Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits / Dorothea L. FLORIS in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 35p. Titre : Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits Type de document : texte imprimé Auteurs : Dorothea L. FLORIS, Auteur ; Anita D. BARBER, Auteur ; Mary Beth NEBEL, Auteur ; Mary MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; Deana CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; John SUCKLING, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur Article en page(s) : 35p. Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/physiopathology  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Female  Functional Laterality/physiology  Humans  Image Processing, Computer-Assisted  Language  Magnetic Resonance Imaging  Male  Neuropsychological Tests  Autism  Hemispheric specialization  Intrinsic functional connectivity  Lateralization  Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328 [article] Atypical lateralization of motor circuit functional connectivity in children with autism is associated with motor deficits [texte imprimé] / Dorothea L. FLORIS, Auteur ; Anita D. BARBER, Auteur ; Mary Beth NEBEL, Auteur ; Mary MARTINELLI, Auteur ; Meng-Chuan LAI, Auteur ; Deana CROCETTI, Auteur ; Simon BARON-COHEN, Auteur ; John SUCKLING, Auteur ; James J. PEKAR, Auteur ; Stewart H. MOSTOFSKY, Auteur . - 35p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 35p. Mots-clés : Autism Spectrum Disorder/physiopathology  Brain/diagnostic imaging/physiopathology  Case-Control Studies  Child  Female  Functional Laterality/physiology  Humans  Image Processing, Computer-Assisted  Language  Magnetic Resonance Imaging  Male  Neuropsychological Tests  Autism  Hemispheric specialization  Intrinsic functional connectivity  Lateralization  Motor deficits Index. décimale : PER Périodiques Résumé : BACKGROUND: Atypical lateralization of language-related functions has been repeatedly found in individuals with autism spectrum conditions (ASC). Few studies have, however, investigated deviations from typically occurring asymmetry of other lateralized cognitive and behavioural domains. Motor deficits are among the earliest and most prominent symptoms in individuals with ASC and precede core social and communicative symptoms. METHODS: Here, we investigate whether motor circuit connectivity is (1) atypically lateralized in children with ASC and (2) whether this relates to core autistic symptoms and motor performance. Participants comprised 44 right-handed high-functioning children with autism (36 males, 8 females) and 80 typically developing control children (58 males, 22 females) matched on age, sex and performance IQ. We examined lateralization of functional motor circuit connectivity based on homotopic seeds derived from peak activations during a finger tapping paradigm. Motor performance was assessed using the Physical and Neurological Examination for Subtle Signs (PANESS). RESULTS: Children with ASC showed rightward lateralization in mean motor circuit connectivity compared to typically developing children, and this was associated with poorer performance on all three PANESS measures. CONCLUSIONS: Our findings reveal that atypical lateralization in ASC is not restricted to language functions but is also present in circuits subserving motor functions and may underlie motor deficits in children with ASC. Future studies should investigate whether this is an age-invariant finding extending to adolescents and adults and whether these asymmetries relate to atypical lateralization in the language domain. En ligne : http://dx.doi.org/10.1186/s13229-016-0096-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=328

Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome / Gráinne M. MCALONAN in Journal of Child Psychology and Psychiatry, 49-12 (December 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1287-1295 Titre : Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome Type de document : texte imprimé Auteurs : Gráinne M. MCALONAN, Auteur ; John SUCKLING, Auteur ; Naikei WONG, Auteur ; Vinci CHEUNG, Auteur ; Nina LIENENKAEMPER, Auteur ; Charlton CHEUNG, Auteur ; Siew E. CHUA, Auteur Année de publication : 2008 Article en page(s) : p.1287-1295 Langues : Anglais (eng) Mots-clés : Asperger's-disorder autistic-disorder brain-imaging Index. décimale : PER Périodiques Résumé : Background: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance imaging (MRI) studies of autism are in disagreement. One possible reason is that the diagnosis of autism takes precedence over Asperger's syndrome and a distinction in language acquisition is rarely made. We therefore planned to examine a whole brain hypothesis that the patterns of grey matter differences in Asperger's syndrome and HFA can be distinguished. Methods: We used voxel-based computational morphometry to map grey matter volume differences in 33 children with either Asperger's syndrome or high-functioning autism compared to 55 typical developing control children balanced for age, IQ, gender, maternal language and ethnicity. Results: Children with HFA had significantly smaller grey matter volumes in subcortical, posterior cingulate and precuneus regions than the Asperger's group. Compared to controls, children with HFA had smaller grey matter volumes in predominantly fronto-pallidal regions, while children with Asperger's had less grey matter in mainly bilateral caudate and left thalamus. In addition we found a significant negative correlation between the size of a grey matter cluster around BA44 language area and the age of acquisition of phrase speech in the children with HFA. When the groups were combined we confirmed a mixed picture of smaller grey matter volumes in frontal, basal ganglia, temporal and parietal regions. Conclusions: Our study suggests that the underlying neurobiology in HFA and Asperger's syndrome is at least partly discrete. Future studies should therefore consider the history of language acquisition as a valuable tool to refine investigation of aetiological factors and management options in pervasive developmental disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01933.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=644 [article] Distinct patterns of grey matter abnormality in high-functioning autism and Asperger's syndrome [texte imprimé] / Gráinne M. MCALONAN, Auteur ; John SUCKLING, Auteur ; Naikei WONG, Auteur ; Vinci CHEUNG, Auteur ; Nina LIENENKAEMPER, Auteur ; Charlton CHEUNG, Auteur ; Siew E. CHUA, Auteur . - 2008 . - p.1287-1295. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-12 (December 2008) . - p.1287-1295 Mots-clés : Asperger's-disorder autistic-disorder brain-imaging Index. décimale : PER Périodiques Résumé : Background: Autism exists across a wide spectrum and there is considerable debate as to whether children with Asperger's syndrome, who have normal language milestones, should be considered to comprise a subgroup distinct other from high-functioning children with autism (HFA), who have a history of delayed language development. Magnetic resonance imaging (MRI) studies of autism are in disagreement. One possible reason is that the diagnosis of autism takes precedence over Asperger's syndrome and a distinction in language acquisition is rarely made. We therefore planned to examine a whole brain hypothesis that the patterns of grey matter differences in Asperger's syndrome and HFA can be distinguished. Methods: We used voxel-based computational morphometry to map grey matter volume differences in 33 children with either Asperger's syndrome or high-functioning autism compared to 55 typical developing control children balanced for age, IQ, gender, maternal language and ethnicity. Results: Children with HFA had significantly smaller grey matter volumes in subcortical, posterior cingulate and precuneus regions than the Asperger's group. Compared to controls, children with HFA had smaller grey matter volumes in predominantly fronto-pallidal regions, while children with Asperger's had less grey matter in mainly bilateral caudate and left thalamus. In addition we found a significant negative correlation between the size of a grey matter cluster around BA44 language area and the age of acquisition of phrase speech in the children with HFA. When the groups were combined we confirmed a mixed picture of smaller grey matter volumes in frontal, basal ganglia, temporal and parietal regions. Conclusions: Our study suggests that the underlying neurobiology in HFA and Asperger's syndrome is at least partly discrete. Future studies should therefore consider the history of language acquisition as a valuable tool to refine investigation of aetiological factors and management options in pervasive developmental disorders. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01933.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=644

Failure to deactivate the default mode network indicates a possible endophenotype of autism / Michael D. SPENCER in Molecular Autism, (December 2012)  

Public ISBD [article]  inMolecular Autism > (December 2012) . - 9 p. Titre : Failure to deactivate the default mode network indicates a possible endophenotype of autism Type de document : texte imprimé Auteurs : Michael D. SPENCER, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Andrew J. CALDER, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur Année de publication : 2012 Article en page(s) : 9 p. Langues : Anglais (eng) Mots-clés : Autism  Default mode network  Functional MRI  Endophenotype Index. décimale : PER Périodiques Résumé : BACKGROUND:Reduced activity during cognitively demanding tasks has been reported in the default mode network in typically developing controls and individuals with autism. However, no study has investigated the default mode network (DMN) in first-degree relatives of those with autism (such as siblings) and it is not known whether atypical activation of the DMN is specific to autism or whether it is also present in unaffected relatives. Here we use functional magnetic resonance imaging to investigate the pattern of task-related deactivation during completion of a visual search task, the Embedded Figures Task, in teenagers with autism, their unaffected siblings and typically developing controls.FINDINGS:We identified striking reductions in deactivation during the Embedded Figures Task in unaffected siblings compared to controls in brain regions corresponding to the default mode network. Adolescents with autism and their unaffected siblings similarly failed to deactivate regions, including posterior cingulate and bilateral inferior parietal cortex.CONCLUSIONS:This suggests that a failure to deactivate these regions is a functional endophenotype of autism, related to familial risk for the condition shared between individuals with autism and their siblings. En ligne : http://dx.doi.org/10.1186/2040-2392-3-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202 [article] Failure to deactivate the default mode network indicates a possible endophenotype of autism [texte imprimé] / Michael D. SPENCER, Auteur ; Lindsay R. CHURA, Auteur ; Rosemary J. HOLT, Auteur ; John SUCKLING, Auteur ; Andrew J. CALDER, Auteur ; Edward T. BULLMORE, Auteur ; Simon BARON-COHEN, Auteur . - 2012 . - 9 p. Langues : Anglais (eng) in Molecular Autism > (December 2012) . - 9 p. Mots-clés : Autism  Default mode network  Functional MRI  Endophenotype Index. décimale : PER Périodiques Résumé : BACKGROUND:Reduced activity during cognitively demanding tasks has been reported in the default mode network in typically developing controls and individuals with autism. However, no study has investigated the default mode network (DMN) in first-degree relatives of those with autism (such as siblings) and it is not known whether atypical activation of the DMN is specific to autism or whether it is also present in unaffected relatives. Here we use functional magnetic resonance imaging to investigate the pattern of task-related deactivation during completion of a visual search task, the Embedded Figures Task, in teenagers with autism, their unaffected siblings and typically developing controls.FINDINGS:We identified striking reductions in deactivation during the Embedded Figures Task in unaffected siblings compared to controls in brain regions corresponding to the default mode network. Adolescents with autism and their unaffected siblings similarly failed to deactivate regions, including posterior cingulate and bilateral inferior parietal cortex.CONCLUSIONS:This suggests that a failure to deactivate these regions is a functional endophenotype of autism, related to familial risk for the condition shared between individuals with autism and their siblings. En ligne : http://dx.doi.org/10.1186/2040-2392-3-15 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=202

From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition / Adam M.H. YOUNG in Molecular Autism, 7 (2016)  

Public ISBD [article]  inMolecular Autism > 7 (2016) . - 9p. Titre : From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition Type de document : texte imprimé Auteurs : Adam M.H. YOUNG, Auteur ; Bhismadev CHAKRABARTI, Auteur ; David ROBERTS, Auteur ; Meng-Chuan LAI, Auteur ; John SUCKLING, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : 9p. Langues : Anglais (eng) Mots-clés : Amniotic Fluid/chemistry  Animals  Antigens, Surface/immunology  Autism Spectrum Disorder/genetics/immunology/pathology  Autoantibodies/analysis  Body Fluids/chemistry  Brain/embryology/immunology/pathology  Brain Chemistry  Chemokines/analysis  Cytokines/analysis  Female  Glutamic Acid/metabolism  HLA Antigens/immunology  Haplorhini  Humans  Immunity, Maternally-Acquired  Inflammation  Inflammation Mediators/analysis  Lipopolysaccharides/blood  Maternal-Fetal Exchange  Mice  Nerve Tissue Proteins/immunology  Neuroglia/physiology  Neuroimaging  Pregnancy  Pregnancy Complications, Infectious/blood  Prenatal Exposure Delayed Effects  Signal Transduction  Autism  Brain  NF-kappaB Index. décimale : PER Périodiques Résumé : Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. En ligne : http://dx.doi.org/10.1186/s13229-016-0068-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329 [article] From molecules to neural morphology: understanding neuroinflammation in autism spectrum condition [texte imprimé] / Adam M.H. YOUNG, Auteur ; Bhismadev CHAKRABARTI, Auteur ; David ROBERTS, Auteur ; Meng-Chuan LAI, Auteur ; John SUCKLING, Auteur ; Simon BARON-COHEN, Auteur . - 9p. Langues : Anglais (eng) in Molecular Autism > 7 (2016) . - 9p. Mots-clés : Amniotic Fluid/chemistry  Animals  Antigens, Surface/immunology  Autism Spectrum Disorder/genetics/immunology/pathology  Autoantibodies/analysis  Body Fluids/chemistry  Brain/embryology/immunology/pathology  Brain Chemistry  Chemokines/analysis  Cytokines/analysis  Female  Glutamic Acid/metabolism  HLA Antigens/immunology  Haplorhini  Humans  Immunity, Maternally-Acquired  Inflammation  Inflammation Mediators/analysis  Lipopolysaccharides/blood  Maternal-Fetal Exchange  Mice  Nerve Tissue Proteins/immunology  Neuroglia/physiology  Neuroimaging  Pregnancy  Pregnancy Complications, Infectious/blood  Prenatal Exposure Delayed Effects  Signal Transduction  Autism  Brain  NF-kappaB Index. décimale : PER Périodiques Résumé : Growing evidence points toward a critical role for early (prenatal) atypical neurodevelopmental processes in the aetiology of autism spectrum condition (ASC). One such process that could impact early neural development is inflammation. We review the evidence for atypical expression of molecular markers in the amniotic fluid, serum, cerebrospinal fluid (CSF), and the brain parenchyma that suggest a role for inflammation in the emergence of ASC. This is complemented with a number of neuroimaging and neuropathological studies describing microglial activation. Implications for treatment are discussed. En ligne : http://dx.doi.org/10.1186/s13229-016-0068-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=329

Neural self-representation in autistic women and association with 'compensatory camouflaging' / Meng-Chuan LAI in Autism, 23-5 (July 2019)  

Public ISBD [article]  inAutism > 23-5 (July 2019) . - p.1210-1223 Titre : Neural self-representation in autistic women and association with 'compensatory camouflaging' Type de document : texte imprimé Auteurs : Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Amber N.V. RUIGROK, Auteur ; Edward T. BULLMORE, Auteur ; John SUCKLING, Auteur ; Bonnie AUYEUNG, Auteur ; Francesca HAPPE, Auteur ; Peter SZATMARI, Auteur ; Simon BARON-COHEN, Auteur Article en page(s) : p.1210-1223 Langues : Anglais (eng) Mots-clés : adult  autism  camouflaging  compensation  functional magnetic resonance imaging  gender  heterogeneity  mentalizing  self  sex Index. décimale : PER Périodiques Résumé : Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neural sex/gender differences are related to behavioural sex/gender differences in autism. Here, we examined whether atypical neural responses during mentalizing and self-representation are sex/gender-dependent in autistic adults and explored whether 'camouflaging' (acting as if behaviourally neurotypical) is associated with sex/gender-dependent neural responses. In total, N = 119 adults (33 typically developing males, 29 autistic males, 29 typically developing females and 28 autistic females) participated in a task-related functional magnetic resonance imaging paradigm to assess neural activation within right temporo-parietal junction and ventromedial prefrontal cortex during mentalizing and self-representation. Camouflaging in autism was quantified as the discrepancy between extrinsic behaviour in social-interpersonal contexts and intrinsic status. While autistic men showed hypoactive right temporo-parietal junction mentalizing and ventromedial prefrontal cortex self-representation responses compared to typically developing men, such neural responses in autistic women were not different from typically developing women. In autistic women only, increasing camouflaging was associated with heightened ventromedial prefrontal cortex self-representation response. There is a lack of impaired neural self-representation and mentalizing in autistic women compared to typically developing women. Camouflaging is heightened in autistic women and may relate to neural self-representation response. These results reveal brain-behaviour relations that help explain sex/gender-heterogeneity in social brain function in autism. En ligne : http://dx.doi.org/10.1177/1362361318807159 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Neural self-representation in autistic women and association with 'compensatory camouflaging' [texte imprimé] / Meng-Chuan LAI, Auteur ; Michael V. LOMBARDO, Auteur ; Bhismadev CHAKRABARTI, Auteur ; Amber N.V. RUIGROK, Auteur ; Edward T. BULLMORE, Auteur ; John SUCKLING, Auteur ; Bonnie AUYEUNG, Auteur ; Francesca HAPPE, Auteur ; Peter SZATMARI, Auteur ; Simon BARON-COHEN, Auteur . - p.1210-1223. Langues : Anglais (eng) in Autism > 23-5 (July 2019) . - p.1210-1223 Mots-clés : adult  autism  camouflaging  compensation  functional magnetic resonance imaging  gender  heterogeneity  mentalizing  self  sex Index. décimale : PER Périodiques Résumé : Prior work has revealed sex/gender-dependent autistic characteristics across behavioural and neural/biological domains. It remains unclear whether and how neural sex/gender differences are related to behavioural sex/gender differences in autism. Here, we examined whether atypical neural responses during mentalizing and self-representation are sex/gender-dependent in autistic adults and explored whether 'camouflaging' (acting as if behaviourally neurotypical) is associated with sex/gender-dependent neural responses. In total, N = 119 adults (33 typically developing males, 29 autistic males, 29 typically developing females and 28 autistic females) participated in a task-related functional magnetic resonance imaging paradigm to assess neural activation within right temporo-parietal junction and ventromedial prefrontal cortex during mentalizing and self-representation. Camouflaging in autism was quantified as the discrepancy between extrinsic behaviour in social-interpersonal contexts and intrinsic status. While autistic men showed hypoactive right temporo-parietal junction mentalizing and ventromedial prefrontal cortex self-representation responses compared to typically developing men, such neural responses in autistic women were not different from typically developing women. In autistic women only, increasing camouflaging was associated with heightened ventromedial prefrontal cortex self-representation response. There is a lack of impaired neural self-representation and mentalizing in autistic women compared to typically developing women. Camouflaging is heightened in autistic women and may relate to neural self-representation response. These results reveal brain-behaviour relations that help explain sex/gender-heterogeneity in social brain function in autism. En ligne : http://dx.doi.org/10.1177/1362361318807159 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

Psychological Correlates of Handedness and Corpus Callosum Asymmetry in Autism: The left Hemisphere Dysfunction Theory Revisited / Dorothea L. FLORIS in Journal of Autism and Developmental Disorders, 43-8 (August 2013)  

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Single-participant structural similarity matrices lead to greater accuracy in classification of participants than function in autism in MRI / Matthew J. LEMING in Molecular Autism, 12 (2021)  

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Subgrouping autism and ADHD based on structural MRI population modelling centiles / Clara PECCI-TERROBA in Molecular Autism, 16 (2025)  

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The oxytocin receptor gene predicts brain activity during an emotion recognition task in autism / Florina UZEFOVSKY in Molecular Autism, 10 (2019)  

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