The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders / Isaac Ho Wai WONG in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2478-2489 Titre : The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders Type de document : texte imprimé Auteurs : Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur Article en page(s) : p.2478-2489 Langues : Anglais (eng) Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Index. décimale : PER Périodiques Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders [texte imprimé] / Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur . - p.2478-2489. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2478-2489 Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Index. décimale : PER Périodiques Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

The Unique Roles of Executive Function in Co-Occurring Psychopathologies in Autism / Shing-Him NG in Autism Research, 19-8 (August 2026)  

Public ISBD [article]  inAutism Research > 19-8 (August 2026) . - p.e70296 Titre : The Unique Roles of Executive Function in Co-Occurring Psychopathologies in Autism Type de document : texte imprimé Auteurs : Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Angela Man Wai LAM, Auteur ; Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Maciej GABRYSIAK, Auteur ; Petrina Yau Pok LAU, Auteur ; Sandra Sau Man CHAN, Auteur ; Tyler M. MOORE, Auteur ; Kosha RUPAREL, Auteur ; Raquel E. GUR, Auteur ; Ruben C. GUR, Auteur ; Oscar Wing Ho WONG, Auteur Article en page(s) : p.e70296 Langues : Anglais (eng) Mots-clés : ADHD  anxiety  autism  cognition  executive function Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) often experience co-occurring psychiatric conditions, such as anxiety and attention-deficit/hyperactivity disorder (ADHD), which significantly impair daily functioning. However, the underlying mechanisms linking these conditions to core ASD features remain poorly understood. This study examined relationships between anxiety, ADHD symptoms, and multi-domain neurocognitive abilities in a clinic-based sample of 701 Chinese children with ASD (mean age 8?years, 13.4% female), using the Hong Kong version of the Penn Computerized Neurocognitive Battery. Initial correlations revealed negative associations between cognitive performance and ADHD symptoms, but no direct links with anxiety. Ordinal regression demonstrated that poorer executive function (EF) independently predicted greater ADHD severity along a continuum from no ADHD to subclinical features to co-occurring ADHD, in a dose-dependent manner, even after controlling for core autism symptoms, other cognitive domains, and full-scale IQ. Moderation analyses showed that stronger EF specifically buffered the associations between sensory hyper-responsiveness/sensory-seeking and anxiety symptoms?an effect not seen with other cognitive domains or full-scale IQ. These findings indicate that EF plays a unique, compensatory role in modulating the two most common co-occurring psychopathologies in ASD. Systematic assessment of EF could support early risk stratification, while EF-targeted interventions may help mitigate the burden of ADHD and anxiety in children with ASD. En ligne : https://doi.org/10.1002/aur.70296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589 [article] The Unique Roles of Executive Function in Co-Occurring Psychopathologies in Autism [texte imprimé] / Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Angela Man Wai LAM, Auteur ; Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Maciej GABRYSIAK, Auteur ; Petrina Yau Pok LAU, Auteur ; Sandra Sau Man CHAN, Auteur ; Tyler M. MOORE, Auteur ; Kosha RUPAREL, Auteur ; Raquel E. GUR, Auteur ; Ruben C. GUR, Auteur ; Oscar Wing Ho WONG, Auteur . - p.e70296. Langues : Anglais (eng) in Autism Research > 19-8 (August 2026) . - p.e70296 Mots-clés : ADHD  anxiety  autism  cognition  executive function Index. décimale : PER Périodiques Résumé : ABSTRACT Children with autism spectrum disorder (ASD) often experience co-occurring psychiatric conditions, such as anxiety and attention-deficit/hyperactivity disorder (ADHD), which significantly impair daily functioning. However, the underlying mechanisms linking these conditions to core ASD features remain poorly understood. This study examined relationships between anxiety, ADHD symptoms, and multi-domain neurocognitive abilities in a clinic-based sample of 701 Chinese children with ASD (mean age 8?years, 13.4% female), using the Hong Kong version of the Penn Computerized Neurocognitive Battery. Initial correlations revealed negative associations between cognitive performance and ADHD symptoms, but no direct links with anxiety. Ordinal regression demonstrated that poorer executive function (EF) independently predicted greater ADHD severity along a continuum from no ADHD to subclinical features to co-occurring ADHD, in a dose-dependent manner, even after controlling for core autism symptoms, other cognitive domains, and full-scale IQ. Moderation analyses showed that stronger EF specifically buffered the associations between sensory hyper-responsiveness/sensory-seeking and anxiety symptoms?an effect not seen with other cognitive domains or full-scale IQ. These findings indicate that EF plays a unique, compensatory role in modulating the two most common co-occurring psychopathologies in ASD. Systematic assessment of EF could support early risk stratification, while EF-targeted interventions may help mitigate the burden of ADHD and anxiety in children with ASD. En ligne : https://doi.org/10.1002/aur.70296 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=589

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