2 recherche sur le mot-clé 'functional gastrointestinal disorder'

An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study / Oscar W.H. WONG in Autism Research, 14-10 (October 2021)  

Public ISBD [article]  inAutism Research > 14-10 (October 2021) . - p.2131-2142 Titre : An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study Type de document : texte imprimé Auteurs : Oscar W.H. WONG, Auteur ; Angela M.W. LAM, Auteur ; Kelly Y.C. LAI, Auteur ; Suk Ling MA, Auteur ; Se-fong HUNG, Auteur ; Sandra CHAN, Auteur ; Sunny WONG, Auteur ; Patrick W.L. LEUNG, Auteur Article en page(s) : p.2131-2142 Langues : Anglais (eng) Mots-clés : Anxiety/complications  Autism Spectrum Disorder/complications/epidemiology  Autistic Disorder/complications/epidemiology  Case-Control Studies  Child  Child, Preschool  Gastrointestinal Diseases/complications/epidemiology  Humans  Male  abdominal pain  anxiety  autism  constipation  functional gastrointestinal disorder  gut-brain axis  nausea Index. décimale : PER Périodiques Résumé : Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in autism suggests complex reciprocal relationships, which are seldom explored in non-treatment-seeking FGID. The relationships between subtypes of FGID and anxiety are also unclear. This study recruited boys with autism and age-matched typically developing (TD) boys, aged 4-11 years, who were not actively seeking help for gastrointestinal problems. Their parents completed the Rome IV Diagnostic Questionnaires for Pediatric FGID. Four groups of children with and without autism/FGID were identified and compared on their anxiety level using the Spence children's anxiety scale. In 69 boys with autism and 69 age-matched TD boys, FGID were identified in 22 and 16 boys, respectively. ANCOVA demonstrated a significant interaction effect of autism and FGID on anxiety (F[1, 129] = 5.43, p = 0.021), while conditional logistic regression identified an interaction effect of autism and anxiety on the odds of FGID (OR 1.038, 95% CI 1.002-1.075, p = 0.038). Explorative post hoc analysis showed higher anxiety in functional nausea and vomiting disorder (p = 0.033) and functional abdominal pain disorder (p = 0.029) among boys with autism than TD boys with the same respective subtypes of FGID. In summary, among prepubertal boys with autism, the presence of FGID that are non-treatment-seeking in nature, has a significantly stronger association with higher levels of anxiety than TD boys. The strength of association may be more prominent in subtypes of FGID. Possible pathomechanisms including the underlying microbiota spectra and inflammatory paths should be explored in future studies. LAY SUMMARY: Anxiety and gastrointestinal problems are common symptoms in autism. Given that gut health could be linked to emotions, their association in young boys with autism was studied. The presence of nausea vomiting, or abdominal pain were associated with raised anxiety among boys with autism, yet this was not observed in typically developing boys. This suggests that anxiety among autistic children could be partly explained by the presence of FGID. En ligne : http://dx.doi.org/10.1002/aur.2555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study [texte imprimé] / Oscar W.H. WONG, Auteur ; Angela M.W. LAM, Auteur ; Kelly Y.C. LAI, Auteur ; Suk Ling MA, Auteur ; Se-fong HUNG, Auteur ; Sandra CHAN, Auteur ; Sunny WONG, Auteur ; Patrick W.L. LEUNG, Auteur . - p.2131-2142. Langues : Anglais (eng) in Autism Research > 14-10 (October 2021) . - p.2131-2142 Mots-clés : Anxiety/complications  Autism Spectrum Disorder/complications/epidemiology  Autistic Disorder/complications/epidemiology  Case-Control Studies  Child  Child, Preschool  Gastrointestinal Diseases/complications/epidemiology  Humans  Male  abdominal pain  anxiety  autism  constipation  functional gastrointestinal disorder  gut-brain axis  nausea Index. décimale : PER Périodiques Résumé : Children with autism commonly suffer from comorbid functional gastrointestinal disorders (FGID) and anxiety. The raised prevalence of both conditions in autism suggests complex reciprocal relationships, which are seldom explored in non-treatment-seeking FGID. The relationships between subtypes of FGID and anxiety are also unclear. This study recruited boys with autism and age-matched typically developing (TD) boys, aged 4-11 years, who were not actively seeking help for gastrointestinal problems. Their parents completed the Rome IV Diagnostic Questionnaires for Pediatric FGID. Four groups of children with and without autism/FGID were identified and compared on their anxiety level using the Spence children's anxiety scale. In 69 boys with autism and 69 age-matched TD boys, FGID were identified in 22 and 16 boys, respectively. ANCOVA demonstrated a significant interaction effect of autism and FGID on anxiety (F[1, 129] = 5.43, p = 0.021), while conditional logistic regression identified an interaction effect of autism and anxiety on the odds of FGID (OR 1.038, 95% CI 1.002-1.075, p = 0.038). Explorative post hoc analysis showed higher anxiety in functional nausea and vomiting disorder (p = 0.033) and functional abdominal pain disorder (p = 0.029) among boys with autism than TD boys with the same respective subtypes of FGID. In summary, among prepubertal boys with autism, the presence of FGID that are non-treatment-seeking in nature, has a significantly stronger association with higher levels of anxiety than TD boys. The strength of association may be more prominent in subtypes of FGID. Possible pathomechanisms including the underlying microbiota spectra and inflammatory paths should be explored in future studies. LAY SUMMARY: Anxiety and gastrointestinal problems are common symptoms in autism. Given that gut health could be linked to emotions, their association in young boys with autism was studied. The presence of nausea vomiting, or abdominal pain were associated with raised anxiety among boys with autism, yet this was not observed in typically developing boys. This suggests that anxiety among autistic children could be partly explained by the presence of FGID. En ligne : http://dx.doi.org/10.1002/aur.2555 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders / Isaac Ho Wai WONG in Autism Research, 18-12 (December 2025)  

Public ISBD [article]  inAutism Research > 18-12 (December 2025) . - p.2478-2489 Titre : The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders Type de document : texte imprimé Auteurs : Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur Article en page(s) : p.2478-2489 Langues : Anglais (eng) Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Index. décimale : PER Périodiques Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] The Distinctive Clinical Profiles of Children With Autism Suffering From Different Subtypes of Rome IV Functional Gastrointestinal Disorders [texte imprimé] / Isaac Ho Wai WONG, Auteur ; Sze-Mai NG, Auteur ; Angela Man Wai LAM, Auteur ; Sandra Sau Man CHAN, Auteur ; Shing-Him NG, Auteur ; Jet LEUNG, Auteur ; Keith Chun Lok LEE, Auteur ; Arthur Chun Chi WONG, Auteur ; Yuqi WU, Auteur ; Francis Ka Leung CHAN, Auteur ; Siew Chien NG, Auteur ; Oscar Wing Ho WONG, Auteur . - p.2478-2489. Langues : Anglais (eng) in Autism Research > 18-12 (December 2025) . - p.2478-2489 Mots-clés : anxiety  autism  feeding problems  functional gastrointestinal disorder  gut-brain axis  nutrition  sensory hyperresponsiveness Index. décimale : PER Périodiques Résumé : ABSTRACT Functional gastrointestinal disorders (FGIDs) are prevalent in children with autism and can interact with the neuropsychiatric symptoms bidirectionally. Moreover, FGIDs may affect feeding to jeopardize nutritional intake. Existing research often overlooks the heterogeneity of FGIDs. Understanding the clinical correlates of individual FGID subtypes may clarify the underlying gut-brain interactions to guide management. This study compared the core autistic symptoms, co-occurring psychopathologies, feeding behavior and dietary intake among 737 Chinese children with autism (mean age?=?7.76?years; 642 males and 95 females) who either experienced no FGID or experienced one of the three subtypes of ROME-IV FGID. FGIDs were present in 19.8% of participants and MANCOVA revealed distinct clinical profiles across FGID subtypes. Functional abdominal pain disorders (FAPD) were associated with more severe neuropsychiatric symptoms, including restricted and repetitive behavior, anxiety, sensory hyperresponsiveness, externalizing behavior, and feeding patterns of emotional under-eating, slowness in eating, and increased satiety response. Functional defecation disorders (FDD) were characterized by food fussiness, slowness in eating, increased satiety response, and decreased intake of water, protein and fiber. With a small sample size of six, functional nausea and vomiting disorders (FNVD) were associated with emotional overeating. These findings suggest FGID subtypes involve distinct gut-brain interactions. Sensory dysregulation may underlie the link between FAPD and neuropsychiatric symptoms, while food fussiness in FDD may contribute to constipation via reduced fiber and water intake. The management of FGIDs in autism should be tailored to specific subtypes and their clinical correlates. En ligne : https://doi.org/10.1002/aur.70138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578