : Edmund J. S. SONUGA-BARKE, Auteur ; Mark KENNEDY, Auteur ; Dennis GOLM, Auteur ; Nicky KNIGHTS, Auteur ; Hanna KOVSHOFF, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Thomas G. O'CONNOR, Auteur ; Wolff SCHLOTZ, Auteur Article en page(s) : p.631-640 Langues : Anglais (eng) Mots-clés : Romanian adoptees  adversity  insecure other  institutional deprivation  longitudinal Index. décimale : PER Périodiques Résumé : Institutionally deprived young children often display distinctive patterns of attachment, classified as insecure/other (INS/OTH), with their adoptive parents. The associations between INS/OTH and developmental trajectories of mental health and neurodevelopmental symptoms were examined. Age 4 attachment status was determined for 97 Romanian adoptees exposed to up to 24 months of deprivation in Romanian orphanages and 49 nondeprived UK adoptees. Autism, inattention/overactivity and disinhibited-social-engagement symptoms, emotional problems, and IQ were measured at 4, 6, 11, and 15 years and in young adulthood. Romanian adoptees with over 6 months deprivation (Rom>6) were more often classified as INS/OTH than UK and Romanian adoptees with less than 6 months deprivation combined. INS/OTH was associated with cognitive impairment at age 4 years. The interaction between deprivation, attachment status, and age for autism spectrum disorder assessment was significant, with greater symptom persistence in Rom>6 INS/OTH(+) than other groups. This effect was reduced when IQ at age 4 was controlled for. Age 4 INS/OTH in Rom>6 was associated with worse autism spectrum disorder outcomes up to two decades later. Its association with cognitive impairment at age 4 is consistent with INS/OTH being an early marker of this negative developmental trajectory, rather than its cause. En ligne : http://dx.doi.org/10.1017/s0954579419000506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426 [article] Adoptees' responses to separation from, and reunion with, their adoptive parent at age 4 years is associated with long-term persistence of autism symptoms following early severe institutional deprivation [Texte imprimé et/ou numérique] / Edmund J. S. SONUGA-BARKE, Auteur ; Mark KENNEDY, Auteur ; Dennis GOLM, Auteur ; Nicky KNIGHTS, Auteur ; Hanna KOVSHOFF, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Thomas G. O'CONNOR, Auteur ; Wolff SCHLOTZ, Auteur . - p.631-640. Langues : Anglais (eng) in Development and Psychopathology > 32-2 (May 2020) . - p.631-640 Mots-clés : Romanian adoptees  adversity  insecure other  institutional deprivation  longitudinal Index. décimale : PER Périodiques Résumé : Institutionally deprived young children often display distinctive patterns of attachment, classified as insecure/other (INS/OTH), with their adoptive parents. The associations between INS/OTH and developmental trajectories of mental health and neurodevelopmental symptoms were examined. Age 4 attachment status was determined for 97 Romanian adoptees exposed to up to 24 months of deprivation in Romanian orphanages and 49 nondeprived UK adoptees. Autism, inattention/overactivity and disinhibited-social-engagement symptoms, emotional problems, and IQ were measured at 4, 6, 11, and 15 years and in young adulthood. Romanian adoptees with over 6 months deprivation (Rom>6) were more often classified as INS/OTH than UK and Romanian adoptees with less than 6 months deprivation combined. INS/OTH was associated with cognitive impairment at age 4 years. The interaction between deprivation, attachment status, and age for autism spectrum disorder assessment was significant, with greater symptom persistence in Rom>6 INS/OTH(+) than other groups. This effect was reduced when IQ at age 4 was controlled for. Age 4 INS/OTH in Rom>6 was associated with worse autism spectrum disorder outcomes up to two decades later. Its association with cognitive impairment at age 4 is consistent with INS/OTH being an early marker of this negative developmental trajectory, rather than its cause. En ligne : http://dx.doi.org/10.1017/s0954579419000506 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=426

Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study / Mark KENNEDY in Journal of Child Psychology and Psychiatry, 57-10 (October 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1113-1125 Titre : Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study Type de document : Texte imprimé et/ou numérique Auteurs : Mark KENNEDY, Auteur ; Jana KREPPNER, Auteur ; Nicky KNIGHTS, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Dennis GOLM, Auteur ; Michael RUTTER, Auteur ; Wolff SCHLOTZ, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur Article en page(s) : p.1113-1125 Langues : Anglais (eng) Mots-clés : Adult attention-deficit/hyperactivity disorder  institutional deprivation  Romanian adoptees  adult onset  longitudinal  adversity Index. décimale : PER Périodiques Résumé : Background Early-life institutional deprivation is associated with attention-deficit/hyperactivity disorder (ADHD) later in childhood and adolescence. In this article, we examine, for the first time, the persistence of deprivation-related ADHD into young adulthood in a sample of individuals adopted as young children by UK families after periods in extremely depriving Romanian orphanages. Methods We estimated rates of ADHD at age 15 years and in young adulthood (ages 22–25 years) in individuals at low (LoDep; nondeprived UK adoptees and Romanian adoptees with less than 6-month institutional exposure) and high deprivation-related risk (HiDep; Romanian adoptees with more than 6-month exposure). Estimates were based on parent report using DSM-5 childhood symptom and impairment criteria. At age 15, data were available for 108 LoDep and 86 HiDep cases, while in young adulthood, the numbers were 83 and 60, respectively. Data on education and employment status, IQ, co-occurring symptoms of young adult disinhibited social engagement (DSE), autism spectrum disorder (ASD), cognitive impairment, conduct disorder (CD), callous-unemotional (CU) traits, anxiety, depression and quality of life (QoL) were also collected. Results ADHD rates in the LoDep group were similar to the general population in adolescence (5.6%) and adulthood (3.8%). HiDep individuals were, respectively, nearly four (19%) and over seven (29.3%) times more likely to meet criteria, than LoDep. Nine ‘onset’ young adult cases emerged, but these had a prior childhood history of elevated ADHD behaviours at ages 6, 11 and 15 years. Young adult ADHD was equally common in males and females, was predominantly inattentive in presentation and co-occurred with high levels of ASD, DSE and CU features. ADHD was associated with high unemployment and low educational attainment. Conclusion We provide the first evidence of a strong persistence into adulthood of a distinctively complex and impairing deprivation-related variant of ADHD. Our results confirm the powerful association of early experience with later development in a way that suggests a role for deep-seated alterations to brain structure and function. En ligne : http://dx.doi.org/10.1111/jcpp.12576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Early severe institutional deprivation is associated with a persistent variant of adult attention-deficit/hyperactivity disorder: clinical presentation, developmental continuities and life circumstances in the English and Romanian Adoptees study [Texte imprimé et/ou numérique] / Mark KENNEDY, Auteur ; Jana KREPPNER, Auteur ; Nicky KNIGHTS, Auteur ; Robert KUMSTA, Auteur ; Barbara MAUGHAN, Auteur ; Dennis GOLM, Auteur ; Michael RUTTER, Auteur ; Wolff SCHLOTZ, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur . - p.1113-1125. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-10 (October 2016) . - p.1113-1125 Mots-clés : Adult attention-deficit/hyperactivity disorder  institutional deprivation  Romanian adoptees  adult onset  longitudinal  adversity Index. décimale : PER Périodiques Résumé : Background Early-life institutional deprivation is associated with attention-deficit/hyperactivity disorder (ADHD) later in childhood and adolescence. In this article, we examine, for the first time, the persistence of deprivation-related ADHD into young adulthood in a sample of individuals adopted as young children by UK families after periods in extremely depriving Romanian orphanages. Methods We estimated rates of ADHD at age 15 years and in young adulthood (ages 22–25 years) in individuals at low (LoDep; nondeprived UK adoptees and Romanian adoptees with less than 6-month institutional exposure) and high deprivation-related risk (HiDep; Romanian adoptees with more than 6-month exposure). Estimates were based on parent report using DSM-5 childhood symptom and impairment criteria. At age 15, data were available for 108 LoDep and 86 HiDep cases, while in young adulthood, the numbers were 83 and 60, respectively. Data on education and employment status, IQ, co-occurring symptoms of young adult disinhibited social engagement (DSE), autism spectrum disorder (ASD), cognitive impairment, conduct disorder (CD), callous-unemotional (CU) traits, anxiety, depression and quality of life (QoL) were also collected. Results ADHD rates in the LoDep group were similar to the general population in adolescence (5.6%) and adulthood (3.8%). HiDep individuals were, respectively, nearly four (19%) and over seven (29.3%) times more likely to meet criteria, than LoDep. Nine ‘onset’ young adult cases emerged, but these had a prior childhood history of elevated ADHD behaviours at ages 6, 11 and 15 years. Young adult ADHD was equally common in males and females, was predominantly inattentive in presentation and co-occurred with high levels of ASD, DSE and CU features. ADHD was associated with high unemployment and low educational attainment. Conclusion We provide the first evidence of a strong persistence into adulthood of a distinctively complex and impairing deprivation-related variant of ADHD. Our results confirm the powerful association of early experience with later development in a way that suggests a role for deep-seated alterations to brain structure and function. En ligne : http://dx.doi.org/10.1111/jcpp.12576 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Poverty, early care, and stress reactivity in adolescence: Findings from a prospective, longitudinal study in South Africa / Richard M. PASCO FEARON in Development and Psychopathology, 29-2 (May 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-2 (May 2017) . - p.449-464 Titre : Poverty, early care, and stress reactivity in adolescence: Findings from a prospective, longitudinal study in South Africa Type de document : Texte imprimé et/ou numérique Auteurs : Richard M. PASCO FEARON, Auteur ; Mark TOMLINSON, Auteur ; Robert KUMSTA, Auteur ; Sarah SKEEN, Auteur ; Lynne MURRAY, Auteur ; Peter J. COOPER, Auteur ; Barak MORGAN, Auteur Article en page(s) : p.449-464 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A considerable body of evidence suggests that early caregiving may affect the short-term functioning and longer term development of the hypothalamic–pituitary–adrenocortical axis. Despite this, most research to date has been cross-sectional in nature or restricted to relatively short-term longitudinal follow-ups. More important, there is a paucity of research on the role of caregiving in low- and middle-income countries, where the protective effects of high-quality care in buffering the child's developing stress regulation systems may be crucial. In this paper, we report findings from a longitudinal study (N = 232) conducted in an impoverished periurban settlement in Cape Town, South Africa. We measured caregiving sensitivity and security of attachment in infancy and followed children up at age 13 years, when we conducted assessments of hypothalamus–pituitary–adrenocortical axis reactivity, as indexed by salivary cortisol during the Trier Social Stress Test. The findings indicated that insecure attachment was predictive of reduced cortisol responses to social stress, particularly in boys, and that attachment status moderated the impact of contextual adversity on stress responses: secure children in highly adverse circumstances did not show the blunted cortisol response shown by their insecure counterparts. Some evidence was found that sensitivity of care in infancy was also associated with cortisol reactivity, but in this case, insensitivity was associated with heightened cortisol reactivity, and only for girls. The discussion focuses on the potentially important role of caregiving in the long-term calibration of the stress system and the need to better understand the social and biological mechanisms shaping the stress response across development in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/s0954579417000104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Poverty, early care, and stress reactivity in adolescence: Findings from a prospective, longitudinal study in South Africa [Texte imprimé et/ou numérique] / Richard M. PASCO FEARON, Auteur ; Mark TOMLINSON, Auteur ; Robert KUMSTA, Auteur ; Sarah SKEEN, Auteur ; Lynne MURRAY, Auteur ; Peter J. COOPER, Auteur ; Barak MORGAN, Auteur . - p.449-464. Langues : Anglais (eng) in Development and Psychopathology > 29-2 (May 2017) . - p.449-464 Index. décimale : PER Périodiques Résumé : A considerable body of evidence suggests that early caregiving may affect the short-term functioning and longer term development of the hypothalamic–pituitary–adrenocortical axis. Despite this, most research to date has been cross-sectional in nature or restricted to relatively short-term longitudinal follow-ups. More important, there is a paucity of research on the role of caregiving in low- and middle-income countries, where the protective effects of high-quality care in buffering the child's developing stress regulation systems may be crucial. In this paper, we report findings from a longitudinal study (N = 232) conducted in an impoverished periurban settlement in Cape Town, South Africa. We measured caregiving sensitivity and security of attachment in infancy and followed children up at age 13 years, when we conducted assessments of hypothalamus–pituitary–adrenocortical axis reactivity, as indexed by salivary cortisol during the Trier Social Stress Test. The findings indicated that insecure attachment was predictive of reduced cortisol responses to social stress, particularly in boys, and that attachment status moderated the impact of contextual adversity on stress responses: secure children in highly adverse circumstances did not show the blunted cortisol response shown by their insecure counterparts. Some evidence was found that sensitivity of care in infancy was also associated with cortisol reactivity, but in this case, insensitivity was associated with heightened cortisol reactivity, and only for girls. The discussion focuses on the potentially important role of caregiving in the long-term calibration of the stress system and the need to better understand the social and biological mechanisms shaping the stress response across development in low- and middle-income countries. En ligne : http://dx.doi.org/10.1017/s0954579417000104 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model / Dennis GOLM in Journal of Child Psychology and Psychiatry, 61-9 (September 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1043-1053 Titre : Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model Type de document : Texte imprimé et/ou numérique Auteurs : Dennis GOLM, Auteur ; Barbara MAUGHAN, Auteur ; Edward D. BARKER, Auteur ; Jonathan HILL, Auteur ; Mark KENNEDY, Auteur ; Nicky KNIGHTS, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Wolff SCHLOTZ, Auteur ; Michael RUTTER, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur Article en page(s) : p.1043-1053 Langues : Anglais (eng) Mots-clés : Institutional deprivation  anxiety  depression  developmental cascades  emotional problems  longitudinal  natural experiment  neurodevelopmental problems  prospective Index. décimale : PER Périodiques Résumé : BACKGROUND: Using data from the English & Romanian Adoptees (ERA) study, we recently reported that early time-limited exposure to severe institutional deprivation is associated with early-onset and persistent neurodevelopmental problems and later-onset emotional problems. Here, we examine possible reasons for the late emergence of emotional problems in this cohort. Our main focus is on testing a developmental cascade mediated via the functional impact of early-appearing neurodevelopmental problems on late adolescent functioning. We also explore a second putative pathway via sensitization to stress. METHODS: The ERA study includes 165 Romanian individuals who spent their early lives in grossly depriving institutions and were subsequently adopted into UK families, along with 52 UK adoptees with no history of deprivation. Age six years symptoms of neurodevelopmental problems and age 15 anxiety/depression symptoms were assessed via parental reports. Young adult symptoms of depression and anxiety were assessed by both parent and self-reports; young adults also completed measures of stress reactivity, exposure to adverse life events, and functioning in work and interpersonal relationships. RESULTS: The path between early institutional deprivation and adult emotional problems was mediated via the impact of early neurodevelopmental problems on unemployment and poor friendship functioning during the transition to adulthood. The findings with regard to early deprivation, later life stress reactivity, and emotional problems were inconclusive. CONCLUSIONS: Our analysis suggests that the risk for adult depression and anxiety following extreme institutional deprivation is explained through the effects of early neurodevelopmental problems on later social and vocational functioning. Future research should more fully examine the role of stress susceptibility in this model. En ligne : http://dx.doi.org/10.1111/jcpp.13205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430 [article] Why does early childhood deprivation increase the risk for depression and anxiety in adulthood? A developmental cascade model [Texte imprimé et/ou numérique] / Dennis GOLM, Auteur ; Barbara MAUGHAN, Auteur ; Edward D. BARKER, Auteur ; Jonathan HILL, Auteur ; Mark KENNEDY, Auteur ; Nicky KNIGHTS, Auteur ; Jana KREPPNER, Auteur ; Robert KUMSTA, Auteur ; Wolff SCHLOTZ, Auteur ; Michael RUTTER, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur . - p.1043-1053. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-9 (September 2020) . - p.1043-1053 Mots-clés : Institutional deprivation  anxiety  depression  developmental cascades  emotional problems  longitudinal  natural experiment  neurodevelopmental problems  prospective Index. décimale : PER Périodiques Résumé : BACKGROUND: Using data from the English & Romanian Adoptees (ERA) study, we recently reported that early time-limited exposure to severe institutional deprivation is associated with early-onset and persistent neurodevelopmental problems and later-onset emotional problems. Here, we examine possible reasons for the late emergence of emotional problems in this cohort. Our main focus is on testing a developmental cascade mediated via the functional impact of early-appearing neurodevelopmental problems on late adolescent functioning. We also explore a second putative pathway via sensitization to stress. METHODS: The ERA study includes 165 Romanian individuals who spent their early lives in grossly depriving institutions and were subsequently adopted into UK families, along with 52 UK adoptees with no history of deprivation. Age six years symptoms of neurodevelopmental problems and age 15 anxiety/depression symptoms were assessed via parental reports. Young adult symptoms of depression and anxiety were assessed by both parent and self-reports; young adults also completed measures of stress reactivity, exposure to adverse life events, and functioning in work and interpersonal relationships. RESULTS: The path between early institutional deprivation and adult emotional problems was mediated via the impact of early neurodevelopmental problems on unemployment and poor friendship functioning during the transition to adulthood. The findings with regard to early deprivation, later life stress reactivity, and emotional problems were inconclusive. CONCLUSIONS: Our analysis suggests that the risk for adult depression and anxiety following extreme institutional deprivation is explained through the effects of early neurodevelopmental problems on later social and vocational functioning. Future research should more fully examine the role of stress susceptibility in this model. En ligne : http://dx.doi.org/10.1111/jcpp.13205 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=430

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