Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication / Karen J. MATHEWSON in Autism Research, 4-2 (April 2011)  

Public ISBD [article]  inAutism Research > 4-2 (April 2011) . - p.98-108 Titre : Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication Type de document : Texte imprimé et/ou numérique Auteurs : Karen J. MATHEWSON, Auteur ; Irene E. DRMIC, Auteur ; Michelle K. JETHA, Auteur ; Susan E. BRYSON, Auteur ; Joel O. GOLDBERG, Auteur ; Geoffrey B. C. HALL, Auteur ; Diane L. SANTESSO, Auteur ; Sidney SEGALOWITZ, Auteur ; Louis A. SCHMIDT, Auteur Année de publication : 2011 Article en page(s) : p.98-108 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASD)  heart period  respiratory sinus arrhythmia (RSA)  Stroop task Index. décimale : PER Périodiques Résumé : Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. En ligne : http://dx.doi.org/10.1002/aur.176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 [article] Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication [Texte imprimé et/ou numérique] / Karen J. MATHEWSON, Auteur ; Irene E. DRMIC, Auteur ; Michelle K. JETHA, Auteur ; Susan E. BRYSON, Auteur ; Joel O. GOLDBERG, Auteur ; Geoffrey B. C. HALL, Auteur ; Diane L. SANTESSO, Auteur ; Sidney SEGALOWITZ, Auteur ; Louis A. SCHMIDT, Auteur . - 2011 . - p.98-108. Langues : Anglais (eng) in Autism Research > 4-2 (April 2011) . - p.98-108 Mots-clés : autism spectrum disorders (ASD)  heart period  respiratory sinus arrhythmia (RSA)  Stroop task Index. décimale : PER Périodiques Résumé : Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. En ligne : http://dx.doi.org/10.1002/aur.176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121

Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders / Jeremy GOLDBERG in Journal of Autism and Developmental Disorders, 39-1 (January 2009)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104 Titre : Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur Année de publication : 2009 Article en page(s) : p.97-104 Langues : Anglais (eng) Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660 [article] Cortical Serotonin Type-2 Receptor Density in Parents of Children with Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Jeremy GOLDBERG, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Peter SZATMARI, Auteur ; George M. ANDERSON, Auteur ; Claude NAHMIAS, Auteur ; Geoffrey B. C. HALL, Auteur ; Ann THOMPSON, Auteur . - 2009 . - p.97-104. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 39-1 (January 2009) . - p.97-104 Mots-clés : Autism Positron-emission-tomography Setoperone [18Fluoro]setoperone Serotonin Endophenotype Index. décimale : PER Périodiques Résumé : Parents (N = 19) of children with autism spectrum disorders (ASD) and adult controls (N = 17) underwent positron emission tomography (PET) using [18F]setoperone to image cortical serotonin type-2 (5-HT2) receptors. The 5-HT2 binding potentials (BPs) were calculated by ratioing [18F]setoperone intensity in regions of interest (ROI) to cerebellar intensity. Cortical 5-HT2 BPs were significantly lower in parents compared to controls and platelet 5-HT levels were significantly negatively correlated with cortical 5-HT2 BP in parents. Lower cortical 5-HT2 receptor density in parents of children with ASD is consistent with reports of diminished 5-HT2 expression and functioning in individuals with ASD. Further research should examine the relationship of reduced 5-HT2 receptor expression to underlying causation and to clinical and neurochemical correlates of autistic behavior. En ligne : http://dx.doi.org/10.1007/s10803-008-0604-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=660

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