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Auteur Christine M. FREITAG |
Documents disponibles écrits par cet auteur (22)
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Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder / Leonie POLZER in Autism Research, 15-11 (November 2022)
[article]
Titre : Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Leonie POLZER, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur Article en page(s) : p.2167-2180 Langues : Anglais (eng) Mots-clés : Child Humans Child, Preschool Autism Spectrum Disorder/diagnosis Locus Coeruleus Norepinephrine Attention/physiology Pupil/physiology attention eye-tracking technology preschool pupil Index. décimale : PER Périodiques Résumé : Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus-norpinephrine (LC-NE) system modulates sensory reactivity and is a promising underlying mechanism. LC-NE activity is indexed by a stimulus-evoked pupillary response (SEPR) and partially by a luminance-adaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video-based eye tracking in young children (18-65 months) with ASD (n = 57) and typically developing (TD) children (n = 39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non-social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC-NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed. En ligne : http://dx.doi.org/10.1002/aur.2818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488
in Autism Research > 15-11 (November 2022) . - p.2167-2180[article] Pupillometric measures of altered stimulus-evoked locus coeruleus-norepinephrine activity explain attenuated social attention in preschoolers with autism spectrum disorder [Texte imprimé et/ou numérique] / Leonie POLZER, Auteur ; Christine M. FREITAG, Auteur ; Nico BAST, Auteur . - p.2167-2180.
Langues : Anglais (eng)
in Autism Research > 15-11 (November 2022) . - p.2167-2180
Mots-clés : Child Humans Child, Preschool Autism Spectrum Disorder/diagnosis Locus Coeruleus Norepinephrine Attention/physiology Pupil/physiology attention eye-tracking technology preschool pupil Index. décimale : PER Périodiques Résumé : Attenuated social attention has been described as a reduced preference for social compared to geometric motion in preschoolers with autism spectrum disorder (ASD). The locus coeruleus-norpinephrine (LC-NE) system modulates sensory reactivity and is a promising underlying mechanism. LC-NE activity is indexed by a stimulus-evoked pupillary response (SEPR) and partially by a luminance-adaptation pupillary response (LAPR), which were both shown to be aberrant in ASD. We examined whether SEPR and LAPR explain an attenuated social motion preference. We applied pupillometry via video-based eye tracking in young children (18-65 months) with ASD (n = 57) and typically developing (TD) children (n = 39) during a preferential looking paradigm of competing social and geometric motion and a changing light condition paradigm. We found an attenuated social motion preference in the ASD compared to the TD group. This was accompanied by atypical pupillometry showing a smaller SEPR to social motion, a larger SEPR to geometric motion and a reduced LAPR to a dark screen. SEPR but not LAPR explained the group difference in social motion preference. An ASD diagnosis was statistically predicted by the social motion preference, while this effect was mediated by the inclusion of SEPR to geometric and social motion. Our findings suggest a decreased sensory reactivity to social and increased reactivity to non-social motion in ASD, which may concurrently contribute to an attenuated social attention. The LC-NE system is supported as a promising underlying mechanism of altered social attention in young children with ASD, while the specificity of findings remains to be addressed. En ligne : http://dx.doi.org/10.1002/aur.2818 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=488 Quantitative Assessment of Neuromotor Function in Adolescents with High Functioning Autism and Asperger Syndrome / Christine M. FREITAG in Journal of Autism and Developmental Disorders, 37-5 (May 2007)
[article]
Titre : Quantitative Assessment of Neuromotor Function in Adolescents with High Functioning Autism and Asperger Syndrome Type de document : Texte imprimé et/ou numérique Auteurs : Christine M. FREITAG, Auteur ; Christina KLESER, Auteur ; Marc SCHNEIDER, Auteur ; Alexander VON GONTARD, Auteur Année de publication : 2007 Article en page(s) : p.948-959 Langues : Anglais (eng) Mots-clés : High-functioning-autism Asperger-syndrome neuromotor-function Index. décimale : PER Périodiques Résumé : Background: Motor impairment in children with Asperger Syndrome (AS) or High functioning autism (HFA) has been reported previously. This study presents results of a quantitative assessment of neuromotor skills in 14–22 year old HFA/AS.
Methods: 16 HFA/AS and 16 IQ-matched controls were assessed by the Zurich Neuromotor Assessment (ZNA).
Results: The HFA/AS group showed strongest impairments of dynamic balance skills and diadochokinesis. Motor abilities were associated with degree of social withdrawal in the full sample and severity of current autistic symptoms in the HFA/AS group.
Conclusion: Similar motor patterns as in younger children were found in the older adolescents. The association of autistic symptoms with motor performance points towards an essential role of motor impairment in autism spectrum disorders.
En ligne : http://dx.doi.org/10.1007/s10803-006-0235-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140
in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.948-959[article] Quantitative Assessment of Neuromotor Function in Adolescents with High Functioning Autism and Asperger Syndrome [Texte imprimé et/ou numérique] / Christine M. FREITAG, Auteur ; Christina KLESER, Auteur ; Marc SCHNEIDER, Auteur ; Alexander VON GONTARD, Auteur . - 2007 . - p.948-959.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.948-959
Mots-clés : High-functioning-autism Asperger-syndrome neuromotor-function Index. décimale : PER Périodiques Résumé : Background: Motor impairment in children with Asperger Syndrome (AS) or High functioning autism (HFA) has been reported previously. This study presents results of a quantitative assessment of neuromotor skills in 14–22 year old HFA/AS.
Methods: 16 HFA/AS and 16 IQ-matched controls were assessed by the Zurich Neuromotor Assessment (ZNA).
Results: The HFA/AS group showed strongest impairments of dynamic balance skills and diadochokinesis. Motor abilities were associated with degree of social withdrawal in the full sample and severity of current autistic symptoms in the HFA/AS group.
Conclusion: Similar motor patterns as in younger children were found in the older adolescents. The association of autistic symptoms with motor performance points towards an essential role of motor impairment in autism spectrum disorders.
En ligne : http://dx.doi.org/10.1007/s10803-006-0235-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case-control study / Luke MASON ; Christine ECKER ; Sarah BAUMEISTER ; Tobias BANASCHEWSKI ; Emily J. H. JONES ; Declan G. M. MURPHY ; Jan K. BUITELAAR ; Eva LOTH ; Gahan PANDINA ; Christine M. FREITAG in Molecular Autism, 14 (2023)
[article]
Titre : Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case-control study Type de document : Texte imprimé et/ou numérique Auteurs : Luke MASON, Auteur ; Christine ECKER, Auteur ; Sarah BAUMEISTER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Emily J. H. JONES, Auteur ; Declan G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Eva LOTH, Auteur ; Gahan PANDINA, Auteur ; Christine M. FREITAG, Auteur Article en page(s) : 5 p. Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : BACKGROUND: Attenuated social attention is a key marker of autism spectrum disorder (ASD). Recent neuroimaging findings also emphasize an altered processing of sensory salience in ASD. The locus coeruleus-norepinephrine system (LC-NE) has been established as a modulator of this sensory salience processing (SSP). We tested the hypothesis that altered LC-NE functioning contributes to different SSP and results in diverging social attention in ASD. METHODS: We analyzed the baseline eye-tracking data of the EU-AIMS Longitudinal European Autism Project (LEAP) for subgroups of autistic participants (n=166, age=6-30 years, IQ=61-138, gender [female/male]=41/125) or neurotypical development (TD; n=166, age=6-30 years, IQ=63-138, gender [female/male]=49/117) that were matched for demographic variables and data quality. Participants watched brief movie scenes (k=85) depicting humans in social situations (human) or without humans (non-human). SSP was estimated by gazes on physical and motion salience and a corresponding pupillary response that indexes phasic activity of the LC-NE. Social attention is estimated by gazes on faces via manual areas of interest definition. SSP is compared between groups and related to social attention by linear mixed models that consider temporal dynamics within scenes. Models are controlled for comorbid psychopathology, gaze behavior, and luminance. RESULTS: We found no group differences in gazes on salience, whereas pupillary responses were associated with altered gazes on physical and motion salience. In ASD compared to TD, we observed pupillary responses that were higher for non-human scenes and lower for human scenes. In ASD, we observed lower gazes on faces across the duration of the scenes. Crucially, this different social attention was influenced by gazes on physical salience and moderated by pupillary responses. LIMITATIONS: The naturalistic study design precluded experimental manipulations and stimulus control, while effect sizes were small to moderate. Covariate effects of age and IQ indicate that the findings differ between age and developmental subgroups. CONCLUSIONS: Pupillary responses as a proxy of LC-NE phasic activity during visual attention are suggested to modulate sensory salience processing and contribute to attenuated social attention in ASD. En ligne : http://dx.doi.org/10.1186/s13229-023-00537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513
in Molecular Autism > 14 (2023) . - 5 p.[article] Sensory salience processing moderates attenuated gazes on faces in autism spectrum disorder: a case-control study [Texte imprimé et/ou numérique] / Luke MASON, Auteur ; Christine ECKER, Auteur ; Sarah BAUMEISTER, Auteur ; Tobias BANASCHEWSKI, Auteur ; Emily J. H. JONES, Auteur ; Declan G. M. MURPHY, Auteur ; Jan K. BUITELAAR, Auteur ; Eva LOTH, Auteur ; Gahan PANDINA, Auteur ; Christine M. FREITAG, Auteur . - 5 p.
Langues : Anglais (eng)
in Molecular Autism > 14 (2023) . - 5 p.
Index. décimale : PER Périodiques Résumé : BACKGROUND: Attenuated social attention is a key marker of autism spectrum disorder (ASD). Recent neuroimaging findings also emphasize an altered processing of sensory salience in ASD. The locus coeruleus-norepinephrine system (LC-NE) has been established as a modulator of this sensory salience processing (SSP). We tested the hypothesis that altered LC-NE functioning contributes to different SSP and results in diverging social attention in ASD. METHODS: We analyzed the baseline eye-tracking data of the EU-AIMS Longitudinal European Autism Project (LEAP) for subgroups of autistic participants (n=166, age=6-30 years, IQ=61-138, gender [female/male]=41/125) or neurotypical development (TD; n=166, age=6-30 years, IQ=63-138, gender [female/male]=49/117) that were matched for demographic variables and data quality. Participants watched brief movie scenes (k=85) depicting humans in social situations (human) or without humans (non-human). SSP was estimated by gazes on physical and motion salience and a corresponding pupillary response that indexes phasic activity of the LC-NE. Social attention is estimated by gazes on faces via manual areas of interest definition. SSP is compared between groups and related to social attention by linear mixed models that consider temporal dynamics within scenes. Models are controlled for comorbid psychopathology, gaze behavior, and luminance. RESULTS: We found no group differences in gazes on salience, whereas pupillary responses were associated with altered gazes on physical and motion salience. In ASD compared to TD, we observed pupillary responses that were higher for non-human scenes and lower for human scenes. In ASD, we observed lower gazes on faces across the duration of the scenes. Crucially, this different social attention was influenced by gazes on physical salience and moderated by pupillary responses. LIMITATIONS: The naturalistic study design precluded experimental manipulations and stimulus control, while effect sizes were small to moderate. Covariate effects of age and IQ indicate that the findings differ between age and developmental subgroups. CONCLUSIONS: Pupillary responses as a proxy of LC-NE phasic activity during visual attention are suggested to modulate sensory salience processing and contribute to attenuated social attention in ASD. En ligne : http://dx.doi.org/10.1186/s13229-023-00537-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=513 Severe affective and behavioural dysregulation is associated with significant psychosocial adversity and impairment / Viola JUCKSCH in Journal of Child Psychology and Psychiatry, 52-6 (June 2011)
[article]
Titre : Severe affective and behavioural dysregulation is associated with significant psychosocial adversity and impairment Type de document : Texte imprimé et/ou numérique Auteurs : Viola JUCKSCH, Auteur ; Harriet SALBACH-ANDRAE, Auteur ; Klaus LENZ, Auteur ; Kirstin GOTH, Auteur ; Manfred DOPFNER, Auteur ; Fritz POUSTKA, Auteur ; Christine M. FREITAG, Auteur ; Gerd LEHMKUHL, Auteur ; Ulrike LEHMKUHL, Auteur ; Martin HOLTMANN, Auteur Année de publication : 2011 Article en page(s) : p.686-695 Langues : Anglais (eng) Mots-clés : Pediatric dysregulation profile Child Behavior Checklist psychosocial adversity prevalence Index. décimale : PER Périodiques Résumé : Background: Recently, a highly heritable behavioral phenotype of simultaneous deviance on the Anxious/Depressed, Attention Problems, and Aggressive Behavior syndrome scales has been identified on the Child Behavior Checklist (CBCL–Dysregulation Profile, CBCL-DP). This study aims to investigate psychosocial adversity and impairment of the CBCL-DP.
Methods: A total of 9024 patients aged 4–18 years were assessed using the CBCL, and the axes V and VI of ICD-10.
Results: ANOVA revealed significant differences regarding psychosocial adversity and impairment between patients with CBCL-DP phenotype and the clinical control group, patients with attention problems, and patients with attention problems and additional anxious/depressed symptoms as assessed by the CBCL. Patients with CBCL-DP showed significant psychosocial adversity and impairment. However, in most cases patients with aggressive behavior showed equal psychosocial adversity as patients with CBCL-DP.
Conclusions: Findings suggest the CBCL-DP phenotype to be associated with significant psychosocial adversity and impairment either as a cause or an effect of the syndrome. Clinicians should carefully address psychosocial adversity and impairment with particular attention to the adversity and impairment of adolescents with CBCL-DP.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02322.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126
in Journal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.686-695[article] Severe affective and behavioural dysregulation is associated with significant psychosocial adversity and impairment [Texte imprimé et/ou numérique] / Viola JUCKSCH, Auteur ; Harriet SALBACH-ANDRAE, Auteur ; Klaus LENZ, Auteur ; Kirstin GOTH, Auteur ; Manfred DOPFNER, Auteur ; Fritz POUSTKA, Auteur ; Christine M. FREITAG, Auteur ; Gerd LEHMKUHL, Auteur ; Ulrike LEHMKUHL, Auteur ; Martin HOLTMANN, Auteur . - 2011 . - p.686-695.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-6 (June 2011) . - p.686-695
Mots-clés : Pediatric dysregulation profile Child Behavior Checklist psychosocial adversity prevalence Index. décimale : PER Périodiques Résumé : Background: Recently, a highly heritable behavioral phenotype of simultaneous deviance on the Anxious/Depressed, Attention Problems, and Aggressive Behavior syndrome scales has been identified on the Child Behavior Checklist (CBCL–Dysregulation Profile, CBCL-DP). This study aims to investigate psychosocial adversity and impairment of the CBCL-DP.
Methods: A total of 9024 patients aged 4–18 years were assessed using the CBCL, and the axes V and VI of ICD-10.
Results: ANOVA revealed significant differences regarding psychosocial adversity and impairment between patients with CBCL-DP phenotype and the clinical control group, patients with attention problems, and patients with attention problems and additional anxious/depressed symptoms as assessed by the CBCL. Patients with CBCL-DP showed significant psychosocial adversity and impairment. However, in most cases patients with aggressive behavior showed equal psychosocial adversity as patients with CBCL-DP.
Conclusions: Findings suggest the CBCL-DP phenotype to be associated with significant psychosocial adversity and impairment either as a cause or an effect of the syndrome. Clinicians should carefully address psychosocial adversity and impairment with particular attention to the adversity and impairment of adolescents with CBCL-DP.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02322.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126 START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial / Christine M. FREITAG ; Arne POPMA ; Lucres NAUTA-JANSEN ; Kerstin KONRAD ; Eva UNTERNAEHRER ; Katharina ACKERMANN ; Anka BERNHARD ; Anne MARTINELLI ; Helena OLDENHOF ; Malou GUNDLACH ; Gregor KOHLS ; Martin PRÄTZLICH ; Meinhard KIESER ; Ronald LIMPRECHT ; Nora M. RASCHLE ; Noortje VRIENDS ; Robert L. TRESTMAN ; Marietta KIRCHNER ; Linda KERSTEN in Journal of Child Psychology and Psychiatry, 65-3 (March 2023)
[article]
Titre : START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial Type de document : Texte imprimé et/ou numérique Auteurs : Christine M. FREITAG, Auteur ; Arne POPMA, Auteur ; Lucres NAUTA-JANSEN, Auteur ; Kerstin KONRAD, Auteur ; Eva UNTERNAEHRER, Auteur ; Katharina ACKERMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Helena OLDENHOF, Auteur ; Malou GUNDLACH, Auteur ; Gregor KOHLS, Auteur ; Martin PRÄTZLICH, Auteur ; Meinhard KIESER, Auteur ; Ronald LIMPRECHT, Auteur ; Nora M. RASCHLE, Auteur ; Noortje VRIENDS, Auteur ; Robert L. TRESTMAN, Auteur ; Marietta KIRCHNER, Auteur ; Linda KERSTEN, Auteur Article en page(s) : p.316-327 Index. décimale : PER Périodiques Résumé : Background Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive-behavioral, dialectical behavior therapy-oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods A total of 127 girls were included in this prospective, cluster randomized, multi-center, parallel group, quasi-randomized, controlled phase III trial, which tested the efficacy of START NOW (n?=?72) compared with standard care (treatment as usual, TAU, n?=?55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (+1.5) years on average (range: 12?20?years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post-treatment (T3), and (2) between T1 and 12-week follow-up (T4). Results Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW?=??4.87, ?2.49; TAU?=??4.94, ?2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU (?0.056; 95% CI?=??1.860, 1.749; Hedge's g?=??0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 (?2.326; 95% CI?=??4.274, ?0.378; Hedge's g?=??0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent-reported irritability at post assessment. Conclusions Although START NOW did not result in greater symptom reduction from baseline to post-treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow-up with a medium effect size, which indicates a clinically meaningful delayed treatment effect. En ligne : https://doi.org/10.1111/jcpp.13896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520
in Journal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.316-327[article] START NOW: a cognitive behavioral skills training for adolescent girls with conduct or oppositional defiant disorder ? a randomized clinical trial [Texte imprimé et/ou numérique] / Christine M. FREITAG, Auteur ; Arne POPMA, Auteur ; Lucres NAUTA-JANSEN, Auteur ; Kerstin KONRAD, Auteur ; Eva UNTERNAEHRER, Auteur ; Katharina ACKERMANN, Auteur ; Anka BERNHARD, Auteur ; Anne MARTINELLI, Auteur ; Helena OLDENHOF, Auteur ; Malou GUNDLACH, Auteur ; Gregor KOHLS, Auteur ; Martin PRÄTZLICH, Auteur ; Meinhard KIESER, Auteur ; Ronald LIMPRECHT, Auteur ; Nora M. RASCHLE, Auteur ; Noortje VRIENDS, Auteur ; Robert L. TRESTMAN, Auteur ; Marietta KIRCHNER, Auteur ; Linda KERSTEN, Auteur . - p.316-327.
in Journal of Child Psychology and Psychiatry > 65-3 (March 2023) . - p.316-327
Index. décimale : PER Périodiques Résumé : Background Conduct disorder (CD) and oppositional defiant disorder (ODD) both convey a high risk for maladjustment later in life and are understudied in girls. Here, we aimed at confirming the efficacy of START NOW, a cognitive-behavioral, dialectical behavior therapy-oriented skills training program aiming to enhance emotion regulation skills, interpersonal and psychosocial adjustment, adapted for female adolescents with CD or ODD. Methods A total of 127 girls were included in this prospective, cluster randomized, multi-center, parallel group, quasi-randomized, controlled phase III trial, which tested the efficacy of START NOW (n?=?72) compared with standard care (treatment as usual, TAU, n?=?55). All female adolescents had a clinical diagnosis of CD or ODD, were 15.6 (+1.5) years on average (range: 12?20?years), and were institutionalized in youth welfare institutions. The two primary endpoints were the change in number of CD/ODD symptoms between (1) baseline (T1) and post-treatment (T3), and (2) between T1 and 12-week follow-up (T4). Results Both treatment groups showed reduced CD/ODD symptoms at T3 compared with T1 (95% CI: START NOW?=??4.87, ?2.49; TAU?=??4.94, ?2.30). There was no significant mean difference in CD/ODD symptom reduction from T1 to T3 between START NOW and TAU (?0.056; 95% CI?=??1.860, 1.749; Hedge's g?=??0.011). However, the START NOW group showed greater mean symptom reduction from T1 to T4 (?2.326; 95% CI?=??4.274, ?0.378; Hedge's g?=??0.563). Additionally, secondary endpoint results revealed a reduction in staff reported aggression and parent-reported irritability at post assessment. Conclusions Although START NOW did not result in greater symptom reduction from baseline to post-treatment compared with TAU, the START NOW group showed greater symptom reduction from baseline to follow-up with a medium effect size, which indicates a clinically meaningful delayed treatment effect. En ligne : https://doi.org/10.1111/jcpp.13896 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 The Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses / Joseph D. BUXBAUM in Molecular Autism, (May 2014)
PermalinkUsing the brief observation of social communication change (BOSCC) to measure autism-specific development / Janina KITZEROW in Autism Research, 9-9 (September 2016)
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