Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study / Shane CLEARY in Autism Research, 19-1 (January 2026)  

Public ISBD [article]  inAutism Research > 19-1 (January 2026) . - p.e70143 Titre : Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study Type de document : texte imprimé Auteurs : Shane CLEARY, Auteur ; Sarah ASBURY, Auteur ; Russell J. SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Rosanna WEKSBERG, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammad AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jane A. FOSTER, Auteur Article en page(s) : p.e70143 Langues : Anglais (eng) Mots-clés : attention deficit hyperactivity disorder  autism spectrum disorder  based on MeSH terms  behavioral phenotypes  cluster analysis  gastrointestinal symptoms  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : ABSTRACT Neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), have heterogeneous behavioral phenotypes and substantial symptom overlap. Identifying transdiagnostic subgroups may help clarify this heterogeneity. This study aimed to identify behavior-based subgroups of children with NDD and explore links between gastrointestinal (GI) symptoms and behavioral symptoms. Using data from the Province of Ontario Neurodevelopmental Disorders (POND) network, we applied a heterogeneous mixture model (HMM) to behavioral data from 1716 participants, including typically developing (TD, n?=?210), ASD (n?=?747), and ADHD (n?=?759) and identified six distinct clusters. Five of the clusters included individuals with TD, ADHD, and ASD diagnoses. The remaining cluster exhibited the most severe behavior phenotype and was exclusively ADHD and ASD participants. Notably, GI symptoms were significantly more prevalent in the cluster with the most severe behavioral profile (?2 (5)?=?64.4, p? En ligne : https://doi.org/10.1002/aur.70143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578 [article] Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study [texte imprimé] / Shane CLEARY, Auteur ; Sarah ASBURY, Auteur ; Russell J. SCHACHAR, Auteur ; Jennifer CROSBIE, Auteur ; Robert NICOLSON, Auteur ; Rosanna WEKSBERG, Auteur ; Elizabeth KELLEY, Auteur ; Jessica JONES, Auteur ; Muhammad AYUB, Auteur ; Stelios GEORGIADES, Auteur ; Evdokia ANAGNOSTOU, Auteur ; Jane A. FOSTER, Auteur . - p.e70143. Langues : Anglais (eng) in Autism Research > 19-1 (January 2026) . - p.e70143 Mots-clés : attention deficit hyperactivity disorder  autism spectrum disorder  based on MeSH terms  behavioral phenotypes  cluster analysis  gastrointestinal symptoms  neurodevelopmental disorders Index. décimale : PER Périodiques Résumé : ABSTRACT Neurodevelopmental disorders (NDD), including autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD), have heterogeneous behavioral phenotypes and substantial symptom overlap. Identifying transdiagnostic subgroups may help clarify this heterogeneity. This study aimed to identify behavior-based subgroups of children with NDD and explore links between gastrointestinal (GI) symptoms and behavioral symptoms. Using data from the Province of Ontario Neurodevelopmental Disorders (POND) network, we applied a heterogeneous mixture model (HMM) to behavioral data from 1716 participants, including typically developing (TD, n?=?210), ASD (n?=?747), and ADHD (n?=?759) and identified six distinct clusters. Five of the clusters included individuals with TD, ADHD, and ASD diagnoses. The remaining cluster exhibited the most severe behavior phenotype and was exclusively ADHD and ASD participants. Notably, GI symptoms were significantly more prevalent in the cluster with the most severe behavioral profile (?2 (5)?=?64.4, p? En ligne : https://doi.org/10.1002/aur.70143 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=578

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