The gut-microbiota-brain axis in autism: what Drosophila models can offer? / Safa SALIM in Journal of Neurodevelopmental Disorders, 13 (2021)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 13 (2021) Titre : The gut-microbiota-brain axis in autism: what Drosophila models can offer? Type de document : texte imprimé Auteurs : Safa SALIM, Auteur ; Ayesha BANU, Auteur ; Amira ALWA, Auteur ; Swetha B.M. GOWDA, Auteur ; Farhan MOHAMMAD, Auteur Langues : Anglais (eng) Mots-clés : Animals  Autism Spectrum Disorder  Autistic Disorder  Brain  Drosophila  Gastrointestinal Microbiome  Humans  Autism spectrum disorders  Gastrointestinal issues  Gut-microbiome-brain axis Index. décimale : PER Périodiques Résumé : The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD. En ligne : https://dx.doi.org/10.1186/s11689-021-09378-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574 [article] The gut-microbiota-brain axis in autism: what Drosophila models can offer? [texte imprimé] / Safa SALIM, Auteur ; Ayesha BANU, Auteur ; Amira ALWA, Auteur ; Swetha B.M. GOWDA, Auteur ; Farhan MOHAMMAD, Auteur. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 13 (2021) Mots-clés : Animals  Autism Spectrum Disorder  Autistic Disorder  Brain  Drosophila  Gastrointestinal Microbiome  Humans  Autism spectrum disorders  Gastrointestinal issues  Gut-microbiome-brain axis Index. décimale : PER Périodiques Résumé : The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointestinal issues are a common comorbidity in patients with autism spectrum disorder (ASD). Although gut microbiome and microbial metabolites have been implicated in the etiology of ASD, the underlying molecular mechanism remains largely unknown. In this review, we have summarized recent findings in human and animal models highlighting the role of the gut-brain axis in ASD. We have discussed genetic and neurobehavioral characteristics of Drosophila as an animal model to study the role of GUMBA in ASD. The utility of Drosophila fruit flies as an amenable genetic tool, combined with axenic and gnotobiotic approaches, and availability of transgenic flies may reveal mechanistic insight into gut-microbiota-brain interactions and the impact of its alteration on behaviors relevant to neurological disorders like ASD. En ligne : https://dx.doi.org/10.1186/s11689-021-09378-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=574

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